NZ333497A - High dose liposomal aerosol formulations comprising cyclosporin A or budesonide - Google Patents

High dose liposomal aerosol formulations comprising cyclosporin A or budesonide

Info

Publication number: NZ333497A
Authority: NZ; New Zealand
Prior art keywords: cyclosporin; budesonide; aerosol composition; liposome; high dose
Prior art date: 1996-07-03

Application number

NZ333497A

Other languages

English (en)

Inventor

J Clifford Waldrep

Vernon Knight

Melanie B Black

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-03

Filing date

1997-07-02

Publication date

2000-06-23

1996-10-16 Priority claimed from US08/731,605 external-priority patent/US5958378A/en

1997-07-02 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

2000-06-23 Publication of NZ333497A publication Critical patent/NZ333497A/en

Links

239000000443 aerosol Substances 0.000 title claims abstract description 147
239000000203 mixture Substances 0.000 title claims abstract description 123
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 110
229930105110 Cyclosporin A Natural products 0.000 title claims abstract description 110
108010036949 Cyclosporine Proteins 0.000 title claims abstract description 110
229960001265 ciclosporin Drugs 0.000 title claims abstract description 110
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 title claims abstract description 35
229960004436 budesonide Drugs 0.000 title claims abstract description 35
238000009472 formulation Methods 0.000 title description 64
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MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Otolaryngology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NZ333497A 1996-07-03 1997-07-02 High dose liposomal aerosol formulations comprising cyclosporin A or budesonide NZ333497A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US67565496A	1996-07-03	1996-07-03
US08/731,605 US5958378A (en)	1996-07-03	1996-10-16	High dose liposomal aerosol formulations containing cyclosporin A or budesonide
PCT/US1997/011696 WO1998000111A1 (en)	1996-07-03	1997-07-02	High dose liposomal aerosol formulations

Publications (1)

Publication Number	Publication Date
NZ333497A true NZ333497A (en)	2000-06-23

Family

ID=27101390

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ333497A NZ333497A (en)	1996-07-03	1997-07-02	High dose liposomal aerosol formulations comprising cyclosporin A or budesonide

Country Status (10)

Country	Link
EP (1)	EP0959874B1 (2)
JP (1)	JP2001524930A (2)
CN (1)	CN1094345C (2)
AT (2)	ATE268163T1 (2)
AU (1)	AU732124B2 (2)
CA (1)	CA2259185C (2)
DE (2)	DE69736083T2 (2)
NZ (1)	NZ333497A (2)
TW (1)	TW497974B (2)
WO (1)	WO1998000111A1 (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2013027042A1 (en)	2011-08-19	2013-02-28	Nufarm Uk Limited	Novel inhibitor compositions and methods of use

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US6417172B1 (en) *	1995-06-05	2002-07-09	Eisai Co., Ltd.	Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5863910A (en) *	1996-01-12	1999-01-26	Bolonick; Joel	Treatment of chronic inflammatory disorders of the gastrointestinal tract
US6090407A (en)	1997-09-23	2000-07-18	Research Development Foundation	Small particle liposome aerosols for delivery of anti-cancer drugs
US7348025B2 (en)	1997-09-23	2008-03-25	Research Development Foundation	Small particle liposome aerosols for delivery of anticancer drugs
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6946117B1 (en)	1997-09-29	2005-09-20	Nektar Therapeutics	Stabilized preparations for use in nebulizers
US6433040B1 (en)	1997-09-29	2002-08-13	Inhale Therapeutic Systems, Inc.	Stabilized bioactive preparations and methods of use
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- 1997-02-17 TW TW086101859A patent/TW497974B/zh not_active IP Right Cessation
- 1997-07-02 CA CA002259185A patent/CA2259185C/en not_active Expired - Fee Related
- 1997-07-02 WO PCT/US1997/011696 patent/WO1998000111A1/en not_active Ceased
- 1997-07-02 AU AU36508/97A patent/AU732124B2/en not_active Ceased
- 1997-07-02 DE DE69736083T patent/DE69736083T2/de not_active Expired - Lifetime
- 1997-07-02 DE DE69729391T patent/DE69729391T2/de not_active Expired - Lifetime
- 1997-07-02 AT AT97933287T patent/ATE268163T1/de not_active IP Right Cessation
- 1997-07-02 AT AT04009645T patent/ATE328583T1/de not_active IP Right Cessation
- 1997-07-02 CN CN97196141A patent/CN1094345C/zh not_active Expired - Fee Related
- 1997-07-02 NZ NZ333497A patent/NZ333497A/en not_active IP Right Cessation
- 1997-07-02 EP EP97933287A patent/EP0959874B1/en not_active Expired - Lifetime
- 1997-07-02 JP JP50449998A patent/JP2001524930A/ja active Pending

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Publication number	Publication date
CA2259185C (en)	2009-12-15
ATE268163T1 (de)	2004-06-15
DE69736083T2 (de)	2006-12-28
DE69729391T2 (de)	2005-06-02
AU732124B2 (en)	2001-04-12
CN1094345C (zh)	2002-11-20
AU3650897A (en)	1998-01-21
CN1224347A (zh)	1999-07-28
ATE328583T1 (de)	2006-06-15
EP0959874B1 (en)	2004-06-02
EP0959874A1 (en)	1999-12-01
DE69736083D1 (de)	2006-07-20
TW497974B (en)	2002-08-11
WO1998000111A1 (en)	1998-01-08
DE69729391D1 (de)	2004-07-08
JP2001524930A (ja)	2001-12-04
CA2259185A1 (en)	1998-01-08
EP0959874A4 (2)	1999-12-22

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Date	Code	Title
2001-07-27	RENW	Renewal (renewal fees accepted)
2004-07-30	RENW	Renewal (renewal fees accepted)
2007-07-27	RENW	Renewal (renewal fees accepted)
2010-08-27	RENW	Renewal (renewal fees accepted)
2017-07-28	EXPY	Patent expired

Publication	Publication Date	Title
US5958378A (en)	1999-09-28	High dose liposomal aerosol formulations containing cyclosporin A or budesonide
CA2259185C (en)	2009-12-15	High dose liposomal aerosol formulations
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JP6357481B2 (ja)	2018-07-11	プロスタサイクリン化合物およびプロスタサイクリン化合物を使用する方法
US20070065369A1 (en)	2007-03-22	Novel methods and composition for delivering macromolecules to or via the respiratory tract
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WO2015138423A9 (en)	2015-11-12	Prostacylin compositions and methods for using the same
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US20020076383A1 (en)	2002-06-20	Composition and method for treatment of otitis external
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Khale et al.	2011	Liposomal Nebulising Solutions of Salbutamol Sulphate-A Characterisation Study
CN121313612A (zh)	2026-01-13	一种长效干粉微球吸入剂及制备方法和应用

NZ333497A - High dose liposomal aerosol formulations comprising cyclosporin A or budesonide - Google Patents

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