ATE268163T1 - Hochdosierte liposomale aerosolformulierung - Google Patents

Hochdosierte liposomale aerosolformulierung

Info

Publication number: ATE268163T1
Authority: AT; Austria
Prior art keywords: high dose; compounds; phospholipid; aerosol composition; liposome aerosol
Prior art date: 1996-07-03

Application number

AT97933287T

Other languages

English (en)

Inventor

J Clifford Waldrep

Vernon Knight

Melanie B Black

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-03

Filing date

1997-07-02

Publication date

2004-06-15

1996-10-16 Priority claimed from US08/731,605 external-priority patent/US5958378A/en

1997-07-02 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

2004-06-15 Application granted granted Critical

2004-06-15 Publication of ATE268163T1 publication Critical patent/ATE268163T1/de

Links

239000000443 aerosol Substances 0.000 title abstract 5
239000000203 mixture Substances 0.000 title abstract 5
238000009472 formulation Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
239000002502 liposome Substances 0.000 abstract 4
150000003904 phospholipids Chemical class 0.000 abstract 4
229930105110 Cyclosporin A Natural products 0.000 abstract 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 2
108010036949 Cyclosporine Proteins 0.000 abstract 2
229960001265 ciclosporin Drugs 0.000 abstract 2
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 abstract 1
230000001093 anti-cancer Effects 0.000 abstract 1
230000000843 anti-fungal effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
229960004436 budesonide Drugs 0.000 abstract 1
239000003862 glucocorticoid Substances 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
229940037128 systemic glucocorticoids Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Dispersion Chemistry (AREA)
Otolaryngology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97933287T 1996-07-03 1997-07-02 Hochdosierte liposomale aerosolformulierung ATE268163T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US67565496A	1996-07-03	1996-07-03
US08/731,605 US5958378A (en)	1996-07-03	1996-10-16	High dose liposomal aerosol formulations containing cyclosporin A or budesonide
PCT/US1997/011696 WO1998000111A1 (en)	1996-07-03	1997-07-02	High dose liposomal aerosol formulations

Publications (1)

Publication Number	Publication Date
ATE268163T1 true ATE268163T1 (de)	2004-06-15

Family

ID=27101390

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT97933287T ATE268163T1 (de)	1996-07-03	1997-07-02	Hochdosierte liposomale aerosolformulierung
AT04009645T ATE328583T1 (de)	1996-07-03	1997-07-02	Hochdosierte liposomale aerosolformulierung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT04009645T ATE328583T1 (de)	1996-07-03	1997-07-02	Hochdosierte liposomale aerosolformulierung

Country Status (10)

Country	Link
EP (1)	EP0959874B1 (de)
JP (1)	JP2001524930A (de)
CN (1)	CN1094345C (de)
AT (2)	ATE268163T1 (de)
AU (1)	AU732124B2 (de)
CA (1)	CA2259185C (de)
DE (2)	DE69736083T2 (de)
NZ (1)	NZ333497A (de)
TW (1)	TW497974B (de)
WO (1)	WO1998000111A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6417172B1 (en) *	1995-06-05	2002-07-09	Eisai Co., Ltd.	Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5863910A (en) *	1996-01-12	1999-01-26	Bolonick; Joel	Treatment of chronic inflammatory disorders of the gastrointestinal tract
US7348025B2 (en)	1997-09-23	2008-03-25	Research Development Foundation	Small particle liposome aerosols for delivery of anticancer drugs
US6090407A (en)	1997-09-23	2000-07-18	Research Development Foundation	Small particle liposome aerosols for delivery of anti-cancer drugs
US6433040B1 (en)	1997-09-29	2002-08-13	Inhale Therapeutic Systems, Inc.	Stabilized bioactive preparations and methods of use
US6946117B1 (en)	1997-09-29	2005-09-20	Nektar Therapeutics	Stabilized preparations for use in nebulizers
US6565885B1 (en)	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US20020006901A1 (en)	1999-02-05	2002-01-17	Aldo T. Iacono	Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease
CA2375371A1 (en) *	1999-06-04	2000-12-14	Skyepharma Inc.	Oil-core compositions for the sustained release of hydrophobic drugs
AU777338B2 (en) *	1999-12-04	2004-10-14	Research Development Foundation	Carbon dioxide enhancement of inhalation therapy
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
DK1280520T4 (en)	2000-05-10	2018-06-25	Novartis Ag	Phospholipid based powders for drug delivery
WO2003053411A1 (en)	2001-12-19	2003-07-03	Nektar Therapeutics	Pulmonary delivery of aminoglycosides
CA2486622A1 (en) *	2002-05-20	2003-12-04	Research Development Foundation	Aerosol drug inhibition of lung metastases
US20050255154A1 (en)	2004-05-11	2005-11-17	Lena Pereswetoff-Morath	Method and composition for treating rhinitis
RU2468797C2 (ru) *	2005-06-09	2012-12-10	Биолипокс Аб	Способ и композиция для лечения воспалительных нарушений
DE102006051512A1 (de) *	2005-12-06	2007-06-14	Pari GmbH Spezialisten für effektive Inhalation	Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
CN101502484B (zh) *	2006-12-26	2011-04-20	济南康泉医药科技有限公司	同载糖皮质激素和化疗药物的抗癌缓释剂
CA2705159A1 (en) *	2007-11-09	2009-05-14	Map Pharmaceuticals, Inc.	Methods for administering corticosteroid formulations
DK2544663T3 (en)	2010-03-12	2018-04-16	Berg Llc	INTRAVENOUS FORMULATIONS OF COENZYM Q10 (CoQ10) AND PROCEDURES FOR USING IT
US9144575B2 (en)	2010-07-28	2015-09-29	Life Technologies Corporation	Anti-viral azide containing compounds
US20120028335A1 (en)	2010-07-28	2012-02-02	Life Technologies Corporation	Anti-viral azide-containing compounds
CN103442694B (zh) *	2010-08-05	2015-09-09	皮拉马尔企业有限公司	治疗感染性疾病的肺部给药的抗感染分子微粒制剂
CN102008713B (zh) *	2010-12-02	2012-10-24	深圳海王药业有限公司	环孢素a前体脂质体、药物组合物及其制备方法
JP5932993B2 (ja) *	2011-06-17	2016-06-08	バーグエルエルシー	吸入可能な医薬組成物
GB201114332D0 (en)	2011-08-19	2011-10-05	Nufarm Uk Ltd	Novel inhibitor compositions and methods of use
CN108977412A (zh)	2012-01-26	2018-12-11	生命科技公司	用于提高病毒感染性的方法
CN113038930A (zh)	2018-06-27	2021-06-25	呼吸治疗公司	冻干形式的药物组合物
US12303593B2 (en)	2018-06-27	2025-05-20	Breath Therapeutics Gmbh	Inhalable compositions comprising macrocyclic immunosuppressants
EA202092892A1 (ru) *	2018-12-04	2021-05-27	Брес Терапьютикс Гмбх	Ингаляционные композиции, содержащие макроциклические иммуносупрессанты

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8403905D0 (sv) *	1984-07-30	1984-07-30	Draco Ab	Liposomes and steroid esters
SE8603812D0 (sv) *	1986-09-12	1986-09-12	Draco Ab	Administration of liposomes to mammals
US5049388A (en) *	1986-11-06	1991-09-17	Research Development Foundation	Small particle aerosol liposome and liposome-drug combinations for medical use
IE63869B1 (en) *	1986-11-06	1995-06-14	Res Dev Foundation	Aerosols containing liposomes and method for their preparation
US4906476A (en) *	1988-12-14	1990-03-06	Liposome Technology, Inc.	Novel liposome composition for sustained release of steroidal drugs in lungs
MX9201782A (es) *	1991-04-19	1992-10-01	Sandoz Ag	Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
DE4203306A1 (de) *	1992-02-06	1993-08-12	Ig Spruehtechnik Gmbh	Asthma oder pulmonal-aerosolzubereitungen mit lecithin
AR002009A1 (es) *	1994-12-22	1998-01-07	Astra Ab	Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.

1997
- 1997-02-17 TW TW086101859A patent/TW497974B/zh not_active IP Right Cessation
- 1997-07-02 NZ NZ333497A patent/NZ333497A/en not_active IP Right Cessation
- 1997-07-02 AU AU36508/97A patent/AU732124B2/en not_active Ceased
- 1997-07-02 EP EP97933287A patent/EP0959874B1/de not_active Expired - Lifetime
- 1997-07-02 CN CN97196141A patent/CN1094345C/zh not_active Expired - Fee Related
- 1997-07-02 WO PCT/US1997/011696 patent/WO1998000111A1/en not_active Ceased
- 1997-07-02 AT AT97933287T patent/ATE268163T1/de not_active IP Right Cessation
- 1997-07-02 DE DE69736083T patent/DE69736083T2/de not_active Expired - Lifetime
- 1997-07-02 DE DE69729391T patent/DE69729391T2/de not_active Expired - Lifetime
- 1997-07-02 AT AT04009645T patent/ATE328583T1/de not_active IP Right Cessation
- 1997-07-02 JP JP50449998A patent/JP2001524930A/ja active Pending
- 1997-07-02 CA CA002259185A patent/CA2259185C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69729391T2 (de)	2005-06-02
AU732124B2 (en)	2001-04-12
TW497974B (en)	2002-08-11
EP0959874A4 (de)	1999-12-22
DE69736083T2 (de)	2006-12-28
WO1998000111A1 (en)	1998-01-08
JP2001524930A (ja)	2001-12-04
CA2259185C (en)	2009-12-15
ATE328583T1 (de)	2006-06-15
CN1094345C (zh)	2002-11-20
NZ333497A (en)	2000-06-23
DE69736083D1 (de)	2006-07-20
EP0959874B1 (de)	2004-06-02
CN1224347A (zh)	1999-07-28
EP0959874A1 (de)	1999-12-01
DE69729391D1 (de)	2004-07-08
CA2259185A1 (en)	1998-01-08
AU3650897A (en)	1998-01-21

Legal Events

Date	Code	Title	Description
2004-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE328583T1 (de)	2006-06-15	Hochdosierte liposomale aerosolformulierung
CA1223819A (en)	1987-07-07	Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
UA29469C2 (uk)	2000-11-15	Ліпосомальна фармацевтична композиція для внутрішньовенного введення
NZ509418A (en)	2003-06-30	Pharmaceutical formulations for aerosols with two or more active substances
NO944957L (no)	1994-12-21	Galenisk blanding, fremgangsmåte for fremstilling av denne, samt anvendelse derav
CA2033725A1 (en)	1991-07-25	Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
IL91656A0 (en)	1990-04-29	Pharmaceutical composition containing a benzodiazepine derivative
WO1998058629A3 (en)	1999-03-18	Preparation of pharmaceutical compositions
CA2156288A1 (en)	1994-09-01	Glycerol derivative, device and pharmaceutical composition
EA200300473A1 (ru)	2003-08-28	Терапевтическая композиция на основе митоксантрона (варианты) и липидный препарат, способ его получения и способ лечения заболевания млекопитающего с его использованием
ES2157307T3 (es)	2001-08-16	Composicion topica que contiene un antagonista de sustancia p.
ATE324907T1 (de)	2006-06-15	Verbindung und arzneizusammensetzung zur verabreichung von wirkstoffen
ATE554750T1 (de)	2012-05-15	Hydrophobe pharmazeutische wirkstoffe enthaltende zubereitungen
BR9912694A (pt)	2002-01-02	Composto para preparar medicamento de administração pulmonar
WO1998013024A3 (en)	1998-06-18	Hyaluronic drug delivery system
KR960028918A (ko)	1996-08-17	국소용 약제학적 조성물
IL117889A0 (en)	1996-08-04	Pharmaceutical compositions containing lipophilic compounds
DE69939180D1 (de)	2008-09-04	Pharmazeutische zubereitungen zur externen anwendung, die nicht steroidale antiinflammatorische und analgetische wirkstoffe enthalten
NZ506429A (en)	2003-03-28	Erythropoietin liposomal dispersion
ITMI921831A1 (it)	1994-01-28	Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive
GEP19991872B (en)	1999-12-06	Novel Taxoids, Preparations Thereof, and Pharmaceutical Compositions Containing Same
SE9403389D0 (sv)	1994-10-06	Pharmaceutical composition containing derivattves of sex hormones
IT1260155B (it)	1996-03-28	Uso terapeutico della fosforil-l-serina-n-acil-sfingosina
AU2809697A (en)	1997-11-12	Pharmaceutical compositions containing alkylaryl polyether alcohol polymer
ES2057542T3 (es)	1994-10-16	Agentes terapeuticos.