ATE268163T1 - Hochdosierte liposomale aerosolformulierung - Google Patents

Hochdosierte liposomale aerosolformulierung

Info

Publication number: ATE268163T1
Authority: AT; Austria
Prior art keywords: high dose; compounds; phospholipid; aerosol composition; liposome aerosol
Prior art date: 1996-07-03

Application number

AT97933287T

Other languages

English (en)

Inventor

J Clifford Waldrep

Vernon Knight

Melanie B Black

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-03

Filing date

1997-07-02

Publication date

2004-06-15

1996-10-16 Priority claimed from US08/731,605 external-priority patent/US5958378A/en

1997-07-02 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

2004-06-15 Application granted granted Critical

2004-06-15 Publication of ATE268163T1 publication Critical patent/ATE268163T1/de

Links

239000000443 aerosol Substances 0.000 title abstract 5
239000000203 mixture Substances 0.000 title abstract 5
238000009472 formulation Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
239000002502 liposome Substances 0.000 abstract 4
150000003904 phospholipids Chemical class 0.000 abstract 4
229930105110 Cyclosporin A Natural products 0.000 abstract 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 2
108010036949 Cyclosporine Proteins 0.000 abstract 2
229960001265 ciclosporin Drugs 0.000 abstract 2
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 abstract 1
230000001093 anti-cancer Effects 0.000 abstract 1
230000000843 anti-fungal effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
229960004436 budesonide Drugs 0.000 abstract 1
239000003862 glucocorticoid Substances 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
229940037128 systemic glucocorticoids Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Dispersion Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Otolaryngology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97933287T 1996-07-03 1997-07-02 Hochdosierte liposomale aerosolformulierung ATE268163T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US67565496A	1996-07-03	1996-07-03
US08/731,605 US5958378A (en)	1996-07-03	1996-10-16	High dose liposomal aerosol formulations containing cyclosporin A or budesonide
PCT/US1997/011696 WO1998000111A1 (en)	1996-07-03	1997-07-02	High dose liposomal aerosol formulations

Publications (1)

Publication Number	Publication Date
ATE268163T1 true ATE268163T1 (de)	2004-06-15

Family

ID=27101390

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04009645T ATE328583T1 (de)	1996-07-03	1997-07-02	Hochdosierte liposomale aerosolformulierung
AT97933287T ATE268163T1 (de)	1996-07-03	1997-07-02	Hochdosierte liposomale aerosolformulierung

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT04009645T ATE328583T1 (de)	1996-07-03	1997-07-02	Hochdosierte liposomale aerosolformulierung

Country Status (10)

Country	Link
EP (1)	EP0959874B1 (de)
JP (1)	JP2001524930A (de)
CN (1)	CN1094345C (de)
AT (2)	ATE328583T1 (de)
AU (1)	AU732124B2 (de)
CA (1)	CA2259185C (de)
DE (2)	DE69729391T2 (de)
NZ (1)	NZ333497A (de)
TW (1)	TW497974B (de)
WO (1)	WO1998000111A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6417172B1 (en) *	1995-06-05	2002-07-09	Eisai Co., Ltd.	Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5863910A (en) *	1996-01-12	1999-01-26	Bolonick; Joel	Treatment of chronic inflammatory disorders of the gastrointestinal tract
US7348025B2 (en)	1997-09-23	2008-03-25	Research Development Foundation	Small particle liposome aerosols for delivery of anticancer drugs
US6090407A (en)	1997-09-23	2000-07-18	Research Development Foundation	Small particle liposome aerosols for delivery of anti-cancer drugs
US6565885B1 (en)	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
US6433040B1 (en)	1997-09-29	2002-08-13	Inhale Therapeutic Systems, Inc.	Stabilized bioactive preparations and methods of use
US6946117B1 (en)	1997-09-29	2005-09-20	Nektar Therapeutics	Stabilized preparations for use in nebulizers
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US20020006901A1 (en) *	1999-02-05	2002-01-17	Aldo T. Iacono	Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease
AU763945B2 (en) *	1999-06-04	2003-08-07	Skyepharma Inc.	Oil-core compositions for the sustained release of hydrophobic drugs
RU2270683C2 (ru) *	1999-12-04	2006-02-27	Рисерч Дивелопмент Фаундейшн	Увеличение эффективности ингаляционной терапии с помощью диоксида углерода
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
PT1280520E (pt)	2000-05-10	2014-12-16	Novartis Ag	Pós à base de fosfolípidos para administração de fármacos
TWI324518B (en)	2001-12-19	2010-05-11	Nektar Therapeutics	Pulmonary delivery of aminoglycosides
AU2003237863A1 (en) *	2002-05-20	2003-12-12	Research Development Foundation	Aerosol drug inhibition of lung metastases
US20050255154A1 (en)	2004-05-11	2005-11-17	Lena Pereswetoff-Morath	Method and composition for treating rhinitis
EP1888033B1 (de)	2005-06-09	2014-02-19	Meda AB	Verfahren und zusammensetzung zur behandlung von entzündlichen erkrankungen
DE102006051512A1 (de) *	2005-12-06	2007-06-14	Pari GmbH Spezialisten für effektive Inhalation	Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
CN101502484B (zh) *	2006-12-26	2011-04-20	济南康泉医药科技有限公司	同载糖皮质激素和化疗药物的抗癌缓释剂
US20090149432A1 (en) *	2007-11-09	2009-06-11	Shrewsbury Stephen B	Methods for administering corticosteroid formulations
BR112012022916B1 (pt)	2010-03-12	2021-11-09	Berg Llc	Formulações intravenosas de coenzima q10 (coq10), bem como método de preparação e uso da mesma
US20120028335A1 (en)	2010-07-28	2012-02-02	Life Technologies Corporation	Anti-viral azide-containing compounds
US20130209550A1 (en)	2010-07-28	2013-08-15	Life Technologies Corporation	Anti-Viral Azide Containing Compounds
CA2807357A1 (en) *	2010-08-05	2012-02-09	Geetanjali Chandrashekhar Chimote	Microparticle formulation for pulmonary drug delivery of anti-infective molecule for treatment of infectious diseases
CN102008713B (zh) *	2010-12-02	2012-10-24	深圳海王药业有限公司	环孢素a前体脂质体、药物组合物及其制备方法
US20140239525A1 (en) *	2011-06-17	2014-08-28	Board Of Regents, University Of Texas System	Inhalable pharmaceutical compositions
GB201114332D0 (en)	2011-08-19	2011-10-05	Nufarm Uk Ltd	Novel inhibitor compositions and methods of use
US9890361B2 (en)	2012-01-26	2018-02-13	Life Technologies Corporation	Methods for increasing the infectivity of viruses utilizing alkyne-modified fatty acids
EP3813862A1 (de) *	2018-06-27	2021-05-05	Breath Therapeutics GmbH	Inhalierbare zusammensetzungen mit makrocyclischen immunsuppressiva
IL279760B2 (en) *	2018-06-27	2025-10-01	Breath Therapeutics Gmbh	Pharmaceutical preparations in lyophilized form
EA202092892A1 (ru) *	2018-12-04	2021-05-27	Брес Терапьютикс Гмбх	Ингаляционные композиции, содержащие макроциклические иммуносупрессанты

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8403905D0 (sv) *	1984-07-30	1984-07-30	Draco Ab	Liposomes and steroid esters
SE8603812D0 (sv) *	1986-09-12	1986-09-12	Draco Ab	Administration of liposomes to mammals
US5049388A (en) *	1986-11-06	1991-09-17	Research Development Foundation	Small particle aerosol liposome and liposome-drug combinations for medical use
IE63869B1 (en) *	1986-11-06	1995-06-14	Res Dev Foundation	Aerosols containing liposomes and method for their preparation
US4906476A (en) *	1988-12-14	1990-03-06	Liposome Technology, Inc.	Novel liposome composition for sustained release of steroidal drugs in lungs
MX9201782A (es) *	1991-04-19	1992-10-01	Sandoz Ag	Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
DE4203306A1 (de) *	1992-02-06	1993-08-12	Ig Spruehtechnik Gmbh	Asthma oder pulmonal-aerosolzubereitungen mit lecithin
SA95160463B1 (ar) *	1994-12-22	2005-10-04	استرا أكتيبولاج	مساحيق للاستنشاق

1997
- 1997-02-17 TW TW086101859A patent/TW497974B/zh not_active IP Right Cessation
- 1997-07-02 CN CN97196141A patent/CN1094345C/zh not_active Expired - Fee Related
- 1997-07-02 DE DE69729391T patent/DE69729391T2/de not_active Expired - Lifetime
- 1997-07-02 WO PCT/US1997/011696 patent/WO1998000111A1/en not_active Ceased
- 1997-07-02 AT AT04009645T patent/ATE328583T1/de not_active IP Right Cessation
- 1997-07-02 DE DE69736083T patent/DE69736083T2/de not_active Expired - Lifetime
- 1997-07-02 EP EP97933287A patent/EP0959874B1/de not_active Expired - Lifetime
- 1997-07-02 AT AT97933287T patent/ATE268163T1/de not_active IP Right Cessation
- 1997-07-02 JP JP50449998A patent/JP2001524930A/ja active Pending
- 1997-07-02 AU AU36508/97A patent/AU732124B2/en not_active Ceased
- 1997-07-02 CA CA002259185A patent/CA2259185C/en not_active Expired - Fee Related
- 1997-07-02 NZ NZ333497A patent/NZ333497A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ333497A (en)	2000-06-23
DE69736083T2 (de)	2006-12-28
DE69729391D1 (de)	2004-07-08
CN1094345C (zh)	2002-11-20
CA2259185A1 (en)	1998-01-08
WO1998000111A1 (en)	1998-01-08
DE69736083D1 (de)	2006-07-20
EP0959874B1 (de)	2004-06-02
AU732124B2 (en)	2001-04-12
TW497974B (en)	2002-08-11
DE69729391T2 (de)	2005-06-02
JP2001524930A (ja)	2001-12-04
CA2259185C (en)	2009-12-15
ATE328583T1 (de)	2006-06-15
EP0959874A4 (de)	1999-12-22
EP0959874A1 (de)	1999-12-01
AU3650897A (en)	1998-01-21
CN1224347A (zh)	1999-07-28

Legal Events

Date	Code	Title	Description
2004-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69729391D1 (de)	2004-07-08	Hochdosierte liposomale aerosolformulierung
CA1223819A (en)	1987-07-07	Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
UA29469C2 (uk)	2000-11-15	Ліпосомальна фармацевтична композиція для внутрішньовенного введення
AU4308093A (en)	1994-01-24	Galenic composition for topical use
BR0114713A (pt)	2004-01-13	Formulação lipossÈmica de mitoxantrona
NZ509418A (en)	2003-06-30	Pharmaceutical formulations for aerosols with two or more active substances
CA2033725A1 (en)	1991-07-25	Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
IL91656A0 (en)	1990-04-29	Pharmaceutical composition containing a benzodiazepine derivative
WO1998058629A3 (en)	1999-03-18	Preparation of pharmaceutical compositions
CA2156288A1 (en)	1994-09-01	Glycerol derivative, device and pharmaceutical composition
CA2301017A1 (en)	1999-03-11	Use of propyl gallate to increase bioavailability of orally administered pharmaceutical compounds
ES2157307T3 (es)	2001-08-16	Composicion topica que contiene un antagonista de sustancia p.
KR960028918A (ko)	1996-08-17	국소용 약제학적 조성물
WO1998013024A3 (en)	1998-06-18	Hyaluronic drug delivery system
IL117889A0 (en)	1996-08-04	Pharmaceutical compositions containing lipophilic compounds
NZ506429A (en)	2003-03-28	Erythropoietin liposomal dispersion
ITMI921831A1 (it)	1994-01-28	Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive
GEP19991872B (en)	1999-12-06	Novel Taxoids, Preparations Thereof, and Pharmaceutical Compositions Containing Same
CA2348474A1 (en)	2000-05-18	Pharmaceutically active composition and dispensing device
IT1260155B (it)	1996-03-28	Uso terapeutico della fosforil-l-serina-n-acil-sfingosina
AU2809697A (en)	1997-11-12	Pharmaceutical compositions containing alkylaryl polyether alcohol polymer
ES2057542T3 (es)	1994-10-16	Agentes terapeuticos.
MX9708934A (es)	1998-03-31	Formulaciones auto-emulsificantes de farmacos lipofilicos.
MX9705592A (es)	1997-11-29	Composiciones farmaceuticas que contienen corticosteroides y preparacion de las mismas.