NZ541828A - Use of EP2 selective receptor agonists in medical treatment - Google Patents

Use of EP2 selective receptor agonists in medical treatment

Info

Publication number: NZ541828A
Authority: NZ; New Zealand
Prior art keywords: alkylene; crc4; alkyl; independently; substituted
Prior art date: 2003-03-04

Application number

NZ541828A

Other languages

English (en)

Inventor

Alexander Angelo Constan

Prakash Raj Keshary

David Burton Maclean

Vishwas Madhav Paralkar

Doina Cosma Roman

David Duane Thompson

Timothy Michael Wright

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-04

Filing date

2004-02-23

Publication date

2008-06-30

2004-02-23 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2008-06-30 Publication of NZ541828A publication Critical patent/NZ541828A/en

Links

229940044601 receptor agonist Drugs 0.000 title claims abstract description 61
239000000018 receptor agonist Substances 0.000 title claims abstract description 61
238000011282 treatment Methods 0.000 title description 20
150000001875 compounds Chemical class 0.000 claims abstract description 455
208000030016 Avascular necrosis Diseases 0.000 claims abstract description 12
206010031264 Osteonecrosis Diseases 0.000 claims abstract description 12
239000003814 drug Substances 0.000 claims abstract description 11
238000004519 manufacturing process Methods 0.000 claims abstract description 8
WOHRHWDYFNWPNG-UHFFFAOYSA-N evatanepag Chemical compound C1=CC(C(C)(C)C)=CC=C1CN(S(=O)(=O)C=1C=NC=CC=1)CC1=CC=CC(OCC(O)=O)=C1 WOHRHWDYFNWPNG-UHFFFAOYSA-N 0.000 claims abstract description 7
-1 R1R2-amino Chemical group 0.000 claims description 213
125000000217 alkyl group Chemical group 0.000 claims description 110
125000002947 alkylene group Chemical group 0.000 claims description 98
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 88
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 82
150000003839 salts Chemical class 0.000 claims description 80
229920006395 saturated elastomer Polymers 0.000 claims description 63
125000001424 substituent group Chemical group 0.000 claims description 58
229910052757 nitrogen Inorganic materials 0.000 claims description 49
125000001153 fluoro group Chemical group F* 0.000 claims description 45
125000005842 heteroatom Chemical group 0.000 claims description 36
229910052717 sulfur Inorganic materials 0.000 claims description 35
239000011593 sulfur Chemical group 0.000 claims description 35
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125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 33
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 33
229910052799 carbon Inorganic materials 0.000 claims description 31
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 28
229910052760 oxygen Inorganic materials 0.000 claims description 28
239000001301 oxygen Substances 0.000 claims description 28
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 28
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 26
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125000005843 halogen group Chemical group 0.000 claims description 20
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125000002619 bicyclic group Chemical group 0.000 claims description 17
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125000004043 oxo group Chemical group O=* 0.000 claims description 17
125000001589 carboacyl group Chemical group 0.000 claims description 14
125000003118 aryl group Chemical group 0.000 claims description 13
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 13
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125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 8
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
125000001309 chloro group Chemical group Cl* 0.000 claims description 7
125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 claims description 5
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 5
125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 claims description 5
125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
125000004430 oxygen atom Chemical group O* 0.000 claims description 5
125000005236 alkanoylamino group Chemical group 0.000 claims description 4
125000003342 alkenyl group Chemical group 0.000 claims description 4
125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 4
125000005115 alkyl carbamoyl group Chemical group 0.000 claims description 4
125000000304 alkynyl group Chemical group 0.000 claims description 4
125000002950 monocyclic group Chemical group 0.000 claims description 4
125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 4
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 4
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125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 3
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235000019000 fluorine Nutrition 0.000 claims description 3
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 3
125000005422 alkyl sulfonamido group Chemical group 0.000 claims description 2
125000005518 carboxamido group Chemical group 0.000 claims description 2
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125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
125000000753 cycloalkyl group Chemical group 0.000 claims 1
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108010088540 Prostaglandin E receptors Proteins 0.000 abstract description 2
238000000034 method Methods 0.000 description 122
239000000651 prodrug Substances 0.000 description 118
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ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 114
238000005160 1H NMR spectroscopy Methods 0.000 description 113
238000002360 preparation method Methods 0.000 description 108
239000000243 solution Substances 0.000 description 100
239000002253 acid Substances 0.000 description 98
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 93
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101001117519 Homo sapiens Prostaglandin E2 receptor EP2 subtype Proteins 0.000 description 76
102100024448 Prostaglandin E2 receptor EP2 subtype Human genes 0.000 description 74
101000836978 Homo sapiens Sperm-associated antigen 11B Proteins 0.000 description 72
239000000203 mixture Substances 0.000 description 68
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238000006243 chemical reaction Methods 0.000 description 66
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 50
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WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 46
235000019439 ethyl acetate Nutrition 0.000 description 43
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 43
229910000041 hydrogen chloride Inorganic materials 0.000 description 42
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 39
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 36
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 34
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 34
239000002585 base Substances 0.000 description 34
229910052943 magnesium sulfate Inorganic materials 0.000 description 34
239000002904 solvent Substances 0.000 description 34
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 32
125000004076 pyridyl group Chemical group 0.000 description 32
239000003153 chemical reaction reagent Substances 0.000 description 30
125000001544 thienyl group Chemical group 0.000 description 30
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 29
239000000556 agonist Substances 0.000 description 24
150000001412 amines Chemical class 0.000 description 24
125000000335 thiazolyl group Chemical group 0.000 description 24
210000000988 bone and bone Anatomy 0.000 description 23
239000003054 catalyst Substances 0.000 description 23
239000000047 product Substances 0.000 description 23
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 22
OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 22
230000029936 alkylation Effects 0.000 description 22
238000005804 alkylation reaction Methods 0.000 description 22
238000006460 hydrolysis reaction Methods 0.000 description 22
125000002883 imidazolyl group Chemical group 0.000 description 22
150000001299 aldehydes Chemical class 0.000 description 21
230000007062 hydrolysis Effects 0.000 description 21
239000011159 matrix material Substances 0.000 description 21
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 21
239000000010 aprotic solvent Substances 0.000 description 20
210000004027 cell Anatomy 0.000 description 20
125000002541 furyl group Chemical group 0.000 description 20
102000005962 receptors Human genes 0.000 description 20
108020003175 receptors Proteins 0.000 description 20
239000007787 solid Substances 0.000 description 20
239000002168 alkylating agent Substances 0.000 description 19
229940100198 alkylating agent Drugs 0.000 description 19
150000001408 amides Chemical class 0.000 description 19
150000003180 prostaglandins Chemical class 0.000 description 19
125000000714 pyrimidinyl group Chemical group 0.000 description 19
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UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 18
239000005557 antagonist Substances 0.000 description 18
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 18
238000003818 flash chromatography Methods 0.000 description 18
150000003456 sulfonamides Chemical class 0.000 description 18
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 17
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239000003921 oil Substances 0.000 description 17
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239000002552 dosage form Substances 0.000 description 16
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125000000623 heterocyclic group Chemical group 0.000 description 12
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RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 12
208000010392 Bone Fractures Diseases 0.000 description 11
125000004432 carbon atom Chemical group C* 0.000 description 11
230000008878 coupling Effects 0.000 description 11
238000010168 coupling process Methods 0.000 description 11
238000005984 hydrogenation reaction Methods 0.000 description 11
229940094443 oxytocics prostaglandins Drugs 0.000 description 11
238000006268 reductive amination reaction Methods 0.000 description 11
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HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
150000001732 carboxylic acid derivatives Chemical group 0.000 description 10
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230000008439 repair process Effects 0.000 description 10
101100258328 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) crc-2 gene Proteins 0.000 description 9
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INLLPKCGLOXCIV-UHFFFAOYSA-N bromoethene Chemical compound BrC=C INLLPKCGLOXCIV-UHFFFAOYSA-N 0.000 description 6
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BNWCETAHAJSBFG-UHFFFAOYSA-N tert-butyl 2-bromoacetate Chemical compound CC(C)(C)OC(=O)CBr BNWCETAHAJSBFG-UHFFFAOYSA-N 0.000 description 1
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SZFWEFVZMLHZQU-UHFFFAOYSA-N tert-butyl 5-[3-[3-(3-chlorophenyl)propyl-(2-chlorophenyl)sulfonylamino]propyl]thiophene-2-carboxylate Chemical compound S1C(C(=O)OC(C)(C)C)=CC=C1CCCN(S(=O)(=O)C=1C(=CC=CC=1)Cl)CCCC1=CC=CC(Cl)=C1 SZFWEFVZMLHZQU-UHFFFAOYSA-N 0.000 description 1
WAGUYACUHZNGJG-UHFFFAOYSA-N tert-butyl 5-[3-[3-(3-chlorophenyl)propylamino]propyl]thiophene-2-carboxylate Chemical compound S1C(C(=O)OC(C)(C)C)=CC=C1CCCNCCCC1=CC=CC(Cl)=C1 WAGUYACUHZNGJG-UHFFFAOYSA-N 0.000 description 1
HFPUIDDBBWKTNO-UHFFFAOYSA-N tert-butyl 5-bromothiophene-2-carboxylate Chemical compound CC(C)(C)OC(=O)C1=CC=C(Br)S1 HFPUIDDBBWKTNO-UHFFFAOYSA-N 0.000 description 1
DSPYCWLYGXGJNJ-UHFFFAOYSA-N tert-butyl n-prop-2-ynylcarbamate Chemical compound CC(C)(C)OC(=O)NCC#C DSPYCWLYGXGJNJ-UHFFFAOYSA-N 0.000 description 1
KJHXSOOIOVLNPZ-UHFFFAOYSA-N tert-butyl thiophene-2-carboxylate Chemical compound CC(C)(C)OC(=O)C1=CC=CS1 KJHXSOOIOVLNPZ-UHFFFAOYSA-N 0.000 description 1
229910021515 thallium hydroxide Inorganic materials 0.000 description 1
QGYXCSSUHCHXHB-UHFFFAOYSA-M thallium(i) hydroxide Chemical compound [OH-].[Tl+] QGYXCSSUHCHXHB-UHFFFAOYSA-M 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
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238000004809 thin layer chromatography Methods 0.000 description 1
229930192474 thiophene Natural products 0.000 description 1
229950004815 tigestol Drugs 0.000 description 1
229940032666 tiludronate disodium Drugs 0.000 description 1
229960005324 tiludronic acid Drugs 0.000 description 1
AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
238000004448 titration Methods 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 description 1
229960005026 toremifene Drugs 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000006211 transdermal dosage form Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1
125000004306 triazinyl group Chemical group 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
UKRDPEFKFJNXQM-UHFFFAOYSA-N vinylsilane Chemical class [SiH3]C=C UKRDPEFKFJNXQM-UHFFFAOYSA-N 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
239000002699 waste material Substances 0.000 description 1
230000004580 weight loss Effects 0.000 description 1
210000000707 wrist Anatomy 0.000 description 1
125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
229960004276 zoledronic acid Drugs 0.000 description 1

Classifications

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NZ541828A 2003-03-04 2004-02-23 Use of EP2 selective receptor agonists in medical treatment NZ541828A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45188903P	2003-03-04	2003-03-04
PCT/IB2004/000553 WO2004078169A1 (fr)	2003-03-04	2004-02-23	Utilisation d'agonistes selectifs du recepteur ep2 dans un traitement medical

Publications (1)

Publication Number	Publication Date
NZ541828A true NZ541828A (en)	2008-06-30

Family

ID=32962656

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ541828A NZ541828A (en)	2003-03-04	2004-02-23	Use of EP2 selective receptor agonists in medical treatment

Country Status (14)

Country	Link
EP (1)	EP1601351A1 (fr)
JP (1)	JP2006519250A (fr)
KR (1)	KR20050105511A (fr)
CN (1)	CN1859903A (fr)
AU (1)	AU2004216898A1 (fr)
BR (1)	BRPI0408061A (fr)
CA (1)	CA2518193A1 (fr)
CL (1)	CL2004000412A1 (fr)
MX (1)	MXPA05009398A (fr)
NZ (1)	NZ541828A (fr)
PL (1)	PL378748A1 (fr)
TW (1)	TW200424176A (fr)
WO (1)	WO2004078169A1 (fr)
ZA (1)	ZA200506532B (fr)

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GB0324269D0 (en)	2003-10-16	2003-11-19	Pharmagene Lab Ltd	EP4 receptor antagonists
CA2605214C (fr)	2004-12-31	2016-07-12	Reddy Us Therapeutics, Inc.	Nouveaux derives de benzylamine en tant qu'inhibiteurs de cetp
US8604055B2 (en)	2004-12-31	2013-12-10	Dr. Reddy's Laboratories Ltd.	Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US7915316B2 (en) *	2005-08-22	2011-03-29	Allergan, Inc	Sulfonamides
US7696235B2 (en) *	2005-08-29	2010-04-13	Allergan, Inc.	EP2 receptor agonists for treating glaucoma
RU2425876C2 (ru)	2006-03-24	2011-08-10	Чилдрен'З Медикал Сентер Корпорейшн	Способ модулирования роста гематопоэтических стволовых клеток
AU2007280130B2 (en)	2006-07-28	2011-09-22	Pfizer Products Inc.	EP2 agonists
EP3824885A1 (fr) *	2006-10-20	2021-05-26	Children's Medical Center Corporation	Procédé pour améliorer la régénération tissulaire
EP2195656A4 (fr) *	2007-08-21	2011-10-19	Senomyx Inc	Recepteurs humains t2r sensibles aux composes amers qui provoquent le gout amer, et utilisation de ceux-ci
HRP20190509T1 (hr) *	2008-03-12	2019-05-03	Ube Industries, Ltd.	Spoj piridilaminooctene kiseline
WO2010096264A2 (fr)	2009-02-03	2010-08-26	Children's Medical Center Corporation	Procédés permettant d'améliorer la greffe de cellules souches hématopoïétiques et les cellules progénitrices hématopoïétiques
WO2010091052A2 (fr)	2009-02-03	2010-08-12	Children's Medical Center Corporation	Procédés de renforcement de greffe de cellule souche hématopoïétique/progénitrice
PT2415763E (pt) *	2009-03-30	2016-03-30	Ube Industries	Composição farmacêutica para tratamento ou prevenção do glaucoma
WO2010116270A1 (fr)	2009-04-10	2010-10-14	Pfizer Inc.	Agonistes de ep2/4
EP2476668B1 (fr) *	2009-09-11	2013-11-06	Ube Industries, Ltd.	Composés aniline
WO2011030865A1 (fr) *	2009-09-11	2011-03-17	宇部興産株式会社	Composés benzyliques substitués
US20120226036A1 (en) *	2009-09-11	2012-09-06	Ube Industries, Ltd.	Substituted carbonyl compound
JP2011057633A (ja) *	2009-09-11	2011-03-24	Ube Industries Ltd	ピリジルアミノ酢酸化合物を含有する医薬
WO2011030872A1 (fr) *	2009-09-11	2011-03-17	宇部興産株式会社	Composés sulfonamide
WO2011030871A1 (fr) *	2009-09-11	2011-03-17	宇部興産株式会社	Composés hétéroaryle n-substitués
WO2011030873A1 (fr) *	2009-09-11	2011-03-17	宇部興産株式会社	Composés benzyliques
CN102666490A (zh) *	2009-12-25	2012-09-12	宇部兴产株式会社	氨基吡啶化合物
EP2744803A2 (fr)	2011-08-18	2014-06-25	Dr. Reddy's Laboratories Ltd.	Composés amines hétérocycliques substitués comme inhibiteurs de la protéine de transfert d'ester cholesterylique (cetp)
MX352074B (es)	2011-09-27	2017-11-08	Dr Reddys Laboratories Ltd	Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis.
EP2785350B1 (fr)	2011-12-02	2018-05-02	Fate Therapeutics, Inc.	Méthodes améliorées permettant de traiter l'ischémie
JP6220791B2 (ja)	2011-12-02	2017-10-25	フェイトセラピューティクス，インコーポレイテッド	増強された幹細胞組成物
EP2804605A4 (fr) *	2012-01-20	2015-07-08	Acucela Inc	Composés hétérocycliques substitués pour le traitement d'une maladie
US20140142092A1 (en) *	2012-11-16	2014-05-22	Allergan, Inc.	Compounds and methods for skin repair
WO2014150602A1 (fr)	2013-03-15	2014-09-25	Fate Therapeutics, Inc.	Essai d'activité biologique de cellules pour un potentiel thérapeutique
HK1219103A1 (en)	2013-03-28	2017-03-24	Ube Industries, Ltd.	Substituted biaryl compound
DK3143026T3 (da)	2014-05-13	2024-09-30	Novartis Ag	Forbindelser og sammensætninger til induktion af chondrogenese
CN106397149B (zh) *	2016-08-26	2019-05-21	大连奇凯医药科技有限公司	五氟苯甲醛的制备方法
CN115636761B (zh) *	2021-07-20	2024-07-05	中国石油天然气股份有限公司	一种油溶性表面活性剂、驱油剂及其应用

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UA67754C2 (uk) *	1997-10-10	2004-07-15	Пфайзер, Інк.	Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
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2004
- 2004-02-23 CA CA002518193A patent/CA2518193A1/fr not_active Abandoned
- 2004-02-23 NZ NZ541828A patent/NZ541828A/en unknown
- 2004-02-23 BR BRPI0408061-0A patent/BRPI0408061A/pt not_active IP Right Cessation
- 2004-02-23 JP JP2006506276A patent/JP2006519250A/ja not_active Withdrawn
- 2004-02-23 KR KR1020057016414A patent/KR20050105511A/ko not_active Ceased
- 2004-02-23 WO PCT/IB2004/000553 patent/WO2004078169A1/fr not_active Ceased
- 2004-02-23 MX MXPA05009398A patent/MXPA05009398A/es unknown
- 2004-02-23 AU AU2004216898A patent/AU2004216898A1/en not_active Abandoned
- 2004-02-23 CN CNA2004800085767A patent/CN1859903A/zh active Pending
- 2004-02-23 EP EP04713611A patent/EP1601351A1/fr not_active Withdrawn
- 2004-02-23 PL PL378748A patent/PL378748A1/pl not_active Application Discontinuation
- 2004-03-01 TW TW093105312A patent/TW200424176A/zh unknown
- 2004-03-02 CL CL200400412A patent/CL2004000412A1/es unknown
2005
- 2005-08-16 ZA ZA200506532A patent/ZA200506532B/en unknown

Also Published As

Publication number	Publication date
JP2006519250A (ja)	2006-08-24
CN1859903A (zh)	2006-11-08
CL2004000412A1 (es)	2005-02-04
KR20050105511A (ko)	2005-11-04
BRPI0408061A (pt)	2006-02-14
TW200424176A (en)	2004-11-16
WO2004078169A1 (fr)	2004-09-16
CA2518193A1 (fr)	2004-09-16
PL378748A1 (pl)	2006-05-15
EP1601351A1 (fr)	2005-12-07
AU2004216898A1 (en)	2004-09-16
ZA200506532B (en)	2007-03-28
MXPA05009398A (es)	2005-12-05
WO2004078169A8 (fr)	2005-04-21

Legal Events

Date	Code	Title	Description
2008-01-31	RENW	Renewal (renewal fees accepted)
2008-10-31	PSEA	Patent sealed

Publication	Publication Date	Title
NZ541828A (en)	2008-06-30	Use of EP2 selective receptor agonists in medical treatment
AP1156A (en)	2003-06-30	Prostaglandin agonista and thier use in treatment of bone disorders.
CA2275479C (fr)	2007-05-08	Prevention de la perte de masse osseuse et reconstitution de celle-ci au moyen de certains agonistes de la prostaglandine
US20050203086A1 (en)	2005-09-15	Methods of treatment using an EP2 selective receptor agonist
MXPA00003478A (en)	2001-11-21	Prostaglandin agonists and their use to treat bone disorders
CZ20001280A3 (cs)	2000-12-13	Agonisté prostaglandinu a jejich použití pro léčení chorob kostí