OA08166A - Nouvelles 2-amino-oxazolines et leur procédé d'obtention. - Google Patents

Nouvelles 2-amino-oxazolines et leur procédé d'obtention.

Info

Publication number: OA08166A
Authority: OA; OAPI
Prior art keywords: radical; lower alkyl; hydrogen; equal; denotes
Prior art date: 1984-07-05

Application number

OA58630A

Other languages

English (en)

French (fr)

Original Assignee

Abert Rolland S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-05

Filing date

1985-07-05

Publication date

1987-03-31

1985-07-05 Application filed by Abert Rolland S A filed Critical Abert Rolland S A

1987-03-31 Publication of OA08166A publication Critical patent/OA08166A/xx

Links

YAXGBZDYGZBRBQ-UHFFFAOYSA-N 4,5-dihydro-1,3-oxazol-2-amine Chemical class NC1=NCCO1 YAXGBZDYGZBRBQ-UHFFFAOYSA-N 0.000 title abstract 2
-1 alkyl radical Chemical class 0.000 abstract 11
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
150000007524 organic acids Chemical class 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

OA58630A 1984-07-05 1985-07-05 Nouvelles 2-amino-oxazolines et leur procédé d'obtention. OA08166A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH326384		1984-07-05

Publications (1)

Publication Number	Publication Date
OA08166A true OA08166A (fr)	1987-03-31

Family

ID=4252197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA58630A OA08166A (fr)	1984-07-05	1985-07-05	Nouvelles 2-amino-oxazolines et leur procédé d'obtention.

Country Status (14)

Country	Link
EP (1)	EP0167459B1 (de)
JP (1)	JPS61155375A (de)
AT (1)	ATE69222T1 (de)
AU (1)	AU579872B2 (de)
CA (1)	CA1258040A (de)
DD (1)	DD240015A5 (de)
DE (1)	DE3584584D1 (de)
DK (1)	DK302185A (de)
ES (2)	ES8700853A1 (de)
HU (1)	HU193333B (de)
MA (1)	MA20480A1 (de)
OA (1)	OA08166A (de)
PL (1)	PL254398A1 (de)
PT (1)	PT80779B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2632860A1 (fr) *	1988-06-21	1989-12-22	Rolland Sa A	Nouveaux medicaments antidepresseurs et les compositions pharmaceutiques en renfermant
US5948820A (en) *	1994-08-22	1999-09-07	Yoshitomi Pharmaceutical Industries, Ltd.	Benzene compound and pharmaceutical use thereof
DE69524962T4 (de) *	1994-08-22	2003-08-28	Mitsubishi Pharma Corp., Osaka	Benzolderivate und deren medizinische verwendung
MXPA04006709A (es)	2002-01-11	2004-10-04	Sankyo Co	Derivados de aminoalcohol o derivados de acido fosfonico y composiciones farmaceuticas que los contienen.
KR20110136901A (ko)	2004-02-24	2011-12-21	상꾜 가부시키가이샤	아미노 알코올 화합물
CA2675221C (en) *	2007-02-02	2016-02-23	F. Hoffmann-La Roche Ag	Novel 2-aminooxazolines as taar1 ligands
MX2009008465A (es)	2007-02-15	2009-08-20	Hoffmann La Roche	Nuevas 2-aminooxazolinas como ligandos de taar1.
CN101952260B (zh) *	2008-02-18	2013-02-13	弗·哈夫曼-拉罗切有限公司	4,5-二氢-*唑-2-基胺衍生物
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
ES2556633T3 (es) *	2008-07-24	2016-01-19	F. Hoffmann-La Roche Ag	Derivados de 4,5-dihidro-oxazol-2-ilo
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
US8673950B2 (en)	2010-11-02	2014-03-18	Hoffmann-Laroche Inc.	Dihydrooxazol-2-amine derivatives
RS60825B1 (sr)	2016-03-17	2020-10-30	Hoffmann La Roche	Aktivnost derivata 5-etiol-4-metil-pirazol-3-karboksamida kao agonista taar-a

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2448M (fr) *	1963-02-27	1964-04-06	Mcneilab Inc	Composé de la classe des 2-amino-5-aryl-oxazolines et compositions pharmaceutiques le contenant.
FR2444673A1 (fr) *	1978-12-20	1980-07-18	Science Union & Cie	Nouvelles trifluoroethylamines, leurs procedes d'obtention et leur emploi comme medicament
US4647557A (en) *	1982-12-28	1987-03-03	Gerard Moinet	Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them

1985
- 1985-07-03 DK DK302185A patent/DK302185A/da not_active Application Discontinuation
- 1985-07-04 MA MA20705A patent/MA20480A1/fr unknown
- 1985-07-04 DE DE8585401360T patent/DE3584584D1/de not_active Expired - Fee Related
- 1985-07-04 AT AT85401360T patent/ATE69222T1/de not_active IP Right Cessation
- 1985-07-04 EP EP85401360A patent/EP0167459B1/de not_active Expired - Lifetime
- 1985-07-04 DD DD85278275A patent/DD240015A5/de unknown
- 1985-07-05 ES ES544926A patent/ES8700853A1/es not_active Expired
- 1985-07-05 JP JP60148123A patent/JPS61155375A/ja active Pending
- 1985-07-05 PT PT80779A patent/PT80779B/pt unknown
- 1985-07-05 HU HU852621A patent/HU193333B/hu unknown
- 1985-07-05 PL PL25439885A patent/PL254398A1/xx unknown
- 1985-07-05 OA OA58630A patent/OA08166A/xx unknown
- 1985-07-05 CA CA000486391A patent/CA1258040A/fr not_active Expired
- 1985-07-08 AU AU44681/85A patent/AU579872B2/en not_active Expired - Fee Related
1986
- 1986-03-15 ES ES553058A patent/ES8705364A1/es not_active Expired

Also Published As

Publication number	Publication date
JPS61155375A (ja)	1986-07-15
ATE69222T1 (de)	1991-11-15
PT80779B (fr)	1987-01-12
HUT38918A (en)	1986-07-28
AU579872B2 (en)	1988-12-15
AU4468185A (en)	1986-01-30
ES553058A0 (es)	1987-05-01
ES544926A0 (es)	1986-10-16
EP0167459A3 (en)	1987-02-25
PT80779A (fr)	1985-08-01
DD240015A5 (de)	1986-10-15
DE3584584D1 (de)	1991-12-12
EP0167459A2 (de)	1986-01-08
CA1258040A (fr)	1989-08-01
ES8700853A1 (es)	1986-10-16
PL254398A1 (en)	1986-06-17
HU193333B (en)	1987-09-28
EP0167459B1 (de)	1991-11-06
MA20480A1 (fr)	1986-04-01
DK302185A (da)	1986-01-06
ES8705364A1 (es)	1987-05-01
DK302185D0 (da)	1985-07-03

Publication	Publication Date	Title
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
AU579872B2 (en)	1988-12-15	2-amino-4-substituted oxazolines
FI892787A0 (fi)	1989-06-07	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi
EA200100755A1 (ru)	2001-12-24	4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
BG96978A (bg)	1993-12-24	Производни и аналози на 2-дезокси-2,3-дидехидро-n- ацетилнеураминовата киселина и използването им като противовирусни средства
FI904327A0 (fi)	1990-09-03	N-substituerad-4-pyrimidinaminer och -pyrimidindiaminer, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
NO854671L (no)	1986-05-26	Fremgangsmaate for fremstilling av farmakologisk aktive substituerte imidazoler.
ATE128975T1 (de)	1995-10-15	Harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente.
MX9203163A (es)	1992-07-31	Esteres morfolinoetilicos de acido micofenolico y composiciones.
PT94297A (pt)	1991-02-08	Processo para a preparacao de n-hetero-aril-purin-6-aminas e de composicoes farmaceuticas que as contem
DE60105610D1 (en)	2004-10-21	Pyrazinonderivate
ES8800936A1 (es)	1987-12-01	Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona
ATE14312T1 (de)	1985-08-15	Phenolester.
ES2262504T3 (es)	2006-12-01	Derivados del acido piroglutamico y compuestos afines que inhiben la adhesion de leucocitos mediada por la vla-4.
PE20000645A1 (es)	2000-07-26	Derivados de 3-(2-oxo-[1,3`]bipirrolidinil-3-ilidenmetil)-cefemos
BR8900317A (pt)	1989-09-19	Processo para a preparacao de compostos herbicidas e compostos herbicidas
FI875251A0 (fi)	1987-11-27	Foerfarande foer framstaellning av 2-arylpropionsyror.
DE3769451D1 (de)	1991-05-23	Indan-derivate, verfahren zu ihrer herstellung und die erhaltenen zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen.
ATE201877T1 (de)	2001-06-15	Kondensierte heterocyclische glutaminsäurederivate als antiproliferative mittel
PT88338A (pt)	1989-06-30	Process for the manufacture of imidazo-benzodiazepines and of pharmaceutical compositions containing the same
ES8800938A1 (es)	1987-12-16	Procedimiento para preparar derivados berbanicos biologicamente activos.
ATE5724T1 (de)	1984-01-15	Guanidinverbindungen, verfahren zu deren herstellung und diese enthaltende zusammensetzungen.
DK0377532T3 (da)	1992-09-14	Thioformamidderivater
ATE73801T1 (de)	1992-04-15	Heterocyclische oxophthalazinylessigsaeure.