DK302185A - 2-amino-oxazoliner samt fremgangsmaade til deres fremstilling - Google Patents

2-amino-oxazoliner samt fremgangsmaade til deres fremstilling Download PDF

Info

Publication number: DK302185A
Authority: DK; Denmark
Prior art keywords: radical; lower alkyl; hydrogen; equal; denotes
Prior art date: 1984-07-05

Application number

DK302185A

Other languages

English (en)

Other versions

DK302185D0 (da

Original Assignee

Rolland Sa A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-05

Filing date

1985-07-03

Publication date

1986-01-06

1985-07-03 Application filed by Rolland Sa A filed Critical Rolland Sa A

1985-07-03 Publication of DK302185D0 publication Critical patent/DK302185D0/da

1986-01-06 Publication of DK302185A publication Critical patent/DK302185A/da

Links

238000000034 method Methods 0.000 title 1
-1 alkyl radical Chemical class 0.000 abstract 11
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
150000007524 organic acids Chemical class 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
YAXGBZDYGZBRBQ-UHFFFAOYSA-N 4,5-dihydro-1,3-oxazol-2-amine Chemical class NC1=NCCO1 YAXGBZDYGZBRBQ-UHFFFAOYSA-N 0.000 abstract 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

DK302185A 1984-07-05 1985-07-03 2-amino-oxazoliner samt fremgangsmaade til deres fremstilling DK302185A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH326384		1984-07-05

Publications (2)

Publication Number	Publication Date
DK302185D0 DK302185D0 (da)	1985-07-03
DK302185A true DK302185A (da)	1986-01-06

Family

ID=4252197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK302185A DK302185A (da)	1984-07-05	1985-07-03	2-amino-oxazoliner samt fremgangsmaade til deres fremstilling

Country Status (14)

Country	Link
EP (1)	EP0167459B1 (da)
JP (1)	JPS61155375A (da)
AT (1)	ATE69222T1 (da)
AU (1)	AU579872B2 (da)
CA (1)	CA1258040A (da)
DD (1)	DD240015A5 (da)
DE (1)	DE3584584D1 (da)
DK (1)	DK302185A (da)
ES (2)	ES8700853A1 (da)
HU (1)	HU193333B (da)
MA (1)	MA20480A1 (da)
OA (1)	OA08166A (da)
PL (1)	PL254398A1 (da)
PT (1)	PT80779B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2632860A1 (fr) *	1988-06-21	1989-12-22	Rolland Sa A	Nouveaux medicaments antidepresseurs et les compositions pharmaceutiques en renfermant
ATE211726T1 (de) *	1994-08-22	2002-01-15	Welfide Corp	Benzolderivate und deren medizinische verwendung
US5948820A (en) *	1994-08-22	1999-09-07	Yoshitomi Pharmaceutical Industries, Ltd.	Benzene compound and pharmaceutical use thereof
DE60328161D1 (de)	2002-01-11	2009-08-13	Daiichi Sankyo Co Ltd	Aminoalkoholderivat oder phosphonsäurederivat und diese enthaltende medizinische zusammensetzung
WO2005079788A1 (ja)	2004-02-24	2005-09-01	Sankyo Company, Limited	アミノアルコール化合物
MX2009008255A (es) *	2007-02-02	2009-08-12	Hoffmann La Roche	Nuevas 2-aminooxazolinas como ligandos taar1.
KR101222412B1 (ko) *	2007-02-15	2013-01-15	에프. 호프만-라 로슈 아게	Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
KR101259240B1 (ko) *	2008-02-18	2013-04-29	시에나 바이오테크 에스.피.에이.	4,5-다이하이드로-옥사졸-2-일 아민 유도체
CN102083805A (zh) *	2008-07-24	2011-06-01	弗·哈夫曼-拉罗切有限公司	4,5-二氢-唑-2-基衍生物
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
US8673950B2 (en)	2010-11-02	2014-03-18	Hoffmann-Laroche Inc.	Dihydrooxazol-2-amine derivatives
JP6814814B2 (ja)	2016-03-17	2021-01-20	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	Ｔａａｒのアゴニストとしての活性を有する５−エチル−４−メチル−ピラゾール−３−カルボキサミド誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2448M (fr) *	1963-02-27	1964-04-06	Mcneilab Inc	Composé de la classe des 2-amino-5-aryl-oxazolines et compositions pharmaceutiques le contenant.
FR2444673A1 (fr) *	1978-12-20	1980-07-18	Science Union & Cie	Nouvelles trifluoroethylamines, leurs procedes d'obtention et leur emploi comme medicament
US4647557A (en) *	1982-12-28	1987-03-03	Gerard Moinet	Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them

1985
- 1985-07-03 DK DK302185A patent/DK302185A/da not_active Application Discontinuation
- 1985-07-04 AT AT85401360T patent/ATE69222T1/de not_active IP Right Cessation
- 1985-07-04 DE DE8585401360T patent/DE3584584D1/de not_active Expired - Fee Related
- 1985-07-04 DD DD85278275A patent/DD240015A5/de unknown
- 1985-07-04 MA MA20705A patent/MA20480A1/fr unknown
- 1985-07-04 EP EP85401360A patent/EP0167459B1/fr not_active Expired - Lifetime
- 1985-07-05 JP JP60148123A patent/JPS61155375A/ja active Pending
- 1985-07-05 PT PT80779A patent/PT80779B/pt unknown
- 1985-07-05 ES ES544926A patent/ES8700853A1/es not_active Expired
- 1985-07-05 CA CA000486391A patent/CA1258040A/fr not_active Expired
- 1985-07-05 PL PL25439885A patent/PL254398A1/xx unknown
- 1985-07-05 HU HU852621A patent/HU193333B/hu unknown
- 1985-07-05 OA OA58630A patent/OA08166A/xx unknown
- 1985-07-08 AU AU44681/85A patent/AU579872B2/en not_active Expired - Fee Related
1986
- 1986-03-15 ES ES553058A patent/ES8705364A1/es not_active Expired

Also Published As

Publication number	Publication date
OA08166A (fr)	1987-03-31
AU4468185A (en)	1986-01-30
EP0167459A3 (en)	1987-02-25
ES544926A0 (es)	1986-10-16
JPS61155375A (ja)	1986-07-15
EP0167459B1 (fr)	1991-11-06
HUT38918A (en)	1986-07-28
CA1258040A (fr)	1989-08-01
EP0167459A2 (fr)	1986-01-08
PL254398A1 (en)	1986-06-17
AU579872B2 (en)	1988-12-15
ATE69222T1 (de)	1991-11-15
DE3584584D1 (de)	1991-12-12
DD240015A5 (de)	1986-10-15
HU193333B (en)	1987-09-28
MA20480A1 (fr)	1986-04-01
ES8700853A1 (es)	1986-10-16
ES8705364A1 (es)	1987-05-01
PT80779A (fr)	1985-08-01
DK302185D0 (da)	1985-07-03
ES553058A0 (es)	1987-05-01
PT80779B (fr)	1987-01-12

Legal Events

Date	Code	Title	Description
1989-10-30	AHS	Application shelved for other reasons than non-payment
1990-03-12	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK302185D0 (da)	1985-07-03	2-amino-oxazoliner samt fremgangsmaade til deres fremstilling
MX9202142A (es)	1993-06-01	Nuevos derivados de urea, proceso para su preparacion, y composicion farmaceutica que los comprende.
FI885594A0 (fi)	1988-12-01	Tiazolidindioner anvaendbara foer saenkande av blodsockerhalten samt atherosklerosis hindrande medel.
FI892787A0 (fi)	1989-06-07	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi
YU12992A (sh)	1995-01-31	2-amino-1,2,3,4,-tetrahidronaftaleni supstituisani u prstenu
ES8801807A1 (es)	1988-03-01	Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES8800936A1 (es)	1987-12-01	Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona
ES2010284A6 (es)	1989-11-01	Procedimiento para preparar derivados de tiourea.
BR9809643A (pt)	2000-10-03	Compostos heterocìclicos, seu processo de preparo e as composições farmacêuticas que os contêm
PT97766A (pt)	1992-03-31	Processo depreparacao de derivados de isocromano e de composicoes farmaceuticas que os contem
PE20000645A1 (es)	2000-07-26	Derivados de 3-(2-oxo-[1,3`]bipirrolidinil-3-ilidenmetil)-cefemos
DK160486C (da)	1991-08-26	N-(4-amino-2,2-diphenyl-butyl)- eller n-(3-amino-2,2-diphenyl-propyl) urinstofforbindelser, fremgangsmaade til fremstilling af disse, samt en farmaceutisk komposition
DE69925250D1 (de)	2005-06-16	Aktivatoren der kalium-kanäle
DE69427394D1 (de)	2001-07-12	Kondensierte heterocyclische glutaminsäurederivate als antiproliferative mittel
DK146585D0 (da)	1985-04-01	1,2,4-thiadiziner, praeparater med indhold deraf samt fremgangsmaade til deres fremstilling
IL83216A (en)	1991-07-18	1((5-(10->9)abeo-6-methylergolin-8beta-yl)methyl)-imidazolidine-(and hexahydropyrimidine)-2,4-dione derivatives,their preparation and pharmaceutical compositions containing them
GB1481948A (en)	1977-08-03	2-(disubstituted-amino)-4-phenyl-imidazolines and their use in pharmaceutical compositions
IL82122A0 (en)	1987-10-30	Stable injectable antiemetic compositions containing benzamide derivatives
ATE73801T1 (de)	1992-04-15	Heterocyclische oxophthalazinylessigsaeure.