OA08958A - Hydrate de B-lactame cristallin - Google Patents

Hydrate de B-lactame cristallin

Info

Publication number
OA08958A
OA08958A OA59444A OA59444A OA08958A OA 08958 A OA08958 A OA 08958A OA 59444 A OA59444 A OA 59444A OA 59444 A OA59444 A OA 59444A OA 08958 A OA08958 A OA 08958A
Authority
OA
OAPI
Prior art keywords
cristallin
lactame
hydrate
lactame cristallin
Prior art date
Application number
OA59444A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of OA08958A publication Critical patent/OA08958A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
OA59444A 1987-10-06 1988-10-05 Hydrate de B-lactame cristallin OA08958A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10576687A 1987-10-06 1987-10-06

Publications (1)

Publication Number Publication Date
OA08958A true OA08958A (en) 1990-11-30

Family

ID=22307671

Family Applications (1)

Application Number Title Priority Date Filing Date
OA59444A OA08958A (en) 1987-10-06 1988-10-05 Hydrate de B-lactame cristallin

Country Status (32)

Country Link
EP (1) EP0311366B1 (cs)
JP (1) JP2641745B2 (cs)
KR (1) KR970002637B1 (cs)
CN (1) CN1029966C (cs)
AR (1) AR248407A1 (cs)
AT (1) ATE103916T1 (cs)
AU (1) AU598155B2 (cs)
BG (1) BG47036A3 (cs)
CA (1) CA1334970C (cs)
CS (1) CS270594B2 (cs)
DD (1) DD273634A5 (cs)
DE (1) DE3888913T2 (cs)
DK (1) DK170070B1 (cs)
EG (1) EG18529A (cs)
ES (1) ES2063049T3 (cs)
FI (1) FI884554L (cs)
HK (1) HK15497A (cs)
HU (1) HU206348B (cs)
IE (1) IE62108B1 (cs)
IL (1) IL87905A (cs)
MX (1) MX13277A (cs)
MY (1) MY104063A (cs)
NO (1) NO884416L (cs)
NZ (1) NZ226450A (cs)
OA (1) OA08958A (cs)
PH (1) PH31002A (cs)
PL (1) PL152022B1 (cs)
PT (1) PT88662B (cs)
SU (1) SU1731058A3 (cs)
UA (1) UA19149A (cs)
YU (1) YU46699B (cs)
ZA (1) ZA887409B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU46700B (sh) * 1987-10-07 1994-04-05 Eli Lilly And Co. Kristalni monohidrat i kristalni mono- i bis (n-n'-dimetilformamid) solvati beta-laktamskog antibiotika
CA2002597C (en) * 1988-11-14 1999-03-23 Thomas M. Eckrich Solvates of b-lactam antibiotic
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
CA2034592C (en) * 1990-01-26 2001-06-05 Ralph R. Pfeiffer Crystalline hydrochloride of new beta-lactam antibiotic and process therefor
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5352782A (en) * 1993-06-04 1994-10-04 Eli Lilly And Company Process for preparing crystalline β-lactam monohydrate
US5374719A (en) * 1993-06-04 1994-12-20 Eli Lilly And Company Process for converting loracarbef dihydrate to loracarbef monohydrate
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5412094A (en) * 1993-06-28 1995-05-02 Eli Lilly And Company Bicyclic beta-lactam/paraben complexes
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
KR20070120617A (ko) 2001-01-26 2007-12-24 쉐링 코포레이션 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
IL156445A0 (en) 2001-01-26 2004-01-04 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
EP1429756B1 (en) 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
CA2504916A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
WO2004081002A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
DE602004018617D1 (de) 2003-03-07 2009-02-05 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004081004A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
YU46700B (sh) * 1987-10-07 1994-04-05 Eli Lilly And Co. Kristalni monohidrat i kristalni mono- i bis (n-n'-dimetilformamid) solvati beta-laktamskog antibiotika

Also Published As

Publication number Publication date
DK170070B1 (da) 1995-05-15
KR970002637B1 (ko) 1997-03-07
MX13277A (es) 1993-11-01
SU1731058A3 (ru) 1992-04-30
CS666688A2 (en) 1989-11-14
NZ226450A (en) 1990-05-28
JP2641745B2 (ja) 1997-08-20
CN1029966C (zh) 1995-10-11
DK553788A (da) 1989-04-07
DD273634A5 (de) 1989-11-22
EG18529A (en) 1993-04-30
IL87905A0 (en) 1989-03-31
DE3888913T2 (de) 1994-08-11
EP0311366A1 (en) 1989-04-12
CA1334970C (en) 1995-03-28
ZA887409B (en) 1990-06-27
JPH01128983A (ja) 1989-05-22
PT88662B (pt) 1992-12-31
IE883015L (en) 1989-04-06
DK553788D0 (da) 1988-10-04
PH31002A (en) 1997-12-23
IE62108B1 (en) 1994-12-14
AU2337288A (en) 1989-04-06
ATE103916T1 (de) 1994-04-15
HK15497A (en) 1997-02-14
NO884416D0 (no) 1988-10-05
PT88662A (pt) 1988-11-01
CN1032793A (zh) 1989-05-10
ES2063049T3 (es) 1995-01-01
KR890006644A (ko) 1989-06-15
PL152022B1 (en) 1990-10-31
AU598155B2 (en) 1990-06-14
MY104063A (en) 1993-11-30
FI884554A0 (fi) 1988-10-04
YU184588A (en) 1990-02-28
CS270594B2 (en) 1990-07-12
YU46699B (sh) 1994-04-05
IL87905A (en) 1992-06-21
FI884554A7 (fi) 1989-04-07
UA19149A (uk) 1997-12-25
BG47036A3 (bg) 1990-04-16
HU206348B (en) 1992-10-28
EP0311366B1 (en) 1994-04-06
NO884416L (no) 1989-04-07
HUT48884A (en) 1989-07-28
AR248407A1 (es) 1995-08-18
DE3888913D1 (de) 1994-05-11
PL275093A1 (en) 1989-05-02
FI884554L (fi) 1989-04-07

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