OA10038A - Bordetella pertussis vaccine - Google Patents

Bordetella pertussis vaccine Download PDF

Info

Publication number
OA10038A
OA10038A OA59614A OA59614A OA10038A OA 10038 A OA10038 A OA 10038A OA 59614 A OA59614 A OA 59614A OA 59614 A OA59614 A OA 59614A OA 10038 A OA10038 A OA 10038A
Authority
OA
OAPI
Prior art keywords
coding sequence
pertussis toxin
amino acid
pertussis
subunit
Prior art date
Application number
OA59614A
Other languages
English (en)
Inventor
Carine Capiau
Camille Locht
Original Assignee
Smithkline Biolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Biolog filed Critical Smithkline Biolog
Publication of OA10038A publication Critical patent/OA10038A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
OA59614A 1988-07-22 1989-07-17 Bordetella pertussis vaccine OA10038A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22299188A 1988-07-22 1988-07-22

Publications (1)

Publication Number Publication Date
OA10038A true OA10038A (en) 1996-10-14

Family

ID=22834543

Family Applications (1)

Application Number Title Priority Date Filing Date
OA59614A OA10038A (en) 1988-07-22 1989-07-17 Bordetella pertussis vaccine

Country Status (16)

Country Link
EP (1) EP0352250B1 (de)
JP (1) JP2798986B2 (de)
KR (1) KR900001852A (de)
AP (1) AP8900132A0 (de)
AT (1) ATE142697T1 (de)
AU (1) AU3827089A (de)
DE (1) DE68927144T2 (de)
DK (1) DK355789A (de)
FI (1) FI893512A7 (de)
HU (1) HUT52701A (de)
IL (1) IL90994A0 (de)
NO (1) NO892997L (de)
NZ (1) NZ229954A (de)
OA (1) OA10038A (de)
PT (1) PT91248A (de)
ZA (1) ZA895573B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE106747T1 (de) * 1987-06-24 1994-06-15 Teijin Ltd Bordetella pertussis-varianten.
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
ATE127347T1 (de) * 1989-04-28 1995-09-15 Sclavo Spa Pertussistoxin-mutanten, dieselbe produzierende bordetella-stämme und ihre verwendung als vakzin gegen pertussis.
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
ATE143692T1 (de) * 1989-11-29 1996-10-15 Smithkline Beecham Biolog Neuer impfstoff
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
DE69434000T3 (de) * 1993-10-05 2008-11-06 UCB Pharma Ltd., Slough Impfstoffzusammensetzungen
US20030072774A1 (en) * 1994-06-10 2003-04-17 Diane M. Gajewczyk Proteinaceous adjuvants

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340373C (en) * 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
US4762710A (en) * 1986-06-16 1988-08-09 The United States Of America As Represented By The Department Of Health And Human Services Novel method of preparing toxoid by oxidation and metal ions
IT1223334B (it) * 1987-11-02 1990-09-19 Sclavo Spa Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
ATE127347T1 (de) * 1989-04-28 1995-09-15 Sclavo Spa Pertussistoxin-mutanten, dieselbe produzierende bordetella-stämme und ihre verwendung als vakzin gegen pertussis.

Also Published As

Publication number Publication date
EP0352250A3 (de) 1990-11-14
EP0352250A2 (de) 1990-01-24
IL90994A0 (en) 1990-02-09
ZA895573B (en) 1990-07-25
FI893512L (fi) 1990-01-23
JP2798986B2 (ja) 1998-09-17
JPH0284183A (ja) 1990-03-26
EP0352250B1 (de) 1996-09-11
NO892997L (no) 1990-01-23
AP8900132A0 (en) 1991-01-14
AU3827089A (en) 1990-01-25
DK355789D0 (da) 1989-07-18
KR900001852A (ko) 1990-02-27
FI893512A7 (fi) 1990-01-23
HK1004568A1 (en) 1998-11-27
DE68927144D1 (de) 1996-10-17
ATE142697T1 (de) 1996-09-15
HUT52701A (en) 1990-08-28
DK355789A (da) 1990-01-23
FI893512A0 (fi) 1989-07-20
PT91248A (pt) 1990-02-08
NO892997D0 (no) 1989-07-21
NZ229954A (en) 1992-09-25
DE68927144T2 (de) 1997-03-20

Similar Documents

Publication Publication Date Title
EP0322115B2 (de) Gentechnische Detoxifikation des Pertussistoxins
US6040427A (en) Vaccine
Sebo et al. Cell-invasive activity of epitope-tagged adenylate cyclase of Bordetella pertussis allows in vitro presentation of a foreign epitope to CD8+ cytotoxic T cells
US5358868A (en) Genetic detoxification of pertussis toxin
US5221618A (en) Genetic detoxification of pertussis toxin
US5244657A (en) Genetic detoxification of pertussis toxin
US5332583A (en) Vaccine containing genetically-detoxified pertussis holotoxin
CA2221480A1 (en) Mutants of streptococcal toxin a and methods of use
OA10038A (en) Bordetella pertussis vaccine
CA2113562C (en) Poultry mycoplasma antigens, gene thereof and recombinant vectors containing the gene as well as vaccines utilizing the same
AU7625798A (en) Mutants of streptococcal toxin A and methods of use
US6309648B1 (en) Protective epitopes of adenyl cyclase-haemolysin (AC-Hly), their application to the treatment or to the prevention of bordetella infections
EP0502016B1 (de) Neuer impfstoff
CA2475993C (en) Defective entities and uses therefor
HK1004568B (en) Bordetella pertussis vaccine
AU2002357406B2 (en) Defective entities and uses therefor
EP0420743A1 (de) Impfstoff zum Schutz gegen Schweinhämophilus
WO1997023503A1 (en) Vaccine component
HK1004569B (en) Novel vaccine