OA10235A - Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders - Google Patents

Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders Download PDF

Info

Publication number
OA10235A
OA10235A OA60720A OA60720A OA10235A OA 10235 A OA10235 A OA 10235A OA 60720 A OA60720 A OA 60720A OA 60720 A OA60720 A OA 60720A OA 10235 A OA10235 A OA 10235A
Authority
OA
OAPI
Prior art keywords
methyl
pyridinyl
fluoro
bis
indeno
Prior art date
Application number
OA60720A
Other languages
English (en)
Inventor
Teleha Christopher Allan
Wilkerson Wendell Wilkie
Earl Richard Alan
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/216,881 external-priority patent/US5594001A/en
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of OA10235A publication Critical patent/OA10235A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
OA60720A 1993-04-08 1995-10-06 Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders OA10235A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4401293A 1993-04-08 1993-04-08
US08/216,881 US5594001A (en) 1993-04-08 1994-03-28 Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders

Publications (1)

Publication Number Publication Date
OA10235A true OA10235A (en) 1997-10-07

Family

ID=26721086

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60720A OA10235A (en) 1993-04-08 1995-10-06 Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders

Country Status (21)

Country Link
US (1) US5990132A (ro)
EP (1) EP0693069A1 (ro)
JP (1) JPH08509713A (ro)
CN (2) CN1058495C (ro)
AU (1) AU690906B2 (ro)
BR (1) BR9405954A (ro)
CA (1) CA2160112A1 (ro)
CZ (1) CZ251995A3 (ro)
FI (1) FI954775A7 (ro)
HU (1) HUT74104A (ro)
IL (1) IL109237A (ro)
LV (1) LV11179B (ro)
NO (1) NO308745B1 (ro)
NZ (1) NZ265183A (ro)
OA (1) OA10235A (ro)
PL (1) PL178570B1 (ro)
RO (1) RO115162B1 (ro)
RU (1) RU2152944C1 (ro)
SI (1) SI9420022A (ro)
SK (1) SK124695A3 (ro)
WO (1) WO1994024131A1 (ro)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750528A (en) * 1995-02-01 1998-05-12 The Dupont Merck Pharmaceutical Company Blockade of neuronal m-channels as a therapeutic approach to the treatment of neurological disease
US6262081B1 (en) * 1998-07-10 2001-07-17 Dupont Pharmaceuticals Company Composition for and method of treating neurological disorders
RU2424234C2 (ru) * 2005-08-05 2011-07-20 Ибриженикс Са Новые ингибиторы цистеиновых протеаз и их терапевтическое применение
JP5581607B2 (ja) * 2008-06-05 2014-09-03 住友化学株式会社 高分子化合物及びそれを用いた有機トランジスタ
RS58700B1 (sr) 2012-10-12 2019-06-28 Broad Inst Inc Gsk3 inhibitori i postupci njihove primene
KR101560061B1 (ko) 2012-11-30 2015-10-15 주식회사 엘지화학 신규한 화합물 및 이를 이용한 유기 전자 소자
US9593113B2 (en) 2013-08-22 2017-03-14 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
WO2015027015A1 (en) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Imidazole-derived modulators of the glucocorticoid receptor
KR101723997B1 (ko) * 2014-02-05 2017-04-06 브이엠 온콜로지 엘엘씨 화합물의 조성물 및 이의 용도
GB201417369D0 (en) * 2014-10-01 2014-11-12 Redx Pharma Ltd Compounds
EP3544961B1 (en) * 2016-11-07 2021-08-18 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m4
CA3058198A1 (en) 2017-04-05 2018-10-11 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1052346A (ro) * 1964-09-09
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
RU2045529C1 (ru) * 1988-04-26 1995-10-10 Ниссан Кемикал Индастриз Лтд. Способ получения мевалонолактоновых производных
FI935279L (fi) * 1991-05-29 1993-11-26 Pfizer Tricykliska polyhydroxyltyrosinkinasininhibitorer
CA2128233A1 (en) * 1992-01-16 1993-07-22 Wendell Wilkie Wilkerson Novel neurotransmitter releasers useful for cognition enhancement
RU2051151C1 (ru) * 1992-01-16 1995-12-27 Дзе Дюпон Мерк Фармасьютикал Компани Азотсодержащие гетероциклические производные флуорена
US5272269A (en) * 1992-01-16 1993-12-21 The Du Pont Merck Pharmaceutical Company Disubstituted polycyclic systems and preparative methods therefor
US5185447A (en) * 1992-01-29 1993-02-09 Du Pont Merck Pharmaceutical Company Polycyclic ketones and preparative methods therefor
US5359070A (en) * 1993-02-11 1994-10-25 The Du Pont Merck Pharmaceutical Company Unsymmetrical bis-imides as anticancer agents

Also Published As

Publication number Publication date
US5990132A (en) 1999-11-23
SI9420022A (en) 1996-10-31
NO308745B1 (no) 2000-10-23
CN1295072A (zh) 2001-05-16
CN1122135A (zh) 1996-05-08
NZ265183A (en) 1997-11-24
HUT74104A (en) 1996-11-28
FI954775A0 (fi) 1995-10-06
RU2152944C1 (ru) 2000-07-20
PL310997A1 (en) 1996-01-22
CA2160112A1 (en) 1994-10-27
PL178570B1 (pl) 2000-05-31
IL109237A (en) 1998-02-08
JPH08509713A (ja) 1996-10-15
NO953989D0 (no) 1995-10-06
IL109237A0 (en) 1994-07-31
SK124695A3 (en) 1996-06-05
CZ251995A3 (en) 1996-01-17
RO115162B1 (ro) 1999-11-30
AU690906B2 (en) 1998-05-07
HU9502929D0 (en) 1995-11-28
LV11179B (en) 1997-06-20
AU6554994A (en) 1994-11-08
NO953989L (no) 1995-12-07
WO1994024131A1 (en) 1994-10-27
BR9405954A (pt) 1995-12-26
CN1058495C (zh) 2000-11-15
LV11179A (lv) 1996-04-20
EP0693069A1 (en) 1996-01-24
FI954775L (fi) 1995-10-06
FI954775A7 (fi) 1995-10-06

Similar Documents

Publication Publication Date Title
JP7299382B2 (ja) Tnf活性のモジュレーターとしての縮合五環式イミダゾール誘導体
DE69811070T2 (de) 9-azabicyclo(3.3.1)non-2-ene und nonanderivate als liganden der nicotinergen rezeptoren
CN105814055B (zh) 作为tnf活性调节剂的稠合咪唑和吡唑衍生物
DE69826883T2 (de) Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren
DE69619704T2 (de) Heteroacylcarbonsäureamiderivate
NO884835L (no) Fremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-furo-og-tieno (2,3.-c)pyridiner.
TW201718493A (zh) 作為magl抑制劑的胺基甲酸1,1,1-三氟-3-羥基丙烷-2-基酯衍生物及胺基甲酸1,1,1-三氟-4-羥基丁烷-2-基酯衍生物
US5594001A (en) Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
CN105814022A (zh) 作为tnf活性调节剂的稠合的二环杂芳族衍生物
RU2190612C2 (ru) Новые производные индол-2,3-дион-3-оксима
OA10235A (en) Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders
CN102137866A (zh) 羟吲哚化合物
JPH01249769A (ja) 向精神性ヘテロビシクロアルキルピペラジン誘導体
CA2579059A1 (en) Chemical compounds
CA2144636A1 (en) 3,3'- disubstituted-1,3-dihydro-2h-pyrrolo [2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
EP1025100B1 (de) 3-substituierte tetrahydropyridopyrimidinon-derivate, ihre herstellung und verwendung
CN115466289A (zh) 具有tyk2抑制活性的化合物,包含其的药物组合物,及其应用
EP0623132B1 (en) Disubstituted polycyclic systems as cognition enhancers
KR19990082192A (ko) 축합 2,3-벤조디아제핀 유도체 및 에이엠피에이 수용체 억제제로서의 그 용도
DE19746612A1 (de) 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung
NO860048L (no) Octahydroindolizin-forbindelser med analgetisk virkning.
WO1993021185A1 (en) Substituted nitrogen containing spiro compounds for use in treating cognitive deficits
US5308851A (en) Bispyridyl-containing heterocycles useful for treating cognitive disorders
HK40075865A (en) Compounds having tyk2 inhibitory activity, pharmaceutical composition comprising the same, and use thereof
JPWO2001032173A1 (ja) カイニン酸神経細胞毒性阻害剤