OA10712A - 1,4-Dihydropyridine compounds as bradykinin antagonists - Google Patents

1,4-Dihydropyridine compounds as bradykinin antagonists Download PDF

Info

Publication number: OA10712A
Authority: OA; OAPI
Prior art keywords: dimethyl; dihydropyridine; dichlorophenyl; carbonylmethyl; oxo
Prior art date: 1996-02-19

Application number

OA9800111A

Other languages

English (en)

Inventor

Takafumi Ikeda

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-19

Filing date

1998-07-10

Publication date

2001-06-04

1998-07-10 Application filed by Pfizer filed Critical Pfizer

2001-06-04 Publication of OA10712A publication Critical patent/OA10712A/en

Links

YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title description 18
239000003152 bradykinin antagonist Substances 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims abstract description 54
-1 8-azabicyclo[3.2.1]octyl Chemical group 0.000 claims abstract description 35
150000003839 salts Chemical class 0.000 claims abstract description 9
208000002193 Pain Diseases 0.000 claims abstract description 8
230000036407 pain Effects 0.000 claims abstract description 8
208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 7
206010020751 Hypersensitivity Diseases 0.000 claims abstract description 6
208000004221 Multiple Trauma Diseases 0.000 claims abstract description 6
206010033645 Pancreatitis Diseases 0.000 claims abstract description 6
230000007815 allergy Effects 0.000 claims abstract description 6
208000006673 asthma Diseases 0.000 claims abstract description 6
230000009385 viral infection Effects 0.000 claims abstract description 6
206010019196 Head injury Diseases 0.000 claims abstract description 5
201000009240 nasopharyngitis Diseases 0.000 claims abstract description 5
125000004356 hydroxy functional group Chemical group O* 0.000 claims abstract description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 3
125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 claims abstract description 3
125000004434 sulfur atom Chemical group 0.000 claims abstract description 3
238000000034 method Methods 0.000 claims description 51
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 41
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 39
239000002253 acid Substances 0.000 claims description 14
125000000217 alkyl group Chemical group 0.000 claims description 8
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
201000010099 disease Diseases 0.000 claims description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
239000003937 drug carrier Substances 0.000 claims description 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
125000001309 chloro group Chemical group Cl* 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
239000008194 pharmaceutical composition Substances 0.000 claims description 2
NVOCCLHJGMFCLO-UHFFFAOYSA-N dimethyl 2-(benzenesulfinylmethyl)-4-(2,6-dichlorophenyl)-6-[2-oxo-2-[4-(5-oxocyclooctyl)piperazin-1-yl]ethyl]-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound N1C(CS(=O)C=2C=CC=CC=2)=C(C(=O)OC)C(C=2C(=CC=CC=2Cl)Cl)C(C(=O)OC)=C1CC(=O)N(CC1)CCN1C1CCCC(=O)CCC1 NVOCCLHJGMFCLO-UHFFFAOYSA-N 0.000 claims 1
125000004193 piperazinyl group Chemical group 0.000 claims 1
101800004538 Bradykinin Proteins 0.000 abstract description 13
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract description 13
102100035792 Kininogen-1 Human genes 0.000 abstract description 13
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract description 13
206010061218 Inflammation Diseases 0.000 abstract description 7
230000004054 inflammatory process Effects 0.000 abstract description 7
230000003042 antagnostic effect Effects 0.000 abstract description 3
125000001475 halogen functional group Chemical group 0.000 abstract description 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 abstract 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 42
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VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 24
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235000019198 oils Nutrition 0.000 description 16
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 14
101150041968 CDC13 gene Proteins 0.000 description 13
HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 13
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UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 12
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IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 8
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
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YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 7
239000012267 brine Substances 0.000 description 7
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239000000284 extract Substances 0.000 description 7
229910052943 magnesium sulfate Inorganic materials 0.000 description 7
235000019341 magnesium sulphate Nutrition 0.000 description 7
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102000005962 receptors Human genes 0.000 description 7
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HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
239000003795 chemical substances by application Substances 0.000 description 6
238000001816 cooling Methods 0.000 description 6
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
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QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 5
241000124008 Mammalia Species 0.000 description 5
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125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 5
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JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 5
210000003932 urinary bladder Anatomy 0.000 description 5
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
230000037396 body weight Effects 0.000 description 4
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239000003085 diluting agent Substances 0.000 description 4
229960000443 hydrochloric acid Drugs 0.000 description 4
235000011167 hydrochloric acid Nutrition 0.000 description 4
239000010410 layer Substances 0.000 description 4
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229910052757 nitrogen Inorganic materials 0.000 description 4
238000000967 suction filtration Methods 0.000 description 4
150000003462 sulfoxides Chemical class 0.000 description 4
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
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KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 3
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HJGMRAKQWLKWMH-UHFFFAOYSA-N 8-methyl-8-azabicyclo[3.2.1]octan-3-amine Chemical compound C1C(N)CC2CCC1N2C HJGMRAKQWLKWMH-UHFFFAOYSA-N 0.000 description 2
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DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000005557 antagonist Substances 0.000 description 2
239000007900 aqueous suspension Substances 0.000 description 2
238000003556 assay Methods 0.000 description 2
238000010533 azeotropic distillation Methods 0.000 description 2
150000003935 benzaldehydes Chemical class 0.000 description 2
HUMNYLRZRPPJDN-UHFFFAOYSA-N benzenecarboxaldehyde Natural products O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
UYRCOTSOPWOSJK-JXTBTVDRSA-N bradykinin antagonist Chemical compound C1C2=CC=CC=C2CC1[C@@H](NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)[C@H]1N(C[C@H](O)C1)C(=O)C1N(CCC1)C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=N)CCCCCCC(=N)N[C@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N1C(CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)NC(C1CC2=CC=CC=C2C1)C(=O)NC(CO)C(=O)N[C@H](C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O)C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(=N)N)C(O)=O UYRCOTSOPWOSJK-JXTBTVDRSA-N 0.000 description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
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Organic Chemistry (AREA)
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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Immunology (AREA)
Biomedical Technology (AREA)
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Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Otolaryngology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Hydrogenated Pyridines (AREA)

OA9800111A 1996-02-19 1998-07-10 1,4-Dihydropyridine compounds as bradykinin antagonists OA10712A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IB9600132		1996-02-19

Publications (1)

Publication Number	Publication Date
OA10712A true OA10712A (en)	2001-06-04

Family

ID=11004406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9800111A OA10712A (en)	1996-02-19	1998-07-10	1,4-Dihydropyridine compounds as bradykinin antagonists

Country Status (34)

Country	Link
US (1)	US6131226A (id)
EP (1)	EP0882044B1 (id)
JP (1)	JP3167335B2 (id)
KR (1)	KR19990082678A (id)
CN (1)	CN1211251A (id)
AR (1)	AR005841A1 (id)
AT (1)	ATE220676T1 (id)
AU (1)	AU1396497A (id)
BG (1)	BG102678A (id)
BR (1)	BR9707568A (id)
CA (1)	CA2245857C (id)
CO (1)	CO4650041A1 (id)
CZ (1)	CZ258698A3 (id)
DE (1)	DE69714019T2 (id)
DK (1)	DK0882044T3 (id)
ES (1)	ES2177921T3 (id)
HN (1)	HN1997000013A (id)
HR (1)	HRP970094A2 (id)
HU (1)	HUP9902810A3 (id)
ID (1)	ID16434A (id)
IL (1)	IL124867A0 (id)
IS (1)	IS4783A (id)
MA (1)	MA26419A1 (id)
NO (1)	NO983776D0 (id)
NZ (1)	NZ325455A (id)
OA (1)	OA10712A (id)
PE (1)	PE36298A1 (id)
PL (1)	PL328514A1 (id)
PT (1)	PT882044E (id)
SI (1)	SI0882044T1 (id)
TN (1)	TNSN97037A1 (id)
TR (1)	TR199801593T2 (id)
WO (1)	WO1997030048A1 (id)
ZA (1)	ZA971357B (id)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH11106375A (ja) *	1997-08-18	1999-04-20	Pfizer Pharmaceut Inc	ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物
EP1110962A1 (en) *	1999-12-10	2001-06-27	Pfizer Inc.	Process for preparing 1,4-dihydropyridine compounds
US6653313B2 (en) *	2000-08-10	2003-11-25	Warner-Lambert Company Llc	1,4-dihydropyridine compounds as bradykinin antagonists
GB0427281D0 (en) *	2004-12-14	2005-01-12	3M Innovative Properties Co	Methods of providing medicinal metal components having through holes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5120750A (en) *	1989-01-17	1992-06-09	Synphar Laboratories, Inc.	Generation of 1,4-dihydropyridine derivatives
WO1996006083A1 (en)	1994-08-24	1996-02-29	Pfizer Pharmaceuticals Inc.	2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists
MX9701245A (es) *	1996-02-19	1998-04-30	Pfizer	Compuestos de 1,4 dihidropiridina.

1996
- 1996-02-18 TN TNTNSN97037A patent/TNSN97037A1/fr unknown
1997
- 1997-01-27 IL IL12486797A patent/IL124867A0/xx unknown
- 1997-01-27 AT AT97900401T patent/ATE220676T1/de not_active IP Right Cessation
- 1997-01-27 CZ CZ982586A patent/CZ258698A3/cs unknown
- 1997-01-27 AU AU13964/97A patent/AU1396497A/en not_active Abandoned
- 1997-01-27 ES ES97900401T patent/ES2177921T3/es not_active Expired - Lifetime
- 1997-01-27 KR KR1019980706424A patent/KR19990082678A/ko not_active Ceased
- 1997-01-27 WO PCT/IB1997/000058 patent/WO1997030048A1/en not_active Ceased
- 1997-01-27 NZ NZ325455A patent/NZ325455A/xx unknown
- 1997-01-27 PL PL97328514A patent/PL328514A1/xx unknown
- 1997-01-27 DK DK97900401T patent/DK0882044T3/da active
- 1997-01-27 US US09/125,137 patent/US6131226A/en not_active Expired - Fee Related
- 1997-01-27 DE DE69714019T patent/DE69714019T2/de not_active Expired - Fee Related
- 1997-01-27 EP EP97900401A patent/EP0882044B1/en not_active Expired - Lifetime
- 1997-01-27 SI SI9730361T patent/SI0882044T1/xx unknown
- 1997-01-27 CN CN97192240A patent/CN1211251A/zh active Pending
- 1997-01-27 HN HN1997000013A patent/HN1997000013A/es unknown
- 1997-01-27 JP JP52913897A patent/JP3167335B2/ja not_active Expired - Fee Related
- 1997-01-27 HU HU9902810A patent/HUP9902810A3/hu unknown
- 1997-01-27 TR TR1998/01593T patent/TR199801593T2/xx unknown
- 1997-01-27 CA CA002245857A patent/CA2245857C/en not_active Expired - Fee Related
- 1997-01-27 BR BR9707568A patent/BR9707568A/pt active Search and Examination
- 1997-01-27 PT PT97900401T patent/PT882044E/pt unknown
- 1997-02-10 PE PE1997000085A patent/PE36298A1/es not_active Application Discontinuation
- 1997-02-13 CO CO97007547A patent/CO4650041A1/es unknown
- 1997-02-17 AR ARP970100614A patent/AR005841A1/es unknown
- 1997-02-18 HR HRPCT/IB96/00132A patent/HRP970094A2/xx not_active Application Discontinuation
- 1997-02-18 ID IDP970467A patent/ID16434A/id unknown
- 1997-02-18 ZA ZA971357A patent/ZA971357B/xx unknown
- 1997-02-18 MA MA24498A patent/MA26419A1/fr unknown
1998
- 1998-06-25 IS IS4783A patent/IS4783A/is unknown
- 1998-07-10 OA OA9800111A patent/OA10712A/en unknown
- 1998-08-10 BG BG102678A patent/BG102678A/xx unknown
- 1998-08-18 NO NO983776A patent/NO983776D0/no unknown

Also Published As

Publication number	Publication date
NO983776L (no)	1998-08-18
MA26419A1 (fr)	2004-12-20
JP3167335B2 (ja)	2001-05-21
CO4650041A1 (es)	1998-09-03
CA2245857A1 (en)	1997-08-21
TR199801593T2 (xx)	1999-12-21
ZA971357B (en)	1998-08-18
ES2177921T3 (es)	2002-12-16
CA2245857C (en)	2002-10-01
US6131226A (en)	2000-10-17
IS4783A (is)	1998-06-25
KR19990082678A (ko)	1999-11-25
HRP970094A2 (en)	1998-06-30
DE69714019T2 (de)	2002-11-14
AR005841A1 (es)	1999-07-14
BG102678A (en)	1999-04-30
DK0882044T3 (da)	2002-09-02
WO1997030048A1 (en)	1997-08-21
EP0882044A1 (en)	1998-12-09
ID16434A (id)	1997-09-25
BR9707568A (pt)	1999-07-27
NZ325455A (en)	1999-07-29
PL328514A1 (en)	1999-02-01
CZ258698A3 (cs)	1999-06-16
HUP9902810A2 (hu)	2000-05-28
PE36298A1 (es)	1998-07-18
TNSN97037A1 (fr)	2005-03-15
HUP9902810A3 (en)	2000-09-28
EP0882044B1 (en)	2002-07-17
HN1997000013A (es)	1997-06-26
IL124867A0 (en)	1999-01-26
JPH11507949A (ja)	1999-07-13
ATE220676T1 (de)	2002-08-15
NO983776D0 (no)	1998-08-18
AU1396497A (en)	1997-09-02
CN1211251A (zh)	1999-03-17
PT882044E (pt)	2002-11-29
SI0882044T1 (en)	2002-10-31
DE69714019D1 (de)	2002-08-22

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