OA10804A - Substituted N-[(aminoiminomethyl or aminomethyl) phenyl]propyl amides - Google Patents

Substituted N-[(aminoiminomethyl or aminomethyl) phenyl]propyl amides Download PDF

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OA10804A
OA10804A OA9800100A OA9800100A OA10804A OA 10804 A OA10804 A OA 10804A OA 9800100 A OA9800100 A OA 9800100A OA 9800100 A OA9800100 A OA 9800100A OA 10804 A OA10804 A OA 10804A
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OAPI
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compound
nmr
mmol
optionally substituted
solution
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OA9800100A
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English (en)
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Kevin R Guertin
Scott I Klein
Alfred P Spada
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Rhone Poulenc Rorer Pharma
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Publication of OA10804A publication Critical patent/OA10804A/en

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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OA9800100A 1996-01-02 1998-07-01 Substituted N-[(aminoiminomethyl or aminomethyl) phenyl]propyl amides OA10804A (en)

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CA2241904C (en) * 1996-01-02 2004-12-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
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AU8749598A (en) * 1997-08-26 1999-03-16 Ihara Chemical Industry Co. Ltd. Biarylalkylenecarbamic acid derivatives and bacteriocides for agricultural an d horticultural use
US6740682B2 (en) 1997-08-29 2004-05-25 Tularik Limited Meta-benzamidine derivatives as serine protease inhibitors
ES2224620T3 (es) * 1998-03-23 2005-03-01 Aventis Pharmaceuticals Inc. Derivados de piperidinilo y n-aminopiperidinilo.
AU758567B2 (en) * 1998-06-08 2003-03-27 Ajinomoto Co., Inc. Benzamidine derivative
CA2348740A1 (en) 1998-12-23 2000-07-06 Ruth R. Wexler Thrombin or factor xa inhibitors
CA2358091A1 (en) * 1998-12-23 2000-07-06 Eli Lilly And Company Antithrombotic amides
CZ20012350A3 (cs) 1998-12-24 2001-09-12 Aventis Pharmaceuticals Products Inc. Substituované (aminoiminomethyl nebo aminomethyl) benzoheteroarylové sloučeniny
CA2358581C (en) 1999-01-02 2010-02-02 Aventis Pharma Deutschland Gmbh Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
EP1022268A1 (en) * 1999-01-02 2000-07-26 Aventis Pharma Deutschland GmbH Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
US6794412B1 (en) * 1999-03-11 2004-09-21 Bristol-Myers Squibb Pharma Company Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin
US6855715B1 (en) 1999-06-14 2005-02-15 Eli Lilly And Company Serine protease inhibitors
DE60027204T2 (de) * 1999-10-28 2006-11-23 Sankyo Co., Ltd. Benzamidinderivate
IL149398A0 (en) 1999-11-02 2002-11-10 Aventis Pharma Gmbh USE OF RUSSELL'S VIPER VENOM-INDUCED PLASMA FACTOR Xa ACTIVITY TO MONITOR THE ACTIVITY OF FACTOR Xa INHIBITORS
DE10006601A1 (de) 2000-02-15 2001-08-16 Clariant Gmbh Verfahren zur Herstellung von 4-(4'-Carboxyphenyl)pyridin
GB0108903D0 (en) * 2000-10-05 2001-05-30 Aventis Pharm Prod Inc Novel crystalline forms of a factor Xa inhibitor
EP1569912B1 (en) 2002-12-03 2015-04-29 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
DE102006048300A1 (de) 2006-01-26 2007-08-02 Hellstern, Peter, Prof. Dr.med. Inhibitoren des Blutgerinnungsfaktors Xa zur Verwendung als Antikoagulans
CN102438981B (zh) * 2009-04-17 2015-04-22 德国麦氏大药厂 1-氨基-1,3,3,5,5-五甲基环己烷甲磺酸盐的合成
JP2013500298A (ja) 2009-07-29 2013-01-07 サノフイ 高齢かつ腎障害の非ｓｔ上昇型心筋梗塞患者の処置のためのオタミキサバン
GB0919194D0 (en) 2009-11-02 2009-12-16 Lytix Biopharma As Compounds
BR112013024801A2 (pt) 2011-03-29 2016-12-20 Sanofi Sa formulações de otamixaban com estabilidade aprimorada
MX2013011266A (es) 2011-03-29 2014-03-27 Sanofi Sa Sal de acido benzoico de otamixaban.
US9120776B2 (en) 2011-09-22 2015-09-01 Takeda Pharmaceutical Company Limited Condensed heterocyclic compound
EP2890381A1 (en) 2012-08-31 2015-07-08 Sanofi Otamixaban for use in the treatment of non-st elevation acute coronary syndrome in patients planned to undergo coronary artery bypass grafting
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
US10351750B2 (en) 2017-02-03 2019-07-16 Saudi Arabian Oil Company Drilling fluid compositions with enhanced rheology and methods of using same
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide

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BR9612423A (pt) 1999-12-28
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CN1273128C (zh) 2006-09-06
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DE69628856D1 (de) 2003-07-31
PT906094E (pt) 2003-11-28
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KR100348338B1 (ko) 2003-06-02
NO310719B1 (no) 2001-08-20
ATE243512T1 (de) 2003-07-15
HUP9900930A2 (hu) 1999-08-30
SI0906094T1 (en) 2003-12-31
AU1520797A (en) 1997-07-28
ES2197257T3 (es) 2004-01-01
CZ9802010A3 (cs) 1999-09-15
HUP9900930A3 (en) 2001-11-28
EP0906094B1 (en) 2003-06-25
PL327633A1 (en) 1998-12-21
NO983039D0 (no) 1998-06-30
NO983039L (no) 1998-09-02
CZ297544B6 (cs) 2007-02-07
AP861A (en) 2000-08-01
IL125163A0 (en) 1999-01-26
EP0906094A1 (en) 1999-04-07
BG64143B1 (bg) 2004-02-27
BR9612423B1 (pt) 2010-11-30
EA001932B1 (ru) 2001-10-22
US6140504A (en) 2000-10-31
PL185460B1 (pl) 2003-05-30
HU228355B1 (en) 2013-03-28
SK284507B6 (sk) 2005-05-05
CA2241904A1 (en) 1997-07-10
SI9620136A (sl) 1999-04-30
JP4053597B2 (ja) 2008-02-27
AU723338B2 (en) 2000-08-24
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