OA10958A - Trovafloxacin mesylate tablet - Google Patents

Trovafloxacin mesylate tablet Download PDF

Info

Publication number: OA10958A
Authority: OA; OAPI
Prior art keywords: composition; weight; cellulose; tablet; trovafloxacin
Prior art date: 1998-01-21

Application number

OA9900009A

Other languages

English (en)

Inventor

Alton Dale Johnson

Christopher Mickael Sinko

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-21

Filing date

1999-01-15

Publication date

2001-10-31

1999-01-15 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2001-10-31 Publication of OA10958A publication Critical patent/OA10958A/en

Links

229960005021 trovafloxacin mesylate Drugs 0.000 title claims abstract description 28
DYNZICQDCVYXFW-AHZSKCOESA-N trovafloxacin mesylate Chemical compound CS(O)(=O)=O.C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F DYNZICQDCVYXFW-AHZSKCOESA-N 0.000 title claims abstract description 28
239000000203 mixture Substances 0.000 claims abstract description 55
229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 16
235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 16
239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 16
229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 16
239000000314 lubricant Substances 0.000 claims abstract description 12
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 17
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 12
239000007888 film coating Substances 0.000 claims description 12
238000009501 film coating Methods 0.000 claims description 12
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 12
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235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 10
239000007884 disintegrant Substances 0.000 claims description 8
235000010980 cellulose Nutrition 0.000 claims description 7
229920002678 cellulose Polymers 0.000 claims description 7
239000001913 cellulose Substances 0.000 claims description 7
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 6
239000011248 coating agent Substances 0.000 claims description 4
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SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 5
238000004090 dissolution Methods 0.000 abstract description 22
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229960000497 trovafloxacin Drugs 0.000 description 16
WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 description 16
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NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000001259 polydextrose Substances 0.000 description 1
235000013856 polydextrose Nutrition 0.000 description 1
229940035035 polydextrose Drugs 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000000634 powder X-ray diffraction Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
238000012207 quantitative assay Methods 0.000 description 1
239000003306 quinoline derived antiinfective agent Substances 0.000 description 1
238000009490 roller compaction Methods 0.000 description 1
235000002020 sage Nutrition 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000012898 sample dilution Substances 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000013112 stability test Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229940071138 stearyl fumarate Drugs 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000001789 thuja occidentalis l. leaf oil Substances 0.000 description 1
239000010678 thyme oil Substances 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
235000013976 turmeric Nutrition 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000003643 water by type Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
239000009637 wintergreen oil Substances 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

OA9900009A 1998-01-21 1999-01-15 Trovafloxacin mesylate tablet OA10958A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US7201398P	1998-01-21	1998-01-21

Publications (1)

Publication Number	Publication Date
OA10958A true OA10958A (en)	2001-10-31

Family

ID=22105016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900009A OA10958A (en)	1998-01-21	1999-01-15	Trovafloxacin mesylate tablet

Country Status (34)

Country	Link
US (1)	US6187341B1 (fr)
EP (1)	EP0930068A3 (fr)
JP (1)	JPH11269072A (fr)
KR (1)	KR100314977B1 (fr)
CN (1)	CN1227743A (fr)
AP (1)	AP1094A (fr)
AR (1)	AR012780A1 (fr)
AU (1)	AU758381B2 (fr)
BG (1)	BG103106A (fr)
BR (1)	BR9900116A (fr)
CA (1)	CA2259698C (fr)
CO (1)	CO4810225A1 (fr)
DZ (1)	DZ2712A1 (fr)
EA (1)	EA003247B1 (fr)
GT (1)	GT199900004A (fr)
HR (1)	HRP990023A2 (fr)
HU (1)	HUP9900154A3 (fr)
ID (1)	ID23735A (fr)
IL (1)	IL128051A0 (fr)
IS (1)	IS4947A (fr)
MA (1)	MA24747A1 (fr)
NO (1)	NO990243L (fr)
NZ (1)	NZ333838A (fr)
OA (1)	OA10958A (fr)
PA (1)	PA8466701A1 (fr)
PE (1)	PE20000169A1 (fr)
PL (1)	PL330981A1 (fr)
SG (1)	SG70666A1 (fr)
SK (1)	SK4299A3 (fr)
TN (1)	TNSN99007A1 (fr)
TR (1)	TR199900089A2 (fr)
TW (1)	TW518224B (fr)
YU (1)	YU2399A (fr)
ZA (1)	ZA99393B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE279193T1 (de) *	1998-11-10	2004-10-15	Bayer Healthcare Ag	Pharmazeutische zubereitung von moxifloxacin
CA2382834A1 (fr) *	1999-09-20	2001-03-29	Alza Corporation	Procede destine a reduire la transformation polymorphique d'un medicament
AR025976A1 (es) *	1999-10-08	2002-12-26	Affinium Pharm Inc	Inhibidores de fab i.
FR2808441B1 (fr) *	2000-05-04	2004-06-18	Oreal	Utilisation de fibres dans une composition de soin ou de maquillage pour matifier la peau
DE10031043A1 (de) *	2000-06-26	2002-02-14	Bayer Ag	Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
CA2444597A1 (fr) *	2001-04-06	2002-10-06	Affinium Pharmaceuticals, Inc.	Inhibiteurs de fab i
EP1396263A1 (fr) *	2002-08-09	2004-03-10	Warner-Lambert Company	Compositions d'enrobage pour tablettes et caplets
CA2508792C (fr)	2002-12-06	2013-02-05	Affinium Pharmaceuticals, Inc.	Composes heterocycliques, procedes de production de ceux-ci et utilisation de ceux-ci dans un traitement
CN100415284C (zh) *	2002-12-30	2008-09-03	毛友昌	六味木香片的制备方法
WO2004082586A2 (fr)	2003-03-17	2004-09-30	Affinium Pharmaceuticals, Inc.	Compositions comportant plusieurs agents antibiotiques, et leurs procedes de mise en oeuvre
ES2297067T3 (es) *	2003-03-19	2008-05-01	The Jordanian Pharmaceutical Manufacturing Co. Ltd.	Composiciones farmaceuticas no higroscopicas que contienen acidos quinolinacarboxilicos de hidratados.
US8906413B2 (en)	2003-05-12	2014-12-09	Supernus Pharmaceuticals, Inc.	Drug formulations having reduced abuse potential
US20050019397A1 (en) *	2003-07-23	2005-01-27	Jacobs Richard L.	Cellulosic fiber containing composition
CA2568914C (fr)	2004-06-04	2013-09-24	Affinium Pharmaceuticals, Inc.	Agents therapeutiques, et methodes de fabrication et d'utilisation
AU2005295482B2 (en) *	2004-10-15	2011-03-31	Supernus Pharmaceuticals Inc.	Less abusable pharmaceutical preparations
EP1973902A2 (fr) *	2005-12-05	2008-10-01	Affinium Pharmaceuticals, Inc.	Agents therapeutiques et ses procédés de fabrication et d utilisation
EP2687533B1 (fr)	2006-07-20	2017-07-19	Debiopharm International SA	Dérivés d'acrylamide en tant qu'inhibiteurs de FAB I
US8263613B2 (en) *	2007-02-16	2012-09-11	Affinium Pharmaceuticals, Inc.	Salts, prodrugs and polymorphs of fab I inhibitors
SMT201900411T1 (it)	2012-06-19	2019-09-09	Debiopharm Int Sa	Derivati di profaramci di (e)-n-metil-n-((3-metilbenzofuran-2-il)metil -3-(7-osso-5,6,7,8-tetraidro-1,8-naftiridin-3-il)acrilammide
BR122023021456A2 (pt)	2016-02-26	2024-02-20	Debiopharm International S.A.	Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
FI3923914T3 (fi)	2019-02-14	2023-04-27	Debiopharm Int Sa	Afabisiiniformulaatio, menetelmä sen valmistamiseksi
MA56184A (fr)	2019-06-14	2022-04-20	Debiopharm Int Sa	Afabicine pour utilisation dans le traitement d'infections bactériennes impliquant un biofilm
JP2025529185A (ja) *	2022-08-30	2025-09-04	パンネックスセラピューティクスインコーポレイテッド	パネキシン－１調節剤及びパネキシン－１が関与する疾患の治療方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5286754A (en)	1986-01-21	1994-02-15	Bayer Aktiengesellschaft	Pharmaceutical formulations of ciprofloxacin
DE3601566A1 (de) *	1986-01-21	1987-07-23	Bayer Ag	Pharmazeutische zubereitungen von ciprofloxacin
US4957554A (en)	1989-08-16	1990-09-18	Minnesota Mining And Manufacturing Company	Dimensionally-controlled ceramics
DE4120646A1 (de)	1991-06-22	1992-12-24	Bayer Ag	7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
NZ312199A (en) *	1995-08-29	1999-06-29	Pfizer	Zwitterionic forms of trovafloxacin

1999
- 1999-01-11 PA PA19998466701A patent/PA8466701A1/es unknown
- 1999-01-13 EP EP99300258A patent/EP0930068A3/fr not_active Withdrawn
- 1999-01-14 SK SK42-99A patent/SK4299A3/sk unknown
- 1999-01-14 TR TR1999/00089A patent/TR199900089A2/xx unknown
- 1999-01-14 IL IL12805199A patent/IL128051A0/xx unknown
- 1999-01-14 AP APAP/P/1999/001443A patent/AP1094A/en active
- 1999-01-15 ID IDP990036D patent/ID23735A/id unknown
- 1999-01-15 MA MA25433A patent/MA24747A1/fr unknown
- 1999-01-15 GT GT199900004A patent/GT199900004A/es unknown
- 1999-01-15 OA OA9900009A patent/OA10958A/en unknown
- 1999-01-15 PE PE1999000036A patent/PE20000169A1/es not_active Application Discontinuation
- 1999-01-19 AR ARP990100191A patent/AR012780A1/es not_active Application Discontinuation
- 1999-01-19 CA CA002259698A patent/CA2259698C/fr not_active Expired - Fee Related
- 1999-01-19 BR BR9900116-0A patent/BR9900116A/pt not_active IP Right Cessation
- 1999-01-19 IS IS4947A patent/IS4947A/is unknown
- 1999-01-19 JP JP11010298A patent/JPH11269072A/ja active Pending
- 1999-01-20 AU AU12173/99A patent/AU758381B2/en not_active Ceased
- 1999-01-20 NZ NZ333838A patent/NZ333838A/xx unknown
- 1999-01-20 DZ DZ990013A patent/DZ2712A1/fr active
- 1999-01-20 TN TNTNSN99007A patent/TNSN99007A1/fr unknown
- 1999-01-20 US US09/233,823 patent/US6187341B1/en not_active Expired - Fee Related
- 1999-01-20 PL PL99330981A patent/PL330981A1/xx unknown
- 1999-01-20 CN CN99101232A patent/CN1227743A/zh active Pending
- 1999-01-20 SG SG1999000117A patent/SG70666A1/en unknown
- 1999-01-20 HU HU9900154A patent/HUP9900154A3/hu unknown
- 1999-01-20 NO NO990243A patent/NO990243L/no not_active Application Discontinuation
- 1999-01-20 YU YU2399A patent/YU2399A/sh unknown
- 1999-01-20 ZA ZA9900393A patent/ZA99393B/xx unknown
- 1999-01-20 KR KR1019990001589A patent/KR100314977B1/ko not_active Expired - Fee Related
- 1999-01-21 CO CO99003190A patent/CO4810225A1/es unknown
- 1999-01-21 HR HR60/072,013A patent/HRP990023A2/hr not_active Application Discontinuation
- 1999-01-21 TW TW088100897A patent/TW518224B/zh not_active IP Right Cessation
- 1999-01-21 BG BG103106A patent/BG103106A/xx unknown
- 1999-01-21 EA EA199900046A patent/EA003247B1/ru not_active IP Right Cessation

Also Published As

Publication number	Publication date
ID23735A (id)	2000-05-11
DZ2712A1 (fr)	2003-09-01
PA8466701A1 (es)	2000-09-29
SG70666A1 (en)	2000-02-22
KR100314977B1 (ko)	2001-11-24
JPH11269072A (ja)	1999-10-05
HRP990023A2 (en)	1999-08-31
HUP9900154A3 (en)	2000-12-28
AU1217399A (en)	1999-08-12
CO4810225A1 (es)	1999-06-30
US6187341B1 (en)	2001-02-13
CA2259698C (fr)	2003-04-15
IS4947A (is)	1999-07-22
AR012780A1 (es)	2000-11-08
HUP9900154A2 (hu)	1999-09-28
AP9901443A0 (en)	1999-03-31
BR9900116A (pt)	2000-05-02
KR19990068014A (ko)	1999-08-25
EA199900046A3 (ru)	1999-12-29
GT199900004A (es)	2000-07-08
CA2259698A1 (fr)	1999-07-21
AU758381B2 (en)	2003-03-20
PE20000169A1 (es)	2000-03-10
BG103106A (en)	1999-08-31
EP0930068A2 (fr)	1999-07-21
EA199900046A2 (ru)	1999-08-26
TR199900089A3 (tr)	1999-10-21
AP1094A (en)	2002-08-19
NZ333838A (en)	2000-03-27
TR199900089A2 (xx)	1999-10-21
HU9900154D0 (en)	1999-03-29
PL330981A1 (en)	1999-08-02
IL128051A0 (en)	1999-11-30
EA003247B1 (ru)	2003-02-27
CN1227743A (zh)	1999-09-08
NO990243L (no)	1999-07-22
ZA99393B (en)	2000-07-21
SK4299A3 (en)	2000-06-12
YU2399A (sh)	2002-06-19
TW518224B (en)	2003-01-21
NO990243D0 (no)	1999-01-20
TNSN99007A1 (fr)	2005-11-10
EP0930068A3 (fr)	1999-12-22
MA24747A1 (fr)	1999-10-01

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HK1019558A (en)	2000-02-18	Trovafloxacin mesylate tablet
CZ9399A3 (cs)	2000-06-14	Tableta obsahující methansulfonát trovafloxacinu
JP2009538905A (ja)	2009-11-12	感湿性薬物を含んで成る安定性製剤及びその製造方法
KR100561785B1 (ko)	2006-03-16	염산 세페타메트 피복실을 포함하는 경구 투여용 속붕해성정제의 조성물 및 이의 제조방법
TW202435886A (zh)	2024-09-16	米爾維仙(milvexian)醫藥組合物
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WO2003007968A1 (fr)	2003-01-30	Composition cardiotonique