OA10958A - Trovafloxacin mesylate tablet - Google Patents

Trovafloxacin mesylate tablet Download PDF

Info

Publication number: OA10958A
Authority: OA; OAPI
Prior art keywords: composition; weight; cellulose; tablet; trovafloxacin
Prior art date: 1998-01-21

Application number

OA9900009A

Other languages

English (en)

Inventor

Alton Dale Johnson

Christopher Mickael Sinko

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-21

Filing date

1999-01-15

Publication date

2001-10-31

1999-01-15 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2001-10-31 Publication of OA10958A publication Critical patent/OA10958A/en

Links

229960005021 trovafloxacin mesylate Drugs 0.000 title claims abstract description 28
DYNZICQDCVYXFW-AHZSKCOESA-N trovafloxacin mesylate Chemical compound CS(O)(=O)=O.C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F DYNZICQDCVYXFW-AHZSKCOESA-N 0.000 title claims abstract description 28
239000000203 mixture Substances 0.000 claims abstract description 55
229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 16
235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 16
239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 16
229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 16
239000000314 lubricant Substances 0.000 claims abstract description 12
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 17
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 12
239000007888 film coating Substances 0.000 claims description 12
238000009501 film coating Methods 0.000 claims description 12
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 12
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235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 10
239000007884 disintegrant Substances 0.000 claims description 8
235000010980 cellulose Nutrition 0.000 claims description 7
229920002678 cellulose Polymers 0.000 claims description 7
239000001913 cellulose Substances 0.000 claims description 7
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 6
239000011248 coating agent Substances 0.000 claims description 4
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SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 5
238000004090 dissolution Methods 0.000 abstract description 22
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229960000497 trovafloxacin Drugs 0.000 description 16
WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 description 16
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NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000001259 polydextrose Substances 0.000 description 1
235000013856 polydextrose Nutrition 0.000 description 1
229940035035 polydextrose Drugs 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000000634 powder X-ray diffraction Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
238000012207 quantitative assay Methods 0.000 description 1
239000003306 quinoline derived antiinfective agent Substances 0.000 description 1
238000009490 roller compaction Methods 0.000 description 1
235000002020 sage Nutrition 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000012898 sample dilution Substances 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000013112 stability test Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229940071138 stearyl fumarate Drugs 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000001789 thuja occidentalis l. leaf oil Substances 0.000 description 1
239000010678 thyme oil Substances 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
235000013976 turmeric Nutrition 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000003643 water by type Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
239000009637 wintergreen oil Substances 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

OA9900009A 1998-01-21 1999-01-15 Trovafloxacin mesylate tablet OA10958A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US7201398P	1998-01-21	1998-01-21

Publications (1)

Publication Number	Publication Date
OA10958A true OA10958A (en)	2001-10-31

Family

ID=22105016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900009A OA10958A (en)	1998-01-21	1999-01-15	Trovafloxacin mesylate tablet

Country Status (34)

Country	Link
US (1)	US6187341B1 (fr)
EP (1)	EP0930068A3 (fr)
JP (1)	JPH11269072A (fr)
KR (1)	KR100314977B1 (fr)
CN (1)	CN1227743A (fr)
AP (1)	AP1094A (fr)
AR (1)	AR012780A1 (fr)
AU (1)	AU758381B2 (fr)
BG (1)	BG103106A (fr)
BR (1)	BR9900116A (fr)
CA (1)	CA2259698C (fr)
CO (1)	CO4810225A1 (fr)
DZ (1)	DZ2712A1 (fr)
EA (1)	EA003247B1 (fr)
GT (1)	GT199900004A (fr)
HR (1)	HRP990023A2 (fr)
HU (1)	HUP9900154A3 (fr)
ID (1)	ID23735A (fr)
IL (1)	IL128051A0 (fr)
IS (1)	IS4947A (fr)
MA (1)	MA24747A1 (fr)
NO (1)	NO990243L (fr)
NZ (1)	NZ333838A (fr)
OA (1)	OA10958A (fr)
PA (1)	PA8466701A1 (fr)
PE (1)	PE20000169A1 (fr)
PL (1)	PL330981A1 (fr)
SG (1)	SG70666A1 (fr)
SK (1)	SK4299A3 (fr)
TN (1)	TNSN99007A1 (fr)
TR (1)	TR199900089A3 (fr)
TW (1)	TW518224B (fr)
YU (1)	YU2399A (fr)
ZA (1)	ZA99393B (fr)

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BR9915208A (pt) *	1998-11-10	2001-07-31	Bayer Ag	Preparado farmacêutico de moxifloxacina
AU1188601A (en) *	1999-09-20	2001-04-24	Alza Corporation	Process for lessening polymorphic conversion of a drug
ECSP003699A (es) *	1999-10-08	2002-04-23	Smithkline Beecham Corp	Inhibidores de fab i
FR2808441B1 (fr) *	2000-05-04	2004-06-18	Oreal	Utilisation de fibres dans une composition de soin ou de maquillage pour matifier la peau
DE10031043A1 (de) *	2000-06-26	2002-02-14	Bayer Ag	Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
DE60230934D1 (de) *	2001-04-06	2009-03-05	Affinium Pharm Inc	Fab-i-inhibitoren
EP1396263A1 (fr) *	2002-08-09	2004-03-10	Warner-Lambert Company	Compositions d'enrobage pour tablettes et caplets
EP1575951B1 (fr)	2002-12-06	2014-06-25	Debiopharm International SA	Composes heterocycliques, procedes de production de ceux-ci et utilisation de ceux-ci dans un traitement
CN100415284C (zh) *	2002-12-30	2008-09-03	毛友昌	六味木香片的制备方法
WO2004082586A2 (fr)	2003-03-17	2004-09-30	Affinium Pharmaceuticals, Inc.	Compositions comportant plusieurs agents antibiotiques, et leurs procedes de mise en oeuvre
EP1459739B1 (fr) *	2003-03-19	2008-01-02	The Jordanian Pharmaceutical Manufacturing Co. Ltd.	Compositions pharmaceutiques non-hygroscopique contenant des acides carboxiliques quinilones non-hydratés
US8906413B2 (en) *	2003-05-12	2014-12-09	Supernus Pharmaceuticals, Inc.	Drug formulations having reduced abuse potential
WO2005009395A2 (fr) *	2003-07-23	2005-02-03	L. Perrigo Company	Composition contenant des fibres cellulosiques
US8450307B2 (en)	2004-06-04	2013-05-28	Affinium Pharmaceuticals, Inc.	Therapeutic agents, and methods of making and using the same
WO2006044805A2 (fr) *	2004-10-15	2006-04-27	Supernus Pharmaceuticals, Inc.	Preparations pharmaceutiques pour lesquelles le risque d'abus est reduit
CA2632476A1 (fr) *	2005-12-05	2007-06-14	Affinium Pharmaceuticals, Inc.	Agents therapeutiques et ses procedes de fabrication et d'utilisation
EP2687533B1 (fr)	2006-07-20	2017-07-19	Debiopharm International SA	Dérivés d'acrylamide en tant qu'inhibiteurs de FAB I
WO2008098374A1 (fr) *	2007-02-16	2008-08-21	Affinium Pharmaceuticals, Inc.	Sels, promédicaments et polymorphes d'inhibiteurs de fab 1
KR101720885B1 (ko)	2012-06-19	2017-03-28	데비오팜 인터네셔날 에스 에이	(e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체
RS61312B1 (sr)	2016-02-26	2021-02-26	Debiopharm Int Sa	Lek za lečenje infekcija dijabetskog stopala
MY203711A (en)	2019-02-14	2024-07-15	Debiopharm Int Sa	Afabicin formulation, method for making the same and uses thereof
JP7418475B2 (ja)	2019-06-14	2024-01-19	デバイオファームインターナショナルエス．エー．	バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用
EP4580618A2 (fr) *	2022-08-30	2025-07-09	Pannex Therapeutics Inc.	Modulateurs de pannexine-1 et procédés de traitement de troubles dans lesquels la pannexine-1 est impliquée

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DE3601566A1 (de) *	1986-01-21	1987-07-23	Bayer Ag	Pharmazeutische zubereitungen von ciprofloxacin
US5286754A (en)	1986-01-21	1994-02-15	Bayer Aktiengesellschaft	Pharmaceutical formulations of ciprofloxacin
US4957554A (en)	1989-08-16	1990-09-18	Minnesota Mining And Manufacturing Company	Dimensionally-controlled ceramics
DE4120646A1 (de)	1991-06-22	1992-12-24	Bayer Ag	7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
PL325170A1 (en) *	1995-08-29	1998-07-06	Pfizer	Bipolar forms of throwaflocacin

1999
- 1999-01-11 PA PA19998466701A patent/PA8466701A1/es unknown
- 1999-01-13 EP EP99300258A patent/EP0930068A3/fr not_active Withdrawn
- 1999-01-14 TR TR1999/00089A patent/TR199900089A3/tr unknown
- 1999-01-14 SK SK42-99A patent/SK4299A3/sk unknown
- 1999-01-14 IL IL12805199A patent/IL128051A0/xx unknown
- 1999-01-14 AP APAP/P/1999/001443A patent/AP1094A/en active
- 1999-01-15 PE PE1999000036A patent/PE20000169A1/es not_active Application Discontinuation
- 1999-01-15 ID IDP990036D patent/ID23735A/id unknown
- 1999-01-15 OA OA9900009A patent/OA10958A/en unknown
- 1999-01-15 GT GT199900004A patent/GT199900004A/es unknown
- 1999-01-15 MA MA25433A patent/MA24747A1/fr unknown
- 1999-01-19 IS IS4947A patent/IS4947A/is unknown
- 1999-01-19 JP JP11010298A patent/JPH11269072A/ja active Pending
- 1999-01-19 AR ARP990100191A patent/AR012780A1/es not_active Application Discontinuation
- 1999-01-19 CA CA002259698A patent/CA2259698C/fr not_active Expired - Fee Related
- 1999-01-19 BR BR9900116-0A patent/BR9900116A/pt not_active IP Right Cessation
- 1999-01-20 NO NO990243A patent/NO990243L/no not_active Application Discontinuation
- 1999-01-20 NZ NZ333838A patent/NZ333838A/xx unknown
- 1999-01-20 DZ DZ990013A patent/DZ2712A1/fr active
- 1999-01-20 KR KR1019990001589A patent/KR100314977B1/ko not_active Expired - Fee Related
- 1999-01-20 US US09/233,823 patent/US6187341B1/en not_active Expired - Fee Related
- 1999-01-20 CN CN99101232A patent/CN1227743A/zh active Pending
- 1999-01-20 ZA ZA9900393A patent/ZA99393B/xx unknown
- 1999-01-20 YU YU2399A patent/YU2399A/sh unknown
- 1999-01-20 SG SG1999000117A patent/SG70666A1/en unknown
- 1999-01-20 AU AU12173/99A patent/AU758381B2/en not_active Ceased
- 1999-01-20 PL PL99330981A patent/PL330981A1/xx unknown
- 1999-01-20 TN TNTNSN99007A patent/TNSN99007A1/fr unknown
- 1999-01-20 HU HU9900154A patent/HUP9900154A3/hu unknown
- 1999-01-21 TW TW088100897A patent/TW518224B/zh not_active IP Right Cessation
- 1999-01-21 CO CO99003190A patent/CO4810225A1/es unknown
- 1999-01-21 EA EA199900046A patent/EA003247B1/ru not_active IP Right Cessation
- 1999-01-21 BG BG103106A patent/BG103106A/xx unknown
- 1999-01-21 HR HR60/072,013A patent/HRP990023A2/hr not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0930068A3 (fr)	1999-12-22
TNSN99007A1 (fr)	2005-11-10
CN1227743A (zh)	1999-09-08
HRP990023A2 (en)	1999-08-31
DZ2712A1 (fr)	2003-09-01
HUP9900154A2 (hu)	1999-09-28
EP0930068A2 (fr)	1999-07-21
NO990243L (no)	1999-07-22
KR19990068014A (ko)	1999-08-25
KR100314977B1 (ko)	2001-11-24
SK4299A3 (en)	2000-06-12
EA199900046A2 (ru)	1999-08-26
CO4810225A1 (es)	1999-06-30
AR012780A1 (es)	2000-11-08
AP9901443A0 (en)	1999-03-31
SG70666A1 (en)	2000-02-22
AU1217399A (en)	1999-08-12
US6187341B1 (en)	2001-02-13
BR9900116A (pt)	2000-05-02
NZ333838A (en)	2000-03-27
EA199900046A3 (ru)	1999-12-29
CA2259698A1 (fr)	1999-07-21
TR199900089A2 (xx)	1999-10-21
GT199900004A (es)	2000-07-08
PE20000169A1 (es)	2000-03-10
NO990243D0 (no)	1999-01-20
JPH11269072A (ja)	1999-10-05
PL330981A1 (en)	1999-08-02
HUP9900154A3 (en)	2000-12-28
TW518224B (en)	2003-01-21
ZA99393B (en)	2000-07-21
AP1094A (en)	2002-08-19
MA24747A1 (fr)	1999-10-01
EA003247B1 (ru)	2003-02-27
IS4947A (is)	1999-07-22
ID23735A (id)	2000-05-11
AU758381B2 (en)	2003-03-20
IL128051A0 (en)	1999-11-30
HU9900154D0 (en)	1999-03-29
BG103106A (en)	1999-08-31
PA8466701A1 (es)	2000-09-29
CA2259698C (fr)	2003-04-15
TR199900089A3 (tr)	1999-10-21
YU2399A (sh)	2002-06-19

Publication	Publication Date	Title
OA10958A (en)	2001-10-31	Trovafloxacin mesylate tablet
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US9642806B2 (en)	2017-05-09	Antifungal compositions with improved bioavailability
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IL154731A (en)	2008-11-26	Pharmacological preparation in the form of a hydrophilic gel creates a matrix for delayed release and a method for its preparation
US20100172982A1 (en)	2010-07-08	Sustained release formulations of divalproex sodium
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HK1019558A (en)	2000-02-18	Trovafloxacin mesylate tablet
CZ9399A3 (cs)	2000-06-14	Tableta obsahující methansulfonát trovafloxacinu
JP2009538905A (ja)	2009-11-12	感湿性薬物を含んで成る安定性製剤及びその製造方法
KR100561785B1 (ko)	2006-03-16	염산 세페타메트 피복실을 포함하는 경구 투여용 속붕해성정제의 조성물 및 이의 제조방법
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