OA11069A - Intranasal formulations for treating sexual disorders - Google Patents

Intranasal formulations for treating sexual disorders Download PDF

Info

Publication number: OA11069A
Authority: OA; OAPI
Prior art keywords: intranasal; sildenafil; formulation; mesylate; solution
Prior art date: 1998-06-22

Application number

OA9900137A

Other languages

English (en)

Inventor

Ann Billotte

Peter James Dunn

Brian Thomas Henry

Peter Vallance Marshall

Joanna Jayne Woods

Original Assignee

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-22

Filing date

1999-06-18

Publication date

2002-03-13

1998-06-22 Priority claimed from GBGB9813452.1A external-priority patent/GB9813452D0/en

1998-09-24 Priority claimed from GBGB9820837.4A external-priority patent/GB9820837D0/en

1999-02-13 Priority claimed from GBGB9903177.5A external-priority patent/GB9903177D0/en

1999-06-18 Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev

2002-03-13 Publication of OA11069A publication Critical patent/OA11069A/en

Links

239000000203 mixture Substances 0.000 title claims abstract description 37
238000009472 formulation Methods 0.000 title claims abstract description 28
208000012201 sexual and gender identity disease Diseases 0.000 title claims abstract description 7
208000015891 sexual disease Diseases 0.000 title claims abstract description 7
WEWNUXJEVSROFW-UHFFFAOYSA-N 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4h-pyrazolo[4,3-d]pyrimidin-7-one;methanesulfonic acid Chemical compound CS(O)(=O)=O.CCCC1=NN(C)C(C(N=2)=O)=C1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 WEWNUXJEVSROFW-UHFFFAOYSA-N 0.000 claims abstract description 25
201000001881 impotence Diseases 0.000 claims abstract description 6
208000010228 Erectile Dysfunction Diseases 0.000 claims abstract description 5
BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims description 32
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 16
229960003310 sildenafil Drugs 0.000 claims description 15
239000000843 powder Substances 0.000 claims description 14
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 8
229960001948 caffeine Drugs 0.000 claims description 8
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 8
239000002245 particle Substances 0.000 claims description 5
239000007864 aqueous solution Substances 0.000 claims description 4
150000004683 dihydrates Chemical class 0.000 claims description 4
150000004682 monohydrates Chemical class 0.000 claims description 4
239000003085 diluting agent Substances 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 2
239000000243 solution Substances 0.000 description 22
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 12
238000010521 absorption reaction Methods 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
229940079593 drug Drugs 0.000 description 10
239000003814 drug Substances 0.000 description 10
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 8
239000003795 chemical substances by application Substances 0.000 description 7
210000003928 nasal cavity Anatomy 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 5
206010028735 Nasal congestion Diseases 0.000 description 5
230000037058 blood plasma level Effects 0.000 description 5
150000001875 compounds Chemical class 0.000 description 5
239000003112 inhibitor Substances 0.000 description 5
239000000047 product Substances 0.000 description 5
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230000024883 vasodilation Effects 0.000 description 5
ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 4
241000282472 Canis lupus familiaris Species 0.000 description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 description 4
235000019445 benzyl alcohol Nutrition 0.000 description 4
239000007922 nasal spray Substances 0.000 description 4
229960003966 nicotinamide Drugs 0.000 description 4
235000005152 nicotinamide Nutrition 0.000 description 4
239000011570 nicotinamide Substances 0.000 description 4
239000002590 phosphodiesterase V inhibitor Substances 0.000 description 4
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 4
235000012141 vanillin Nutrition 0.000 description 4
101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 description 3
AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 3
101150098694 PDE5A gene Proteins 0.000 description 3
230000017531 blood circulation Effects 0.000 description 3
102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 description 3
ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000001914 filtration Methods 0.000 description 3
239000008103 glucose Substances 0.000 description 3
230000001965 increasing effect Effects 0.000 description 3
229940097496 nasal spray Drugs 0.000 description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
239000008137 solubility enhancer Substances 0.000 description 3
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 3
239000008215 water for injection Substances 0.000 description 3
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
239000000872 buffer Substances 0.000 description 2
239000002775 capsule Substances 0.000 description 2
230000002708 enhancing effect Effects 0.000 description 2
239000008187 granular material Substances 0.000 description 2
230000007794 irritation Effects 0.000 description 2
230000036470 plasma concentration Effects 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000007787 solid Substances 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
238000003109 Karl Fischer titration Methods 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
206010028741 Nasal inflammation Diseases 0.000 description 1
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000003466 anti-cipated effect Effects 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000002585 base Substances 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000011109 contamination Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
230000001856 erectile effect Effects 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000011888 foil Substances 0.000 description 1
239000012458 free base Substances 0.000 description 1
239000003906 humectant Substances 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
230000008338 local blood flow Effects 0.000 description 1
230000007774 longterm Effects 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
239000000155 melt Substances 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
OIXMUQLVDNPHNS-UHFFFAOYSA-N methanesulfonic acid;hydrate Chemical compound O.CS(O)(=O)=O OIXMUQLVDNPHNS-UHFFFAOYSA-N 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
229910000403 monosodium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
210000001331 nose Anatomy 0.000 description 1
239000002304 perfume Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000010992 reflux Methods 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
229960002639 sildenafil citrate Drugs 0.000 description 1
DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
238000002411 thermogravimetry Methods 0.000 description 1
ZENOXNGFMSCLLL-UHFFFAOYSA-N vanillyl alcohol Natural products COC1=CC(CO)=CC=C1O ZENOXNGFMSCLLL-UHFFFAOYSA-N 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Otolaryngology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

OA9900137A 1998-06-22 1999-06-18 Intranasal formulations for treating sexual disorders OA11069A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9813452.1A GB9813452D0 (en)	1998-06-22	1998-06-22	Pharmaceutical formulations
GBGB9820837.4A GB9820837D0 (en)	1998-09-24	1998-09-24	Pharmaceutical formulations
GBGB9903177.5A GB9903177D0 (en)	1999-02-13	1999-02-13	Pharmaceutical formulations

Publications (1)

Publication Number	Publication Date
OA11069A true OA11069A (en)	2002-03-13

Family

ID=27269368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900137A OA11069A (en)	1998-06-22	1999-06-18	Intranasal formulations for treating sexual disorders

Country Status (40)

Country	Link
US (2)	US20020040139A1 (is)
EP (1)	EP0967214B1 (is)
JP (1)	JP3263379B2 (is)
KR (1)	KR100345824B1 (is)
AP (1)	AP1178A (is)
AR (1)	AR016993A1 (is)
AT (1)	ATE269866T1 (is)
AU (1)	AU746865B2 (is)
BG (1)	BG64372B1 (is)
BR (1)	BR9903273A (is)
CA (1)	CA2275554C (is)
CZ (1)	CZ294856B6 (is)
DE (1)	DE69918222T2 (is)
DK (1)	DK0967214T3 (is)
DZ (1)	DZ2826A1 (is)
EA (1)	EA001903B1 (is)
ES (1)	ES2221733T3 (is)
GT (1)	GT199900095A (is)
HN (1)	HN1999000096A (is)
HR (1)	HRP990195B1 (is)
HU (1)	HUP9902076A3 (is)
ID (1)	ID23554A (is)
IL (1)	IL130539A0 (is)
IS (1)	IS5085A (is)
MA (1)	MA25089A1 (is)
MY (1)	MY117967A (is)
NO (1)	NO317365B1 (is)
NZ (1)	NZ336382A (is)
OA (1)	OA11069A (is)
PA (1)	PA8476301A1 (is)
PE (1)	PE20000702A1 (is)
PT (1)	PT967214E (is)
SG (1)	SG77246A1 (is)
SI (1)	SI0967214T1 (is)
SK (1)	SK284574B6 (is)
TN (1)	TNSN99129A1 (is)
TR (1)	TR199901444A2 (is)
TW (1)	TWI223598B (is)
UA (1)	UA59385C2 (is)
YU (1)	YU29699A (is)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6200591B1 (en)	1998-06-25	2001-03-13	Anwar A. Hussain	Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
GB9828340D0 (en) *	1998-12-22	1999-02-17	Novartis Ag	Organic compounds
CA2391968A1 (en) *	1999-11-18	2001-05-25	Natco Pharma Limited	An improved pharmaceutical composition for treating male erectile dysfunction
KR20010016165A (ko) *	2000-11-16	2001-03-05	정순학	성기능 장애 치료를 위한 피부에 적용하는 제제
DE10118306A1 (de)	2001-04-12	2002-10-17	Bayer Ag	Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation
DE10118305A1 (de) *	2001-04-12	2002-10-17	Bayer Ag	Zusammensetzungen zur nasalen Applikation
US7645442B2 (en)	2001-05-24	2010-01-12	Alexza Pharmaceuticals, Inc.	Rapid-heating drug delivery article and method of use
CA2446904A1 (en)	2001-05-24	2003-04-03	Alexza Pharmaceuticals, Inc.	Delivery of drug esters through an inhalation route
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
WO2002094219A2 (en) *	2001-05-24	2002-11-28	Alexza Molecular Delivery Corporation	Delivery of erectile dysfunction drugs through an inhalation route
DE10248601B4 (de) *	2002-10-17	2006-05-24	Goldstein, Naum, Dr.habil.nat.	Pharmazeutisches Mittel zur endonasalen Applikation bei der Behandlung von Krankheiten und Störungen des zentralen Nervensystems
US20040105818A1 (en)	2002-11-26	2004-06-03	Alexza Molecular Delivery Corporation	Diuretic aerosols and methods of making and using them
US7913688B2 (en)	2002-11-27	2011-03-29	Alexza Pharmaceuticals, Inc.	Inhalation device for producing a drug aerosol
US7138107B2 (en) *	2003-02-18	2006-11-21	Compellis Pharmaceuticals	Inhibition of olfactory neurosensory function to treat eating disorders and obesity
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1999
- 1999-05-29 TW TW088108934A patent/TWI223598B/zh active
- 1999-06-08 AT AT99304425T patent/ATE269866T1/de not_active IP Right Cessation
- 1999-06-08 EP EP99304425A patent/EP0967214B1/en not_active Expired - Lifetime
- 1999-06-08 DK DK99304425T patent/DK0967214T3/da active
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- 1999-06-08 SI SI9930594T patent/SI0967214T1/xx unknown
- 1999-06-08 ES ES99304425T patent/ES2221733T3/es not_active Expired - Lifetime
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- 1999-06-18 US US09/335,628 patent/US20020040139A1/en not_active Abandoned
- 1999-06-18 HR HR990195A patent/HRP990195B1/xx not_active IP Right Cessation
- 1999-06-18 CA CA002275554A patent/CA2275554C/en not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
HRP990195A2 (en)	2000-02-29
EA001903B1 (ru)	2001-10-22
TWI223598B (en)	2004-11-11
SI0967214T1 (en)	2004-10-31
SG77246A1 (en)	2000-12-19
CA2275554C (en)	2003-06-03
HUP9902076A3 (en)	2002-03-28
DE69918222D1 (de)	2004-07-29
BG103510A (en)	2000-01-31
BR9903273A (pt)	2000-05-09
CZ9902257A3 (cs)	2000-11-15
NO993051D0 (no)	1999-06-21
KR20000006310A (ko)	2000-01-25
IS5085A (is)	1999-12-23
JP3263379B2 (ja)	2002-03-04
YU29699A (sh)	2003-02-28
MY117967A (en)	2004-08-30
ATE269866T1 (de)	2004-07-15
AP1178A (en)	2003-06-30
SK81999A3 (en)	2001-01-18
TR199901444A2 (xx)	2000-01-21
PE20000702A1 (es)	2000-08-16
HU9902076D0 (en)	1999-08-30
NO993051L (no)	1999-12-23
EA199900487A3 (ru)	2000-04-24
EP0967214A1 (en)	1999-12-29
DE69918222T2 (de)	2005-07-28
ES2221733T3 (es)	2005-01-01
AR016993A1 (es)	2001-08-01
PA8476301A1 (es)	2000-09-29
BG64372B1 (bg)	2004-12-30
AU3579499A (en)	2000-01-06
PT967214E (pt)	2004-08-31
GT199900095A (es)	2000-12-13
AU746865B2 (en)	2002-05-02
NZ336382A (en)	1999-11-29
CA2275554A1 (en)	1999-12-22
HRP990195B1 (en)	2003-04-30
IL130539A0 (en)	2000-06-01
DK0967214T3 (da)	2004-09-27
HN1999000096A (es)	2000-12-03
US20020040139A1 (en)	2002-04-04
CZ294856B6 (cs)	2005-03-16
NO317365B1 (no)	2004-10-18
EP0967214B1 (en)	2004-06-23
TNSN99129A1 (fr)	2005-11-10
KR100345824B1 (ko)	2002-07-24
MA25089A1 (fr)	2000-12-31
JP2000034232A (ja)	2000-02-02
AP9901585A0 (en)	1999-06-30
HUP9902076A2 (hu)	2000-05-28
DZ2826A1 (fr)	2003-12-01
UA59385C2 (uk)	2003-09-15
US20030158206A1 (en)	2003-08-21
SK284574B6 (sk)	2005-06-02
EA199900487A2 (ru)	1999-12-29
ID23554A (id)	2000-05-04

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