OA11306A - Composition comprising 5-Ä4-Ä2-(n-2-pyridyl) amino) ethoxyÜbenzylÜbenzylÜthiazolidine-2, 4-dione - Google Patents

Composition comprising 5-Ä4-Ä2-(n-2-pyridyl) amino) ethoxyÜbenzylÜbenzylÜthiazolidine-2, 4-dione Download PDF

Info

Publication number: OA11306A
Authority: OA; OAPI
Prior art keywords: compound; composition; pharmaceutically acceptable; acceptable form; composition according
Prior art date: 1997-06-05

Application number

OA9900267A

Other languages

English (en)

Inventor

Jai Patel

Hamish Ross

Jeffrey Roger Granett

Robin Price

Paul Nigel Wray

Original Assignee

Smithkline Beecham Corp Smithk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-05

Filing date

1999-12-02

Publication date

2003-10-22

1997-06-18 Priority claimed from GBGB9712851.6A external-priority patent/GB9712851D0/en

1999-12-02 Application filed by Smithkline Beecham Corp Smithk filed Critical Smithkline Beecham Corp Smithk

2003-10-22 Publication of OA11306A publication Critical patent/OA11306A/en

Links

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125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 76
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239000003937 drug carrier Substances 0.000 claims abstract description 17
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
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ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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239000008168 almond oil Substances 0.000 description 1
239000004411 aluminium Substances 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
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MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
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235000019441 ethanol Nutrition 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
239000003925 fat Substances 0.000 description 1
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239000007937 lozenge Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
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125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000007789 sealing Methods 0.000 description 1
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229940075582 sorbic acid Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
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239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

OA9900267A 1997-06-05 1999-12-02 Composition comprising 5-Ä4-Ä2-(n-2-pyridyl) amino) ethoxyÜbenzylÜbenzylÜthiazolidine-2, 4-dione OA11306A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9711683.4A GB9711683D0 (en)	1997-06-05	1997-06-05	Composition
GBGB9712851.6A GB9712851D0 (en)	1997-06-18	1997-06-18	Composition

Publications (1)

Publication Number	Publication Date
OA11306A true OA11306A (en)	2003-10-22

Family

ID=26311662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900267A OA11306A (en)	1997-06-05	1999-12-02	Composition comprising 5-Ä4-Ä2-(n-2-pyridyl) amino) ethoxyÜbenzylÜbenzylÜthiazolidine-2, 4-dione

Country Status (29)

Country	Link
EP (1)	EP0998284A1 (id)
JP (1)	JP2001521553A (id)
KR (1)	KR20010013410A (id)
CN (3)	CN1112926C (id)
AP (1)	AP1214A (id)
AR (2)	AR008198A1 (id)
AU (1)	AU8215098A (id)
BG (1)	BG104048A (id)
BR (1)	BR9810405A (id)
CA (2)	CA2333352A1 (id)
CO (1)	CO4940400A1 (id)
DZ (1)	DZ2510A1 (id)
EA (1)	EA002384B1 (id)
GB (1)	GB9711683D0 (id)
HU (1)	HUP0004070A3 (id)
ID (1)	ID24264A (id)
IL (1)	IL133074A0 (id)
MX (1)	MXPA99011322A (id)
NO (2)	NO995938L (id)
NZ (2)	NZ523725A (id)
OA (1)	OA11306A (id)
PE (1)	PE78899A1 (id)
PL (1)	PL337201A1 (id)
SK (1)	SK164899A3 (id)
TR (2)	TR200002790T2 (id)
TW (1)	TW570797B (id)
UY (1)	UY25032A1 (id)
WO (1)	WO1998055122A1 (id)
ZA (2)	ZA984826B (id)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
US20040248945A1 (en)	1999-04-23	2004-12-09	Smithkline Beecham P.L.C.	Thiazolidinedione derivative and its use as antidiabetic
AR023561A1 (es) *	1999-04-23	2002-09-04	Smithkline Beecham Corp	Una forma polimorfica del acido maleico de un derivado de tiazolidin-2, 4 diona, una composicion farmaceutica y el uso de dicho polimorfo para lafabricacion de un medicamento
HRP20010773B1 (en)	1999-04-23	2005-06-30	Smithkline Beecham P.L.C.	Thiazolidinedione derivative and its use as antidiabetic
GB0021978D0 (en)	2000-09-07	2000-10-25	Smithkline Beecham Plc	Novel pharmaceutical
GB0127805D0 (en) *	2001-11-20	2002-01-09	Smithkline Beecham Plc	Pharmaceutical composition
WO2003050112A1 (en) *	2001-12-13	2003-06-19	Smithkline Beecham Plc	Toluenesulfonate hydrates of a thiazolidinedione derivative
GB0129876D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
GB0129871D0 (en) *	2001-12-13	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
GB0130509D0 (en) *	2001-12-20	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
US7435741B2 (en)	2006-05-09	2008-10-14	Teva Pharmaceutical Industries, Ltd.	2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
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1997
- 1997-06-05 GB GBGB9711683.4A patent/GB9711683D0/en active Pending
1998
- 1998-06-02 SK SK1648-99A patent/SK164899A3/sk unknown
- 1998-06-02 CA CA002333352A patent/CA2333352A1/en not_active Abandoned
- 1998-06-02 BR BR9810405-5A patent/BR9810405A/pt not_active IP Right Cessation
- 1998-06-02 PL PL98337201A patent/PL337201A1/xx unknown
- 1998-06-02 CA CA002292629A patent/CA2292629C/en not_active Expired - Fee Related
- 1998-06-02 EA EA199901116A patent/EA002384B1/ru not_active IP Right Cessation
- 1998-06-02 WO PCT/EP1998/003478 patent/WO1998055122A1/en not_active Ceased
- 1998-06-02 TR TR2000/02790T patent/TR200002790T2/xx unknown
- 1998-06-02 KR KR19997011411A patent/KR20010013410A/ko not_active Ceased
- 1998-06-02 EP EP98932144A patent/EP0998284A1/en not_active Withdrawn
- 1998-06-02 JP JP50158799A patent/JP2001521553A/ja not_active Ceased
- 1998-06-02 AP APAP/P/1999/001696A patent/AP1214A/en active
- 1998-06-02 TR TR1999/02963T patent/TR199902963T2/xx unknown
- 1998-06-02 MX MXPA99011322A patent/MXPA99011322A/es unknown
- 1998-06-02 IL IL13307498A patent/IL133074A0/xx unknown
- 1998-06-02 CN CN98805686A patent/CN1112926C/zh not_active Expired - Lifetime
- 1998-06-02 CN CNA2003101199090A patent/CN1526391A/zh active Pending
- 1998-06-02 NZ NZ523725A patent/NZ523725A/en unknown
- 1998-06-02 AU AU82150/98A patent/AU8215098A/en not_active Abandoned
- 1998-06-02 HU HU0004070A patent/HUP0004070A3/hu unknown
- 1998-06-02 ID IDW991520A patent/ID24264A/id unknown
- 1998-06-03 DZ DZ980120A patent/DZ2510A1/xx active
- 1998-06-04 AR ARP980102649A patent/AR008198A1/es not_active Application Discontinuation
- 1998-06-04 AR ARP980102650A patent/AR015120A1/es not_active Application Discontinuation
- 1998-06-04 CO CO98031614A patent/CO4940400A1/es unknown
- 1998-06-04 UY UY25032A patent/UY25032A1/es not_active IP Right Cessation
- 1998-06-04 ZA ZA9804826A patent/ZA984826B/xx unknown
- 1998-06-04 ZA ZA9811572A patent/ZA9811572B/xx unknown
- 1998-06-05 PE PE1998000466A patent/PE78899A1/es not_active Application Discontinuation
- 1998-10-23 TW TW087117536A patent/TW570797B/zh not_active IP Right Cessation
1999
- 1999-12-02 OA OA9900267A patent/OA11306A/en unknown
- 1999-12-03 NO NO995938A patent/NO995938L/no not_active Application Discontinuation
- 1999-12-27 BG BG104048A patent/BG104048A/bg unknown
2001
- 2001-09-03 NZ NZ513922A patent/NZ513922A/xx unknown
2002
- 2002-11-05 CN CN02149972A patent/CN1430959A/zh active Pending
2004
- 2004-02-20 NO NO20040738A patent/NO20040738L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2292629C (en)	2004-01-06
MXPA99011322A (es)	2004-12-02
BG104048A (bg)	2000-07-31
EA002384B1 (ru)	2002-04-25
NO20040738L (no)	2000-02-02
EA199901116A1 (ru)	2000-06-26
NO995938D0 (no)	1999-12-03
NO995938L (no)	2000-02-02
AR015120A1 (es)	2001-04-18
NZ513922A (en)	2001-09-28
AR008198A1 (es)	1999-12-29
TW570797B (en)	2004-01-11
AU8215098A (en)	1998-12-21
WO1998055122A1 (en)	1998-12-10
BR9810405A (pt)	2000-08-29
JP2001521553A (ja)	2001-11-06
KR20010013410A (ko)	2001-02-26
CN1259050A (zh)	2000-07-05
NZ523725A (en)	2004-09-24
HUP0004070A2 (hu)	2002-02-28
CA2292629A1 (en)	1998-12-10
CN1526391A (zh)	2004-09-08
PL337201A1 (en)	2000-08-14
CA2333352A1 (en)	1998-12-10
GB9711683D0 (en)	1997-08-06
CN1112926C (zh)	2003-07-02
ZA984826B (en)	1999-08-03
TR200002790T2 (tr)	2001-11-21
CO4940400A1 (es)	2000-07-24
HUP0004070A3 (en)	2002-03-28
IL133074A0 (en)	2001-03-19
TR199902963T2 (xx)	2000-02-21
DZ2510A1 (fr)	2003-01-25
PE78899A1 (es)	1999-10-22
ID24264A (id)	2000-07-13
ZA9811572B (en)	1999-07-22
CN1430959A (zh)	2003-07-23
AP1214A (en)	2003-10-08
SK164899A3 (en)	2000-11-07
AP9901696A0 (en)	1999-12-31
EP0998284A1 (en)	2000-05-10
UY25032A1 (es)	1998-11-26

Publication	Publication Date	Title
EP1292300B1 (en)	2009-01-07	Combinations od dipeptidyl peptidase iv inhibitors and other antidiabetic agents for the treatment fo diabete mellitus
SK286029B6 (sk)	2008-01-07	Farmaceutický prostriedok a jeho použitie
CA2292629C (en)	2004-01-06	Composition comprising 5-[4-[2-(n-methyl-n-2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
AP1287A (en)	2004-06-26	Treatment of diabetes with rosiglitazone and insulin.
US20030187030A1 (en)	2003-10-02	Composition comprising 5-[4-[2-(N-methyl-N-2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
EP0999845B1 (en)	2007-02-14	Treatment of diabetes with thiazolidinedione and sulphonylurea
AU743269B2 (en)	2002-01-24	Treatment of diabetes with thiazolidinedione and sulphonylurea
US20040106543A1 (en)	2004-06-03	Treatment of diabetes with rosiglitazone and insulin
SK179499A3 (en)	2000-11-07	The use of insulin sensitiser and alpha-glucosidase inhibitive antihyperglycaemic agent
AU778947B2 (en)	2004-12-23	Treatment of diabetes with thiazolidinedione and metformin
AU9513401A (en)	2002-01-17	Composition comprising 5-(4-(2-(N-methyl-N-2-pyridyl) amino)ethoxy)benzyl)thiazolidine-2,4-dione
AU783539B2 (en)	2005-11-10	Treatment of diabetes with thiazolidinedione and sulphonylurea
NZ518076A (en)	2004-02-27	5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (BRL49653) for treating non-insulin dependent diabetes (NIDDM)
AU1552102A (en)	2002-03-28	Treatment of diabetes with rosiglitazone and insulin
MXPA99012065A (en)	2000-08-01	Treatment of diabetes with rosiglitazone and insulin
HK1028200B (en)	2007-10-05	Treatment of diabetes with thiazolidinedione and sulphonylurea
NZ520542A (en)	2004-05-28	Treatment of diabetes with thiazolidinedione and metformin
MXPA99012098A (en)	2000-08-01	Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitor