OA11757A - Calcilytic compounds. - Google Patents
Calcilytic compounds. Download PDFInfo
- Publication number
- OA11757A OA11757A OA1200100199A OA1200100199A OA11757A OA 11757 A OA11757 A OA 11757A OA 1200100199 A OA1200100199 A OA 1200100199A OA 1200100199 A OA1200100199 A OA 1200100199A OA 11757 A OA11757 A OA 11757A
- Authority
- OA
- OAPI
- Prior art keywords
- hydroxy
- cyano
- dimethyl
- napthyl
- phenoxy
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 79
- 230000001126 calcilytic effect Effects 0.000 title abstract description 12
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 67
- XWBDWHCCBGMXKG-UHFFFAOYSA-N ethanamine;hydron;chloride Chemical compound Cl.CCN XWBDWHCCBGMXKG-UHFFFAOYSA-N 0.000 claims description 62
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 61
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 25
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 13
- 230000002159 abnormal effect Effects 0.000 claims description 11
- 210000000988 bone and bone Anatomy 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 102000013830 Calcium-Sensing Receptors Human genes 0.000 claims description 7
- 108010050543 Calcium-Sensing Receptors Proteins 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 208000035475 disorder Diseases 0.000 claims description 7
- 230000000849 parathyroid Effects 0.000 claims description 7
- 208000010392 Bone Fractures Diseases 0.000 claims description 6
- 206010017076 Fracture Diseases 0.000 claims description 6
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000001475 halogen functional group Chemical group 0.000 claims description 6
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 6
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- 229910052731 fluorine Inorganic materials 0.000 claims description 5
- 230000035876 healing Effects 0.000 claims description 5
- 230000013632 homeostatic process Effects 0.000 claims description 5
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 4
- 208000010191 Osteitis Deformans Diseases 0.000 claims description 4
- 208000001132 Osteoporosis Diseases 0.000 claims description 4
- 208000027868 Paget disease Diseases 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 208000027202 mammary Paget disease Diseases 0.000 claims description 4
- 201000008482 osteoarthritis Diseases 0.000 claims description 4
- 201000008968 osteosarcoma Diseases 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 208000028169 periodontal disease Diseases 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 230000036210 malignancy Effects 0.000 claims description 3
- AQTFKGDWFRRIHR-UHFFFAOYSA-L 3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoate;cobalt(2+);hydron Chemical compound [Co+2].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 AQTFKGDWFRRIHR-UHFFFAOYSA-L 0.000 claims description 2
- 208000037147 Hypercalcaemia Diseases 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims description 2
- 230000003042 antagnostic effect Effects 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 2
- 230000000148 hypercalcaemia Effects 0.000 claims description 2
- 208000030915 hypercalcemia disease Diseases 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000001624 naphthyl group Chemical group 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 150000003536 tetrazoles Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 41
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 25
- 239000007787 solid Substances 0.000 description 24
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- 239000002253 acid Substances 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 20
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 19
- 239000011575 calcium Substances 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- 229910052791 calcium Inorganic materials 0.000 description 17
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 14
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- 238000005481 NMR spectroscopy Methods 0.000 description 14
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- 238000009472 formulation Methods 0.000 description 9
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- 150000003839 salts Chemical class 0.000 description 8
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- 230000000694 effects Effects 0.000 description 7
- 235000019439 ethyl acetate Nutrition 0.000 description 7
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 7
- 239000010410 layer Substances 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 230000003834 intracellular effect Effects 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
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- AIHIHVZYAAMDPM-MRVPVSSYSA-N [(2r)-oxiran-2-yl]methyl 3-nitrobenzenesulfonate Chemical compound [O-][N+](=O)C1=CC=CC(S(=O)(=O)OC[C@@H]2OC2)=C1 AIHIHVZYAAMDPM-MRVPVSSYSA-N 0.000 description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11824099P | 1999-02-02 | 1999-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11757A true OA11757A (en) | 2005-07-19 |
Family
ID=22377367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200100199A OA11757A (en) | 1999-02-02 | 2000-02-02 | Calcilytic compounds. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6417215B1 (fr) |
| EP (1) | EP1148876A4 (fr) |
| JP (1) | JP2002536330A (fr) |
| KR (1) | KR20010093285A (fr) |
| CN (1) | CN1346269A (fr) |
| AP (1) | AP2001002220A0 (fr) |
| AU (1) | AU3480200A (fr) |
| BG (1) | BG105847A (fr) |
| BR (1) | BR0007922A (fr) |
| CA (1) | CA2361589A1 (fr) |
| CO (1) | CO5251439A1 (fr) |
| CZ (1) | CZ20012797A3 (fr) |
| EA (1) | EA200100854A1 (fr) |
| HK (1) | HK1042036A1 (fr) |
| HU (1) | HUP0200121A3 (fr) |
| ID (1) | ID29533A (fr) |
| IL (1) | IL144470A0 (fr) |
| MA (1) | MA25379A1 (fr) |
| NO (1) | NO20013769L (fr) |
| OA (1) | OA11757A (fr) |
| PE (1) | PE20001456A1 (fr) |
| SK (1) | SK10982001A3 (fr) |
| WO (1) | WO2000045816A1 (fr) |
| ZA (1) | ZA200106298B (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE411275T1 (de) | 2000-08-11 | 2008-10-15 | Japan Tobacco Inc | Calciumrezeptor-antagonisten |
| ES2273909T3 (es) * | 2000-10-25 | 2007-05-16 | Smithkline Beecham Corporation | Compuestos calciliticos. |
| US6864267B2 (en) * | 2001-07-16 | 2005-03-08 | Smithkline Beecham Corporation | Calcilytic compounds |
| TWI316511B (en) | 2002-11-26 | 2009-11-01 | Smithkline Beecham Corp | Calcilytic compounds |
| WO2004069793A2 (fr) | 2003-01-28 | 2004-08-19 | Bristol-Myers Squibb Company | Nouveaux amines cycliques substitues en position 2 comme modulateurs du recepteur de detection de calcium |
| US7205322B2 (en) | 2003-02-12 | 2007-04-17 | Bristol-Myers Squibb Company | Thiazolidine compounds as calcium sensing receptor modulators |
| BRPI0407097A (pt) | 2003-04-23 | 2006-01-24 | Japan Tobacco Inc | Antagonista do casr |
| EP1630157A4 (fr) * | 2003-05-28 | 2007-05-23 | Japan Tobacco Inc | Antagoniste de casr |
| US7265145B2 (en) | 2003-05-28 | 2007-09-04 | Bristol-Myers Squibb Company | Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method |
| EP1964548A1 (fr) * | 2007-03-02 | 2008-09-03 | Novartis AG | Compositions pharmaceutiques comprenant un agent calcilytique |
| CN102056897B (zh) * | 2008-06-05 | 2014-05-07 | 旭化成制药株式会社 | 磺酰胺化合物及其用途 |
| WO2010103429A1 (fr) | 2009-03-10 | 2010-09-16 | Pfizer Inc. | Dérivés de l'acide 1,1-(diméthyl-éthylamino)-2-hydroxy-propoxy]-éthyl}-3-méthyl-biphényl-4-carboxylique utiles en tant qu'antagonistes des récepteurs du calcium |
| GB201217330D0 (en) | 2012-09-28 | 2012-11-14 | Univ Cardiff | Therapeutic for treating inflammatory lung disorders |
| US20220288076A1 (en) * | 2019-08-13 | 2022-09-15 | Dongguk University Industry-Academic Cooperation Foundation | Pharmaceutical composition for improving or treating post-surgical hypoparathyroidism and treatment method using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122007000050I1 (de) * | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| DE4102024A1 (de) | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE69733649T2 (de) * | 1996-04-09 | 2006-05-18 | NPS Pharmaceuticals, Inc., Salt Lake City | Calcylitische verbindungen |
| UY24949A1 (es) * | 1997-04-08 | 2001-04-30 | Smithkline Beecham Corp | Compuestos calcilíticos |
-
2000
- 2000-02-01 PE PE2000000070A patent/PE20001456A1/es not_active Application Discontinuation
- 2000-02-02 HK HK02101521.4A patent/HK1042036A1/zh unknown
- 2000-02-02 CA CA002361589A patent/CA2361589A1/fr not_active Abandoned
- 2000-02-02 BR BR0007922-7A patent/BR0007922A/pt not_active IP Right Cessation
- 2000-02-02 SK SK1098-2001A patent/SK10982001A3/sk unknown
- 2000-02-02 OA OA1200100199A patent/OA11757A/en unknown
- 2000-02-02 KR KR1020017009467A patent/KR20010093285A/ko not_active Withdrawn
- 2000-02-02 IL IL14447000A patent/IL144470A0/xx unknown
- 2000-02-02 EP EP00913335A patent/EP1148876A4/fr not_active Withdrawn
- 2000-02-02 AU AU34802/00A patent/AU3480200A/en not_active Abandoned
- 2000-02-02 ID IDW00200101673A patent/ID29533A/id unknown
- 2000-02-02 CZ CZ20012797A patent/CZ20012797A3/cs unknown
- 2000-02-02 AP APAP/P/2001/002220A patent/AP2001002220A0/en unknown
- 2000-02-02 JP JP2000596936A patent/JP2002536330A/ja not_active Withdrawn
- 2000-02-02 HU HU0200121A patent/HUP0200121A3/hu unknown
- 2000-02-02 CO CO00006199A patent/CO5251439A1/es unknown
- 2000-02-02 EA EA200100854A patent/EA200100854A1/ru unknown
- 2000-02-02 WO PCT/US2000/002676 patent/WO2000045816A1/fr not_active Ceased
- 2000-02-02 US US09/890,310 patent/US6417215B1/en not_active Expired - Lifetime
- 2000-02-02 CN CN00805996A patent/CN1346269A/zh active Pending
-
2001
- 2001-07-31 ZA ZA200106298A patent/ZA200106298B/en unknown
- 2001-08-01 MA MA26283A patent/MA25379A1/fr unknown
- 2001-08-01 NO NO20013769A patent/NO20013769L/no not_active Application Discontinuation
- 2001-08-27 BG BG105847A patent/BG105847A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2361589A1 (fr) | 2000-08-10 |
| KR20010093285A (ko) | 2001-10-27 |
| EP1148876A4 (fr) | 2003-07-23 |
| MA25379A1 (fr) | 2002-04-01 |
| BR0007922A (pt) | 2001-11-06 |
| SK10982001A3 (sk) | 2001-12-03 |
| ID29533A (id) | 2001-09-06 |
| CO5251439A1 (es) | 2003-02-28 |
| BG105847A (en) | 2002-04-30 |
| ZA200106298B (en) | 2002-10-18 |
| HUP0200121A2 (hu) | 2002-05-29 |
| JP2002536330A (ja) | 2002-10-29 |
| EP1148876A1 (fr) | 2001-10-31 |
| NO20013769D0 (no) | 2001-08-01 |
| WO2000045816A1 (fr) | 2000-08-10 |
| AP2001002220A0 (en) | 2001-09-30 |
| PE20001456A1 (es) | 2001-01-28 |
| EA200100854A1 (ru) | 2002-02-28 |
| IL144470A0 (en) | 2002-05-23 |
| HUP0200121A3 (en) | 2002-11-28 |
| CN1346269A (zh) | 2002-04-24 |
| HK1042036A1 (zh) | 2002-08-02 |
| US6417215B1 (en) | 2002-07-09 |
| AU3480200A (en) | 2000-08-25 |
| CZ20012797A3 (cs) | 2002-01-16 |
| NO20013769L (no) | 2001-09-26 |
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