OA11945A - 13-Methyl erythromycin derivatives. - Google Patents

13-Methyl erythromycin derivatives. Download PDF

Info

Publication number: OA11945A
Authority: OA; OAPI
Prior art keywords: crarb; alkyl; nar; formula; compounds
Prior art date: 1999-05-24

Application number

OA1200100303A

Other languages

English (en)

Inventor

John Philip Dirlam

Takushi Kaneko

Hamish Alastair Irvin Mcarthur

Wei-Guo Su

Yong-Jin Wu

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-24

Filing date

2000-04-25

Publication date

2006-04-13

2000-04-25 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-04-13 Publication of OA11945A publication Critical patent/OA11945A/en

Links

150000001875 compounds Chemical class 0.000 claims abstract description 359
150000003839 salts Chemical class 0.000 claims abstract description 33
239000000651 prodrug Substances 0.000 claims abstract description 24
229940002612 prodrug Drugs 0.000 claims abstract description 24
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 21
238000011282 treatment Methods 0.000 claims abstract description 19
-1 4-pyridin-3-yl-imidazol-1-yl Chemical group 0.000 claims description 114
125000001424 substituent group Chemical group 0.000 claims description 75
125000000217 alkyl group Chemical group 0.000 claims description 50
229910052799 carbon Inorganic materials 0.000 claims description 49
208000015181 infectious disease Diseases 0.000 claims description 38
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 33
125000000304 alkynyl group Chemical group 0.000 claims description 29
229910052739 hydrogen Inorganic materials 0.000 claims description 28
125000003342 alkenyl group Chemical group 0.000 claims description 27
125000004429 atom Chemical group 0.000 claims description 25
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229910052731 fluorine Inorganic materials 0.000 claims description 18
125000000623 heterocyclic group Chemical group 0.000 claims description 16
238000004519 manufacturing process Methods 0.000 claims description 16
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
125000003118 aryl group Chemical group 0.000 claims description 15
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 15
229910052757 nitrogen Inorganic materials 0.000 claims description 13
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125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 11
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 11
241000124008 Mammalia Species 0.000 claims description 11
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
125000004122 cyclic group Chemical group 0.000 claims description 10
125000003545 alkoxy group Chemical group 0.000 claims description 9
229910052736 halogen Inorganic materials 0.000 claims description 8
125000001072 heteroaryl group Chemical group 0.000 claims description 8
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 7
229910052760 oxygen Inorganic materials 0.000 claims description 7
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 6
125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 6
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150000002367 halogens Chemical class 0.000 claims description 6
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SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims description 5
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 5
125000000041 C6-C10 aryl group Chemical group 0.000 claims description 4
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150000003952 β-lactams Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

OA1200100303A 1999-05-24 2000-04-25 13-Methyl erythromycin derivatives. OA11945A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13546899P	1999-05-24	1999-05-24

Publications (1)

Publication Number	Publication Date
OA11945A true OA11945A (en)	2006-04-13

Family

ID=22468240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200100303A OA11945A (en)	1999-05-24	2000-04-25	13-Methyl erythromycin derivatives.

Country Status (32)

Country	Link
US (2)	US20030100518A1 (fr)
EP (1)	EP1180110A1 (fr)
JP (1)	JP2003500414A (fr)
KR (1)	KR20020016799A (fr)
CN (1)	CN1351608A (fr)
AP (1)	AP2001002302A0 (fr)
AR (1)	AR020032A1 (fr)
AU (1)	AU3832100A (fr)
BG (1)	BG106127A (fr)
BR (1)	BR0010938A (fr)
CA (1)	CA2373117C (fr)
CZ (1)	CZ20013733A3 (fr)
DZ (1)	DZ3045A1 (fr)
EA (1)	EA200100983A1 (fr)
EE (1)	EE200100613A (fr)
HK (1)	HK1045523A1 (fr)
HR (1)	HRP20010866A2 (fr)
HU (1)	HUP0201516A3 (fr)
IL (1)	IL145739A0 (fr)
IS (1)	IS6128A (fr)
MA (1)	MA26740A1 (fr)
NO (1)	NO20015172L (fr)
OA (1)	OA11945A (fr)
PA (1)	PA8495101A1 (fr)
PE (1)	PE20010171A1 (fr)
PL (1)	PL352720A1 (fr)
SK (1)	SK15162001A3 (fr)
TN (1)	TNSN00108A1 (fr)
TR (1)	TR200103395T2 (fr)
UY (1)	UY26161A1 (fr)
WO (1)	WO2000071557A1 (fr)
ZA (1)	ZA200109595B (fr)

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JP6437523B2 (ja)	2013-04-04	2018-12-12	プレジデントアンドフェローズオブハーバードカレッジ	マクロライドならびにそれらの調製および使用の方法
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2000
- 2000-04-25 HU HU0201516A patent/HUP0201516A3/hu unknown
- 2000-04-25 IL IL14573900A patent/IL145739A0/xx unknown
- 2000-04-25 AP APAP/P/2001/002302A patent/AP2001002302A0/en unknown
- 2000-04-25 HR HR20010866A patent/HRP20010866A2/hr not_active Application Discontinuation
- 2000-04-25 OA OA1200100303A patent/OA11945A/en unknown
- 2000-04-25 SK SK1516-2001A patent/SK15162001A3/sk unknown
- 2000-04-25 EP EP00917230A patent/EP1180110A1/fr not_active Withdrawn
- 2000-04-25 TR TR2001/03395T patent/TR200103395T2/xx unknown
- 2000-04-25 PL PL00352720A patent/PL352720A1/xx not_active Application Discontinuation
- 2000-04-25 EE EEP200100613A patent/EE200100613A/xx unknown
- 2000-04-25 WO PCT/IB2000/000502 patent/WO2000071557A1/fr not_active Ceased
- 2000-04-25 HK HK02107035.0A patent/HK1045523A1/zh unknown
- 2000-04-25 AU AU38321/00A patent/AU3832100A/en not_active Abandoned
- 2000-04-25 JP JP2000619813A patent/JP2003500414A/ja active Pending
- 2000-04-25 EA EA200100983A patent/EA200100983A1/ru unknown
- 2000-04-25 CZ CZ20013733A patent/CZ20013733A3/cs unknown
- 2000-04-25 CA CA002373117A patent/CA2373117C/fr not_active Expired - Fee Related
- 2000-04-25 KR KR1020017015049A patent/KR20020016799A/ko not_active Ceased
- 2000-04-25 BR BR0010938-0A patent/BR0010938A/pt not_active IP Right Cessation
- 2000-04-25 CN CN00807992A patent/CN1351608A/zh active Pending
- 2000-05-05 PA PA20008495101A patent/PA8495101A1/es unknown
- 2000-05-22 AR ARP000102485A patent/AR020032A1/es not_active Application Discontinuation
- 2000-05-23 PE PE2000000491A patent/PE20010171A1/es not_active Application Discontinuation
- 2000-05-23 TN TNTNSN00108A patent/TNSN00108A1/fr unknown
- 2000-05-23 DZ DZ000088A patent/DZ3045A1/fr active
- 2000-05-24 US US09/577,901 patent/US20030100518A1/en not_active Abandoned
- 2000-05-24 UY UY26161A patent/UY26161A1/es not_active Application Discontinuation
- 2000-05-24 MA MA25990A patent/MA26740A1/fr unknown
2001
- 2001-10-23 NO NO20015172A patent/NO20015172L/no not_active Application Discontinuation
- 2001-10-26 IS IS6128A patent/IS6128A/is unknown
- 2001-11-21 ZA ZA200109595A patent/ZA200109595B/xx unknown
- 2001-11-21 BG BG106127A patent/BG106127A/bg unknown
2003
- 2003-05-19 US US10/441,347 patent/US6777543B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR20020016799A (ko)	2002-03-06
NO20015172L (no)	2002-01-23
IL145739A0 (en)	2002-07-25
HK1045523A1 (zh)	2002-11-29
BR0010938A (pt)	2002-03-19
AR020032A1 (es)	2002-03-27
MA26740A1 (fr)	2004-12-20
BG106127A (bg)	2002-05-31
EP1180110A1 (fr)	2002-02-20
PL352720A1 (en)	2003-09-08
US6777543B2 (en)	2004-08-17
NO20015172D0 (no)	2001-10-23
IS6128A (is)	2001-10-26
CA2373117A1 (fr)	2000-11-30
HRP20010866A2 (en)	2003-06-30
HUP0201516A3 (en)	2003-03-28
HUP0201516A2 (en)	2002-08-28
EE200100613A (et)	2003-02-17
DZ3045A1 (fr)	2004-03-27
PA8495101A1 (es)	2002-08-26
SK15162001A3 (sk)	2003-02-04
JP2003500414A (ja)	2003-01-07
PE20010171A1 (es)	2001-02-10
WO2000071557A1 (fr)	2000-11-30
US20030100518A1 (en)	2003-05-29
AU3832100A (en)	2000-12-12
UY26161A1 (es)	2000-12-29
CN1351608A (zh)	2002-05-29
US20030229031A1 (en)	2003-12-11
TR200103395T2 (tr)	2002-04-22
ZA200109595B (en)	2003-05-28
CZ20013733A3 (cs)	2002-11-13
TNSN00108A1 (fr)	2002-05-30
AP2001002302A0 (en)	2001-10-25
CA2373117C (fr)	2006-02-28
EA200100983A1 (ru)	2002-10-31

Publication	Publication Date	Title
OA11945A (en)	2006-04-13	13-Methyl erythromycin derivatives.
US6825171B2 (en)	2004-11-30	Erythromycin derivatives
US6472371B1 (en)	2002-10-29	Macrolides
AU731301B2 (en)	2001-03-29	Erythromycins and process for their preparation
US6437151B2 (en)	2002-08-20	Erythromycins and process for their preparation
JP2000219697A (ja)	2000-08-08	新規なアザリドとその製造方法
MXPA01010817A (en)	2002-06-05	13-methyl-erythromycin derivatives
MXPA00006602A (en)	2001-06-26	Novel erythromycin derivatives
MXPA00006604A (en)	2001-06-26	Novel macrolides
MXPA00001110A (en)	2001-06-26	Novel azalides and methods of making same