OA12097A - 2,4-Diaminopyrimidine compounds useful as immunosuppressants. - Google Patents

2,4-Diaminopyrimidine compounds useful as immunosuppressants. Download PDF

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Publication number
OA12097A
OA12097A OA1200200156A OA1200200156A OA12097A OA 12097 A OA12097 A OA 12097A OA 1200200156 A OA1200200156 A OA 1200200156A OA 1200200156 A OA1200200156 A OA 1200200156A OA 12097 A OA12097 A OA 12097A
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OA
OAPI
Prior art keywords
alkyl
dihydro
aryl
heteroaryl
composition according
Prior art date
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OA1200200156A
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English (en)
Inventor
Todd Andrew Blumenkopf
Eileen Elliott Mueller
Eric Jan Roskamp
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Pfizer Prod Inc
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Publication of OA12097A publication Critical patent/OA12097A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (16)

12097 Λ -55- 7,8-Dihydro-6H-pynmido[5,4-b}[1,4]thiazine; 3,4-Dihydro-2H-1-thia-4,5,8-tnaza-naphthaiene;6,7-Dihydro-5H-8-thia-1,2,4,5-tetraaza-naohthaiene; 7,8-Dihydro-6H-5-thia-1.2,4,8-tetraaza-naphthalene; 7,8-Dihydro-5H-5-thia-1,2,3,8-tetraaza-naphthaiene; 6,7-Dihydfo-5H-8-thia- 1,2,3,5-tetraaza-naphthaiene; 5,6,7,8-Tetra'nydro-pyrido[3,2-d]pyrimidine; 1,2,3,4-Tetrahydro-pyndo[2,3~d]pyridazine, 5,6,7,8-Tetrahydro-pyrido[2,3-bjpyrazine; 5,6,7,8-Tetrahydro-pyrido[3,2-e][1,2,4]triazine, 5,6,7,8-Tetrahydro-pyrido{2,3-eJ[1,2,4]triazine; 5,6,7,8-Tsirahydro-pyrido[3,2-d][1,2,3]triazine; and 5,6,7,8-Tetrahydro-pyrido[2,3-d][1,2,3}triazine.
15. A pharmaceutical composition comprising an effective amount of acompouna according to ciaim 1, and a pharmaceutical carrier. 16 A pharmaceutical composition according to ciaim 15, for treatment orprévention of a condition in a mammai wherein therapeutic benefit is achieved by modulationof a T-cel! mediated ceiiuiar process. 17 A pharmaceutical composition according to ciaim 15, for treatment orprévention of transpiant rejection in a mammai
18. A pnarmaceutica! composition according to ciaim 15, for treatment orprévention of autoimmune disease in a mammai.
19. A pharmaceutical composition according to ciaim 15, for treatment orprévention of infiammatory disease in a mammai.
20. A pharmaceutical composition according to ciaim 15, for treatment orprévention of aiiergy in a mammai
21. A pharmaceutica! composition according to ciaim 15, for treating 7-ceüieukemia or T-ceil iymphoma in a mammai. 22 A pharmaceutical composition according fc ciaim 15, for the treatment of adisease in a mammai wherein treatment can be effected by inhibiting activation of T-ceils, orthe results of said activation.
23. A pharmaceutical composition according to ciaim 15, further comprising anadditions! agent which modulâtes the mammaiian immune System or wnich is an arsti-inflammatory agent.
24. A pharmaceutical composition according to ciaim 15, usefui in the treatmentof a disorder or condition in a mammai seiected from the aroup consistina of ssthma, haylever, hives, infantile eczema, atopie dermatitis, and other allergie diseases invoivingantibody-mediated (intermediate-type) hvpersensitivity réactions, transpiant rejection,psoriasis, uteerative coiitis, Crohn's disease, iupus, multiple scierosis, rheurnatoid arthritis,type I diabètes, autoimmune thyroid disorders, T-cel! maiignancies mciuding T-ce!1 ieukemiaand T-cel! iymphoma, and Aizhetmer’s disease
25. A pharmaceutical composition according to ciaim 15, usefui to inhibiî tyrosinekinase Lck in a mammai. -56- 1 2097 26 A pharmaceutical composition according to ciasm 16, whersîn said ccmpcunclis proviasd as a pharmacsutically acceptable sait, solvaie or hycrate thereci.
27. Use of a composition of claim 15 in the manufacture of a substance foruse in a method of inhibiting protein tyrosine kinase Lck in a mammal.
28. The use of claim 27 wherein one or more additional agents thatmodulate a mammalian immune response or which are anti-inflammatory agents areused separately or in combination with said composition.
29. Use of a composition according to claim 15 effective in treating orpreventing a disorder or condition selected from asthma, hay fever, hives, infantileeczema, atopie dermatitis, and other allergie diseases involving antibody-mediated(intermediate-type) hypersensitivity reactions, transplant rejection, psoriasis,ulcerative colitis, Crohn’s disease, lupus, multiple sclerosis, rheumatoid arthritis, type1 diabètes, autoimmune thyroid disorders, T-cell malignancies including T-cellleukemia and T-cell lymphoma, and Alzheimer’s disease in the manufacture of amédicament for use in a said method.
30. Use of a pharmaceutical composition according to claim 15, in themanufacture of a médicament for use in a method for treating or preventing transplantrejection in a mammal.
31. Use of a pharmaceutical composition according to claim 15, in themanufacture of a médicament for use in a method for treating or preventingautoimmune disease in a mammal.
32. Use of a pharmaceutical composition according to claim 15, in themanufacture of a médicament for use in a method for treating or preventinginflammatory disease in a mammal.
33. Use of a pharmaceutical composition according to claim 15, in themanufacture of a médicament for use in a method for treating or preventing allergiedisease in a mammal.
OA1200200156A 1999-11-30 2000-11-09 2,4-Diaminopyrimidine compounds useful as immunosuppressants. OA12097A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16822499P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
OA12097A true OA12097A (en) 2006-05-04

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ID=22610621

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OA1200200156A OA12097A (en) 1999-11-30 2000-11-09 2,4-Diaminopyrimidine compounds useful as immunosuppressants.

Country Status (33)

Country Link
EP (1) EP1242403B1 (fr)
JP (1) JP3955468B2 (fr)
KR (1) KR20020059826A (fr)
CN (1) CN1402720A (fr)
AP (1) AP2002002530A0 (fr)
AT (1) ATE315036T1 (fr)
AU (1) AU1047601A (fr)
BG (1) BG106695A (fr)
BR (1) BR0015995A (fr)
CA (1) CA2392971C (fr)
CO (1) CO5261519A1 (fr)
CZ (1) CZ20021703A3 (fr)
DE (1) DE60025385T2 (fr)
EA (1) EA200200411A1 (fr)
EE (1) EE200200275A (fr)
ES (1) ES2253266T3 (fr)
GT (1) GT200000200A (fr)
HN (1) HN2000000264A (fr)
HU (1) HUP0203300A3 (fr)
IL (1) IL149103A0 (fr)
IS (1) IS6339A (fr)
MA (1) MA26846A1 (fr)
MX (1) MXPA02005350A (fr)
NO (1) NO20022557D0 (fr)
OA (1) OA12097A (fr)
PA (1) PA8506801A1 (fr)
PE (1) PE20010900A1 (fr)
PL (1) PL355946A1 (fr)
SV (1) SV2002000231A (fr)
TN (1) TNSN00232A1 (fr)
TR (1) TR200201431T2 (fr)
UY (1) UY26455A1 (fr)
WO (1) WO2001040215A1 (fr)

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US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6989385B2 (en) 2000-12-21 2006-01-24 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2003030909A1 (fr) * 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
CN1319968C (zh) 2002-08-02 2007-06-06 沃泰克斯药物股份有限公司 用作gsk－3的抑制剂的吡唑组合物
DE10237423A1 (de) * 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
US20040204458A1 (en) 2002-08-16 2004-10-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of Lck inhibitors for treatment of immunologic diseases
BRPI0506839A (pt) * 2004-01-16 2007-06-12 Novartis Ag composições e métodos para induzir a cardiomiogênese
RU2407736C2 (ru) * 2004-10-12 2010-12-27 Декод Дженетикс Ехф Пери-замещенные арилсульфонамидные бициклические соединения, предназначенные для лечения окклюзионного заболевания артерий
US20060161001A1 (en) * 2004-12-20 2006-07-20 Amgen Inc. Substituted heterocyclic compounds and methods of use
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
MX2008005814A (es) 2005-11-03 2008-10-15 Vertex Pharma Aminopirimidinas utiles como inhibidores de cinasa.
US7622463B2 (en) 2006-02-14 2009-11-24 Vertex Pharmaceuticals Incorporated Dihydrodiazepines useful as inhibitors of protein kinases
CN101563336A (zh) * 2006-03-16 2009-10-21 诺瓦提斯公司 用于治疗特别是黑素瘤的杂环有机化合物
JP2010526825A (ja) 2007-05-10 2010-08-05 エーエムアール テクノロジー インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンゾ−１，４−ジアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
AU2008312948C1 (en) * 2007-10-16 2012-08-09 Daiichi Sankyo Company, Limited Pyrimidyl indoline compound
CN103492391A (zh) 2009-09-25 2014-01-01 沃泰克斯药物股份有限公司 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法
CN102548994A (zh) 2009-09-25 2012-07-04 沃泰克斯药物股份有限公司 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法
TWI513694B (zh) * 2010-05-11 2015-12-21 Amgen Inc 抑制間變性淋巴瘤激酶的嘧啶化合物
KR101708761B1 (ko) * 2012-04-13 2017-02-21 주식회사 머쉬메드 퓨린 유도체 또는 그의 염을 포함하는 아토피성 피부염의 예방 또는 치료용 조성물
CN104903312B (zh) * 2013-10-07 2019-01-29 卡德门企业有限公司 Rho激酶抑制剂
CN110582491B (zh) 2017-06-30 2023-09-29 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
KR102563325B1 (ko) * 2017-06-30 2023-08-03 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 Ｒｈｏ-관련 단백질 키나아제 억제제, Ｒｈｏ-관련 단백질 키나아제 억제제를 함유하는 약학 조성물, 제조 방법 및 약학 조성물의 용도
JP7311228B2 (ja) * 2017-06-30 2023-07-19 ベイジン タイド ファーマシューティカル カンパニー リミテッド Ｒｈｏ－関連プロテインキナーゼ阻害剤、それを含む医薬組成物並びにその調製方法及び使用

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GB9905075D0 (en) * 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds

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IS6339A (is) 2002-04-12
HUP0203300A2 (hu) 2003-02-28
UY26455A1 (es) 2001-07-31
DE60025385D1 (de) 2006-03-30
EP1242403A1 (fr) 2002-09-25
BG106695A (bg) 2002-12-29
HN2000000264A (es) 2001-05-21
DE60025385T2 (de) 2006-08-24
HUP0203300A3 (en) 2003-10-28
GT200000200A (es) 2002-05-23
PE20010900A1 (es) 2001-09-08
ATE315036T1 (de) 2006-02-15
TR200201431T2 (tr) 2002-09-23
CA2392971A1 (fr) 2001-06-07
BR0015995A (pt) 2002-08-06
CO5261519A1 (es) 2003-03-31
AU1047601A (en) 2001-06-12
SV2002000231A (es) 2002-07-16
CA2392971C (fr) 2008-10-07
EA200200411A1 (ru) 2002-10-31
PL355946A1 (en) 2004-05-31
KR20020059826A (ko) 2002-07-13
MA26846A1 (fr) 2004-12-20
EP1242403B1 (fr) 2006-01-04
JP2003515602A (ja) 2003-05-07
WO2001040215A1 (fr) 2001-06-07
AP2002002530A0 (en) 2002-06-30
CN1402720A (zh) 2003-03-12
PA8506801A1 (es) 2002-04-25
NO20022557L (no) 2002-05-29
CZ20021703A3 (cs) 2003-06-18
NO20022557D0 (no) 2002-05-29
EE200200275A (et) 2003-10-15
MXPA02005350A (es) 2002-12-11
TNSN00232A1 (fr) 2005-11-10
ES2253266T3 (es) 2006-06-01
IL149103A0 (en) 2002-11-10
JP3955468B2 (ja) 2007-08-08

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