OA12147A - PyrroloÄ2,3dÜpyrimidine compositions and their use. - Google Patents

PyrroloÄ2,3dÜpyrimidine compositions and their use. Download PDF

Info

Publication number: OA12147A
Authority: OA; OAPI
Prior art keywords: substituted; phenyl; amino; pyrimidine; deazapurine
Prior art date: 1998-06-02

Application number

OA00000328A

Other languages

English (en)

Inventor

Arlindo L Castelhano

Bryan Mckibben

David J Witter

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-02

Filing date

1999-06-01

Publication date

2006-05-05

1999-06-01 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2006-05-05 Publication of OA12147A publication Critical patent/OA12147A/en

Links

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235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
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238000002731 protein assay Methods 0.000 description 1
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239000003379 purinergic P1 receptor agonist Substances 0.000 description 1
150000003212 purines Chemical class 0.000 description 1
125000003373 pyrazinyl group Chemical group 0.000 description 1
125000003226 pyrazolyl group Chemical group 0.000 description 1
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
DDWJFSYHYPDQEL-UHFFFAOYSA-N pyrimidine;1h-pyrrole Chemical compound C=1C=CNC=1.C1=CN=CN=C1 DDWJFSYHYPDQEL-UHFFFAOYSA-N 0.000 description 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
238000003653 radioligand binding assay Methods 0.000 description 1
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238000011160 research Methods 0.000 description 1
HSSLDCABUXLXKM-UHFFFAOYSA-N resorufin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3N=C21 HSSLDCABUXLXKM-UHFFFAOYSA-N 0.000 description 1
230000004043 responsiveness Effects 0.000 description 1
239000003340 retarding agent Substances 0.000 description 1
238000012340 reverse transcriptase PCR Methods 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
238000006748 scratching Methods 0.000 description 1
230000002393 scratching effect Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
208000013220 shortness of breath Diseases 0.000 description 1
230000020837 signal transduction in absence of ligand Effects 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
239000002356 single layer Substances 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
229960001407 sodium bicarbonate Drugs 0.000 description 1
WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
229910000342 sodium bisulfate Inorganic materials 0.000 description 1
229940100996 sodium bisulfate Drugs 0.000 description 1
229960004599 sodium borate Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
235000011008 sodium phosphates Nutrition 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
229940001482 sodium sulfite Drugs 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
229940041022 streptomycins Drugs 0.000 description 1
125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
229940014800 succinic anhydride Drugs 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical class [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
239000001117 sulphuric acid Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
230000006794 tachycardia Effects 0.000 description 1
230000008685 targeting Effects 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
LFKDJXLFVYVEFG-UHFFFAOYSA-N tert-butyl carbamate Chemical group CC(C)(C)OC(N)=O LFKDJXLFVYVEFG-UHFFFAOYSA-N 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
230000004797 therapeutic response Effects 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
230000002537 thrombolytic effect Effects 0.000 description 1
AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000000844 transformation Methods 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
238000001665 trituration Methods 0.000 description 1
230000007306 turnover Effects 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
125000005500 uronium group Chemical group 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
238000010200 validation analysis Methods 0.000 description 1
208000027185 varicose disease Diseases 0.000 description 1
230000025033 vasoconstriction Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
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238000003260 vortexing Methods 0.000 description 1
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230000004584 weight gain Effects 0.000 description 1
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230000004580 weight loss Effects 0.000 description 1
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238000010626 work up procedure Methods 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
235000014692 zinc oxide Nutrition 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

OA00000328A 1998-06-02 1999-06-01 PyrroloÄ2,3dÜpyrimidine compositions and their use. OA12147A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US8770298P	1998-06-02	1998-06-02
US12321699P	1999-03-08	1999-03-08
US12652799P	1999-03-26	1999-03-26

Publications (1)

Publication Number	Publication Date
OA12147A true OA12147A (en)	2006-05-05

Family

ID=27375739

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA00000328A OA12147A (en)	1998-06-02	1999-06-01	PyrroloÄ2,3dÜpyrimidine compositions and their use.

Country Status (25)

Country	Link
US (3)	US6800633B2 (cs)
EP (2)	EP1082120A1 (cs)
JP (1)	JP4611524B2 (cs)
KR (1)	KR100722194B1 (cs)
CN (1)	CN100528874C (cs)
AP (1)	AP1411A (cs)
AR (1)	AR020590A1 (cs)
AU (1)	AU763658B2 (cs)
BR (1)	BR9911612A (cs)
CA (1)	CA2334200C (cs)
CZ (1)	CZ302486B6 (cs)
DZ (1)	DZ2805A1 (cs)
EA (1)	EA003604B1 (cs)
HU (1)	HUP0103836A3 (cs)
ID (1)	ID27600A (cs)
IL (1)	IL139787A0 (cs)
MX (1)	MXPA00011889A (cs)
NO (1)	NO325233B1 (cs)
NZ (1)	NZ508314A (cs)
OA (1)	OA12147A (cs)
PL (1)	PL204628B1 (cs)
TR (1)	TR200003513T2 (cs)
TW (1)	TWI242435B (cs)
WO (1)	WO1999062518A1 (cs)
YU (1)	YU76100A (cs)

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- 2000-12-01 US US09/728,229 patent/US6800633B2/en not_active Expired - Fee Related
2004
- 2004-03-31 US US10/816,329 patent/US7429574B2/en not_active Expired - Fee Related
2008
- 2008-08-15 US US12/228,867 patent/US20090082369A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO325233B1 (no)	2008-03-03
PL347020A1 (en)	2002-03-11
MXPA00011889A (es)	2003-04-25
PL204628B1 (pl)	2010-01-29
CZ20004443A3 (cs)	2002-03-13
IL139787A0 (en)	2002-02-10
HUP0103836A2 (hu)	2002-02-28
US6800633B2 (en)	2004-10-05
NO20006090D0 (no)	2000-11-30
EP2011499A2 (en)	2009-01-07
CA2334200A1 (en)	1999-12-09
AU4226599A (en)	1999-12-20
US20090082369A1 (en)	2009-03-26
KR20010083042A (ko)	2001-08-31
EP2011499A3 (en)	2010-10-20
EA003604B1 (ru)	2003-06-26
HUP0103836A3 (en)	2003-05-28
CA2334200C (en)	2011-01-25
CN100528874C (zh)	2009-08-19
TWI242435B (en)	2005-11-01
WO1999062518A1 (en)	1999-12-09
US20020028782A1 (en)	2002-03-07
AP1411A (en)	2005-05-10
YU76100A (sh)	2003-12-31
US7429574B2 (en)	2008-09-30
KR100722194B1 (ko)	2007-05-29
JP2002516861A (ja)	2002-06-11
CZ302486B6 (cs)	2011-06-15
TR200003513T2 (tr)	2001-06-21
AP2000002015A0 (en)	2000-12-31
AR020590A1 (es)	2002-05-22
NZ508314A (en)	2004-03-26
DZ2805A1 (fr)	2005-01-30
AU763658B2 (en)	2003-07-31
CN1311680A (zh)	2001-09-05
EA200001245A1 (ru)	2001-08-27
US20050043332A1 (en)	2005-02-24
NO20006090L (no)	2001-01-31
BR9911612A (pt)	2001-02-06
JP4611524B2 (ja)	2011-01-12
EP1082120A1 (en)	2001-03-14
ID27600A (id)	2001-04-12