OA12278A - Outer membrane vesicle vaccine against disease caused by neisseria meningitidis serogroup A and process for the production thereof. - Google Patents
Outer membrane vesicle vaccine against disease caused by neisseria meningitidis serogroup A and process for the production thereof. Download PDFInfo
- Publication number
- OA12278A OA12278A OA1200200362A OA1200200362A OA12278A OA 12278 A OA12278 A OA 12278A OA 1200200362 A OA1200200362 A OA 1200200362A OA 1200200362 A OA1200200362 A OA 1200200362A OA 12278 A OA12278 A OA 12278A
- Authority
- OA
- OAPI
- Prior art keywords
- tank
- bacteria
- omv
- serogroup
- vaccine
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 68
- 238000000034 method Methods 0.000 title claims abstract description 45
- 239000012528 membrane Substances 0.000 title claims abstract description 38
- 230000008569 process Effects 0.000 title claims abstract description 24
- 201000010099 disease Diseases 0.000 title claims abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 8
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 title claims description 3
- 238000004519 manufacturing process Methods 0.000 title description 9
- 241000894006 Bacteria Species 0.000 claims description 45
- 239000000725 suspension Substances 0.000 claims description 29
- 230000001580 bacterial effect Effects 0.000 claims description 28
- 102000004169 proteins and genes Human genes 0.000 claims description 27
- 108090000623 proteins and genes Proteins 0.000 claims description 27
- 239000000872 buffer Substances 0.000 claims description 25
- 239000003599 detergent Substances 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 20
- 238000009295 crossflow filtration Methods 0.000 claims description 19
- 239000008188 pellet Substances 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- 239000003613 bile acid Substances 0.000 claims description 12
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 11
- 238000000703 high-speed centrifugation Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 101710116435 Outer membrane protein Proteins 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 7
- 208000015181 infectious disease Diseases 0.000 claims description 7
- 239000006285 cell suspension Substances 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000005374 membrane filtration Methods 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 235000004252 protein component Nutrition 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 abstract description 7
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 43
- 229940009976 deoxycholate Drugs 0.000 description 40
- 241000699670 Mus sp. Species 0.000 description 27
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 17
- 229930006000 Sucrose Natural products 0.000 description 17
- 239000002158 endotoxin Substances 0.000 description 17
- 229920006008 lipopolysaccharide Polymers 0.000 description 17
- 239000002609 medium Substances 0.000 description 17
- 239000005720 sucrose Substances 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 16
- 238000005119 centrifugation Methods 0.000 description 15
- 229920001282 polysaccharide Polymers 0.000 description 14
- 239000005017 polysaccharide Substances 0.000 description 14
- 150000004676 glycans Chemical class 0.000 description 13
- 230000002779 inactivation Effects 0.000 description 13
- 230000000844 anti-bacterial effect Effects 0.000 description 12
- 239000006228 supernatant Substances 0.000 description 12
- 238000000746 purification Methods 0.000 description 11
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 10
- 201000009906 Meningitis Diseases 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 230000000890 antigenic effect Effects 0.000 description 8
- 230000012010 growth Effects 0.000 description 8
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 7
- 239000000427 antigen Substances 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 230000002458 infectious effect Effects 0.000 description 5
- 238000002955 isolation Methods 0.000 description 5
- 230000002147 killing effect Effects 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 239000007983 Tris buffer Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229960003964 deoxycholic acid Drugs 0.000 description 4
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Chemical class C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 4
- 229960004906 thiomersal Drugs 0.000 description 4
- -1 Bile acid anions Chemical class 0.000 description 3
- 101710164702 Major outer membrane protein Proteins 0.000 description 3
- 241000040340 Oat mosaic virus Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 210000000941 bile Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 238000003119 immunoblot Methods 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 230000005847 immunogenicity Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 208000037941 meningococcal disease Diseases 0.000 description 3
- 239000000693 micelle Substances 0.000 description 3
- 150000003904 phospholipids Chemical class 0.000 description 3
- 229940031937 polysaccharide vaccine Drugs 0.000 description 3
- 238000011045 prefiltration Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- 239000006150 trypticase soy agar Substances 0.000 description 3
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Chemical class OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 2
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 208000002109 Argyria Diseases 0.000 description 2
- 108010060123 Conjugate Vaccines Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- 241000588653 Neisseria Species 0.000 description 2
- 241000838698 Togo Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 229940031670 conjugate vaccine Drugs 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000003760 magnetic stirring Methods 0.000 description 2
- 229940100892 mercury compound Drugs 0.000 description 2
- 150000002731 mercury compounds Chemical class 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000003019 stabilising effect Effects 0.000 description 2
- 239000012137 tryptone Substances 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Chemical class OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- 241000969130 Atthis Species 0.000 description 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- 241001493150 Capim virus Species 0.000 description 1
- 239000004380 Cholic acid Chemical class 0.000 description 1
- 241000134884 Ericales Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 description 1
- 101710105759 Major outer membrane porin Proteins 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 206010027202 Meningitis bacterial Diseases 0.000 description 1
- 208000034762 Meningococcal Infections Diseases 0.000 description 1
- 241000790101 Myriopus Species 0.000 description 1
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 102000017033 Porins Human genes 0.000 description 1
- 108010013381 Porins Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000027645 antigenic variation Effects 0.000 description 1
- 201000009904 bacterial meningitis Diseases 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical class C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 1
- 229960001091 chenodeoxycholic acid Drugs 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical class C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- KSCFJBIXMNOVSH-UHFFFAOYSA-N dyphylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)CO)C=N2 KSCFJBIXMNOVSH-UHFFFAOYSA-N 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000011536 extraction buffer Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229910001679 gibbsite Inorganic materials 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006054 immunological memory Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical group O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
- SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical class C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- 230000003446 memory effect Effects 0.000 description 1
- 229960005037 meningococcal vaccines Drugs 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000013404 process transfer Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019624 protein content Nutrition 0.000 description 1
- 229940023143 protein vaccine Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- BHQCQFFYRZLCQQ-UTLSPDKDSA-N ursocholic acid Chemical class C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-UTLSPDKDSA-N 0.000 description 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical class C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
- 229960001661 ursodiol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20002828A NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA12278A true OA12278A (en) | 2006-05-11 |
Family
ID=19911219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200200362A OA12278A (en) | 2000-06-02 | 2001-06-05 | Outer membrane vesicle vaccine against disease caused by neisseria meningitidis serogroup A and process for the production thereof. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040131642A1 (de) |
| EP (1) | EP1286696B1 (de) |
| AP (1) | AP1690A (de) |
| AT (1) | ATE345143T1 (de) |
| AU (1) | AU2001264427A1 (de) |
| CA (1) | CA2410652A1 (de) |
| DE (1) | DE60124538D1 (de) |
| NO (1) | NO20002828D0 (de) |
| OA (1) | OA12278A (de) |
| WO (1) | WO2001091788A1 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2270173E (pt) | 1999-05-19 | 2016-03-28 | Glaxosmithkline Biologicals Sa | Composições de neisseria de combinação |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| WO2002009643A2 (en) | 2000-07-27 | 2002-02-07 | Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| GB0130123D0 (en) | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| WO2004046177A2 (en) | 2002-11-15 | 2004-06-03 | Chiron Srl | Unexpected surface proteins in neisseria meningitidis |
| CU23313A1 (es) * | 2002-11-27 | 2008-09-25 | Inst Finlay Ct De Investigacia | Mã0/00todo de obtenciã"n de estructuras cocleares. composiciones vacunales y adyuvantes basados en estructuras cocleares y sus intermediarios |
| AU2003288558A1 (en) * | 2002-12-16 | 2004-07-09 | Nasjonalt Folkehelseinstitutt | Meningococcal vaccine based on outer membrane proteins porb2 and pora |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| CU23377A1 (es) * | 2003-11-04 | 2009-05-28 | Ct De Ingenieria Genetica Y Biotecnologia | Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes |
| GB0416120D0 (en) | 2004-07-19 | 2004-08-18 | Health Prot Agency | Stable compositions containing OMV's |
| GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| ES2616294T3 (es) | 2005-01-27 | 2017-06-12 | Children's Hospital & Research Center At Oakland | Vacunas de vesículas basadas en GNA1870 para protección de amplio espectro contra enfermedades provocadas por Neisseria meningitidis |
| WO2007139746A1 (en) | 2006-05-22 | 2007-12-06 | Biovest International Inc. | Rotary actuator valve for a cell culture system |
| MX340096B (es) | 2007-10-19 | 2016-06-27 | Glaxosmithkline Biologicals Sa | Formulaciones de vacuna meningococica. |
| BRPI0907843A2 (pt) | 2008-02-21 | 2015-08-04 | Novartis Ag | Polipeptídeos de fhbp menigocócicos |
| PT2268618E (pt) | 2008-03-03 | 2015-10-12 | Novartis Ag | Compostos e composições moduladores da actividade tlr |
| WO2009158142A1 (en) | 2008-05-30 | 2009-12-30 | The U.S.A., As Represented By The Secretary Of The Army, On Behalf Of Walter Reed Army | Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| JP2012512240A (ja) | 2008-12-17 | 2012-05-31 | ノバルティス アーゲー | ヘモグロビン受容体を含む髄膜炎菌ワクチン |
| WO2010144734A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| JP2013503148A (ja) | 2009-08-27 | 2013-01-31 | ノバルティス アーゲー | アルミニウム、オリゴヌクレオチドおよびポリカチオンを含むアジュバント |
| JP2013502918A (ja) | 2009-08-27 | 2013-01-31 | ノバルティス アーゲー | 髄膜炎菌fHBP配列を含むハイブリッドポリペプチド |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| JP5988492B2 (ja) | 2009-09-02 | 2016-09-07 | ノバルティス アーゲー | Tlr活性モジュレーターを含む免疫原性組成物 |
| GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
| WO2011039631A2 (en) | 2009-09-30 | 2011-04-07 | Novartis Ag | Expression of meningococcal fhbp polypeptides |
| US20130022633A1 (en) | 2009-10-27 | 2013-01-24 | University Of Florence | MENINGOCOCCAL fHBP POLYPEPTIDES |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| BR112012014624A8 (pt) | 2009-12-15 | 2017-12-26 | Novartis Ag | suspensão homogênea de compostos de imunopotenciação e usos dos destes |
| MX2012010609A (es) | 2010-03-18 | 2012-10-03 | Novartis Ag | Vacunas adyuvadas para meningococos serogrupo b. |
| EP2549990A1 (de) | 2010-03-23 | 2013-01-30 | Irm Llc | Verbindungen (cysteinbasierte lipopeptide) und zusammensetzungen als tlr2-agonisten zur behandlung von infektionen, entzündungen, atemwegserkrankungen etc. |
| ES2759484T3 (es) | 2010-09-10 | 2020-05-11 | Glaxosmithkline Biologicals Sa | Meningococo que sobreexpresa NadA y/o NHBA y vesículas de la membrana externa derivadas del mismo |
| EP2707009A1 (de) | 2011-05-12 | 2014-03-19 | Novartis AG | Antipyretika zur verbesserung der verträglichkeit von impfstoffen auf vesikelbasis |
| WO2012171030A2 (en) | 2011-06-10 | 2012-12-13 | Biovest International, Inc. | Method and apparatus for antibody production and purification |
| AU2013214105A1 (en) | 2012-02-02 | 2014-07-24 | Novartis Ag | Promoters for increased protein expression in meningococcus |
| US10598666B2 (en) | 2012-03-08 | 2020-03-24 | Glaxosmithkline Biologicals Sa | In vitro potency assay for protein-based meningococcal vaccines |
| EP2861247B1 (de) | 2012-06-14 | 2020-12-09 | GlaxoSmithKline Biologicals SA | Impfstoffe gegen serogruppe-x-meningokokken |
| CA2920957A1 (en) | 2012-08-28 | 2014-03-06 | Biovest International, Inc. | Biomanufacturing suite and methods for large-scale production of cells, viruses, and biomolecules |
| RU2015106930A (ru) | 2012-09-06 | 2016-10-20 | Новартис Аг | Комбинированные вакцины с менингококком серогруппы в и к/д/с |
| MX363529B (es) | 2012-09-18 | 2019-03-27 | Novartis Ag | Vesículas de membrana externa. |
| CA2900454A1 (en) | 2013-02-07 | 2014-08-14 | Glaxosmithkline Biologicals Sa | Pharmaceutical compositions comprising vesicles |
| KR102779223B1 (ko) | 2014-02-28 | 2025-03-07 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 변형된 수막구균 fhbp 폴리펩티드 |
| US11066453B2 (en) | 2015-05-18 | 2021-07-20 | Biomvis Srl | Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof |
| US12109259B2 (en) | 2016-09-02 | 2024-10-08 | Glaxosmithkline Biologicals Sa | Vaccines for Neisseria gonorrhoeae |
| EP3607967A1 (de) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modifizierte meningokokken fhbp polypeptide |
| AU2019376832B2 (en) | 2018-11-06 | 2024-01-25 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
| CN112410239B (zh) * | 2019-08-22 | 2023-03-24 | 四川大学 | 细菌膜囊泡及其制备方法与应用 |
| WO2025175304A2 (en) | 2024-02-16 | 2025-08-21 | Sanofi Pasteur Inc. | Process for the preparation of deoxycholic acid |
| WO2025183190A1 (ja) * | 2024-02-28 | 2025-09-04 | 株式会社ヤクルト本社 | グラム陽性菌の膜小胞の製造方法及びその膜小胞の利用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2631035B2 (ja) * | 1991-03-12 | 1997-07-16 | アメリカ合衆国 | 多糖類−タンパク質複合体 |
| US5324442A (en) * | 1992-06-16 | 1994-06-28 | Kansas State University Research Foundation | Fermentation process for the production of calcium magnesium road deicer |
| GB9726398D0 (en) * | 1997-12-12 | 1998-02-11 | Isis Innovation | Polypeptide and coding sequences |
| ATE446368T1 (de) * | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| GB9820003D0 (en) * | 1998-09-14 | 1998-11-04 | Smithkline Beecham Biolog | Novel compounds |
| CA2359492A1 (en) * | 1999-01-15 | 2000-07-20 | Smithkline Beecham Biologicals S.A. | Neisseria meningitidis antigen |
| AU756832B2 (en) * | 1999-02-22 | 2003-01-23 | Ncsrt, Inc. | Purification of biological substances |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| WO2002009643A2 (en) * | 2000-07-27 | 2002-02-07 | Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| GB0103170D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
-
2000
- 2000-06-02 NO NO20002828A patent/NO20002828D0/no unknown
-
2001
- 2001-06-05 AU AU2001264427A patent/AU2001264427A1/en not_active Abandoned
- 2001-06-05 AT AT01938851T patent/ATE345143T1/de not_active IP Right Cessation
- 2001-06-05 CA CA002410652A patent/CA2410652A1/en not_active Abandoned
- 2001-06-05 WO PCT/NO2001/000232 patent/WO2001091788A1/en not_active Ceased
- 2001-06-05 OA OA1200200362A patent/OA12278A/en unknown
- 2001-06-05 EP EP01938851A patent/EP1286696B1/de not_active Revoked
- 2001-06-05 AP APAP/P/2002/002681A patent/AP1690A/en active
- 2001-06-05 DE DE60124538T patent/DE60124538D1/de not_active Expired - Lifetime
- 2001-06-05 US US10/296,212 patent/US20040131642A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001091788A1 (en) | 2001-12-06 |
| NO20002828D0 (no) | 2000-06-02 |
| DE60124538D1 (de) | 2006-12-28 |
| AP2002002681A0 (en) | 2002-12-31 |
| ATE345143T1 (de) | 2006-12-15 |
| AP1690A (en) | 2006-12-11 |
| EP1286696B1 (de) | 2006-11-15 |
| EP1286696A1 (de) | 2003-03-05 |
| US20040131642A1 (en) | 2004-07-08 |
| CA2410652A1 (en) | 2001-12-06 |
| AU2001264427A1 (en) | 2001-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| OA12278A (en) | Outer membrane vesicle vaccine against disease caused by neisseria meningitidis serogroup A and process for the production thereof. | |
| EP1644035B1 (de) | Ultrafiltration und ultracentrifugation zur preparation von membran-vesikeln (omv) | |
| RU2325184C2 (ru) | Улучшенные везикулы наружной мембраны бактерий | |
| RU2607021C2 (ru) | Способ бездетергентного получения везикул наружной мембраны грамотрицательной бактерии | |
| US6921537B2 (en) | Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci | |
| TW200817034A (en) | Vaccine | |
| TW200408406A (en) | Vaccine | |
| EA023470B1 (ru) | Новые составы, стабилизирующие иммуногенные композиции и ингибирующие их осаждение | |
| JP2005514388A (ja) | グラム陰性菌由来の外膜小胞およびワクチンとしての使用 | |
| JP2006506467A5 (de) | ||
| EP2988779B1 (de) | Bakterienmutanten zur herstellung von allgemeinen modulen für membranantigene | |
| US7820185B2 (en) | Stable compositions containing OMVs | |
| EP2929894B1 (de) | Impfungsadjuvans, herstellung und impfstoffe damit | |
| Jiskoot et al. | Immunogenic activity of gonococcal protein I in mice with three different lipoidal adjuvants delivered in liposomes and in complexes | |
| WO2004054611A1 (en) | Meningococcal vaccine based on outer membrane proteins porb2 and pora | |
| EP0090660A2 (de) | Neisseria Gonorrhöe Vakzin | |
| RU2005102587A (ru) | Вакцинная композиция, содержащая трансферрин-связывающий белок и hsf из грамотрицательных бактерий |