OA12529A - Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors. - Google Patents

Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors. Download PDF

Info

Publication number: OA12529A
Authority: OA; OAPI
Prior art keywords: pyridin; crc4; spiro; group; alkyl
Prior art date: 2000-10-26

Application number

OA1200300123A

Other languages

English (en)

Inventor

Brian Scott Bronk

Mark Carl Noe

Martin James Wythes

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-26

Filing date

2001-10-23

Publication date

2006-06-02

2001-10-23 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-06-02 Publication of OA12529A publication Critical patent/OA12529A/en

Links

239000003475 metalloproteinase inhibitor Substances 0.000 title abstract description 4
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208000035475 disorder Diseases 0.000 claims abstract description 31
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
150000001875 compounds Chemical class 0.000 claims description 206
-1 (C6-Cio)aryi Chemical group 0.000 claims description 141
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 74
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239000001301 oxygen Substances 0.000 claims description 74
125000000217 alkyl group Chemical group 0.000 claims description 72
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239000002253 acid Substances 0.000 claims description 30
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NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 26
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 23
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OA1200300123A 2000-10-26 2001-10-23 Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors. OA12529A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24338900P	2000-10-26	2000-10-26

Publications (1)

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OA12529A true OA12529A (en)	2006-06-02

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OA1200300123A OA12529A (en)	2000-10-26	2001-10-23	Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors.

Country Status (32)

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EP (1)	EP1332146A2 (es)
JP (1)	JP2004518635A (es)
KR (1)	KR20040004412A (es)
CN (1)	CN1501937A (es)
AP (1)	AP2001002318A0 (es)
AR (1)	AR035069A1 (es)
AU (1)	AU2002210813A1 (es)
BG (1)	BG107653A (es)
BR (1)	BR0114913A (es)
CA (1)	CA2425283A1 (es)
CZ (1)	CZ20031083A3 (es)
EA (1)	EA005762B1 (es)
EC (1)	ECSP034567A (es)
EE (1)	EE200300196A (es)
GT (1)	GT200100213A (es)
HN (1)	HN2001000244A (es)
HR (1)	HRP20030332A2 (es)
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IL (1)	IL154948A0 (es)
IS (1)	IS6762A (es)
MA (1)	MA26957A1 (es)
MX (1)	MXPA03003735A (es)
NO (1)	NO20031853L (es)
OA (1)	OA12529A (es)
PA (1)	PA8531401A1 (es)
PE (1)	PE20020589A1 (es)
PL (1)	PL366201A1 (es)
SK (1)	SK4972003A3 (es)
SV (1)	SV2003000705A (es)
TN (1)	TNSN01149A1 (es)
WO (1)	WO2002034753A2 (es)
ZA (1)	ZA200302190B (es)

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DOP2002000333A (es)	2001-02-14	2002-09-30	Warner Lambert Co	Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
PA8539501A1 (es)	2001-02-14	2002-09-30	Warner Lambert Co	Compuestos triazolo como inhibidores de mmp
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AU2003228701A1 (en) *	2002-04-25	2003-11-10	Bristol-Myers Squibb Company	Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases
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AU2003250470A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidinone fused bicyclic metalloproteinase inhibitors
AU2003249477A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Heterobicylcic metalloproteinase inhibitors
EP1539709A1 (en)	2002-08-13	2005-06-15	Warner-Lambert Company LLC	Azaisoquinoline derivatives as matrix metalloproteinase inhibitors
MXPA05001783A (es)	2002-08-13	2005-04-25	Warner Lambert Co	Derivados de pirimidina-2,4-diona como inhibidores de las metaloproteinasas de matriz.
WO2004014892A1 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Monocyclic derivatives as matrix metalloproteinase inhibitors
PA8578101A1 (es)	2002-08-13	2004-05-07	Warner Lambert Co	Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
WO2004014909A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
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GB0223249D0 (en) *	2002-10-08	2002-11-13	Amersham Plc	Improved imaging agents
WO2004084903A1 (en) *	2003-03-27	2004-10-07	F. Hoffmann-La Roche Ag	Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) *	2003-03-28	2004-10-07	F. Hoffmann-La Roche Ag	Use of a trioxopyrimidine for the treatment of chronic wounds
FR2858232B1 (fr) *	2003-07-29	2006-03-03	Pierre Potier	Utilisation d'un derive de biguanide pour proteger la peau des radiations uvb
AU2005230379B2 (en) *	2004-04-01	2010-07-22	Universite De Liege	Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
DOP2006000268A (es)	2005-12-22	2007-07-31	Pfizer Prod Inc	Agentes antibacterianos
US8153166B2 (en) *	2006-06-08	2012-04-10	Chih-Hsiung Lin	Composition for prophylaxis or treatment of urinary system infection and method thereof
CN102285934B (zh) *	2009-01-08	2013-08-14	四川大学	螺环二烯酮衍生物及其制备方法和用途
KR102168738B1 (ko) *	2012-12-10	2020-10-22	추가이 세이야쿠 가부시키가이샤	히단토인 유도체
KR101594506B1 (ko) *	2014-03-20	2016-02-17	한국화학연구원	골 관련 질환 치료용 조성물
KR102266021B1 (ko)	2014-06-09	2021-06-16	추가이 세이야쿠 가부시키가이샤	히단토인 유도체 함유 의약 조성물
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CN110092790B (zh) *	2019-06-11	2020-07-24	东北农业大学	一种生物碱类化合物及其制备方法和应用
WO2025226892A1 (en) *	2024-04-24	2025-10-30	Septerna, Inc.	Spirocycle-containing diaminomethylene pyrimidine-2,4,6-trione agonists of parathyroid hormone 1 and incretin receptors
WO2025226895A1 (en) *	2024-04-24	2025-10-30	Septerna, Inc.	Agonists of parathyroid hormone 1 and incretin receptors comprising substituted or modified diaminomethylene pyrimidine-2,4,6-triones
CN121648128A (zh) *	2026-02-03	2026-03-13	华中科技大学同济医学院附属同济医院	特拉唑嗪或其药学上可接受的盐在制备用于预防和/或治疗肝纤维化的药物中的应用

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HN2000000137A (es) *	1999-08-12	2001-02-02	Pfizer Prod Inc	Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas

2001
- 2001-10-23 CN CNA018179231A patent/CN1501937A/zh active Pending
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- 2001-10-23 HR HR20030332A patent/HRP20030332A2/hr not_active Application Discontinuation
- 2001-10-23 CZ CZ20031083A patent/CZ20031083A3/cs unknown
- 2001-10-23 EE EEP200300196A patent/EE200300196A/xx unknown
- 2001-10-23 SK SK497-2003A patent/SK4972003A3/sk unknown
- 2001-10-23 OA OA1200300123A patent/OA12529A/en unknown
- 2001-10-23 AP APAP/P/2001/002318A patent/AP2001002318A0/en unknown
- 2001-10-23 MX MXPA03003735A patent/MXPA03003735A/es unknown
- 2001-10-23 IL IL15494801A patent/IL154948A0/xx unknown
- 2001-10-23 WO PCT/IB2001/001986 patent/WO2002034753A2/en not_active Ceased
- 2001-10-23 EP EP01978721A patent/EP1332146A2/en not_active Withdrawn
- 2001-10-23 KR KR10-2003-7005753A patent/KR20040004412A/ko not_active Ceased
- 2001-10-23 PL PL01366201A patent/PL366201A1/xx not_active Application Discontinuation
- 2001-10-23 JP JP2002537743A patent/JP2004518635A/ja not_active Withdrawn
- 2001-10-23 BR BR0114913-0A patent/BR0114913A/pt not_active IP Right Cessation
- 2001-10-23 HU HU0301577A patent/HUP0301577A3/hu unknown
- 2001-10-23 EA EA200300306A patent/EA005762B1/ru not_active IP Right Cessation
- 2001-10-23 CA CA002425283A patent/CA2425283A1/en not_active Abandoned
- 2001-10-24 HN HN2001000244A patent/HN2001000244A/es unknown
- 2001-10-24 AR ARP010104977A patent/AR035069A1/es unknown
- 2001-10-25 TN TNTNSN01149A patent/TNSN01149A1/fr unknown
- 2001-10-25 SV SV2001000705A patent/SV2003000705A/es unknown
- 2001-10-25 PE PE2001001060A patent/PE20020589A1/es not_active Application Discontinuation
- 2001-10-25 GT GT200100213A patent/GT200100213A/es unknown
- 2001-10-26 PA PA20018531401A patent/PA8531401A1/es unknown
2003
- 2003-03-19 ZA ZA200302190A patent/ZA200302190B/en unknown
- 2003-03-20 BG BG107653A patent/BG107653A/bg unknown
- 2003-03-27 IS IS6762A patent/IS6762A/is unknown
- 2003-04-22 MA MA27117A patent/MA26957A1/fr unknown
- 2003-04-24 NO NO20031853A patent/NO20031853L/no not_active Application Discontinuation
- 2003-04-25 EC EC2003004567A patent/ECSP034567A/es unknown

Also Published As

Publication number	Publication date
CN1501937A (zh)	2004-06-02
WO2002034753A2 (en)	2002-05-02
NO20031853D0 (no)	2003-04-24
KR20040004412A (ko)	2004-01-13
EA005762B1 (ru)	2005-06-30
ECSP034567A (es)	2003-06-25
MA26957A1 (fr)	2004-12-20
EE200300196A (et)	2003-10-15
BR0114913A (pt)	2003-07-01
PE20020589A1 (es)	2002-07-06
WO2002034753A3 (en)	2002-08-15
ZA200302190B (en)	2004-04-28
IL154948A0 (en)	2003-10-31
MXPA03003735A (es)	2003-07-28
NO20031853L (no)	2003-06-23
PL366201A1 (en)	2005-01-24
EA200300306A1 (ru)	2003-08-28
HUP0301577A3 (en)	2006-02-28
PA8531401A1 (es)	2003-06-30
GT200100213A (es)	2002-07-03
AU2002210813A1 (en)	2002-05-06
TNSN01149A1 (fr)	2005-11-10
HUP0301577A2 (hu)	2003-11-28
CA2425283A1 (en)	2002-05-02
IS6762A (is)	2003-03-27
SK4972003A3 (en)	2004-05-04
SV2003000705A (es)	2003-01-13
AR035069A1 (es)	2004-04-14
EP1332146A2 (en)	2003-08-06
AP2001002318A0 (en)	2001-12-31
BG107653A (bg)	2003-12-31
HRP20030332A2 (en)	2003-06-30
CZ20031083A3 (cs)	2004-03-17
HN2001000244A (es)	2003-11-07
JP2004518635A (ja)	2004-06-24

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US6841671B2 (en)	2005-01-11	Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
US6706723B2 (en)	2004-03-16	Pyrimidine-2,4,6-trione metalloproteinase inhibitors
EP1501834B1 (en)	2005-09-07	Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors
US6919332B2 (en)	2005-07-19	N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
AU2012335220A1 (en)	2014-05-01	2-thiopyrimidinones
ES2250880T3 (es)	2006-04-16	Inhibidores triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa.
NZ624453B2 (en)	2016-03-30	2-thiopyrimidinones