OA12650A - Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof. - Google Patents

Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof. Download PDF

Info

Publication number: OA12650A
Authority: OA; OAPI
Prior art keywords: crystal; malic acid; diethylamino; oxo; dimethyl
Prior art date: 2001-08-15

Application number

OA1200400044A

Other languages

English (en)

Inventor

Thomas J Fleck

Michael Hawley

Mark T Maloney

Stephen P Prescott

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-15

Filing date

2002-08-13

Publication date

2006-06-19

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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23211067&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA12650(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-08-13 Application filed by Upjohn Co filed Critical Upjohn Co

2006-06-19 Publication of OA12650A publication Critical patent/OA12650A/en

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WINHZLLDWRZWRT-UHFFFAOYSA-N N-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(C=C2C3=CC(F)=CC=C3NC2=O)=C1C WINHZLLDWRZWRT-UHFFFAOYSA-N 0.000 claims abstract description 7
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 80
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RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
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238000002076 thermal analysis method Methods 0.000 description 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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230000007704 transition Effects 0.000 description 1
229950001353 tretamine Drugs 0.000 description 1
IUCJMVBFZDHPDX-UHFFFAOYSA-N tretamine Chemical compound C1CN1C1=NC(N2CC2)=NC(N2CC2)=N1 IUCJMVBFZDHPDX-UHFFFAOYSA-N 0.000 description 1
150000003918 triazines Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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229960003048 vinblastine Drugs 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Oncology (AREA)
Obesity (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)

OA1200400044A 2001-08-15 2002-08-13 Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof. OA12650A (en)

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US31235301P	2001-08-15	2001-08-15

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OA12650A true OA12650A (en)	2006-06-19

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OA1200400044A OA12650A (en)	2001-08-15	2002-08-13	Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof.

Country Status (42)

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US (2)	US20030069298A1 (es)
EP (3)	EP2332934B1 (es)
JP (1)	JP4159988B2 (es)
KR (1)	KR100639281B1 (es)
CN (2)	CN100364991C (es)
AP (1)	AP1660A (es)
AR (1)	AR036261A1 (es)
AU (1)	AU2002324684B2 (es)
BG (1)	BG108553A (es)
BR (1)	BR0211612A (es)
CA (1)	CA2455050C (es)
CO (1)	CO5550431A2 (es)
CU (1)	CU23713B7 (es)
CY (1)	CY1121552T1 (es)
CZ (1)	CZ2004196A3 (es)
DK (2)	DK3168218T3 (es)
EA (1)	EA006445B9 (es)
EC (1)	ECSP044975A (es)
ES (3)	ES2705063T3 (es)
GE (1)	GEP20063777B (es)
HR (1)	HRP20040112B1 (es)
HU (1)	HU229206B1 (es)
IL (1)	IL160097A0 (es)
IS (1)	IS7147A (es)
MA (1)	MA27058A1 (es)
ME (1)	ME00414B (es)
MX (1)	MXPA04001452A (es)
MY (1)	MY139383A (es)
NO (1)	NO326508B1 (es)
NZ (1)	NZ531232A (es)
OA (1)	OA12650A (es)
PL (1)	PL216524B1 (es)
PT (2)	PT3168218T (es)
RS (1)	RS53251B (es)
SI (2)	SI3168218T1 (es)
SK (1)	SK902004A3 (es)
TN (1)	TNSN04028A1 (es)
TR (1)	TR201900509T4 (es)
TW (1)	TWI269796B (es)
UA (1)	UA76483C2 (es)
WO (1)	WO2003016305A1 (es)
ZA (1)	ZA200400706B (es)

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Publication number	Publication date
HK1066542A1 (en)	2005-03-24
HRP20040112A2 (en)	2004-06-30
IL160097A0 (en)	2004-06-20
EP1419151A1 (en)	2004-05-19
TWI269796B (en)	2007-01-01
ECSP044975A (es)	2004-03-23
BG108553A (bg)	2005-04-30
US20030069298A1 (en)	2003-04-10
MY139383A (en)	2009-09-30
SI1419151T1 (sl)	2014-04-30
EA006445B9 (ru)	2017-02-28
EP2332934B1 (en)	2017-03-01
AP1660A (en)	2006-09-09
HRP20040112B1 (en)	2012-03-31
EP3168218A1 (en)	2017-05-17
NO20041054L (no)	2004-03-12
PL216524B1 (pl)	2014-04-30
RS53251B (sr)	2014-08-29
JP4159988B2 (ja)	2008-10-01
CU20040029A7 (es)	2008-03-14
PT3168218T (pt)	2019-01-11
HK1088008A1 (zh)	2006-10-27
JP2005503386A (ja)	2005-02-03
CN100364991C (zh)	2008-01-30
HU229206B1 (en)	2013-09-30
MXPA04001452A (es)	2004-05-20
WO2003016305A1 (en)	2003-02-27
GEP20063777B (en)	2006-03-27
IS7147A (is)	2004-02-10
TR201900509T4 (tr)	2019-02-21
EA006445B1 (ru)	2005-12-29
CN1789264A (zh)	2006-06-21
ES2705063T3 (es)	2019-03-21
SK902004A3 (sk)	2005-03-04
EA200400183A1 (ru)	2004-08-26
PL368317A1 (en)	2005-03-21
CA2455050C (en)	2007-02-20
CN1543462A (zh)	2004-11-03
CN100439360C (zh)	2008-12-03
US7435832B2 (en)	2008-10-14
NZ531232A (en)	2004-11-26
CZ2004196A3 (cs)	2005-01-12
ES2623094T3 (es)	2017-07-10
EP3168218B1 (en)	2018-11-14
TNSN04028A1 (fr)	2006-06-01
KR100639281B1 (ko)	2006-10-31
AP2004002976A0 (en)	2004-03-31
HUP0700036A2 (en)	2008-10-28
EP1419151B1 (en)	2014-02-26
KR20040030074A (ko)	2004-04-08
PT1419151E (pt)	2014-03-27
ES2453164T3 (es)	2014-04-04
NO326508B1 (no)	2008-12-15
CY1121552T1 (el)	2020-05-29
MA27058A1 (fr)	2004-12-20
CA2455050A1 (en)	2003-02-27
EP2332934A1 (en)	2011-06-15
SI3168218T1 (sl)	2019-05-31
ME00414B (me)	2011-10-10
ZA200400706B (en)	2005-05-25
DK1419151T3 (da)	2014-03-31
AR036261A1 (es)	2004-08-25
UA76483C2 (en)	2006-08-15
CU23713B7 (es)	2011-10-05
RS10304A (sr)	2007-02-05
CO5550431A2 (es)	2005-08-31
US20070191458A1 (en)	2007-08-16
DK3168218T3 (en)	2019-01-14
AU2002324684B2 (en)	2006-10-05
BR0211612A (pt)	2004-08-24

Publication	Publication Date	Title
OA12650A (en)	2006-06-19	Crystals including a malic acid salt of N-Ä2-(diethylamino)ethylÜ-5-Ä(5-fluoro-2-oxo-3H-indole-3-ylidene)methylÜ-2,4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof.
AU2002324684A1 (en)	2003-05-29	Crystals including a malic acid salt of N-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3H-indole-3-ylidene) methyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
CA2493310C (en)	2011-01-18	3-z-[1-(4-(n-((4-methyl-piperazin-1-yl)-methylcarbonyl)-n-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition
KR20090045233A (ko)	2009-05-07	속효형 벤조디아제핀 염 및 이의 중합체 형태
TW200838512A (en)	2008-10-01	Crystalline forms of a thiazolidinedione compound and manufacturing methods thereof
WO2004092160A1 (ja)	2004-10-28	臭化物及びその結晶
MXPA04010845A (es)	2005-01-25	Formas cristalinas novedosas de ondansetron, procesos para su preparacion, composiciones farmaceuticas que contienen las formas novedosas y metodos para tratar las nauseas utilizando las mismas.
CN111601793B (zh)	2023-06-16	苯并二环烷烃衍生物的药学上可接受的盐及其多晶型物及其应用
HK1088008B (en)	2008-08-08	2, 4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
HK1066542B (en)	2009-07-10	Crystals including a malic acid salt of n-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxo-3h-indole-3-ylidene) methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
US20020193386A1 (en)	2002-12-19	Polymorphic form of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimidin-4-one and formulations thereof
US20030191140A1 (en)	2003-10-09	Polymorphic form of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimidin-4-one and formulations thereof