OA12711A - 3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists. - Google Patents

3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists. Download PDF

Info

Publication number: OA12711A
Authority: OA; OAPI
Prior art keywords: alkyl; aza; crc4 alkyl; crc4; hex
Prior art date: 2001-10-22

Application number

OA1200400109A

Other languages

English (en)

Inventor

Steven Donald Heck

Stanton Furst Mchardy

Spiros Liras

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-22

Filing date

2002-09-09

Publication date

2006-06-27

2002-09-09 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-06-27 Publication of OA12711A publication Critical patent/OA12711A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Pulmonology (AREA)
Psychology (AREA)
Immunology (AREA)
Gynecology & Obstetrics (AREA)
Nutrition Science (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

OA1200400109A 2001-10-22 2002-09-09 3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists. OA12711A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33851101P	2001-10-22	2001-10-22

Publications (1)

Publication Number	Publication Date
OA12711A true OA12711A (en)	2006-06-27

Family

ID=23325099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200400109A OA12711A (en)	2001-10-22	2002-09-09	3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists.

Country Status (42)

Country	Link
US (3)	US7049335B2 (sr)
EP (1)	EP1440059B1 (sr)
JP (2)	JP4155522B2 (sr)
KR (1)	KR100621292B1 (sr)
CN (1)	CN100368398C (sr)
AP (1)	AP1816A (sr)
AR (1)	AR036905A1 (sr)
AT (1)	ATE392415T1 (sr)
AU (1)	AU2002329557B2 (sr)
BR (1)	BR0213464A (sr)
CA (1)	CA2463264C (sr)
CR (1)	CR7317A (sr)
DE (1)	DE60226161T2 (sr)
DK (1)	DK1440059T3 (sr)
EA (1)	EA006708B1 (sr)
EC (1)	ECSP045077A (sr)
ES (1)	ES2302839T3 (sr)
GE (1)	GEP20084300B (sr)
GT (1)	GT200200216A (sr)
HN (1)	HN2002000299A (sr)
HR (1)	HRP20040288A2 (sr)
HU (1)	HUP0401884A2 (sr)
IL (2)	IL161157A0 (sr)
IS (1)	IS7187A (sr)
MA (1)	MA27141A1 (sr)
MX (1)	MXPA04003730A (sr)
MY (1)	MY136580A (sr)
NO (1)	NO329092B1 (sr)
NZ (1)	NZ531807A (sr)
OA (1)	OA12711A (sr)
PA (1)	PA8556701A1 (sr)
PE (1)	PE20030610A1 (sr)
PL (1)	PL368919A1 (sr)
PT (1)	PT1440059E (sr)
PY (1)	PY0225353A (sr)
RS (1)	RS25104A (sr)
SI (1)	SI1440059T1 (sr)
SV (1)	SV2004001363A (sr)
TN (1)	TNSN04071A1 (sr)
UA (1)	UA75714C2 (sr)
WO (1)	WO2003035622A1 (sr)
ZA (1)	ZA200402172B (sr)

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PL368919A1 (en)	2001-10-22	2005-04-04	Pfizer Products Inc.	3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
MXPA05011070A (es) *	2003-04-14	2005-12-12	Pfizer Prod Inc	Derivados de 3-azabiciclo [3.2.1] octano.
US20050043327A1 (en) *	2003-08-21	2005-02-24	Pfizer Inc	Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) *	2003-10-06	2006-12-26	Pfizer Inc.	Purification process for an azabicyclo[3.1.0]hexane compound
CN101838271A (zh) *	2003-10-14	2010-09-22	辉瑞产品公司	作为甘氨酸转运蛋白抑制剂的二环[3.1.0]衍生物
KR20060096038A (ko) *	2003-10-16	2006-09-05	화이자 프로덕츠 인크.	3-아자비시클로〔3.1.0〕헥산 유도체의 제조법
TW200538113A (en) *	2004-02-23	2005-12-01	Glaxo Group Ltd	Compounds
JPWO2005085228A1 (ja) *	2004-03-05	2008-01-17	萬有製薬株式会社	シクロアルカノピリジン誘導体
US20080227803A1 (en) *	2004-12-14	2008-09-18	Shioonogi & Co., Ltd., A Legal Entity Of Japan	Indolomorphinan Derivative Having Carboxy in 6'-Position
GB0512099D0 (en) *	2005-06-14	2005-07-20	Glaxo Group Ltd	Compounds
GB0517191D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Compounds
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
MY145633A (en) *	2006-03-01	2012-03-15	Theravance Inc	8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2008075162A2 (en) *	2006-12-15	2008-06-26	Pfizer Limited	Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction
TWI409067B (zh)	2007-02-28	2013-09-21	Theravance Inc	８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
WO2009029253A1 (en) *	2007-08-27	2009-03-05	Theravance, Inc.	Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2009029257A1 (en) *	2007-08-27	2009-03-05	Theravance, Inc.	Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
US7902221B2 (en) *	2007-08-27	2011-03-08	Theravance, Inc.	Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
EP2621902B1 (en)	2010-09-28	2017-04-12	Panacea Biotec Ltd	3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders
KR102305244B1 (ko) *	2013-11-20	2021-09-27	우베 고산 가부시키가이샤	신규 3-아자비사이클로[3.1.0]헥산 유도체 및 그 의약 용도
KR20180004734A (ko) *	2015-05-20	2018-01-12	가부시키가이샤산와카가쿠켄큐쇼	신규 3-아자비시클로［3.1.0］헥산 유도체의 염의 결정 및 그의 의약 용도
CA3054122A1 (en)	2017-03-02	2018-09-07	Ube Industries, Ltd.	Therapeutic agent for alcohol use disorders

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US20050043327A1 (en) *	2003-08-21	2005-02-24	Pfizer Inc	Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) *	2003-10-06	2006-12-26	Pfizer Inc.	Purification process for an azabicyclo[3.1.0]hexane compound

2002
- 2002-09-09 PL PL02368919A patent/PL368919A1/xx not_active Application Discontinuation
- 2002-09-09 PT PT02765197T patent/PT1440059E/pt unknown
- 2002-09-09 IL IL16115702A patent/IL161157A0/xx unknown
- 2002-09-09 NZ NZ531807A patent/NZ531807A/xx unknown
- 2002-09-09 OA OA1200400109A patent/OA12711A/en unknown
- 2002-09-09 AT AT02765197T patent/ATE392415T1/de not_active IP Right Cessation
- 2002-09-09 DK DK02765197T patent/DK1440059T3/da active
- 2002-09-09 ES ES02765197T patent/ES2302839T3/es not_active Expired - Lifetime
- 2002-09-09 EP EP02765197A patent/EP1440059B1/en not_active Expired - Lifetime
- 2002-09-09 WO PCT/IB2002/003668 patent/WO2003035622A1/en not_active Ceased
- 2002-09-09 DE DE60226161T patent/DE60226161T2/de not_active Expired - Lifetime
- 2002-09-09 HU HU0401884A patent/HUP0401884A2/hu unknown
- 2002-09-09 BR BR0213464-0A patent/BR0213464A/pt not_active IP Right Cessation
- 2002-09-09 CA CA002463264A patent/CA2463264C/en not_active Expired - Fee Related
- 2002-09-09 GE GEAP20028173A patent/GEP20084300B/en unknown
- 2002-09-09 AP APAP/P/2004/003007A patent/AP1816A/en active
- 2002-09-09 JP JP2003538138A patent/JP4155522B2/ja not_active Expired - Fee Related
- 2002-09-09 AU AU2002329557A patent/AU2002329557B2/en not_active Ceased
- 2002-09-09 KR KR1020047006011A patent/KR100621292B1/ko not_active Expired - Fee Related
- 2002-09-09 MX MXPA04003730A patent/MXPA04003730A/es active IP Right Grant
- 2002-09-09 SI SI200230688T patent/SI1440059T1/sl unknown
- 2002-09-09 HR HRP20040288 patent/HRP20040288A2/hr not_active Application Discontinuation
- 2002-09-09 CN CNB028208854A patent/CN100368398C/zh not_active Expired - Fee Related
- 2002-09-09 UA UA20040402979A patent/UA75714C2/uk unknown
- 2002-09-09 RS YUP-251/04A patent/RS25104A/sr unknown
- 2002-09-09 EA EA200400467A patent/EA006708B1/ru not_active IP Right Cessation
- 2002-10-16 PY PY200200225353A patent/PY0225353A/es unknown
- 2002-10-17 MY MYPI20023878A patent/MY136580A/en unknown
- 2002-10-17 PA PA20028556701A patent/PA8556701A1/es unknown
- 2002-10-18 PE PE2002001032A patent/PE20030610A1/es not_active Application Discontinuation
- 2002-10-18 HN HN2002000299A patent/HN2002000299A/es unknown
- 2002-10-21 AR ARP020103960A patent/AR036905A1/es unknown
- 2002-10-21 SV SV2002001363A patent/SV2004001363A/es not_active Application Discontinuation
- 2002-10-22 US US10/278,142 patent/US7049335B2/en not_active Expired - Fee Related
- 2002-10-22 GT GT200200216A patent/GT200200216A/es unknown
2004
- 2004-03-18 IS IS7187A patent/IS7187A/is unknown
- 2004-03-18 ZA ZA200402172A patent/ZA200402172B/en unknown
- 2004-03-29 IL IL161157A patent/IL161157A/en not_active IP Right Cessation
- 2004-04-15 MA MA27630A patent/MA27141A1/fr unknown
- 2004-04-20 CR CR7317A patent/CR7317A/es unknown
- 2004-04-21 TN TNP2004000071A patent/TNSN04071A1/fr unknown
- 2004-04-21 NO NO20041626A patent/NO329092B1/no not_active IP Right Cessation
- 2004-04-22 EC EC2004005077A patent/ECSP045077A/es unknown
2005
- 2005-02-24 US US11/066,095 patent/US20050171178A1/en not_active Abandoned
2006
- 2006-03-01 US US11/366,903 patent/US20070054950A1/en not_active Abandoned
2007
- 2007-10-19 JP JP2007272602A patent/JP2008069169A/ja active Pending

Also Published As

Publication number	Publication date
EP1440059B1 (en)	2008-04-16
PL368919A1 (en)	2005-04-04
PT1440059E (pt)	2008-05-16
IL161157A0 (en)	2004-08-31
IL161157A (en)	2009-09-01
RS25104A (sr)	2007-02-05
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Publication	Publication Date	Title
OA12711A (en)	2006-06-27	3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists.
AU2002329557A1 (en)	2003-07-03	3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
EP1615893B1 (en)	2009-11-18	2-azabicyclo¬3.3.1 nonane derivatives as opioid receptor antagonists
ES2345437T3 (es)	2010-09-23	Antagonistas de nk1.
JP2006522792A (ja)	2006-10-05	４−フェニル−ピペリジン化合物およびそのオピオイド受容体のモジュレーターとしての使用
EP1615894A2 (en)	2006-01-18	3-azabicyclo 3.2.1 octane derivatives
HK1072052B (en)	2008-07-11	3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
HK1066787B (en)	2010-10-29	Nk1 antagonists