OA12983A - Combination of an aldosterone receptor antagonist and an HMG COA reductase inhibitor. - Google Patents

Combination of an aldosterone receptor antagonist and an HMG COA reductase inhibitor. Download PDF

Info

Publication number: OA12983A
Authority: OA; OAPI
Prior art keywords: hmg; aldostérone; reductase inhibitor; receptor antagonist; iseplerenone
Prior art date: 2001-07-19

Application number

OA1200400005A

Other languages

English (en)

Inventor

Bradley T Keller

Rocha Ricardo

Ellen G Mcmahon

Original Assignee

Pharmacia Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-19

Filing date

2002-07-18

Publication date

2006-10-13

2002-07-18 Application filed by Pharmacia Corp filed Critical Pharmacia Corp

2006-10-13 Publication of OA12983A publication Critical patent/OA12983A/en

Links

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OA1200400005A 2001-07-19 2002-07-18 Combination of an aldosterone receptor antagonist and an HMG COA reductase inhibitor. OA12983A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US30633601P	2001-07-19	2001-07-19

Publications (1)

Publication Number	Publication Date
OA12983A true OA12983A (en)	2006-10-13

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ID=23184836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200400005A OA12983A (en)	2001-07-19	2002-07-18	Combination of an aldosterone receptor antagonist and an HMG COA reductase inhibitor.

Country Status (26)

Country	Link
US (2)	US20030149010A1 (de)
EP (1)	EP1406660B1 (de)
JP (1)	JP2004537553A (de)
KR (1)	KR20040023660A (de)
CN (1)	CN1537019A (de)
AP (1)	AP2004002951A0 (de)
AT (1)	ATE363917T1 (de)
BR (1)	BR0211274A (de)
CA (1)	CA2452678A1 (de)
CO (1)	CO5550464A2 (de)
DE (1)	DE60220522T2 (de)
EA (1)	EA200400029A1 (de)
EC (1)	ECSP044950A (de)
ES (1)	ES2286270T3 (de)
GE (1)	GEP20063811B (de)
IL (1)	IL159588A0 (de)
IS (1)	IS7093A (de)
MA (1)	MA27050A1 (de)
MX (1)	MXPA04000586A (de)
NO (1)	NO20040211L (de)
OA (1)	OA12983A (de)
PL (1)	PL367417A1 (de)
TN (1)	TNSN04001A1 (de)
UA (1)	UA76475C2 (de)
WO (1)	WO2003007993A1 (de)
ZA (1)	ZA200400288B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003901812A0 (en) *	2003-04-15	2003-05-01	Vital Health Sciences Pty Ltd	Phosphates of secondary alcohols
US8026237B2 (en)	2004-07-30	2011-09-27	Exelixis, Inc.	Pyrrole derivatives as pharmaceutical agents
US20090162316A1 (en) *	2005-07-05	2009-06-25	Harvard University	Liver targeted conjugates
CN1310941C (zh) *	2005-07-13	2007-04-18	南京大学	依普利酮的合成方法
SG166829A1 (en) *	2005-11-08	2010-12-29	Ranbaxy Lab Ltd	Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
GB0600967D0 (en) *	2006-01-18	2006-03-01	Imp Innovations Ltd	Methods
WO2007106862A2 (en) *	2006-03-14	2007-09-20	Kinemed, Inc.	The use of statins to stimulate neurogenesis
WO2008021666A2 (en) *	2006-08-18	2008-02-21	Morton Grove Pharmaceuticals, Inc.	Stable liquid levetiracetam compositions and methods
FR2917975B1 (fr) *	2007-06-26	2009-10-16	Ceva Sante Animale Sa	Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
EP2135607A1 (de)	2008-06-18	2009-12-23	Pharnext	Kombination aus Pilocarpin und Methimazol zur Behandlung der Charcot-Marie-Tooth Krankheit und verwandten Erkrankungen
EP2367554A4 (de) *	2008-11-26	2020-03-25	Satiogen Pharmaceuticals, Inc.	Gallensäurerückflusshemmer zur behandlung von adipositas und diabetes
US9387206B2 (en)	2009-11-03	2016-07-12	Pharnext	Therapeutic approaches for treating Alzheimer's disease
EP2322163A1 (de) *	2009-11-03	2011-05-18	Pharnext	Neue therapeutische Ansätze zur Behandlung von Alzheimer-Krankheit
NZ600123A (en) *	2009-11-30	2015-04-24	Aptalis Pharmatech Inc	Compressible-coated pharmaceutical compositions and tablets and methods of manufacture
EP3593802A3 (de)	2010-05-26	2020-03-25	Satiogen Pharmaceuticals, Inc.	Gallensäurerückflusshemmer zur behandlung von diabetes, adipositas und entzündlichen magen-darm-erkrankungen
US9107983B2 (en)	2010-10-27	2015-08-18	Warsaw Orthopedic, Inc.	Osteoconductive matrices comprising statins
US8877221B2 (en)	2010-10-27	2014-11-04	Warsaw Orthopedic, Inc.	Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
US10010515B2 (en)	2011-03-01	2018-07-03	Pharnext	Therapeutic approaches for treating Parkinson's disease
SI2560631T1 (sl)	2011-03-01	2014-06-30	Pharnext	Na baklofenu in akamprosatu temeljeäśa terapija nevroloĺ kih nepravilnosti
US9248111B2 (en)	2011-03-01	2016-02-02	Pharnext	Therapeutic approaches for treating parkinson's disease
US9241933B2 (en)	2011-03-01	2016-01-26	Pharnext	Compositions for treating amyotrophic lateral sclerosis
DE102011015142A1 (de) *	2011-03-17	2012-09-20	Eberhard-Karls-Universität Tübingen Universitätsklinikum	Agens zur Prophylaxe und Behandlung altersassoziierter Krankheiten und Störungen sowie zur Verlängerung der Lebensdauer
US9308190B2 (en)	2011-06-06	2016-04-12	Warsaw Orthopedic, Inc.	Methods and compositions to enhance bone growth comprising a statin
KR102051031B1 (ko)	2011-10-28	2019-12-02	루메나 파마수티컬즈, 인코포레이티드	고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제
BR112014010223B8 (pt)	2011-10-28	2021-02-23	Lumena Pharmaceuticals Llc	uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica
EP2968230A2 (de)	2013-03-15	2016-01-20	Lumena Pharmaceuticals, Inc.	Gallensäurerückflusshemmer zur behandlung von primär sklerosierender cholongitis und entzündlichen darmerkrankungen
KR20160003664A (ko)	2013-03-15	2016-01-11	루메나 파마수티컬즈, 인코포레이티드	바렛 식도 및 위식도 역류 질환 치료용 담즙산 재순환 억제제
MX2016009060A (es) *	2014-01-10	2016-09-09	Critical Care Diagnostics Inc	Metodos y sistemas para determinar el riesgo de falla cardiaca.
CA3129826A1 (en)	2019-02-12	2020-08-20	Mirum Pharmaceuticals, Inc.	Methods for treating cholestasis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100431038B1 (ko) *	1995-07-17	2004-05-12	워너-램버트 캄파니 엘엘씨	결정질[ｒ-(ｒ,ｒ)]-2-(4-플루오로페닐)-베타,델타-디히드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카르보닐]-1ｈ-피롤-1-헵탄산 헤미 칼슘염 (아토르바스타틴)
ID23687A (id) *	1997-04-18	2000-05-11	Searle & Co	Metode penggunaan penghambat siklooksigenase-2 dalam pencegahan penyakit kardiovaskuler
GT199800126A (es) *	1997-08-29	2000-01-29		Terapia de combinacion.
US6638937B2 (en) *	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
UA74141C2 (uk) *	1998-12-09	2005-11-15	Дж.Д. Сірл Енд Ко.	Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
AU4348200A (en) *	1999-04-19	2000-11-02	Regents Of The University Of Michigan, The	Compositions and methods for increasing the bioavailability of lactone ring containing drugs

2002
- 2002-07-18 AT AT02756521T patent/ATE363917T1/de not_active IP Right Cessation
- 2002-07-18 DE DE60220522T patent/DE60220522T2/de not_active Expired - Fee Related
- 2002-07-18 JP JP2003513598A patent/JP2004537553A/ja active Pending
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- 2002-07-18 KR KR10-2004-7000846A patent/KR20040023660A/ko not_active Ceased
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- 2002-07-18 CN CNA028145577A patent/CN1537019A/zh active Pending
- 2002-07-18 EA EA200400029A patent/EA200400029A1/ru unknown
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2003
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2004
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Also Published As

Publication number	Publication date
IL159588A0 (en)	2004-06-01
EA200400029A1 (ru)	2004-08-26
CN1537019A (zh)	2004-10-13
EP1406660B1 (de)	2007-06-06
US20060003975A1 (en)	2006-01-05
NO20040211L (no)	2004-03-16
CO5550464A2 (es)	2005-08-31
EP1406660A1 (de)	2004-04-14
MA27050A1 (fr)	2004-12-20
CA2452678A1 (en)	2003-01-30
BR0211274A (pt)	2004-08-03
KR20040023660A (ko)	2004-03-18
ECSP044950A (es)	2004-02-26
PL367417A1 (en)	2005-02-21
GEP20063811B (en)	2006-05-10
TNSN04001A1 (fr)	2006-06-01
ZA200400288B (en)	2005-06-29
ES2286270T3 (es)	2007-12-01
JP2004537553A (ja)	2004-12-16
DE60220522T2 (de)	2007-09-27
ATE363917T1 (de)	2007-06-15
WO2003007993A1 (en)	2003-01-30
AP2004002951A0 (en)	2004-03-31
UA76475C2 (en)	2006-08-15
MXPA04000586A (es)	2004-04-20
IS7093A (is)	2003-12-23
US20030149010A1 (en)	2003-08-07
DE60220522D1 (de)	2007-07-19

Publication	Publication Date	Title
EP1406660B1 (de)	2007-06-06	Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer
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US20030220312A1 (en)	2003-11-27	Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of cardiovascular disorders
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US20030220310A1 (en)	2003-11-27	Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
JPH04243839A (ja)	1992-08-31	ＨＭＧ　ＣｏＡリダクターゼインヒビター含有医薬
AU2001242985B2 (en)	2005-02-24	New combination of a betablocker and a cholesterol-lowering agent
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US20090023693A1 (en)	2009-01-22	New drospirenone/17beta-estradiol regimen, pharmaceutical combination product and kit for performing this regimen
AU2002322526A1 (en)	2003-03-03	Combination of an aldosterone receptor antagonist and an HMG CoA reductase inhibitor
US20050182036A1 (en)	2005-08-18	Medicinal composition containing an HMG-CoA reductase inhibitor
CZ20024181A3 (cs)	2003-04-16	Farmaceutické prostředky obsahující betablokátor
HK1066480A (en)	2005-03-24	Combination of an aldosterone receptor antagonist and an hmg coa reductase inhibitor
JPH04266822A (ja)	1992-09-22	システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤
CA2494916A1 (en)	2004-02-19	Medicinal composition for lowering blood lipid level
CA2494801A1 (en)	2004-02-12	Medicinal composition containing hmg-coa reductase inhibitor