OA13014A - Morpholine derivatives for use as dopamine agonists in the treatment of i.a sexual dysfunction. - Google Patents

Morpholine derivatives for use as dopamine agonists in the treatment of i.a sexual dysfunction. Download PDF

Info

Publication number: OA13014A
Authority: OA; OAPI
Prior art keywords: compounds; formula; disorder; propylmorpholin; dépréssion
Prior art date: 2002-12-10

Application number

OA1200500171A

Other languages

English (en)

Inventor

Charlotte Moria Norfor Allerton

Andrew Douglas Baxter

Andrew Simon Cook

David Hepworth

Stephen Kwok-Fung Wong

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-10

Filing date

2003-12-02

Publication date

2006-11-10

2002-12-10 Priority claimed from GB0228787A external-priority patent/GB0228787D0/en

2003-04-11 Priority claimed from GB0308460A external-priority patent/GB0308460D0/en

2003-06-12 Priority claimed from GB0313606A external-priority patent/GB0313606D0/en

2003-12-02 Application filed by Pfizer filed Critical Pfizer

2006-11-10 Publication of OA13014A publication Critical patent/OA13014A/en

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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OA1200500171A 2002-12-10 2003-12-02 Morpholine derivatives for use as dopamine agonists in the treatment of i.a sexual dysfunction. OA13014A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0228787A GB0228787D0 (en)	2002-12-10	2002-12-10	Morpholine dopamine agonists
GB0308460A GB0308460D0 (en)	2003-04-11	2003-04-11	Morpholine dopamine agonists
GB0313606A GB0313606D0 (en)	2003-06-12	2003-06-12	Morpholine dopamine agonists

Publications (1)

Publication Number	Publication Date
OA13014A true OA13014A (en)	2006-11-10

Family

ID=32512061

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200500171A OA13014A (en)	2002-12-10	2003-12-02	Morpholine derivatives for use as dopamine agonists in the treatment of i.a sexual dysfunction.

Country Status (36)

Country	Link
EP (1)	EP1572214B1 (de)
JP (3)	JP3889775B2 (de)
KR (1)	KR100796102B1 (de)
AP (1)	AP2005003325A0 (de)
AR (1)	AR042339A1 (de)
AT (1)	ATE460938T1 (de)
AU (1)	AU2003302878B2 (de)
CA (1)	CA2508262C (de)
CO (1)	CO5700781A2 (de)
CR (1)	CR7869A (de)
CY (1)	CY1110130T1 (de)
DE (1)	DE60331769D1 (de)
DK (1)	DK1572214T3 (de)
EA (1)	EA009589B1 (de)
EC (1)	ECSP055850A (de)
ES (1)	ES2339767T3 (de)
GE (1)	GEP20074272B (de)
HN (1)	HN2003000401A (de)
HR (1)	HRP20050523A2 (de)
IS (1)	IS7843A (de)
MA (1)	MA27605A1 (de)
MX (1)	MXPA05006151A (de)
MY (1)	MY144338A (de)
NL (1)	NL1024983C2 (de)
NO (1)	NO330143B1 (de)
NZ (1)	NZ540505A (de)
OA (1)	OA13014A (de)
PA (1)	PA8591601A1 (de)
PE (1)	PE20040906A1 (de)
PL (1)	PL377480A1 (de)
PT (1)	PT1572214E (de)
RS (1)	RS51442B (de)
SI (1)	SI1572214T1 (de)
TW (1)	TW200423944A (de)
UY (1)	UY28117A1 (de)
WO (1)	WO2004052372A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1753763B1 (de) *	2004-05-26	2008-08-13	Pfizer Limited	Indazol- und indolonderivative und deren verwendung als pharmazeutika
JP4198183B2 (ja) *	2004-05-27	2008-12-17	ファイザー・インク	選択的ドーパミンｄ３アゴニストとしてのアミノピリジン誘導体
GB0502509D0 (en)	2005-02-07	2005-03-16	Pfizer Ltd	Novel salt form of a dopamine agonist
TW200740779A (en)	2005-07-22	2007-11-01	Mitsubishi Pharma Corp	Intermediate compound for synthesizing pharmaceutical agent and production method thereof
GB0700786D0 (en) *	2007-01-15	2007-02-21	Pfizer Ltd	Morpholine dopamine agonists for the treatment of pain
CA2800220C (en) *	2010-05-21	2019-04-30	Research Triangle Institute	Phenylmorpholines and analogues thereof
CA2800219C (en)	2010-05-21	2019-03-12	Research Triangle Institute	1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
EP3080284B1 (de)	2013-12-11	2017-10-18	F. Hoffmann-La Roche AG	Verfahren zur herstellung von chiralem 2-(4-aminophenyl)morpholin
GB2543296A (en) *	2015-10-13	2017-04-19	Indivior Uk Ltd	Dopamine D3 receptor antagonists having a morpholine moiety
WO2020210785A1 (en)	2019-04-12	2020-10-15	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	D3 receptor agonist compounds; methods of preparation; intermediates thereof; and methods of use thereof
EP3725768A1 (de) *	2019-04-17	2020-10-21	Newron Pharmaceuticals S.p.A.	Verfahren zur herstellung von substituierten 2-[2-(phenyl)ethylamino]alkanamid-derivaten
CN118684636B (zh) *	2024-05-31	2025-03-11	上海优合贝德医药科技有限公司	一种4-吗啉-1-苯基巯基-2-丁酮的合成工艺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB851311A (en) *	1958-04-02	1960-10-12	Geigy Ag J R	Morpholine compounds and their production
GB9108629D0 (en) *	1991-04-23	1991-06-12	Wellcome Found	Heterocyclic pharmaceutical compounds,preparation and use
GB0130219D0 (en) *	2001-12-18	2002-02-06	Pfizer Ltd	Compounds for the treatment of sexual dysfunction

2003
- 2003-12-02 EA EA200500801A patent/EA009589B1/ru not_active IP Right Cessation
- 2003-12-02 JP JP2005502342A patent/JP3889775B2/ja not_active Expired - Fee Related
- 2003-12-02 CA CA002508262A patent/CA2508262C/en not_active Expired - Fee Related
- 2003-12-02 OA OA1200500171A patent/OA13014A/en unknown
- 2003-12-02 AT AT03812639T patent/ATE460938T1/de active
- 2003-12-02 PL PL377480A patent/PL377480A1/pl not_active Application Discontinuation
- 2003-12-02 MX MXPA05006151A patent/MXPA05006151A/es active IP Right Grant
- 2003-12-02 WO PCT/IB2003/005683 patent/WO2004052372A1/en not_active Ceased
- 2003-12-02 DK DK03812639.7T patent/DK1572214T3/da active
- 2003-12-02 PT PT03812639T patent/PT1572214E/pt unknown
- 2003-12-02 EP EP03812639A patent/EP1572214B1/de not_active Expired - Lifetime
- 2003-12-02 RS YUP-2005/0445A patent/RS51442B/sr unknown
- 2003-12-02 GE GEAP20038838A patent/GEP20074272B/en unknown
- 2003-12-02 KR KR1020057010474A patent/KR100796102B1/ko not_active Expired - Fee Related
- 2003-12-02 SI SI200331801T patent/SI1572214T1/sl unknown
- 2003-12-02 ES ES03812639T patent/ES2339767T3/es not_active Expired - Lifetime
- 2003-12-02 AU AU2003302878A patent/AU2003302878B2/en not_active Ceased
- 2003-12-02 DE DE60331769T patent/DE60331769D1/de not_active Expired - Lifetime
- 2003-12-02 NZ NZ540505A patent/NZ540505A/en not_active IP Right Cessation
- 2003-12-02 HR HR20050523A patent/HRP20050523A2/hr not_active Application Discontinuation
- 2003-12-02 AP AP2005003325A patent/AP2005003325A0/xx unknown
- 2003-12-05 PE PE2003001234A patent/PE20040906A1/es not_active Application Discontinuation
- 2003-12-08 MY MYPI20034690A patent/MY144338A/en unknown
- 2003-12-09 HN HN2003000401A patent/HN2003000401A/es unknown
- 2003-12-09 TW TW092134694A patent/TW200423944A/zh unknown
- 2003-12-09 AR ARP030104524A patent/AR042339A1/es unknown
- 2003-12-10 PA PA20038591601A patent/PA8591601A1/es unknown
- 2003-12-10 UY UY28117A patent/UY28117A1/es not_active Application Discontinuation
- 2003-12-10 NL NL1024981A patent/NL1024983C2/nl not_active IP Right Cessation
2005
- 2005-05-12 IS IS7843A patent/IS7843A/is unknown
- 2005-05-26 NO NO20052557A patent/NO330143B1/no not_active IP Right Cessation
- 2005-06-10 CR CR7869A patent/CR7869A/es unknown
- 2005-06-10 MA MA28324A patent/MA27605A1/fr unknown
- 2005-06-10 EC EC2005005850A patent/ECSP055850A/es unknown
- 2005-06-10 CO CO05056566A patent/CO5700781A2/es not_active Application Discontinuation
2006
- 2006-06-06 JP JP2006157609A patent/JP3920908B2/ja not_active Expired - Fee Related
- 2006-12-27 JP JP2006352505A patent/JP4624341B2/ja not_active Expired - Fee Related
2010
- 2010-04-26 CY CY20101100367T patent/CY1110130T1/el unknown

Also Published As

Publication number	Publication date
HRP20050523A2 (en)	2005-08-31
NO20052557D0 (no)	2005-05-26
ATE460938T1 (de)	2010-04-15
CA2508262A1 (en)	2004-06-24
RS20050445A (sr)	2007-04-10
NZ540505A (en)	2007-02-23
GEP20074272B (en)	2007-12-25
CR7869A (es)	2005-07-08
ES2339767T3 (es)	2010-05-25
MXPA05006151A (es)	2005-08-26
AR042339A1 (es)	2005-06-15
KR20050094813A (ko)	2005-09-28
KR100796102B1 (ko)	2008-01-21
PE20040906A1 (es)	2005-01-24
CY1110130T1 (el)	2015-01-14
AU2003302878A1 (en)	2004-06-30
DE60331769D1 (de)	2010-04-29
ECSP055850A (es)	2005-09-20
SI1572214T1 (sl)	2010-07-30
EA200500801A1 (ru)	2005-12-29
CA2508262C (en)	2009-12-01
EA009589B1 (ru)	2008-02-28
NL1024983C2 (nl)	2005-02-01
JP2006511599A (ja)	2006-04-06
NO330143B1 (no)	2011-02-21
CO5700781A2 (es)	2006-11-30
UY28117A1 (es)	2004-07-30
NO20052557L (no)	2005-09-06
TW200423944A (en)	2004-11-16
AP2005003325A0 (en)	2005-06-30
HN2003000401A (es)	2004-11-23
JP2006232857A (ja)	2006-09-07
JP2007084575A (ja)	2007-04-05
MA27605A1 (fr)	2005-11-01
PL377480A1 (pl)	2006-02-06
WO2004052372A1 (en)	2004-06-24
DK1572214T3 (da)	2010-06-07
JP3920908B2 (ja)	2007-05-30
AU2003302878B2 (en)	2009-04-23
MY144338A (en)	2011-08-29
HK1081850A1 (zh)	2006-05-26
EP1572214A1 (de)	2005-09-14
JP3889775B2 (ja)	2007-03-07
EP1572214B1 (de)	2010-03-17
IS7843A (is)	2005-05-12
PT1572214E (pt)	2010-05-06
PA8591601A1 (es)	2004-12-16
NL1024983A1 (nl)	2004-06-11
JP4624341B2 (ja)	2011-02-02
RS51442B (sr)	2011-04-30

Publication	Publication Date	Title
US20090318451A1 (en)	2009-12-24	Morpholine dopamine agonists for the treatment of pain
EP1572214B1 (de)	2010-03-17	Morpholin-derivate zur verwendung als dopaminagonisten in der behandlung von u.a. sexueller dysfunktion
US20090005354A1 (en)	2009-01-01	New Amino Derivatives and Their Use as Pharmaceuticals
US7902188B2 (en)	2011-03-08	Morpholine dopamine agonists
NL1029139C2 (nl)	2006-06-19	Nieuwe aminopyridinederivaten en hun gebruik als farmaceutica.
JP2008543828A (ja)	2008-12-04	ドーパミン作動薬としての３−フェニルアゼチジン誘導体
US20050267096A1 (en)	2005-12-01	New indazole and indolone derivatives and their use pharmaceuticals
CN100488510C (zh)	2009-05-20	在性功能障碍治疗中用作多巴胺激动剂的吗啉衍生物
HK1116162A (en)	2008-12-19	Morpholine derivatives for use as dopamine agonists in the treatment of i.a. sexual dysfunction
HK1081850B (en)	2009-10-30	Morpholine derivatives for use as dopamine agonists in the treatment of i.a. sexual dysfunction
EP1753763A2 (de)	2007-02-21	Indazol- und indolonderivative und deren verwendung als pharmazeutika
JP2008521789A (ja)	2008-06-26	クロマン化合物
UA79024C2 (en)	2007-05-10	Morpholine derivatives as dopamine agonists for treating sexual dysfunction