OA13308A - Use of polypeptides of cupredoxin family in cancertherapy. - Google Patents

Use of polypeptides of cupredoxin family in cancertherapy. Download PDF

Info

Publication number: OA13308A
Authority: OA; OAPI
Prior art keywords: lys; gly; thr; val; asp
Prior art date: 2003-08-15

Application number

OA1200600056A

Other languages

English (en)

Inventor

Ananda M Chakrabarty

Gupta Tapas K Das

Yoshinori Hiraoka

Vasu Punj

Tohru Yamada

Olga Zaborina

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-15

Filing date

2004-08-10

Publication date

2007-04-13

2004-08-10 Application filed by Univ Illinois filed Critical Univ Illinois

2007-04-13 Publication of OA13308A publication Critical patent/OA13308A/en

Links

108010092351 cupredoxin Proteins 0.000 title claims description 20
229920001184 polypeptide Polymers 0.000 title description 7
102000004196 processed proteins & peptides Human genes 0.000 title description 7
108090000765 processed proteins & peptides Proteins 0.000 title description 7
238000011275 oncology therapy Methods 0.000 title description 2
239000003145 cytotoxic factor Substances 0.000 claims abstract description 137
206010028980 Neoplasm Diseases 0.000 claims abstract description 61
230000030833 cell death Effects 0.000 claims abstract description 48
201000011510 cancer Diseases 0.000 claims abstract description 21
108010007337 Azurin Proteins 0.000 claims description 132
108090000623 proteins and genes Proteins 0.000 claims description 65
230000035772 mutation Effects 0.000 claims description 29
108091034117 Oligonucleotide Proteins 0.000 claims description 16
108090000051 Plastocyanin Proteins 0.000 claims description 14
108090000035 Pseudoazurin Proteins 0.000 claims description 14
108010018850 cytochrome C(551) Proteins 0.000 claims description 12
201000001441 melanoma Diseases 0.000 claims description 11
108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims description 10
108010086158 rusticyanin Proteins 0.000 claims description 10
206010006187 Breast cancer Diseases 0.000 claims description 9
208000026310 Breast neoplasm Diseases 0.000 claims description 9
238000004519 manufacturing process Methods 0.000 claims description 7
230000000890 antigenic effect Effects 0.000 claims description 6
208000032839 leukemia Diseases 0.000 claims description 5
206010009944 Colon cancer Diseases 0.000 claims description 4
206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
206010033128 Ovarian cancer Diseases 0.000 claims description 4
206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
241000589516 Pseudomonas Species 0.000 claims description 4
241000589517 Pseudomonas aeruginosa Species 0.000 claims description 4
102000015098 Tumor Suppressor Protein p53 Human genes 0.000 claims description 4
208000029742 colonic neoplasm Diseases 0.000 claims description 4
102220490404 S-adenosylhomocysteine hydrolase-like protein 1_S66A_mutation Human genes 0.000 claims description 3
102220495868 Translocation protein SEC62_H83F_mutation Human genes 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 3
102200115912 rs121918090 Human genes 0.000 claims description 3
241001453201 Phormidium laminosum Species 0.000 claims description 2
102220094059 rs755931648 Human genes 0.000 claims description 2
102220279444 rs988441570 Human genes 0.000 claims description 2
241000880493 Leptailurus serval Species 0.000 claims 22
108010000998 wheylin-2 peptide Proteins 0.000 claims 19
108010005942 methionylglycine Proteins 0.000 claims 17
108010029020 prolylglycine Proteins 0.000 claims 15
108010083946 Asp-Tyr-Leu-Lys Proteins 0.000 claims 14
MSSXKZBDKZAHCX-UNQGMJICSA-N Phe-Thr-Val Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O MSSXKZBDKZAHCX-UNQGMJICSA-N 0.000 claims 14
JEDIEMIJYSRUBB-FOHZUACHSA-N Thr-Asp-Gly Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O JEDIEMIJYSRUBB-FOHZUACHSA-N 0.000 claims 14
FWOVTJKVUCGVND-UFYCRDLUSA-N Tyr-Met-Phe Chemical compound CSCC[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N FWOVTJKVUCGVND-UFYCRDLUSA-N 0.000 claims 14
AYBKPDHHVADEDA-YUMQZZPRSA-N Gly-His-Asn Chemical compound [H]NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(N)=O)C(O)=O AYBKPDHHVADEDA-YUMQZZPRSA-N 0.000 claims 13
ZZWUYQXMIFTIIY-WEDXCCLWSA-N Gly-Thr-Leu Chemical compound [H]NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O ZZWUYQXMIFTIIY-WEDXCCLWSA-N 0.000 claims 13
IBSGMIPRBMPMHE-IHRRRGAJSA-N Leu-Met-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(O)=O IBSGMIPRBMPMHE-IHRRRGAJSA-N 0.000 claims 13
125000003275 alpha amino acid group Chemical group 0.000 claims 13
SYZWMVSXBZCOBZ-QXEWZRGKSA-N Asn-Val-Met Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](CC(=O)N)N SYZWMVSXBZCOBZ-QXEWZRGKSA-N 0.000 claims 12
RBEATVHTWHTHTJ-KKUMJFAQSA-N Lys-Leu-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O RBEATVHTWHTHTJ-KKUMJFAQSA-N 0.000 claims 12
UUHXBJHVTVGSKM-BQBZGAKWSA-N Pro-Gly-Asn Chemical compound [H]N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(N)=O)C(O)=O UUHXBJHVTVGSKM-BQBZGAKWSA-N 0.000 claims 12
BTWMICVCQLKKNR-DCAQKATOSA-N Val-Leu-Ser Chemical compound CC(C)[C@H]([NH3+])C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C([O-])=O BTWMICVCQLKKNR-DCAQKATOSA-N 0.000 claims 12
AIJAPFVDBFYNKN-WHFBIAKZSA-N Gly-Asn-Asp Chemical compound C([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)CN)C(=O)N AIJAPFVDBFYNKN-WHFBIAKZSA-N 0.000 claims 11
YRRCOJOXAJNSAX-IHRRRGAJSA-N Leu-Pro-Lys Chemical compound CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O)N YRRCOJOXAJNSAX-IHRRRGAJSA-N 0.000 claims 11
108010002311 N-glycylglutamic acid Proteins 0.000 claims 11
108010034529 leucyl-lysine Proteins 0.000 claims 11
KSOBNUBCYHGUKH-UWVGGRQHSA-N Gly-Val-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)CN KSOBNUBCYHGUKH-UWVGGRQHSA-N 0.000 claims 10
108010048397 seryl-lysyl-leucine Proteins 0.000 claims 10
KVBPDJIFRQUQFY-ACZMJKKPSA-N Glu-Cys-Ser Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(O)=O KVBPDJIFRQUQFY-ACZMJKKPSA-N 0.000 claims 9
CUPSDFQZTVVTSK-GUBZILKMSA-N Glu-Lys-Asp Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(O)=O CUPSDFQZTVVTSK-GUBZILKMSA-N 0.000 claims 9
LPCKHUXOGVNZRS-YUMQZZPRSA-N Gly-His-Ser Chemical compound [H]NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(O)=O LPCKHUXOGVNZRS-YUMQZZPRSA-N 0.000 claims 9
ADJWHHZETYAAAX-SRVKXCTJSA-N Leu-Ser-His Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)N ADJWHHZETYAAAX-SRVKXCTJSA-N 0.000 claims 9
BXNGIHFNNNSEOS-UWVGGRQHSA-N Phe-Asn Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 BXNGIHFNNNSEOS-UWVGGRQHSA-N 0.000 claims 9
WYLAVUAWOUVUCA-XVSYOHENSA-N Thr-Phe-Asp Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(O)=O WYLAVUAWOUVUCA-XVSYOHENSA-N 0.000 claims 9
108010092854 aspartyllysine Proteins 0.000 claims 9
XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 9
GJLXVWOMRRWCIB-MERZOTPQSA-N (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanamide Chemical compound C([C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=C(O)C=C1 GJLXVWOMRRWCIB-MERZOTPQSA-N 0.000 claims 8
FRPVPGRXUKFEQE-YDHLFZDLSA-N Phe-Asp-Val Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O FRPVPGRXUKFEQE-YDHLFZDLSA-N 0.000 claims 8
GZFAWAQTEYDKII-YUMQZZPRSA-N Ser-Gly-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)CNC(=O)[C@@H](N)CO GZFAWAQTEYDKII-YUMQZZPRSA-N 0.000 claims 8
JMBRNXUOLJFURW-BEAPCOKYSA-N Thr-Phe-Pro Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N2CCC[C@@H]2C(=O)O)N)O JMBRNXUOLJFURW-BEAPCOKYSA-N 0.000 claims 8
BMGOFDMKDVVGJG-NHCYSSNCSA-N Val-Asp-Lys Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O)N BMGOFDMKDVVGJG-NHCYSSNCSA-N 0.000 claims 8
LBRCLQMZAHRTLV-ZKWXMUAHSA-N Ile-Gly-Ser Chemical compound CC[C@H](C)[C@H](N)C(=O)NCC(=O)N[C@@H](CO)C(O)=O LBRCLQMZAHRTLV-ZKWXMUAHSA-N 0.000 claims 7
HBOABDXGTMMDSE-GUBZILKMSA-N Ser-Arg-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(O)=O HBOABDXGTMMDSE-GUBZILKMSA-N 0.000 claims 7
SWIKDOUVROTZCW-GCJQMDKQSA-N Thr-Asn-Ala Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)O)N)O SWIKDOUVROTZCW-GCJQMDKQSA-N 0.000 claims 7
MECLEFZMPPOEAC-VOAKCMCISA-N Thr-Leu-Lys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)N)O MECLEFZMPPOEAC-VOAKCMCISA-N 0.000 claims 7
108010040443 aspartyl-aspartic acid Proteins 0.000 claims 7
IXTPACPAXIOCRG-ACZMJKKPSA-N Ala-Glu-Cys Chemical compound C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)O)N IXTPACPAXIOCRG-ACZMJKKPSA-N 0.000 claims 6
DYDKXJWQCIVTMR-WDSKDSINSA-N Asp-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC(O)=O DYDKXJWQCIVTMR-WDSKDSINSA-N 0.000 claims 6
CHZKBLABUKSXDM-XIRDDKMYSA-N His-Asn-Trp Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC3=CN=CN3)N CHZKBLABUKSXDM-XIRDDKMYSA-N 0.000 claims 6
JUCZDDVZBMPKRT-IXOXFDKPSA-N His-Thr-Lys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC1=CN=CN1)N)O JUCZDDVZBMPKRT-IXOXFDKPSA-N 0.000 claims 6
HVHRPWQEQHIQJF-AVGNSLFASA-N Leu-Lys-Glu Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O HVHRPWQEQHIQJF-AVGNSLFASA-N 0.000 claims 6
PSBJZLMFFTULDX-IXOXFDKPSA-N Phe-Cys-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC1=CC=CC=C1)N)O PSBJZLMFFTULDX-IXOXFDKPSA-N 0.000 claims 6
UKKROEYWYIHWBD-ZKWXMUAHSA-N Ser-Val-Asp Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O UKKROEYWYIHWBD-ZKWXMUAHSA-N 0.000 claims 6
QTPQHINADBYBNA-DCAQKATOSA-N Val-Ser-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCCCN QTPQHINADBYBNA-DCAQKATOSA-N 0.000 claims 6
108010041407 alanylaspartic acid Proteins 0.000 claims 6
CTWCFPWFIGRAEP-CIUDSAMLSA-N Asp-Lys-Asp Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(O)=O CTWCFPWFIGRAEP-CIUDSAMLSA-N 0.000 claims 5
MYGQXVYRZMKRDB-SRVKXCTJSA-N Leu-Asp-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CCCCN MYGQXVYRZMKRDB-SRVKXCTJSA-N 0.000 claims 5
GCMWRRQAKQXDED-IUCAKERBSA-N Lys-Glu-Gly Chemical compound [NH3+]CCCC[C@H]([NH3+])C(=O)N[C@@H](CCC([O-])=O)C(=O)NCC([O-])=O GCMWRRQAKQXDED-IUCAKERBSA-N 0.000 claims 5
WGILOYIKJVQUPT-DCAQKATOSA-N Lys-Pro-Asp Chemical compound [H]N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(O)=O WGILOYIKJVQUPT-DCAQKATOSA-N 0.000 claims 5
CTJUSALVKAWFFU-CIUDSAMLSA-N Lys-Ser-Cys Chemical compound C(CCN)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O)N CTJUSALVKAWFFU-CIUDSAMLSA-N 0.000 claims 5
MMJJFXWMCMJMQA-STQMWFEESA-N Phe-Pro-Gly Chemical compound C([C@H](N)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)C1=CC=CC=C1 MMJJFXWMCMJMQA-STQMWFEESA-N 0.000 claims 5
ILMLVTGTUJPQFP-FXQIFTODSA-N Pro-Asp-Asp Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O ILMLVTGTUJPQFP-FXQIFTODSA-N 0.000 claims 5
KMWFXJCGRXBQAC-CIUDSAMLSA-N Ser-Cys-Lys Chemical compound C(CCN)C[C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CO)N KMWFXJCGRXBQAC-CIUDSAMLSA-N 0.000 claims 5
IGROJMCBGRFRGI-YTLHQDLWSA-N Thr-Ala-Ala Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O IGROJMCBGRFRGI-YTLHQDLWSA-N 0.000 claims 5
108010036533 arginylvaline Proteins 0.000 claims 5
108010067216 glycyl-glycyl-glycine Proteins 0.000 claims 5
108010057821 leucylproline Proteins 0.000 claims 5
108010003700 lysyl aspartic acid Proteins 0.000 claims 5
QXHVOUSPVAWEMX-ZLUOBGJFSA-N Asp-Asp-Ser Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O QXHVOUSPVAWEMX-ZLUOBGJFSA-N 0.000 claims 4
DPNWSMBUYCLEDG-CIUDSAMLSA-N Asp-Lys-Ser Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O DPNWSMBUYCLEDG-CIUDSAMLSA-N 0.000 claims 4
ZBYLEBZCVKLPCY-FXQIFTODSA-N Asp-Ser-Arg Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O ZBYLEBZCVKLPCY-FXQIFTODSA-N 0.000 claims 4
JSHWXQIZOCVWIA-ZKWXMUAHSA-N Asp-Ser-Val Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(O)=O JSHWXQIZOCVWIA-ZKWXMUAHSA-N 0.000 claims 4
PMNHJLASAAWELO-FOHZUACHSA-N Gly-Asp-Thr Chemical compound [H]NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O PMNHJLASAAWELO-FOHZUACHSA-N 0.000 claims 4
ZQIMMEYPEXIYBB-IUCAKERBSA-N Gly-Glu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CN ZQIMMEYPEXIYBB-IUCAKERBSA-N 0.000 claims 4
QHUREMVLLMNUAX-OSUNSFLBSA-N Ile-Thr-Val Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)O)N QHUREMVLLMNUAX-OSUNSFLBSA-N 0.000 claims 4
QJXHMYMRGDOHRU-NHCYSSNCSA-N Leu-Ile-Gly Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(O)=O QJXHMYMRGDOHRU-NHCYSSNCSA-N 0.000 claims 4
LZWNAOIMTLNMDW-NHCYSSNCSA-N Lys-Asn-Val Chemical compound CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)N LZWNAOIMTLNMDW-NHCYSSNCSA-N 0.000 claims 4
AXHNAGAYRGCDLG-UWVGGRQHSA-N Met-Lys-Gly Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O AXHNAGAYRGCDLG-UWVGGRQHSA-N 0.000 claims 4
XUDRHBPSPAPDJP-SRVKXCTJSA-N Ser-Lys-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CO XUDRHBPSPAPDJP-SRVKXCTJSA-N 0.000 claims 4
UQTNIFUCMBFWEJ-IWGUZYHVSA-N Thr-Asn Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CC(N)=O UQTNIFUCMBFWEJ-IWGUZYHVSA-N 0.000 claims 4
NJWJSLCQEDMGNC-MBLNEYKQSA-N Ala-His-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](C)N)O NJWJSLCQEDMGNC-MBLNEYKQSA-N 0.000 claims 3
QYRMBFWDSFGSFC-OLHMAJIHSA-N Asn-Thr-Asn Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CC(=O)N)N)O QYRMBFWDSFGSFC-OLHMAJIHSA-N 0.000 claims 3
101100505161 Caenorhabditis elegans mel-32 gene Proteins 0.000 claims 3
WXOFKRKAHJQKLT-BQBZGAKWSA-N Cys-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CS WXOFKRKAHJQKLT-BQBZGAKWSA-N 0.000 claims 3
SIYTVHWNKGIGMD-HOTGVXAUSA-N Gly-His-Trp Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CC3=CN=CN3)NC(=O)CN SIYTVHWNKGIGMD-HOTGVXAUSA-N 0.000 claims 3
SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 claims 3
DPTBVFUDCPINIP-JURCDPSOSA-N Ile-Ala-Phe Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 DPTBVFUDCPINIP-JURCDPSOSA-N 0.000 claims 3
CANPXOLVTMKURR-WEDXCCLWSA-N Lys-Gly-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN CANPXOLVTMKURR-WEDXCCLWSA-N 0.000 claims 3
CQRGINSEMFBACV-WPRPVWTQSA-N Met-Val-Gly Chemical compound CSCC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)NCC(O)=O CQRGINSEMFBACV-WPRPVWTQSA-N 0.000 claims 3
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/80—Cytochromes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/415—Cytochromes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Botany (AREA)
Oncology (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

OA1200600056A 2003-08-15 2004-08-10 Use of polypeptides of cupredoxin family in cancertherapy. OA13308A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41455003P	2003-08-15	2003-08-15
US10/720,603 US7491394B2 (en)	2001-02-15	2003-11-24	Cytotoxic factors for modulating cell death

Publications (1)

Publication Number	Publication Date
OA13308A true OA13308A (en)	2007-04-13

Family

ID=34221130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200600056A OA13308A (en)	2003-08-15	2004-08-10	Use of polypeptides of cupredoxin family in cancertherapy.

Country Status (19)

Country	Link
US (4)	US7491394B2 (de)
EP (2)	EP2263682A1 (de)
JP (1)	JP2007502818A (de)
KR (1)	KR20060098358A (de)
AP (1)	AP2006003537A0 (de)
AT (1)	ATE470672T1 (de)
AU (1)	AU2004266632A1 (de)
BR (1)	BRPI0413574A (de)
CA (1)	CA2535581A1 (de)
DE (1)	DE602004027637D1 (de)
EA (1)	EA009897B1 (de)
EC (1)	ECSP066422A (de)
GE (1)	GEP20105022B (de)
IL (1)	IL173576A0 (de)
NO (1)	NO20061168L (de)
NZ (1)	NZ545355A (de)
OA (1)	OA13308A (de)
TN (1)	TNSN06059A1 (de)
WO (1)	WO2005018662A1 (de)

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US7381701B2 (en) *	2001-02-15	2008-06-03	The Borad Of Trustees Of The University Of Illinois	Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
US7618939B2 (en) *	2001-02-15	2009-11-17	The Board Of Trustees Of The University Of Illinois	Compositions and methods to prevent cancer with cupredoxins
US7338766B2 (en)	2001-02-15	2008-03-04	The Board Of Trustees Of The University Of Illinois	Compositions and methods for treating malaria with cupredoxin and cytochrome
US9096663B2 (en) *	2001-02-15	2015-08-04	The Board Of Trustees Of The University Of Illinois	Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
US7491394B2 (en)	2001-02-15	2009-02-17	The Board Of Trustees Of The University Of Illinois	Cytotoxic factors for modulating cell death
WO2006088508A2 (en)	2004-10-07	2006-08-24	Ananda Chakrabarty	Cupredoxin derived transport agents and methods of use thereof
US9968685B2 (en)	2004-10-07	2018-05-15	Brad N. Taylor	Methods to treat cancer with cupredoxins
US10675326B2 (en)	2004-10-07	2020-06-09	The Board Of Trustees Of The University Of Illinois	Compositions comprising cupredoxins for treating cancer
US9434770B2 (en) *	2004-10-07	2016-09-06	Tapas K Das Gupta	Modified cupredoxin derived peptides
JP2008539795A (ja) *	2005-05-20	2008-11-20	ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ	キュプレドキシンを用いたエフリン信号伝達に関する症状を治療するための組成物および方法
JP2009504567A (ja) *	2005-05-20	2009-02-05	ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ	クプレドキシンおよびシトクロムでマラリアを治療するための組成物および方法
EP1883650A4 (de) *	2005-05-20	2009-06-10	Univ Illinois	Zusammensetzungen und verfahren zur behandlung von hiv-infektionen mit cupredoxin und cytochrom c
KR20080034905A (ko) *	2005-07-19	2008-04-22	더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이	쿠프레독신으로 혈관신생을 제어하는 조성물과 방법
KR20080042804A (ko)	2005-07-19	2008-05-15	더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이	뇌혈관장벽을 통하여 뇌 암세포 내로 침투하는 운반제 및이의 이용 방법
US10266868B2 (en)	2006-05-19	2019-04-23	The Board Of Trustees Of The University Of Illinois	Compositions for treating HIV infection with cupredoxin and cytochrome C
BRPI0715027A2 (pt) *	2006-09-11	2013-05-28	Univ Illinois	modificaÇÕes dos peptÍdeos derivados da cupredoxina e seus mÉtodos de utilizaÇço
CN101595124A (zh) *	2006-09-14	2009-12-02	伊利诺斯大学理事会	使用铜氧还蛋白预防癌症的组合物及方法
RU2009125599A (ru) *	2006-12-04	2011-01-20	Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс (Us)	Композиции и способы лечения рака cpg-богатой днк и купредоксинами
WO2008086523A2 (en) *	2007-01-11	2008-07-17	The Board Of Trustees Of The University Of Illinois	Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
WO2008098216A2 (en) *	2007-02-08	2008-08-14	The Board Of Trustees Of The University Of Illinois	Compositions and methods to prevent cancer with cupredoxins
PE20110367A1 (es) *	2008-09-18	2011-06-13	Hoffmann La Roche	DERIVADOS DE 4-CIANO-4-FENIL-PIRROLIDIN-2-CARBOXAMIDAS SUSTITUIDAS COMO INHIBIDORES DE LA INTERACCION p53-MDM2
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WO2016176573A1 (en) *	2015-04-30	2016-11-03	Board Of Regents, The University Of Texas System	Antibacterial polypeptide libraries and methods for screening the same
CN111705026B (zh) *	2020-06-02	2021-11-26	华中农业大学	一种牛支原体Mbov_0280基因突变株及其应用

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US7338766B2 (en)	2001-02-15	2008-03-04	The Board Of Trustees Of The University Of Illinois	Compositions and methods for treating malaria with cupredoxin and cytochrome
US7491394B2 (en)	2001-02-15	2009-02-17	The Board Of Trustees Of The University Of Illinois	Cytotoxic factors for modulating cell death
EP1411963A4 (de)	2001-02-15	2005-01-19	Univ Illinois	Zytotoxische faktoren zur modulierung des zelltods
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WO2006088508A2 (en)	2004-10-07	2006-08-24	Ananda Chakrabarty	Cupredoxin derived transport agents and methods of use thereof
JP2009504567A (ja)	2005-05-20	2009-02-05	ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ	クプレドキシンおよびシトクロムでマラリアを治療するための組成物および方法
EP1883650A4 (de)	2005-05-20	2009-06-10	Univ Illinois	Zusammensetzungen und verfahren zur behandlung von hiv-infektionen mit cupredoxin und cytochrom c
KR20080042804A (ko)	2005-07-19	2008-05-15	더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이	뇌혈관장벽을 통하여 뇌 암세포 내로 침투하는 운반제 및이의 이용 방법

2003
- 2003-11-24 US US10/720,603 patent/US7491394B2/en not_active Expired - Lifetime
2004
- 2004-08-10 AU AU2004266632A patent/AU2004266632A1/en not_active Abandoned
- 2004-08-10 JP JP2006523922A patent/JP2007502818A/ja active Pending
- 2004-08-10 WO PCT/US2004/025982 patent/WO2005018662A1/en not_active Ceased
- 2004-08-10 KR KR1020067002935A patent/KR20060098358A/ko not_active Abandoned
- 2004-08-10 GE GEAP20049294A patent/GEP20105022B/en unknown
- 2004-08-10 AP AP2006003537A patent/AP2006003537A0/xx unknown
- 2004-08-10 BR BRPI0413574-1A patent/BRPI0413574A/pt not_active IP Right Cessation
- 2004-08-10 EA EA200600424A patent/EA009897B1/ru not_active IP Right Cessation
- 2004-08-10 AT AT04780764T patent/ATE470672T1/de not_active IP Right Cessation
- 2004-08-10 EP EP10156218A patent/EP2263682A1/de not_active Withdrawn
- 2004-08-10 CA CA002535581A patent/CA2535581A1/en not_active Abandoned
- 2004-08-10 EP EP04780764A patent/EP1653990B1/de not_active Expired - Lifetime
- 2004-08-10 OA OA1200600056A patent/OA13308A/en unknown
- 2004-08-10 NZ NZ545355A patent/NZ545355A/en unknown
- 2004-08-10 DE DE602004027637T patent/DE602004027637D1/de not_active Expired - Lifetime
2006
- 2006-02-07 IL IL173576A patent/IL173576A0/en unknown
- 2006-02-15 TN TNP2006000059A patent/TNSN06059A1/en unknown
- 2006-03-13 NO NO20061168A patent/NO20061168L/no not_active Application Discontinuation
- 2006-03-15 EC EC2006006422A patent/ECSP066422A/es unknown
- 2006-08-23 US US11/508,173 patent/US7888468B2/en not_active Expired - Fee Related
- 2006-08-25 US US11/509,682 patent/US20080182782A1/en not_active Abandoned
2013
- 2013-11-08 US US14/075,994 patent/US10421801B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO20061168L (no)	2006-05-15
JP2007502818A (ja)	2007-02-15
ECSP066422A (es)	2006-11-24
AU2004266632A1 (en)	2005-03-03
US7491394B2 (en)	2009-02-17
BRPI0413574A (pt)	2006-10-17
US20060292136A1 (en)	2006-12-28
IL173576A0 (en)	2006-07-05
TNSN06059A1 (en)	2007-10-03
GEP20105022B (en)	2010-06-25
EA200600424A1 (ru)	2006-08-25
CA2535581A1 (en)	2005-03-03
US20080182782A1 (en)	2008-07-31
EA009897B1 (ru)	2008-04-28
DE602004027637D1 (de)	2010-07-22
EP1653990B1 (de)	2010-06-09
US10421801B2 (en)	2019-09-24
ATE470672T1 (de)	2010-06-15
NZ545355A (en)	2009-10-30
EP1653990A1 (de)	2006-05-10
AP2006003537A0 (en)	2006-04-30
WO2005018662A1 (en)	2005-03-03
US7888468B2 (en)	2011-02-15
US20060040269A1 (en)	2006-02-23
US20140179617A1 (en)	2014-06-26
KR20060098358A (ko)	2006-09-18
EP2263682A1 (de)	2010-12-22

Publication	Publication Date	Title
US10421801B2 (en)	2019-09-24	Cytotoxic factors for modulating cell death
AU2002311753B2 (en)	2008-04-03	Cytotoxic factors for modulating cell death
US7740857B2 (en)	2010-06-22	Compositions and methods for treating malaria with cupredoxin and cytochrome
AU2002311753A1 (en)	2003-03-27	Cytotoxic factors for modulating cell death
US8372962B2 (en)	2013-02-12	Compositions and methods to control angiogenesis with cupredoxins
SG174784A1 (en)	2011-10-28	Compositions and methods to prevent cancer with cupredoxins
ZA200602126B (en)	2007-09-26	Use of polypeptides of the cupredoxin family in cancer therapy
AU2010201360A1 (en)	2010-04-29	Compositions and methods for treating malaria with cupredoxin and cytochrome
MXPA06001820A (en)	2007-04-20	Use of polypeptides of the cupredoxin family in cancer therapy
KR20080024124A (ko)	2008-03-17	쿠프레독신과 시토크롬 ｃ로 ｈｉｖ 감염을 치료하기 위한조성물과 방법
WO2007024368A2 (en)	2007-03-01	Compositions and methods to control angiogenesis with cupredoxins