PE20000059A1 - Cristales de peptido-1 semejantes a glucagon - Google Patents
Cristales de peptido-1 semejantes a glucagonInfo
- Publication number
- PE20000059A1 PE20000059A1 PE1998001225A PE00122598A PE20000059A1 PE 20000059 A1 PE20000059 A1 PE 20000059A1 PE 1998001225 A PE1998001225 A PE 1998001225A PE 00122598 A PE00122598 A PE 00122598A PE 20000059 A1 PE20000059 A1 PE 20000059A1
- Authority
- PE
- Peru
- Prior art keywords
- glp
- crystals
- zinc
- refers
- procedure
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 4
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 title 1
- 102000051325 Glucagon Human genes 0.000 title 1
- 108060003199 Glucagon Proteins 0.000 title 1
- 101710176384 Peptide 1 Proteins 0.000 title 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1
- 229960004666 glucagon Drugs 0.000 title 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 11
- 102100040918 Pro-glucagon Human genes 0.000 abstract 9
- 101800000224 Glucagon-like peptide 1 Proteins 0.000 abstract 5
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 3
- 239000011701 zinc Substances 0.000 abstract 3
- 229910052725 zinc Inorganic materials 0.000 abstract 3
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 abstract 2
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 abstract 1
- 239000005695 Ammonium acetate Substances 0.000 abstract 1
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-HQMMCQRPSA-N Ethanol-14C Chemical compound C[14CH2]O LFQSCWFLJHTTHZ-HQMMCQRPSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- 229940043376 ammonium acetate Drugs 0.000 abstract 1
- 235000019257 ammonium acetate Nutrition 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 239000001166 ammonium sulphate Substances 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 230000001851 biosynthetic effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- RKTYLMNFRDHKIL-UHFFFAOYSA-N copper;5,10,15,20-tetraphenylporphyrin-22,24-diide Chemical compound [Cu+2].C1=CC(C(=C2C=CC([N-]2)=C(C=2C=CC=CC=2)C=2C=CC(N=2)=C(C=2C=CC=CC=2)C2=CC=C3[N-]2)C=2C=CC=CC=2)=NC1=C3C1=CC=CC=C1 RKTYLMNFRDHKIL-UHFFFAOYSA-N 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR CRISTALES INDIVIDUALES EN FORMA DE VARILLAS PLANAS TETRAGONALES O SEMEJANTES A PLACAS DE MOLECULAS RELACIONADAS CON EL PEPTIDO-1 SEMEJANTE A GLUCAGON (GLP), QUE COMPRENDE PREPARAR UNA SOLUCION DE CRISTALIZACION QUE CONTIENE a)ENTRE 1 mg/ml Y 10 mg/ml DE GLP EL QUE SE SELECIONA DE GLP-1, DERIVADO DE GLP-1, GLP PROTEGIDO CONTRA LA DIPEPTIDIL-PEPTIDASA-IV (DPP-IV), ANALOGO PEPTIDICO DE GLP-1, ANALOGO BIOSINTETICO DE GLP-1; b) ENTRE 10 nM A 50 nM DE UN AGENTE TAMPONANTE A UN pH DE 6-7, EL QUE SE SELECCIONA ENTRE TRIS, ACETATO AMONICO, ACETATO SODICO; c)UN ALCOHOL, MONO O DISACARIDO LOS QUE SE SELECCIONAN DE METANOL, ETANOL, PROPANOL, GLICEROL, TREHALOSA, MANITOL, GLUCOSA, ERITROSA, ENTRE OTROS Y d)OPCIONALMENTE 1% DE SULFATO DE AMONIO O ZINC. EL ZINC TOTAL ESTA EN UNA RELACION MOLAR DE 0,5 A 1,7 CON RESPECTO AL GLP-1. TAMBIEN SE REFIERE A UN PROCEDIMIENTO QUE COMPRENDE ADEMAS SUMERGIR LOS CRISTALES DE GLP EN UNA SOLUCION QUE CONTIENE CINC. EL CRISTAL DE GLP-1 ESTIMULA LA SECRECION DE INSULINA PRESENTA UNA ACCION PROLONGADA IN VIVO Y PUEDE SER UTIL EN EL TRATAMIENTO DE LA DIABETES, OBESIDAD, AFECCIONES RELACIONADAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6972897P | 1997-12-16 | 1997-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000059A1 true PE20000059A1 (es) | 2000-02-09 |
Family
ID=22090845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998001225A PE20000059A1 (es) | 1997-12-16 | 1998-12-15 | Cristales de peptido-1 semejantes a glucagon |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6380357B2 (es) |
| EP (1) | EP0926159A3 (es) |
| JP (1) | JP2002508332A (es) |
| KR (1) | KR20010033146A (es) |
| CN (1) | CN1281369A (es) |
| AR (1) | AR019806A1 (es) |
| AU (1) | AU1821899A (es) |
| BR (1) | BR9813658A (es) |
| CA (1) | CA2315243A1 (es) |
| CO (1) | CO5040043A1 (es) |
| CZ (1) | CZ20002104A3 (es) |
| EA (1) | EA200000652A1 (es) |
| HR (1) | HRP20000409A2 (es) |
| HU (1) | HUP0100046A2 (es) |
| ID (1) | ID25534A (es) |
| IL (1) | IL136377A0 (es) |
| NO (1) | NO20003081L (es) |
| NZ (1) | NZ505182A (es) |
| PE (1) | PE20000059A1 (es) |
| PL (1) | PL341210A1 (es) |
| SV (1) | SV1998000147A (es) |
| TR (1) | TR200001726T2 (es) |
| WO (1) | WO1999030731A1 (es) |
| ZA (1) | ZA9811466B (es) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138486B2 (en) | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
| US6849708B1 (en) * | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US6380357B2 (en) * | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
| US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| EP2280004B1 (en) | 1999-06-29 | 2016-04-20 | MannKind Corporation | Pharmaceutical formulations comprising insulin complexed with a diketopiperazine |
| HUP0204281A3 (en) | 2000-01-27 | 2007-03-28 | Lilly Co Eli | Process for sulubilizing glucagon-like peptide 1 (glp-1) compounds |
| US6844321B2 (en) * | 2000-01-31 | 2005-01-18 | Novo Nordisk A/S | Crystallization of a GLP-1 analogue |
| AU2001228327A1 (en) * | 2000-01-31 | 2001-08-14 | Novo-Nordisk A/S | Crystallisation of a glp-1 analogue |
| EP1274720A4 (en) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | FUSION PROTEINS CONTAINING ALBUMIN |
| US20020061838A1 (en) * | 2000-05-17 | 2002-05-23 | Barton Holmquist | Peptide pharmaceutical formulations |
| PT1695983E (pt) * | 2000-06-16 | 2009-05-05 | Lilly Co Eli | Análogos do peptídeo-1 do tipo glucagon |
| US7199217B2 (en) | 2000-12-13 | 2007-04-03 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| EP2186824A3 (en) | 2000-12-13 | 2010-09-22 | Eli Lilly & Company | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| US20030119734A1 (en) * | 2001-06-28 | 2003-06-26 | Flink James M. | Stable formulation of modified GLP-1 |
| CA2458371A1 (en) | 2001-08-23 | 2003-03-06 | Eli Lilly And Company | Glucagon-like peptide-1 analogs |
| KR20040054729A (ko) * | 2001-10-18 | 2004-06-25 | 브리스톨-마이어스 스큅 컴퍼니 | 인간 글루카곤-유사-펩티드-1 모방체, 및 당뇨병 및 이와관련된 증상의 치료에 있어서 이의 용도 |
| PT1463751E (pt) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Proteínas de fusão de albumina |
| CN1332711C (zh) * | 2002-02-20 | 2007-08-22 | 埃米球科技有限公司 | 施用glp－1分子的方法 |
| EP1494732B1 (en) | 2002-03-20 | 2008-01-30 | MannKind Corporation | Inhalation apparatus |
| US20080260838A1 (en) * | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| JP2006523609A (ja) * | 2002-12-31 | 2006-10-19 | アルタス ファーマシューティカルズ インコーポレイテッド | タンパク質結晶およびイオン性ポリマーの複合体 |
| CA2512052C (en) | 2002-12-31 | 2016-06-21 | Altus Pharmaceuticals Inc. | Human growth hormone crystals and methods for preparing them |
| CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CA2518465A1 (en) * | 2003-03-25 | 2004-10-14 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US7638638B2 (en) | 2003-05-14 | 2009-12-29 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2004105781A2 (en) * | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
| WO2004105790A1 (en) * | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
| JP4936884B2 (ja) * | 2003-06-03 | 2012-05-23 | ノボ・ノルデイスク・エー／エス | 安定化された薬学的ペプチド組成物 |
| US7094800B2 (en) * | 2003-07-25 | 2006-08-22 | Sanofi-Aventis Deutschland Gmbh | Cyanopyrrolidides, process for their preparation and their use as medicaments |
| US7008957B2 (en) * | 2003-07-25 | 2006-03-07 | Sanofi-Aventis Deutschland Gmbh | Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments |
| US7094794B2 (en) * | 2003-07-28 | 2006-08-22 | Sanofi-Aventis Deutschland Gmbh | Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use |
| DE10335092B3 (de) * | 2003-08-01 | 2005-02-03 | Aventis Pharma Deutschland Gmbh | Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung |
| US8921311B2 (en) | 2003-08-01 | 2014-12-30 | Mannkind Corporation | Method for treating hyperglycemia |
| KR20060041309A (ko) * | 2003-08-13 | 2006-05-11 | 다케다 야쿠힌 고교 가부시키가이샤 | ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도 |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US20060247167A1 (en) * | 2003-09-01 | 2006-11-02 | Novo Nordisk A/S | Stable formulations of peptides |
| EP1663295A2 (en) * | 2003-09-01 | 2006-06-07 | Novo Nordisk A/S | Stable formulations of peptides |
| JP2007505121A (ja) * | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
| WO2005030751A2 (en) * | 2003-09-08 | 2005-04-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| PT1687019T (pt) * | 2003-11-20 | 2018-02-26 | Novo Nordisk As | Formulações de péptidos que contêm polietileno glicol que são ótimas para produção e para utilização em dispositivos de injeção |
| CA2550695A1 (en) * | 2003-12-16 | 2005-06-30 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Glp-1 pharmaceutical compositions |
| US20060286129A1 (en) * | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EA013427B1 (ru) * | 2004-03-15 | 2010-04-30 | Такеда Фармасьютикал Компани Лимитед | Ингибиторы дипептидилпептидазы |
| JP2008501714A (ja) * | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
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-
1998
- 1998-12-11 US US09/209,799 patent/US6380357B2/en not_active Expired - Lifetime
- 1998-12-14 HR HR20000409A patent/HRP20000409A2/hr not_active Application Discontinuation
- 1998-12-14 AU AU18218/99A patent/AU1821899A/en not_active Abandoned
- 1998-12-14 JP JP2000538710A patent/JP2002508332A/ja not_active Withdrawn
- 1998-12-14 ZA ZA9811466A patent/ZA9811466B/xx unknown
- 1998-12-14 CA CA002315243A patent/CA2315243A1/en not_active Abandoned
- 1998-12-14 ID IDW20001139A patent/ID25534A/id unknown
- 1998-12-14 SV SV1998000147A patent/SV1998000147A/es unknown
- 1998-12-14 NZ NZ505182A patent/NZ505182A/en unknown
- 1998-12-14 KR KR1020007006521A patent/KR20010033146A/ko not_active Withdrawn
- 1998-12-14 EP EP98310245A patent/EP0926159A3/en not_active Withdrawn
- 1998-12-14 CN CN98812093A patent/CN1281369A/zh active Pending
- 1998-12-14 PL PL98341210A patent/PL341210A1/xx not_active Application Discontinuation
- 1998-12-14 TR TR2000/01726T patent/TR200001726T2/xx unknown
- 1998-12-14 EA EA200000652A patent/EA200000652A1/ru unknown
- 1998-12-14 HU HU0100046A patent/HUP0100046A2/hu unknown
- 1998-12-14 CO CO98074132A patent/CO5040043A1/es unknown
- 1998-12-14 BR BR9813658-5A patent/BR9813658A/pt not_active IP Right Cessation
- 1998-12-14 WO PCT/US1998/026480 patent/WO1999030731A1/en not_active Ceased
- 1998-12-14 IL IL13637798A patent/IL136377A0/xx unknown
- 1998-12-14 CZ CZ20002104A patent/CZ20002104A3/cs unknown
- 1998-12-15 AR ARP980106356A patent/AR019806A1/es unknown
- 1998-12-15 PE PE1998001225A patent/PE20000059A1/es not_active Application Discontinuation
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2000
- 2000-06-15 NO NO20003081A patent/NO20003081L/no not_active Application Discontinuation
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2001
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2005
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|---|---|
| NO20003081D0 (no) | 2000-06-15 |
| HUP0100046A2 (hu) | 2001-05-28 |
| WO1999030731A1 (en) | 1999-06-24 |
| US6380357B2 (en) | 2002-04-30 |
| SV1998000147A (es) | 1999-08-18 |
| IL136377A0 (en) | 2001-06-14 |
| CO5040043A1 (es) | 2001-05-29 |
| US6555521B2 (en) | 2003-04-29 |
| TR200001726T2 (tr) | 2000-10-23 |
| JP2002508332A (ja) | 2002-03-19 |
| AR019806A1 (es) | 2002-03-20 |
| PL341210A1 (en) | 2001-03-26 |
| EA200000652A1 (ru) | 2000-12-25 |
| ID25534A (id) | 2000-10-12 |
| NO20003081L (no) | 2000-08-08 |
| BR9813658A (pt) | 2000-10-10 |
| USRE41133E1 (en) | 2010-02-16 |
| NZ505182A (en) | 2002-05-31 |
| CZ20002104A3 (cs) | 2001-08-15 |
| CN1281369A (zh) | 2001-01-24 |
| EP0926159A2 (en) | 1999-06-30 |
| US20010014666A1 (en) | 2001-08-16 |
| AU1821899A (en) | 1999-07-05 |
| CA2315243A1 (en) | 1999-06-24 |
| HRP20000409A2 (en) | 2000-10-31 |
| ZA9811466B (en) | 2000-06-14 |
| EP0926159A3 (en) | 2003-11-26 |
| KR20010033146A (ko) | 2001-04-25 |
| US20030045464A1 (en) | 2003-03-06 |
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