PE20001593A1 - Aralquilo mono-aciloxi utiles como relajantes musculares - Google Patents
Aralquilo mono-aciloxi utiles como relajantes muscularesInfo
- Publication number
- PE20001593A1 PE20001593A1 PE2000000069A PE0000692000A PE20001593A1 PE 20001593 A1 PE20001593 A1 PE 20001593A1 PE 2000000069 A PE2000000069 A PE 2000000069A PE 0000692000 A PE0000692000 A PE 0000692000A PE 20001593 A1 PE20001593 A1 PE 20001593A1
- Authority
- PE
- Peru
- Prior art keywords
- bis
- dibromide
- acetoxybenzyl
- alkyl
- aralkyl
- Prior art date
Links
- 229940035363 muscle relaxants Drugs 0.000 title abstract 2
- 239000003158 myorelaxant agent Substances 0.000 title abstract 2
- -1 3-ACETOXYBENZYL Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- ZVJLHYHGQFVDPA-UHFFFAOYSA-N butanedioic acid dihydrobromide Chemical compound Br.Br.OC(=O)CCC(O)=O ZVJLHYHGQFVDPA-UHFFFAOYSA-N 0.000 abstract 1
- XAPUCCGEWRETMT-UHFFFAOYSA-N cyclobutane-1,2-dicarboxylic acid dihydrobromide Chemical compound Br.Br.OC(=O)C1CCC1C(O)=O XAPUCCGEWRETMT-UHFFFAOYSA-N 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- WKRUYJNGABNNMK-UHFFFAOYSA-N pentanedioic acid dihydrobromide Chemical compound Br.Br.OC(=O)CCCC(O)=O WKRUYJNGABNNMK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A DERIVADOS DE BIS-AMONIO CUATERNARIO DE ARALQUILO Y ARALQUENILO ACILOXI SUSTITUIDOS DE ESTERES DE AMINOALCANOLES CICLICOS DE ACIDOS DICARBOXILICOS, DE FORMULA a, b; DONDE R1 Y R1` SON ARALQUILO, ARALQUENILO MONOACILOXI SUSTITUIDO; R2 Y R2' SON ALQUILO, ALQUENILO, ALQUINILO; A ES ALCANODICARBONILO, ALQUENODICARBONILO, ENTRE OTROS; n, m Y p SON 0-2; R3 Y R3' SON H, CH3, ALQUILO; R4 Y R4' SON H, CH3, ALQUILO; R3 Y R4 JUNTOS FORMAN CH=CH, (CH2)h-Y-(CH2)k, GRUPO a; Y ES CH2, O, S; h Y k SON 0-3; R3' Y R4' FORMAN JUNTOS (CH2)h-Y-(CH2)k. Y ES CH2, O, S; h, k SON 0-3; R1 Y R1', R2 Y R2' R3 Y R3', R4 Y R4' SON IGUALES Y DIFERENTES; X ES UN ANION FARMACEUTICAMENTE ACEPTABLE. SON COMPUESTOS PREFERIDOS BIS[N-(4-ACETOXIBENCIL)TROPANO-3O-IL]CICLOBUTANO-1,2-DICARBOXILICO DIBROMURO; BIS[N-(3-ACETOXIBENCIL)TROPANO-3O-IL]CICLOBUTANO-1,2-DICARBOXILATO DIBROMURO; BIS[N-(4-ACETOXIBENCIL)GRANATANIO-3-IL]SUCCINATO DIBROMURO, BIS-[N-(4-ACETOXIBENCIL)GRANATANIO-3-IL]GLUTARATO DIBROMURO, ENTRE OTROS. EL COMPUESTO I ES UN BLOQUEADOR MUSCULAR Y PUEDEN SER UTILES COMO RELAJANTES MUSCULARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11839299P | 1999-02-01 | 1999-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001593A1 true PE20001593A1 (es) | 2001-01-16 |
Family
ID=22378296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000069A PE20001593A1 (es) | 1999-02-01 | 2000-01-31 | Aralquilo mono-aciloxi utiles como relajantes musculares |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1150673A4 (es) |
| JP (1) | JP2002535366A (es) |
| KR (1) | KR20010108125A (es) |
| CN (1) | CN1338934A (es) |
| AR (1) | AR022472A1 (es) |
| AU (1) | AU2634900A (es) |
| BR (1) | BR0007863A (es) |
| CA (1) | CA2360790A1 (es) |
| CO (1) | CO5170470A1 (es) |
| CZ (1) | CZ20012780A3 (es) |
| HK (1) | HK1039455A1 (es) |
| HU (1) | HUP0200413A3 (es) |
| IL (1) | IL144249A0 (es) |
| MX (1) | MXPA01007783A (es) |
| NO (1) | NO20013741L (es) |
| NZ (1) | NZ513064A (es) |
| PE (1) | PE20001593A1 (es) |
| PL (1) | PL349099A1 (es) |
| TR (1) | TR200102196T2 (es) |
| WO (1) | WO2000044377A1 (es) |
| ZA (1) | ZA200105882B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0204087D0 (en) * | 2002-02-21 | 2002-04-10 | Legislator 1563 Ltd | Di-ester derivatives as short acting neuromuscular blockers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2746964A (en) * | 1953-11-02 | 1956-05-22 | Lakeside Lab Inc | Dicarboxylic acid esters of nu-alkyl-3-hydroxypiperidine and salts thereof |
| AT292702B (de) * | 1968-12-29 | 1971-09-10 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur Herstellung von neuen N-Metyl-piperidin-Derivaten sowie der Säureadditionssalze und der Oniumderivate dieser Verbindungen |
| US5494898A (en) * | 1991-02-13 | 1996-02-27 | Ohmeda Pharmaceutical Products Division Inc. | Peptide skeletal muscle relaxants |
| US5990124A (en) * | 1997-10-24 | 1999-11-23 | Gyermek; Laszlo | Neuromuscular relaxants |
-
2000
- 2000-01-31 PE PE2000000069A patent/PE20001593A1/es not_active Application Discontinuation
- 2000-01-31 WO PCT/US2000/002228 patent/WO2000044377A1/en not_active Ceased
- 2000-01-31 HK HK02100995.3A patent/HK1039455A1/zh unknown
- 2000-01-31 AU AU26349/00A patent/AU2634900A/en not_active Abandoned
- 2000-01-31 HU HU0200413A patent/HUP0200413A3/hu unknown
- 2000-01-31 KR KR1020017009305A patent/KR20010108125A/ko not_active Withdrawn
- 2000-01-31 NZ NZ513064A patent/NZ513064A/en unknown
- 2000-01-31 PL PL00349099A patent/PL349099A1/xx not_active Application Discontinuation
- 2000-01-31 BR BR0007863-8A patent/BR0007863A/pt not_active IP Right Cessation
- 2000-01-31 TR TR2001/02196T patent/TR200102196T2/xx unknown
- 2000-01-31 CA CA002360790A patent/CA2360790A1/en not_active Abandoned
- 2000-01-31 CN CN00803305A patent/CN1338934A/zh active Pending
- 2000-01-31 JP JP2000595680A patent/JP2002535366A/ja not_active Withdrawn
- 2000-01-31 CZ CZ20012780A patent/CZ20012780A3/cs unknown
- 2000-01-31 EP EP00904621A patent/EP1150673A4/en not_active Withdrawn
- 2000-01-31 MX MXPA01007783A patent/MXPA01007783A/es unknown
- 2000-01-31 IL IL14424900A patent/IL144249A0/xx unknown
- 2000-02-01 AR ARP000100432A patent/AR022472A1/es not_active Application Discontinuation
- 2000-02-01 CO CO00005913A patent/CO5170470A1/es not_active Application Discontinuation
-
2001
- 2001-07-17 ZA ZA200105882A patent/ZA200105882B/en unknown
- 2001-07-31 NO NO20013741A patent/NO20013741L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL349099A1 (en) | 2002-07-01 |
| CZ20012780A3 (cs) | 2002-01-16 |
| NO20013741D0 (no) | 2001-07-31 |
| KR20010108125A (ko) | 2001-12-07 |
| HUP0200413A2 (en) | 2002-06-29 |
| ZA200105882B (en) | 2003-02-18 |
| EP1150673A1 (en) | 2001-11-07 |
| AU2634900A (en) | 2000-08-18 |
| IL144249A0 (en) | 2002-05-23 |
| EP1150673A4 (en) | 2002-04-24 |
| CO5170470A1 (es) | 2002-06-27 |
| CA2360790A1 (en) | 2000-08-03 |
| AR022472A1 (es) | 2002-09-04 |
| NO20013741L (no) | 2001-09-19 |
| TR200102196T2 (tr) | 2002-01-21 |
| WO2000044377A1 (en) | 2000-08-03 |
| CN1338934A (zh) | 2002-03-06 |
| HK1039455A1 (zh) | 2002-04-26 |
| JP2002535366A (ja) | 2002-10-22 |
| MXPA01007783A (es) | 2002-08-20 |
| BR0007863A (pt) | 2001-11-06 |
| HUP0200413A3 (en) | 2002-11-28 |
| NZ513064A (en) | 2003-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |