PE20001596A1 - Derivados de morfolina - Google Patents
Derivados de morfolinaInfo
- Publication number
- PE20001596A1 PE20001596A1 PE2000000258A PE0002582000A PE20001596A1 PE 20001596 A1 PE20001596 A1 PE 20001596A1 PE 2000000258 A PE2000000258 A PE 2000000258A PE 0002582000 A PE0002582000 A PE 0002582000A PE 20001596 A1 PE20001596 A1 PE 20001596A1
- Authority
- PE
- Peru
- Prior art keywords
- ilo
- alkyl
- ethyl
- phenyl
- cr4r5c
- Prior art date
Links
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical class C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 title abstract 6
- -1 n-PROPLO Chemical class 0.000 abstract 5
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 3
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 2
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 2
- TUCNEACPLKLKNU-UHFFFAOYSA-N acetyl Chemical compound C[C]=O TUCNEACPLKLKNU-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE MORFOLINA DE FORMULA I, DONDE: Ar ES FENILO SUSTITUIDO POR HALOGENO; ALQUILO C1-C3; X ES R2N, R3CH; R1 ES Cl, Br, ALQUILO C1-C3, TRIFLUOROMETILO; R2 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, CR4R5C(O)NR6R7; R3 ES CR4R5C(O)NR6R7; R4 Y R5 SON METILO, ETILO, n-PROPLO, n-BUTILO; O JUNTO A C FORMAN UN CICLOALQUILO C3-C6; R6 Y R7 SON H, ALQUILO C1-C3 O JUNTO A N FORMAN UN HETEROCICLO COMO AZETIDIN-1-ILO, PIRROLIDIN-1-ILO, PIPERIDIN-1-ILO, MORFOLIN-4-ILO, TIOMORFOLIN-4-ILO, PERHIDROAZEPIN-1-ILO. SON COMPUETOS PREFERIDOS 2-[2-(4-CICLOHEXILPIPERAZIN-1-IL)ETIL]-2-(3,4-DICLOROFENIL)-4-[2-[3,5-BIS(TRIFLUOROMETIL)FENIL]ACETIL]MORFOLINA (ISOMERO +), 2-[2-[4-(1-CARBAMOILCICLOHEXIL)PIPERIDIN-1-IL]ETIL]-2-(3,4-DICLOROFENIL)-4-[2-[3,5-BIS-(TRIFLUOROMETIL)FENIL]ACETIL]MORFOLINA (ISOMERO +), ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION ; COMPUESTOS INTERMEDIOS; UNA COMPOSICION QUE COMPRENDE DE 0,1 mg A 1000 mg DE PRINCIPIO ACTIVO. EL COMPUESTO I IMPLICADOS CON LA SUSTANCIA P Y/O LOS RECEPTORES NK1 POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE PATOLOGIAS DEL SISTEMA RESPIRATORIO, GASTROINTESTINAL, URINARIO, INMUNITARIO, CARDIOVASCULAR, MIGRANA, INFLAMACIONES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9903854A FR2791346B3 (fr) | 1999-03-25 | 1999-03-25 | Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001596A1 true PE20001596A1 (es) | 2001-04-01 |
Family
ID=9543720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000258A PE20001596A1 (es) | 1999-03-25 | 2000-03-27 | Derivados de morfolina |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6506750B1 (es) |
| EP (1) | EP1165528B1 (es) |
| JP (1) | JP3853155B2 (es) |
| KR (1) | KR100696340B1 (es) |
| CN (1) | CN100422160C (es) |
| AR (1) | AR023139A1 (es) |
| AT (1) | ATE275136T1 (es) |
| AU (1) | AU756855B2 (es) |
| BG (1) | BG64623B1 (es) |
| BR (1) | BR0009281B1 (es) |
| CA (1) | CA2366829C (es) |
| CO (1) | CO5160340A1 (es) |
| CZ (1) | CZ300911B6 (es) |
| DE (1) | DE60013418T2 (es) |
| DK (1) | DK1165528T3 (es) |
| EE (1) | EE04525B1 (es) |
| ES (1) | ES2226794T3 (es) |
| FR (1) | FR2791346B3 (es) |
| HK (1) | HK1042092B (es) |
| HR (1) | HRP20010704B1 (es) |
| HU (1) | HUP0201863A3 (es) |
| ID (1) | ID29871A (es) |
| IL (2) | IL145041A0 (es) |
| IS (1) | IS2338B (es) |
| ME (2) | MEP12008A (es) |
| MX (1) | MXPA01009643A (es) |
| NO (1) | NO321576B1 (es) |
| NZ (1) | NZ513674A (es) |
| PE (1) | PE20001596A1 (es) |
| PL (1) | PL205318B1 (es) |
| PT (1) | PT1165528E (es) |
| RS (1) | RS50085B (es) |
| RU (1) | RU2222537C2 (es) |
| SI (1) | SI1165528T1 (es) |
| SK (1) | SK286977B6 (es) |
| TR (1) | TR200102639T2 (es) |
| TW (1) | TW534906B (es) |
| UA (1) | UA73931C2 (es) |
| UY (1) | UY26079A1 (es) |
| WO (1) | WO2000058292A1 (es) |
| ZA (1) | ZA200106981B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1353918B1 (en) * | 2000-11-28 | 2005-01-12 | Smithkline Beecham Plc | Morpholine derivatives as antagonists of orexin receptors |
| FR2824828B1 (fr) * | 2001-05-21 | 2005-05-20 | Sanofi Synthelabo | Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| GB0228787D0 (en) * | 2002-12-10 | 2003-01-15 | Pfizer Ltd | Morpholine dopamine agonists |
| AU2003300911A1 (en) | 2002-12-13 | 2004-07-09 | Smithkline Beecham Corporation | Heterocyclic compounds as ccr5 antagonists |
| JO2485B1 (en) * | 2002-12-23 | 2009-01-20 | شركة جانسين فارماسوتيكا ان. في | 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists |
| JP2007515425A (ja) * | 2003-12-22 | 2007-06-14 | シェーリング コーポレイション | 医薬組成物 |
| FR2873373B1 (fr) * | 2004-07-23 | 2006-09-08 | Sanofi Synthelabo | Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique |
| CN103142569B (zh) * | 2013-02-27 | 2016-01-20 | 南京医科大学 | 2,6-二异丙基苯甲酸及其衍生物作为神经保护剂的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ3134U1 (cs) * | 1995-01-10 | 1995-03-17 | Pavel Ing. Janda | Rotor universálního radiálního ventilátoru |
| FR2729954B1 (fr) * | 1995-01-30 | 1997-08-01 | Sanofi Sa | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US5780466A (en) * | 1995-01-30 | 1998-07-14 | Sanofi | Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present |
| HU224225B1 (hu) * | 1995-12-01 | 2005-06-28 | Sankyo Co. Ltd. | Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására |
| JP3192631B2 (ja) * | 1997-05-28 | 2001-07-30 | 三共株式会社 | 飽和複素環化合物からなる医薬 |
| KR100610538B1 (ko) * | 1997-12-04 | 2006-08-09 | 상꾜 가부시키가이샤 | 지환식 아실화 복소환 유도체 |
-
1999
- 1999-03-25 FR FR9903854A patent/FR2791346B3/fr not_active Expired - Lifetime
-
2000
- 2000-03-21 IL IL14504100A patent/IL145041A0/xx unknown
- 2000-03-21 AT AT00911009T patent/ATE275136T1/de active
- 2000-03-21 US US09/937,279 patent/US6506750B1/en not_active Expired - Lifetime
- 2000-03-21 SK SK1346-2001A patent/SK286977B6/sk not_active IP Right Cessation
- 2000-03-21 ME MEP-120/08A patent/MEP12008A/xx unknown
- 2000-03-21 ME MEP-2008-120A patent/ME00057B/me unknown
- 2000-03-21 WO PCT/FR2000/000695 patent/WO2000058292A1/fr not_active Ceased
- 2000-03-21 KR KR1020017012121A patent/KR100696340B1/ko not_active Expired - Fee Related
- 2000-03-21 HU HU0201863A patent/HUP0201863A3/hu unknown
- 2000-03-21 ID IDW00200101969A patent/ID29871A/id unknown
- 2000-03-21 RU RU2001124835/04A patent/RU2222537C2/ru not_active IP Right Cessation
- 2000-03-21 AU AU33016/00A patent/AU756855B2/en not_active Ceased
- 2000-03-21 PL PL351317A patent/PL205318B1/pl not_active IP Right Cessation
- 2000-03-21 MX MXPA01009643A patent/MXPA01009643A/es unknown
- 2000-03-21 HK HK02103933.2A patent/HK1042092B/zh not_active IP Right Cessation
- 2000-03-21 EE EEP200100499A patent/EE04525B1/xx not_active IP Right Cessation
- 2000-03-21 DK DK00911009T patent/DK1165528T3/da active
- 2000-03-21 BR BRPI0009281-9A patent/BR0009281B1/pt not_active IP Right Cessation
- 2000-03-21 SI SI200030536T patent/SI1165528T1/xx unknown
- 2000-03-21 ES ES00911009T patent/ES2226794T3/es not_active Expired - Lifetime
- 2000-03-21 PT PT00911009T patent/PT1165528E/pt unknown
- 2000-03-21 TR TR2001/02639T patent/TR200102639T2/xx unknown
- 2000-03-21 CZ CZ20013365A patent/CZ300911B6/cs not_active IP Right Cessation
- 2000-03-21 HR HR20010704A patent/HRP20010704B1/xx not_active IP Right Cessation
- 2000-03-21 NZ NZ513674A patent/NZ513674A/en not_active IP Right Cessation
- 2000-03-21 RS YUP-682/01A patent/RS50085B/sr unknown
- 2000-03-21 JP JP2000607995A patent/JP3853155B2/ja not_active Expired - Fee Related
- 2000-03-21 CA CA002366829A patent/CA2366829C/fr not_active Expired - Lifetime
- 2000-03-21 CN CNB008055084A patent/CN100422160C/zh not_active Expired - Fee Related
- 2000-03-21 EP EP00911009A patent/EP1165528B1/fr not_active Expired - Lifetime
- 2000-03-21 UA UA2001096121A patent/UA73931C2/uk unknown
- 2000-03-21 DE DE60013418T patent/DE60013418T2/de not_active Expired - Lifetime
- 2000-03-23 AR ARP000101299A patent/AR023139A1/es active IP Right Grant
- 2000-03-24 CO CO00021353A patent/CO5160340A1/es unknown
- 2000-03-24 TW TW089105498A patent/TW534906B/zh not_active IP Right Cessation
- 2000-03-27 UY UY26079A patent/UY26079A1/es not_active IP Right Cessation
- 2000-03-27 PE PE2000000258A patent/PE20001596A1/es not_active Application Discontinuation
-
2001
- 2001-08-21 IL IL145041A patent/IL145041A/en not_active IP Right Cessation
- 2001-08-23 ZA ZA200106981A patent/ZA200106981B/en unknown
- 2001-08-24 IS IS6063A patent/IS2338B/is unknown
- 2001-09-19 BG BG105923A patent/BG64623B1/bg unknown
- 2001-09-24 NO NO20014632A patent/NO321576B1/no not_active IP Right Cessation
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