PE20060723A1 - Derivados de morfina como agentes analgesicos - Google Patents

Derivados de morfina como agentes analgesicos

Info

Publication number: PE20060723A1
Authority: PE; Peru
Prior art keywords: alcoxy; morphinan; ona; cyclopropylmethyl; dihydroxy
Prior art date: 2004-11-04

Application number

PE2005001291A

Other languages

English (en)

Spanish (es)

Inventor

Naoki Izumimoto

Kuniaki Kawamura

Toshikazu Komagata

Original Assignee

Toray Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-04

Filing date

2005-11-03

Publication date

2006-08-29

2005-11-03 Application filed by Toray Industries filed Critical Toray Industries

2006-08-29 Publication of PE20060723A1 publication Critical patent/PE20060723A1/es

Links

BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 2
239000000730 antalgic agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 3
208000002193 Pain Diseases 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
208000000094 Chronic Pain Diseases 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
208000005298 acute pain Diseases 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PE2005001291A 2004-11-04 2005-11-03 Derivados de morfina como agentes analgesicos PE20060723A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2004320583		2004-11-04

Publications (1)

Publication Number	Publication Date
PE20060723A1 true PE20060723A1 (es)	2006-08-29

Family

ID=36319248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE2005001291A PE20060723A1 (es)	2004-11-04	2005-11-03	Derivados de morfina como agentes analgesicos

Country Status (12)

Country	Link
US (1)	US8470845B2 (2)
EP (1)	EP1820505A4 (2)
JP (1)	JP4706636B2 (2)
KR (1)	KR101285645B1 (2)
CN (1)	CN101090722B (2)
AR (1)	AR053098A1 (2)
CA (1)	CA2586181C (2)
MX (1)	MX2007005336A (2)
NO (1)	NO20072832L (2)
PE (1)	PE20060723A1 (2)
TW (1)	TW200621785A (2)
WO (1)	WO2006049248A1 (2)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007055184A1 (ja) *	2005-11-09	2007-05-18	Toray Industries, Inc.	機能性腸障害の治療または予防剤
WO2007072749A1 (ja) *	2005-12-21	2007-06-28	Toray Industries, Inc.	鎮咳剤
FR2902341B1 (fr)	2006-06-16	2011-02-25	Scras	Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR2910327B1 (fr)	2006-12-22	2013-04-26	Scras	Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
AU2008254038B2 (en) *	2007-05-21	2013-01-10	Toray Industries, Inc.	Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation
ES2627217T3 (es) *	2007-05-21	2017-07-27	Toray Industries, Inc.	Partículas micropulverizadas cristalinas
AU2008254039B2 (en) *	2007-05-21	2013-10-24	Toray Industries, Inc.	Method for producing pharmaceutical tablet
FR2930447B1 (fr)	2008-04-25	2010-07-30	Sod Conseils Rech Applic	Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique
DK3761982T3 (da)	2018-03-08	2025-01-02	Victoria Link Ltd	Anvendelse af nalfurafin til behandling af demyeliniserende sygdomme

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4118823B1 (2) *	1964-02-03	1966-10-31
US3318884A (en) *	1965-07-21	1967-05-09	American Cyanamid Co	Substituted 6-amino-6-demethoxythebaine and 6-amino-6-demethoxyoripavine derivatives
NL8102558A (nl) *	1981-05-25	1982-12-16	Alcoa Nederland Bv	Lichtmast met versterking van de opening in het onderste gedeelte.
ES2121988T3 (es) *	1992-01-23	1998-12-16	Toray Industries	Derivado de morfinano y uso medicinal.
NZ268969A (en) *	1993-07-23	1997-06-24	Toray Industries	Morphinan derivatives and pharmaceutical compositions
AU5090796A (en) *	1995-03-03	1996-09-23	Algos Pharmaceutical Corporation	Use of dextromethorphan or dextrorphan for the treatment of urinary incontinence
AU6020300A (en) *	1999-07-19	2001-02-05	Toray Industries, Inc.	Remedies or preventives for frequent urination or urinary incontinence
DE19939044A1 (de) *	1999-08-18	2001-03-15	Gruenenthal Gmbh	Verwendung von Morphinanderivaten als Arzneimittel
JP4340437B2 (ja)	2000-10-31	2009-10-07	レンセラールポリテクニックインスティチュート	８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
BR0314754A (pt) *	2002-10-09	2005-07-26	Toray Industries	Agente terapêutico ou profilático para a frequência urinária ou a incontinência urinária ou um seu sal de adição de ácido farmaceuticamente aceitável, método para terapia ou profilaxia para frequência urinária, urgência urinária ou incontinência urinária, uso de um derivado de morfina tendo um grupo heterocìclico contendo nitrogênio ou de um seu sal de adição de ácido farmaceuticamente aceitável, derivado de morfina ou um seu sal de adição de ácido farmaceuticamente aceitável, produto farmacêutico, e, composição farmacêutica
JP4118824B2 (ja)	2004-02-24	2008-07-16	株式会社日立製作所	優先パケットの遅延を最小化するシェーピング装置
JP4118826B2 (ja)	2004-03-01	2008-07-16	リオン株式会社	補聴器用ケースなどの製造方法及びその装置
TW200533355A (en)	2004-03-30	2005-10-16	Toray Industries	Antipruritic agent

2005
- 2005-11-03 PE PE2005001291A patent/PE20060723A1/es not_active Application Discontinuation
- 2005-11-03 AR ARP050104603A patent/AR053098A1/es not_active Application Discontinuation
- 2005-11-03 TW TW094138512A patent/TW200621785A/zh not_active IP Right Cessation
- 2005-11-04 US US11/667,136 patent/US8470845B2/en not_active Expired - Fee Related
- 2005-11-04 EP EP05799891A patent/EP1820505A4/en not_active Withdrawn
- 2005-11-04 CN CN200580045038XA patent/CN101090722B/zh not_active Expired - Fee Related
- 2005-11-04 CA CA2586181A patent/CA2586181C/en not_active Expired - Fee Related
- 2005-11-04 WO PCT/JP2005/020297 patent/WO2006049248A1/ja not_active Ceased
- 2005-11-04 KR KR1020077011752A patent/KR101285645B1/ko not_active Expired - Fee Related
- 2005-11-04 MX MX2007005336A patent/MX2007005336A/es active IP Right Grant
- 2005-11-04 JP JP2006542444A patent/JP4706636B2/ja not_active Expired - Fee Related
2007
- 2007-06-04 NO NO20072832A patent/NO20072832L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HK1115808A1 (en)	2008-12-12
CA2586181C (en)	2012-11-27
US20070299100A1 (en)	2007-12-27
KR20070085436A (ko)	2007-08-27
CA2586181A1 (en)	2006-05-11
TW200621785A (en)	2006-07-01
WO2006049248A1 (ja)	2006-05-11
TWI356826B (2)	2012-01-21
US8470845B2 (en)	2013-06-25
CN101090722B (zh)	2011-12-21
MX2007005336A (es)	2007-06-25
CN101090722A (zh)	2007-12-19
NO20072832L (no)	2007-08-01
AR053098A1 (es)	2007-04-25
EP1820505A1 (en)	2007-08-22
JP4706636B2 (ja)	2011-06-22
KR101285645B1 (ko)	2013-07-12
EP1820505A4 (en)	2010-01-20
JPWO2006049248A1 (ja)	2008-08-07

Legal Events

Date	Code	Title	Description
2010-04-26	FC	Refusal

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PE20050012A1 (es)	2005-03-12	Compuestos de benzopirano como inhibidores de la ciclooxigenasa-2
PE20070136A1 (es)	2007-03-08	COMPUESTOS DERIVADOS DE N-(PIRIDIN-2-IL)-SULFONAMIDA COMO INHIBIDORES DE LA ENZIMA 11-beta-HIDROXIESTEROIDE DESHIDROGENASA HUMANA TIPO 1
PE20060723A1 (es)	2006-08-29	Derivados de morfina como agentes analgesicos
PE20030497A1 (es)	2003-07-04	Combinaciones de un inhibidor de pde 5 y otros agentes activos
PE20060186A1 (es)	2006-04-18	Antagonistas de cgrp seleccionados, procedimientos para su preparacion asi como su uso como medicamento
PE20081596A1 (es)	2009-02-05	Derivados fluorinados de deferiprona
AR043259A1 (es)	2005-07-20	Metodo para el tratamiento de insuficiencia cardiaca severa y medicamento para ello
AR059501A1 (es)	2008-04-09	Uso de derivados de benzo-heteroaril sulfamida para el tratamiento del dolor
PE20050732A1 (es)	2005-11-02	Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos
PE20090712A1 (es)	2009-06-20	Moduladores de la gamma secretasa