TWI356826B - - Google Patents

Download PDF

Info

Publication number
TWI356826B
TWI356826B TW094138512A TW94138512A TWI356826B TW I356826 B TWI356826 B TW I356826B TW 094138512 A TW094138512 A TW 094138512A TW 94138512 A TW94138512 A TW 94138512A TW I356826 B TWI356826 B TW I356826B
Authority
TW
Taiwan
Prior art keywords
cpm
allyl
group
pain
cyclopropylmethyl
Prior art date
Application number
TW094138512A
Other languages
English (en)
Chinese (zh)
Other versions
TW200621785A (en
Inventor
Naoki Izumimoto
Kuniaki Kawamura
Toshikazu Komagata
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of TW200621785A publication Critical patent/TW200621785A/zh
Application granted granted Critical
Publication of TWI356826B publication Critical patent/TWI356826B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW094138512A 2004-11-04 2005-11-03 Analgesic TW200621785A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004320583 2004-11-04

Publications (2)

Publication Number Publication Date
TW200621785A TW200621785A (en) 2006-07-01
TWI356826B true TWI356826B (2) 2012-01-21

Family

ID=36319248

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094138512A TW200621785A (en) 2004-11-04 2005-11-03 Analgesic

Country Status (12)

Country Link
US (1) US8470845B2 (2)
EP (1) EP1820505A4 (2)
JP (1) JP4706636B2 (2)
KR (1) KR101285645B1 (2)
CN (1) CN101090722B (2)
AR (1) AR053098A1 (2)
CA (1) CA2586181C (2)
MX (1) MX2007005336A (2)
NO (1) NO20072832L (2)
PE (1) PE20060723A1 (2)
TW (1) TW200621785A (2)
WO (1) WO2006049248A1 (2)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007055184A1 (ja) * 2005-11-09 2007-05-18 Toray Industries, Inc. 機能性腸障害の治療または予防剤
WO2007072749A1 (ja) * 2005-12-21 2007-06-28 Toray Industries, Inc. 鎮咳剤
FR2902341B1 (fr) 2006-06-16 2011-02-25 Scras Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR2910327B1 (fr) 2006-12-22 2013-04-26 Scras Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
AU2008254038B2 (en) * 2007-05-21 2013-01-10 Toray Industries, Inc. Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation
ES2627217T3 (es) * 2007-05-21 2017-07-27 Toray Industries, Inc. Partículas micropulverizadas cristalinas
AU2008254039B2 (en) * 2007-05-21 2013-10-24 Toray Industries, Inc. Method for producing pharmaceutical tablet
FR2930447B1 (fr) 2008-04-25 2010-07-30 Sod Conseils Rech Applic Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique
DK3761982T3 (da) 2018-03-08 2025-01-02 Victoria Link Ltd Anvendelse af nalfurafin til behandling af demyeliniserende sygdomme

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4118823B1 (2) * 1964-02-03 1966-10-31
US3318884A (en) * 1965-07-21 1967-05-09 American Cyanamid Co Substituted 6-amino-6-demethoxythebaine and 6-amino-6-demethoxyoripavine derivatives
NL8102558A (nl) * 1981-05-25 1982-12-16 Alcoa Nederland Bv Lichtmast met versterking van de opening in het onderste gedeelte.
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
NZ268969A (en) * 1993-07-23 1997-06-24 Toray Industries Morphinan derivatives and pharmaceutical compositions
AU5090796A (en) * 1995-03-03 1996-09-23 Algos Pharmaceutical Corporation Use of dextromethorphan or dextrorphan for the treatment of urinary incontinence
AU6020300A (en) * 1999-07-19 2001-02-05 Toray Industries, Inc. Remedies or preventives for frequent urination or urinary incontinence
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
JP4340437B2 (ja) 2000-10-31 2009-10-07 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
BR0314754A (pt) * 2002-10-09 2005-07-26 Toray Industries Agente terapêutico ou profilático para a frequência urinária ou a incontinência urinária ou um seu sal de adição de ácido farmaceuticamente aceitável, método para terapia ou profilaxia para frequência urinária, urgência urinária ou incontinência urinária, uso de um derivado de morfina tendo um grupo heterocìclico contendo nitrogênio ou de um seu sal de adição de ácido farmaceuticamente aceitável, derivado de morfina ou um seu sal de adição de ácido farmaceuticamente aceitável, produto farmacêutico, e, composição farmacêutica
JP4118824B2 (ja) 2004-02-24 2008-07-16 株式会社日立製作所 優先パケットの遅延を最小化するシェーピング装置
JP4118826B2 (ja) 2004-03-01 2008-07-16 リオン株式会社 補聴器用ケースなどの製造方法及びその装置
TW200533355A (en) 2004-03-30 2005-10-16 Toray Industries Antipruritic agent

Also Published As

Publication number Publication date
HK1115808A1 (en) 2008-12-12
CA2586181C (en) 2012-11-27
US20070299100A1 (en) 2007-12-27
KR20070085436A (ko) 2007-08-27
CA2586181A1 (en) 2006-05-11
TW200621785A (en) 2006-07-01
WO2006049248A1 (ja) 2006-05-11
US8470845B2 (en) 2013-06-25
PE20060723A1 (es) 2006-08-29
CN101090722B (zh) 2011-12-21
MX2007005336A (es) 2007-06-25
CN101090722A (zh) 2007-12-19
NO20072832L (no) 2007-08-01
AR053098A1 (es) 2007-04-25
EP1820505A1 (en) 2007-08-22
JP4706636B2 (ja) 2011-06-22
KR101285645B1 (ko) 2013-07-12
EP1820505A4 (en) 2010-01-20
JPWO2006049248A1 (ja) 2008-08-07

Similar Documents

Publication Publication Date Title
CN102480959B (zh) 氢可酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物及其前药、制备方法和用途
CN105246897B (zh) 阿片样缩酮化合物和其用途
US8461171B2 (en) Hybrid opioid compounds and compositions
JP2525552B2 (ja) モルヒナン誘導体および医薬用途
CN101827819B (zh) 阿片样物质酰胺季铵盐
AU2015253417B2 (en) Pharmaceutically active dimers linked through phenolic hydroxyl groups
TW200427690A (en) Opioid and opioid-like compounds and uses thereof
WO1998023290A1 (en) Antipruritic agent
JP2010510325A (ja) ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体の（ｓ）−ｎ−立体異性体
JP2004538256A (ja) Ｎ−ブト−３−エチル＝ノルブプレノルフィン及び使用方法
HU231191B1 (hu) Izotóp tartalmú morfin molekulák
CN100586434C (zh) 止痒剂
TWI356826B (2)
JP6929857B2 (ja) ６，７，８，９−テトラヒドロ−５Ｈ−ピリド［２，３−ｄ］アゼピンドーパミンＤ３リガンド
WO2021178691A1 (en) Ibogaine analogs as therapeutics for neurological and psychiatric disorders
JP2014505113A (ja) 末梢作用性μオピオイドアンタゴニスト
JPH0770013A (ja) β３ −アドレナリン作動薬として作用する｛（７Ｓ）−７−［（２Ｒ）−２−（３−クロロフェニル）−２−ヒドロキシエチルアミノ］−５，６，７，８−テトラヒドロナフタレン−２−イルオキシ）酢酸及びその薬学的に許容されうる塩、並びにそれらが存在する薬学的組成物及び研究室用試薬
KR20080081057A (ko) 진해제
WO2020159588A1 (en) Methods of treating diabetic neuropathy with a thiazoline anti-hyperalgesic agent
HK1115808B (en) Analgesic
JP7535569B2 (ja) オピオイドヘキサジエノエート及び選択的に置換されたヘキサジエノエートによってオピオイド受容体の結合を改善する組成物並びに方法
HK1098679A (en) Anti-itching agent
JPWO2001014382A1 (ja) モルヒナン４級アンモニウム塩誘導体を有効成分とする鎮痛薬

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees