PE20171653A1 - Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b - Google Patents

Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b

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Publication number
PE20171653A1
PE20171653A1 PE2017001979A PE2017001979A PE20171653A1 PE 20171653 A1 PE20171653 A1 PE 20171653A1 PE 2017001979 A PE2017001979 A PE 2017001979A PE 2017001979 A PE2017001979 A PE 2017001979A PE 20171653 A1 PE20171653 A1 PE 20171653A1
Authority
PE
Peru
Prior art keywords
antigen
cell maturation
chemeric
receptors targeting
cdrs
Prior art date
Application number
PE2017001979A
Other languages
English (en)
Inventor
Tracy Chia-Chien Kuo
Riggers Javier Fernando Chaparro
Barbra Johnson Sasu
Roman Galetto
Bijan Andre Boldajipour
Cesar Adolfo Sommer
Blarcom Thomas John Van
Thomas Charles Pertel
Arvind Rajpal
Philippe Duchateau
Alexandre Juillerat
Julien Valton
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20171653A1 publication Critical patent/PE20171653A1/es

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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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Abstract

Referido a un receptor del antigeno quimerico (CAR) especifico de antigeno de maduracion de celula B (BCMA) que comprende: una region variable de cadena pesada (VH) que comprende tres CDRs de SEC ID NO: 33, 72, 39, 76, 83, 92, 25 o 8; una region variable de cadena ligera (VL) que comprende tres CDRs de SEC ID NO: 34, 73, 40, 77, 84, 93, 18 o 80. Tambien se refiere a un polinucleotido de codificacion, un vector de expresion y a una composicion farmaceutica. Dicho receptor es util en el tratamiento una condicion asociada con celulas malignas que expresan BCMA, como el cancer.
PE2017001979A 2015-04-13 2016-03-30 Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b PE20171653A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562146825P 2015-04-13 2015-04-13
US201662286473P 2016-01-25 2016-01-25
US201662301177P 2016-02-29 2016-02-29

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PE20171653A1 true PE20171653A1 (es) 2017-11-13

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US (3) US10294304B2 (es)
EP (2) EP3757128B1 (es)
JP (2) JP6921001B2 (es)
KR (3) KR102528825B1 (es)
CN (2) CN114149511A (es)
AU (3) AU2016248947B2 (es)
CA (1) CA2925589A1 (es)
CO (1) CO2017010502A2 (es)
DK (1) DK3283520T3 (es)
ES (2) ES2807591T3 (es)
IL (2) IL297223B2 (es)
MX (2) MX377809B (es)
MY (1) MY188432A (es)
PE (1) PE20171653A1 (es)
PH (1) PH12017501728A1 (es)
RU (1) RU2706582C2 (es)
SG (2) SG10201912666PA (es)
TW (2) TWI631138B (es)
WO (1) WO2016166630A1 (es)
ZA (1) ZA201706384B (es)

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EP3131927B8 (en) 2014-04-14 2020-12-23 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
BR112017001183A2 (pt) 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
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