PE20181165A1 - Derivados de indol mono-o disustituidos como inhibidores de la replicacion viral del dengue - Google Patents

Derivados de indol mono-o disustituidos como inhibidores de la replicacion viral del dengue

Info

Publication number: PE20181165A1
Authority: PE; Peru
Prior art keywords: inhibitors; compounds; dengue viral; relates; medicine
Prior art date: 2015-09-16

Application number

PE2018000399A

Other languages

English (en)

Spanish (es)

Inventor

Bart Rudolf Romanie Kesteleyn

Pierre Jean-Marie Bernard Raboisson

Jean-François Bonfanti

Tim Hugo Maria Jonckers

Dorothee Alice Marie-Eve Bardiot

Arnaud Didier M Marchand

Original Assignee

Janssen Pharmaceuticals Inc

Univ Leuven Kath

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-09-16

Filing date

2016-09-15

Publication date

2018-07-19

2016-09-15 Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc

2018-07-19 Publication of PE20181165A1 publication Critical patent/PE20181165A1/es

Links

208000001490 Dengue Diseases 0.000 title abstract 4
206010012310 Dengue fever Diseases 0.000 title abstract 4
208000025729 dengue disease Diseases 0.000 title abstract 4
239000003112 inhibitor Substances 0.000 title 2
230000029812 viral genome replication Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
208000036142 Viral infection Diseases 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 3
238000002360 preparation method Methods 0.000 abstract 3
230000009385 viral infection Effects 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
150000002475 indoles Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PE2018000399A 2015-09-16 2016-09-15 Derivados de indol mono-o disustituidos como inhibidores de la replicacion viral del dengue PE20181165A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP15185523		2015-09-16
EP16163472		2016-04-01

Publications (1)

Publication Number	Publication Date
PE20181165A1 true PE20181165A1 (es)	2018-07-19

Family

ID=56926217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE2018000399A PE20181165A1 (es)	2015-09-16	2016-09-15	Derivados de indol mono-o disustituidos como inhibidores de la replicacion viral del dengue

Country Status (29)

Country	Link
US (1)	US10765662B2 (fr)
EP (1)	EP3350162B1 (fr)
JP (2)	JP7050666B2 (fr)
KR (1)	KR102646174B1 (fr)
CN (1)	CN108473422B (fr)
AU (1)	AU2016324982B2 (fr)
CA (1)	CA2996979C (fr)
CL (1)	CL2018000696A1 (fr)
CO (1)	CO2018003471A2 (fr)
CR (1)	CR20180213A (fr)
DK (1)	DK3350162T3 (fr)
EA (1)	EA035663B1 (fr)
EC (1)	ECSP18020055A (fr)
ES (1)	ES2893298T3 (fr)
HR (1)	HRP20211352T1 (fr)
HU (1)	HUE055870T2 (fr)
IL (1)	IL258043B (fr)
JO (1)	JOP20160198B1 (fr)
LT (1)	LT3350162T (fr)
MA (1)	MA42810A (fr)
MX (1)	MX381633B (fr)
NI (1)	NI201800039A (fr)
PE (1)	PE20181165A1 (fr)
PH (1)	PH12018500576A1 (fr)
SI (1)	SI3350162T1 (fr)
TW (1)	TWI758255B (fr)
UA (1)	UA122973C2 (fr)
UY (1)	UY36903A (fr)
WO (1)	WO2017046255A1 (fr)

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PT3201176T (pt) *	2014-10-01	2019-03-04	Janssen Pharmaceuticals Inc	Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue
DK3201177T3 (en) *	2014-10-01	2019-03-04	Janssen Pharmaceuticals Inc	MONO OR DISUBSTITUTED INDOLES AS INHIBITORS OF DENGUE VIRUS REPLICATION
JOP20160086B1 (ar)	2015-05-08	2021-08-17	2 Katholieke Univ Leuven Ku Leuven Research And Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar)	2015-09-16	2020-08-27	Katholieke Univ Leuven Ku Leuven Research & Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
ES2828431T3 (es)	2015-12-16	2021-05-26	Loxo Oncology Inc	Compuestos útiles como inhibidores de cinasa
SG11201808138YA (en)	2016-03-31	2018-10-30	Janssen Pharmaceuticals Inc	Substituted indole derivatives as dengue viral replication inhibitors
MA44498A (fr)	2016-03-31	2019-02-06	Janssen Pharmaceuticals Inc	Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
JOP20170069B1 (ar)	2016-04-01	2021-08-17	1 Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EP3436004B1 (fr)	2016-04-01	2024-12-11	Janssen Pharmaceuticals, Inc.	Dérivés substitués de l'indol comme inhibiteurs du virus de la dengue
JOP20180025B1 (ar) *	2017-03-31	2021-08-17	Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) *	2017-03-31	2019-01-30	Univ Leuven Kath	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
SI3630724T1 (sl)	2017-05-22	2021-08-31	Janssen Pharmaceuticals, Inc.	Substituirani derivati indolina kot zaviralci replikacije virusa denga
CA3060583C (fr)	2017-05-22	2024-06-04	Janssen Pharmaceuticals, Inc.	Derives d'indoline substitues utilises en tant qu'inhibiteurs de replication du virus de la dengue
CN119306651B (zh) *	2024-10-11	2025-12-05	山东大学	一种吲哚3-酰胺类衍生物及其制备方法与应用

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JO3633B1 (ar)	2015-09-16	2020-08-27	Katholieke Univ Leuven Ku Leuven Research & Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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MA44498A (fr)	2016-03-31	2019-02-06	Janssen Pharmaceuticals Inc	Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
JOP20170069B1 (ar)	2016-04-01	2021-08-17	1 Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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2016
- 2016-09-06 JO JOP/2016/0198A patent/JOP20160198B1/ar active
- 2016-09-13 TW TW105129689A patent/TWI758255B/zh not_active IP Right Cessation
- 2016-09-15 WO PCT/EP2016/071845 patent/WO2017046255A1/fr not_active Ceased
- 2016-09-15 UA UAA201804007A patent/UA122973C2/uk unknown
- 2016-09-15 LT LTEPPCT/EP2016/071845T patent/LT3350162T/lt unknown
- 2016-09-15 JP JP2018513474A patent/JP7050666B2/ja active Active
- 2016-09-15 DK DK16766010.9T patent/DK3350162T3/da active
- 2016-09-15 PE PE2018000399A patent/PE20181165A1/es unknown
- 2016-09-15 AU AU2016324982A patent/AU2016324982B2/en active Active
- 2016-09-15 MA MA042810A patent/MA42810A/fr unknown
- 2016-09-15 KR KR1020187009763A patent/KR102646174B1/ko active Active
- 2016-09-15 US US15/759,846 patent/US10765662B2/en active Active
- 2016-09-15 HR HRP20211352TT patent/HRP20211352T1/hr unknown
- 2016-09-15 CA CA2996979A patent/CA2996979C/fr active Active
- 2016-09-15 SI SI201631355T patent/SI3350162T1/sl unknown
- 2016-09-15 CR CR20180213A patent/CR20180213A/es unknown
- 2016-09-15 CN CN201680053616.2A patent/CN108473422B/zh active Active
- 2016-09-15 HU HUE16766010A patent/HUE055870T2/hu unknown
- 2016-09-15 EP EP16766010.9A patent/EP3350162B1/fr active Active
- 2016-09-15 EA EA201890722A patent/EA035663B1/ru not_active IP Right Cessation
- 2016-09-15 MX MX2018003255A patent/MX381633B/es unknown
- 2016-09-15 ES ES16766010T patent/ES2893298T3/es active Active
- 2016-09-16 UY UY0001036903A patent/UY36903A/es not_active Application Discontinuation
2018
- 2018-03-12 IL IL258043A patent/IL258043B/en unknown
- 2018-03-14 EC ECIEPI201820055A patent/ECSP18020055A/es unknown
- 2018-03-15 NI NI201800039A patent/NI201800039A/es unknown
- 2018-03-15 CL CL2018000696A patent/CL2018000696A1/es unknown
- 2018-03-15 PH PH12018500576A patent/PH12018500576A1/en unknown
- 2018-03-28 CO CONC2018/0003471A patent/CO2018003471A2/es unknown
2021
- 2021-08-12 JP JP2021131751A patent/JP2021181485A/ja active Pending

Also Published As

Publication number	Publication date
JP2021181485A (ja)	2021-11-25
US10765662B2 (en)	2020-09-08
EP3350162A1 (fr)	2018-07-25
CN108473422B (zh)	2021-06-15
CL2018000696A1 (es)	2018-07-06
IL258043B (en)	2021-08-31
HUE055870T2 (hu)	2021-12-28
CO2018003471A2 (es)	2018-07-10
WO2017046255A1 (fr)	2017-03-23
DK3350162T3 (da)	2021-10-04
KR102646174B1 (ko)	2024-03-08
IL258043A (en)	2018-05-31
ES2893298T3 (es)	2022-02-08
EA035663B1 (ru)	2020-07-23
TWI758255B (zh)	2022-03-21
AU2016324982A1 (en)	2018-03-15
CR20180213A (es)	2018-06-27
MA42810A (fr)	2018-07-25
NI201800039A (es)	2018-07-24
LT3350162T (lt)	2021-09-27
JP2018528220A (ja)	2018-09-27
CN108473422A (zh)	2018-08-31
CA2996979A1 (fr)	2017-03-23
EP3350162B1 (fr)	2021-07-14
HK1257842A1 (en)	2019-11-01
ECSP18020055A (es)	2018-04-30
PH12018500576A1 (en)	2018-10-15
KR20180052672A (ko)	2018-05-18
MX381633B (es)	2025-03-12
AU2016324982B2 (en)	2021-04-15
SI3350162T1 (sl)	2021-11-30
UY36903A (es)	2017-03-31
MX2018003255A (es)	2018-11-09
UA122973C2 (uk)	2021-01-27
US20180256545A1 (en)	2018-09-13
HRP20211352T1 (hr)	2022-02-04
TW201722913A (zh)	2017-07-01
EA201890722A1 (ru)	2018-09-28
JOP20160198B1 (ar)	2022-03-14
JP7050666B2 (ja)	2022-04-08
CA2996979C (fr)	2024-01-30

Publication	Publication Date	Title
ECSP22023220A (es)	2022-05-31	Derivados de indol mono o disustituidos como inhibidores de la replicación viral del dengue
NI201800039A (es)	2018-07-24	Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue
NI201800040A (es)	2018-07-24	Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue
MX2018011785A (es)	2019-02-13	Derivados de indolina sustituidos como inhibidores de la replicacion viral del dengue.
ECSP18073245A (es)	2018-10-31	Derivados de indol sustituidos como inhibidores de la replicación vírica del dengue
ECSP18073264A (es)	2018-10-31	Derivados de compuestos de indol sustituidos como inhibidores de la replicación vírica del dengue
MX2019011606A (es)	2019-11-08	Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue.
CL2017000782A1 (es)	2017-11-03	Derivados de indol mono- o disustituidos como inhibidores de la replicación del virus del dengue
CO2019010292A2 (es)	2019-10-09	Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
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