MA42810A - Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue - Google Patents

Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue

Info

Publication number
MA42810A
MA42810A MA042810A MA42810A MA42810A MA 42810 A MA42810 A MA 42810A MA 042810 A MA042810 A MA 042810A MA 42810 A MA42810 A MA 42810A MA 42810 A MA42810 A MA 42810A
Authority
MA
Morocco
Prior art keywords
monosubstituted
dengue virus
virus replication
indole derivatives
derivatives used
Prior art date
Application number
MA042810A
Other languages
English (en)
Inventor
Dorothée Alice Marie-Eve Bardiot
Jean-François Bonfanti
Tim Hugo Maria Jonckers
Bart Rudolf Romanie Kesteleyn
Arnaud Didier M Marchand
Pierre Jean-Marie Bernard Raboisson
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of MA42810A publication Critical patent/MA42810A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA042810A 2015-09-16 2016-09-15 Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue MA42810A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15185523 2015-09-16
EP16163472 2016-04-01

Publications (1)

Publication Number Publication Date
MA42810A true MA42810A (fr) 2018-07-25

Family

ID=56926217

Family Applications (1)

Application Number Title Priority Date Filing Date
MA042810A MA42810A (fr) 2015-09-16 2016-09-15 Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue

Country Status (29)

Country Link
US (1) US10765662B2 (fr)
EP (1) EP3350162B1 (fr)
JP (2) JP7050666B2 (fr)
KR (1) KR102646174B1 (fr)
CN (1) CN108473422B (fr)
AU (1) AU2016324982B2 (fr)
CA (1) CA2996979C (fr)
CL (1) CL2018000696A1 (fr)
CO (1) CO2018003471A2 (fr)
CR (1) CR20180213A (fr)
DK (1) DK3350162T3 (fr)
EA (1) EA035663B1 (fr)
EC (1) ECSP18020055A (fr)
ES (1) ES2893298T3 (fr)
HR (1) HRP20211352T1 (fr)
HU (1) HUE055870T2 (fr)
IL (1) IL258043B (fr)
JO (1) JOP20160198B1 (fr)
LT (1) LT3350162T (fr)
MA (1) MA42810A (fr)
MX (1) MX381633B (fr)
NI (1) NI201800039A (fr)
PE (1) PE20181165A1 (fr)
PH (1) PH12018500576A1 (fr)
SI (1) SI3350162T1 (fr)
TW (1) TWI758255B (fr)
UA (1) UA122973C2 (fr)
UY (1) UY36903A (fr)
WO (1) WO2017046255A1 (fr)

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GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
US9944598B2 (en) * 2014-10-01 2018-04-17 Janssen Pharmaceuticals, Inc. Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
BR112017006708A2 (pt) * 2014-10-01 2017-12-26 Janssen Pharmaceuticals Inc indóis mono- ou dissubstituídos como inibidores da replicação viral de dengue
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN114605327B (zh) 2015-12-16 2025-03-11 洛克索肿瘤学股份有限公司 可用作激酶抑制剂的化合物
WO2017167953A1 (fr) 2016-03-31 2017-10-05 Janssen Pharmaceuticals, Inc. Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
HRP20210847T1 (hr) 2016-03-31 2021-07-23 Janssen Pharmaceuticals, Inc. Supstituirani derivati indola kao inhibitori replikacije denga virusa
EA201892200A1 (ru) 2016-04-01 2019-03-29 Янссен Фармасьютикалз, Инк. Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) * 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CA3060583C (fr) 2017-05-22 2024-06-04 Janssen Pharmaceuticals, Inc. Derives d'indoline substitues utilises en tant qu'inhibiteurs de replication du virus de la dengue
CR20190531A (es) * 2017-05-22 2020-03-05 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
PH12022551160A1 (en) 2019-11-15 2023-09-25 Janssen Pharmaceuticals Inc Treatment and prevention of dengue disease
CN119306651B (zh) * 2024-10-11 2025-12-05 山东大学 一种吲哚3-酰胺类衍生物及其制备方法与应用

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HRP20210847T1 (hr) 2016-03-31 2021-07-23 Janssen Pharmaceuticals, Inc. Supstituirani derivati indola kao inhibitori replikacije denga virusa
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JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CR20190531A (es) 2017-05-22 2020-03-05 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
CA3060583C (fr) 2017-05-22 2024-06-04 Janssen Pharmaceuticals, Inc. Derives d'indoline substitues utilises en tant qu'inhibiteurs de replication du virus de la dengue

Also Published As

Publication number Publication date
AU2016324982B2 (en) 2021-04-15
JP2021181485A (ja) 2021-11-25
ECSP18020055A (es) 2018-04-30
UY36903A (es) 2017-03-31
JP7050666B2 (ja) 2022-04-08
AU2016324982A1 (en) 2018-03-15
EP3350162B1 (fr) 2021-07-14
CL2018000696A1 (es) 2018-07-06
UA122973C2 (uk) 2021-01-27
DK3350162T3 (da) 2021-10-04
CR20180213A (es) 2018-06-27
JP2018528220A (ja) 2018-09-27
EP3350162A1 (fr) 2018-07-25
NI201800039A (es) 2018-07-24
MX381633B (es) 2025-03-12
LT3350162T (lt) 2021-09-27
US20180256545A1 (en) 2018-09-13
WO2017046255A1 (fr) 2017-03-23
US10765662B2 (en) 2020-09-08
CN108473422A (zh) 2018-08-31
IL258043A (en) 2018-05-31
HUE055870T2 (hu) 2021-12-28
PE20181165A1 (es) 2018-07-19
TWI758255B (zh) 2022-03-21
HRP20211352T1 (hr) 2022-02-04
IL258043B (en) 2021-08-31
MX2018003255A (es) 2018-11-09
SI3350162T1 (sl) 2021-11-30
KR102646174B1 (ko) 2024-03-08
KR20180052672A (ko) 2018-05-18
HK1257842A1 (en) 2019-11-01
CN108473422B (zh) 2021-06-15
TW201722913A (zh) 2017-07-01
EA201890722A1 (ru) 2018-09-28
CO2018003471A2 (es) 2018-07-10
ES2893298T3 (es) 2022-02-08
EA035663B1 (ru) 2020-07-23
PH12018500576A1 (en) 2018-10-15
CA2996979A1 (fr) 2017-03-23
JOP20160198B1 (ar) 2022-03-14
CA2996979C (fr) 2024-01-30

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