PE22896A1 - Ester de hidroxiacetil-piperazin-fenil-oxazolidinonas-substituida - Google Patents

Ester de hidroxiacetil-piperazin-fenil-oxazolidinonas-substituida

Info

Publication number
PE22896A1
PE22896A1 PE1994254930A PE25493094A PE22896A1 PE 22896 A1 PE22896 A1 PE 22896A1 PE 1994254930 A PE1994254930 A PE 1994254930A PE 25493094 A PE25493094 A PE 25493094A PE 22896 A1 PE22896 A1 PE 22896A1
Authority
PE
Peru
Prior art keywords
6alkyl
pct
date
3alkyl
och3
Prior art date
Application number
PE1994254930A
Other languages
English (en)
Inventor
Steven J Brickner
Douglas K Hutchinson
Michael R Barbachyn
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE22896A1 publication Critical patent/PE22896A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIEREN A UN COMPUESTO DE FORMULA GENERAL I DONDE: R ES -C(O)-R`, -PO3 o -P(O)(OH)2, DE PREFERENCIA EL PRIMERO; DONDE R` ES C1-6 ALQUILO, -N(R4)2, C1-6 ALQUIL-N(R4)2 ENTRE OTROS , SOBRE TODO CH3, -CH2N(CH3)2, -C2H4-MORFOLINILO o -CH2OH, ESTOS COMPUESTOS SON ENANTIOMEROS OPTICAMENTE PUROS CON LA CONFIGURACION S EN LA POSICION C5 DEL ANILLO OXAZOLIDINONA; R2 Y R3 SE SELECCIONAN ENTRE H o F DE PREFERENCIA UNO H Y OTRO F; R4 SE SELECCIONA INDEPENDIENTEMENTE DE H o C1-6 ALQUILO. ESTOS COMPUESTOS SE CARACTERIZAN POR SER SOLUBLES EN AGUA, PUEDEN SER ADMINISTRADAS POR VIA INTRAVENOSA, ORAL O TOPICA, DICHOS COMPUESTOS SON ANTIMICROBIANOS ESPECIFICAMENTE ESTAFILOCOCOS, ENTEROCOCOS, ESTREPTOCOCOS RESISTENTES A ANTIBIOTICOS MULTIPLES, ORGANISMOS ANAEROBIOS COMO ESPECIES DE BACTEROIDES Y CLOSTRIDIOS, ACIDO RESISTENTES COMO MYCOBACTERIUM TUBERCULOSIS.
PE1994254930A 1993-11-22 1994-11-17 Ester de hidroxiacetil-piperazin-fenil-oxazolidinonas-substituida PE22896A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15598893A 1993-11-22 1993-11-22

Publications (1)

Publication Number Publication Date
PE22896A1 true PE22896A1 (es) 1996-06-07

Family

ID=22557606

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994254930A PE22896A1 (es) 1993-11-22 1994-11-17 Ester de hidroxiacetil-piperazin-fenil-oxazolidinonas-substituida

Country Status (20)

Country Link
US (1) US5652238A (es)
EP (1) EP0730591B1 (es)
JP (1) JP3698724B2 (es)
KR (1) KR100312903B1 (es)
CN (1) CN1046276C (es)
AT (1) ATE182142T1 (es)
AU (1) AU698699B2 (es)
CA (1) CA2174107C (es)
CO (1) CO4290433A1 (es)
DE (1) DE69419523T2 (es)
DK (1) DK0730591T3 (es)
ES (1) ES2133588T3 (es)
GR (1) GR3031420T3 (es)
IL (1) IL111215A0 (es)
LV (1) LV12538B (es)
NZ (1) NZ274966A (es)
PE (1) PE22896A1 (es)
TW (1) TW427987B (es)
WO (1) WO1995014684A1 (es)
ZA (1) ZA947885B (es)

Families Citing this family (63)

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BR9509673A (pt) * 1994-11-15 1997-09-30 Upjohn Co Compostos e uso dos mesmos
PT1019385E (pt) * 1995-09-15 2004-06-30 Upjohn Co N-oxidos de aminoaril-oxazolidinona
ZA969622B (en) * 1995-12-13 1998-05-15 Upjohn Co Oxazolidinone antibacterial agents having a six-membered heteroaromatic ring.
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9614236D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9614238D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
BR9813985A (pt) * 1997-11-12 2000-09-26 Upjohn Co Derivados de oxazolidinona e composições farmacêuticas
AU780197B2 (en) * 1997-11-18 2005-03-10 Pharmacia & Upjohn Company Method of treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy
DE69830811T2 (de) * 1997-11-18 2006-04-27 Pharmacia & Upjohn Co. Llc, Kalamazoo Verwendung von Oxazolidinonderivaten zur Behandlung von Psoriasis
CN1546030A (zh) * 1997-11-18 2004-11-17 �������Ŷ���Լ��������˾ 噁唑烷酮衍生物在治疗关节炎和减少癌症化学疗法毒性中的应用
US6040306A (en) * 1997-11-18 2000-03-21 Pharmacia & Upjohn Company Method of treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
KR20010015910A (ko) * 1998-01-23 2001-02-26 로렌스 티. 마이젠헬더 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6069141A (en) * 1998-02-13 2000-05-30 Pharmacia & Upjohn Company Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
MY122454A (en) * 1998-06-05 2006-04-29 Upjohn Co Use of oxazolidinones for the preparation of a medicament for transdermal delivery
TR200003595T2 (tr) * 1998-06-05 2001-07-23 Astrazeneca Ab Kimyasal bileşikler
CN1305374A (zh) * 1998-07-14 2001-07-25 法玛西雅厄普约翰美国公司 治疗眼部感染的噁唑烷酮
AR020660A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Composiciones antibioticas para el tratamiento de ojos, oidos y nariz
JP2002535680A (ja) 1999-01-27 2002-10-22 ファルマシア・アンド・アップジョン・カンパニー 延長因子ｐ活性モジュレーターのアッセイ方法
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
PE20010851A1 (es) * 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
US6642238B2 (en) 2000-02-10 2003-11-04 Pharmacia And Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
BR0111280A (pt) * 2000-06-05 2003-06-10 Dong A Pharm Co Ltd Novos derivados de oxazolidinona e um processo para a preparação dos mesmos
BR0112826A (pt) 2000-07-17 2003-06-24 Ranbaxy Lab Ltd Derivados da oxazolidinona como antimicrobianos
PE20020300A1 (es) * 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
US6861433B2 (en) 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
EP1409464A4 (en) * 2001-07-16 2005-11-02 Ranbaxy Lab Ltd OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
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BR0307898A (pt) * 2002-02-22 2004-12-07 Pharmacia Corp Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
BR0308806A (pt) * 2002-03-29 2005-01-04 Upjohn Co Uso de oxazolidinonas para tratar infecções do tipo pé diabético
ES2258234T3 (es) * 2002-08-12 2006-08-16 PHARMACIA & UPJOHN COMPANY LLC N-aril-2-oxazolidinonas y sus derivados.
EP1578734A1 (en) * 2002-08-22 2005-09-28 Orchid Chemicals and Pharmaceuticals Ltd Novel antibacterial agents
AU2002339721A1 (en) * 2002-09-20 2004-04-08 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
JP2006509035A (ja) * 2002-11-21 2006-03-16 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのｎ−（４−（ピペラジン−１−イル）−フェニル−２−オキサゾリジノン−５−カルボキサミド誘導体および関連化合物
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KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
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KR101918678B1 (ko) 2009-02-03 2018-11-14 머크 샤프 앤드 돔 코포레이션 Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형
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Also Published As

Publication number Publication date
IL111215A0 (en) 1994-12-29
DE69419523T2 (de) 1999-11-25
KR100312903B1 (ko) 2002-02-28
DE69419523D1 (en) 1999-08-19
CO4290433A1 (es) 1996-04-17
CA2174107A1 (en) 1995-06-01
DK0730591T3 (da) 2000-01-31
CA2174107C (en) 2005-04-12
AU698699B2 (en) 1998-11-05
ATE182142T1 (de) 1999-07-15
CN1135752A (zh) 1996-11-13
EP0730591A1 (en) 1996-09-11
EP0730591B1 (en) 1999-07-14
JP3698724B2 (ja) 2005-09-21
KR960705818A (ko) 1996-11-08
WO1995014684A1 (en) 1995-06-01
LV12538B (en) 2000-12-20
GR3031420T3 (en) 2000-01-31
ES2133588T3 (es) 1999-09-16
NZ274966A (en) 1998-01-26
CN1046276C (zh) 1999-11-10
TW427987B (en) 2001-04-01
AU8010394A (en) 1995-06-13
LV12538A (en) 2000-10-20
JPH09505582A (ja) 1997-06-03
ZA947885B (en) 1996-04-09
US5652238A (en) 1997-07-29

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