PH12016500864A1 - Microporous zirconium silicate for the treatment of hyperkalemia - Google Patents

Microporous zirconium silicate for the treatment of hyperkalemia

Info

Publication number: PH12016500864A1
Authority: PH; Philippines
Prior art keywords: treatment; hyperkalemia; compositions; zirconium silicate; microporous zirconium
Prior art date: 2013-11-08

Application number

PH12016500864A

Other languages

English (en)

Inventor

Keyser Donald Jeffrey;

Alvaro F Guillem

Original Assignee

Zs Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-11-08

Filing date

2016-05-10

Publication date

2016-07-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53042126&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH12016500864(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2016-05-10 Application filed by Zs Pharma Inc filed Critical Zs Pharma Inc

2016-07-18 Publication of PH12016500864A1 publication Critical patent/PH12016500864A1/en

Links

208000002682 Hyperkalemia Diseases 0.000 title abstract 2
GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 title abstract 2
239000000203 mixture Substances 0.000 abstract 4
101100243022 Mus musculus Pcnt gene Proteins 0.000 abstract 1
206010052779 Transplant rejections Diseases 0.000 abstract 1
208000020832 chronic kidney disease Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
229910001414 potassium ion Inorganic materials 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
239000003053 toxin Substances 0.000 abstract 1
231100000765 toxin Toxicity 0.000 abstract 1
108700012359 toxins Proteins 0.000 abstract 1
208000019553 vascular disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/14—Base exchange silicates, e.g. zeolites

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Analytical Chemistry (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PH12016500864A 2013-11-08 2016-05-10 Microporous zirconium silicate for the treatment of hyperkalemia PH12016500864A1 (en)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US201361901886P	2013-11-08	2013-11-08
US201361914354P	2013-12-10	2013-12-10
US201461930328P	2014-01-22	2014-01-22
US201461930336P	2014-01-22	2014-01-22
US201462005484P	2014-05-30	2014-05-30
US201462015215P	2014-06-20	2014-06-20
US201462053732P	2014-09-22	2014-09-22
PCT/US2014/064548 WO2015070019A1 (fr)	2013-11-08	2014-11-07	Silicate de zirconium microporeux pour le traitement de l'hyperkaliémie

Publications (1)

Publication Number	Publication Date
PH12016500864A1 true PH12016500864A1 (en)	2016-07-18

Family

ID=53042126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH12016500864A PH12016500864A1 (en)	2013-11-08	2016-05-10	Microporous zirconium silicate for the treatment of hyperkalemia

Country Status (14)

Country	Link
US (2)	US20150290242A1 (fr)
EP (2)	EP4378577A3 (fr)
JP (1)	JP2016535754A (fr)
KR (1)	KR102332954B1 (fr)
CN (1)	CN106170283B (fr)
AU (1)	AU2014346576B2 (fr)
CA (1)	CA2929978C (fr)
CL (1)	CL2016001095A1 (fr)
IL (1)	IL245526B (fr)
MX (1)	MX392710B (fr)
PH (1)	PH12016500864A1 (fr)
TW (1)	TW201607543A (fr)
WO (1)	WO2015070019A1 (fr)
ZA (1)	ZA201603171B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20160038538A1 (en) *	2013-11-08	2016-02-11	ZS Pharma, Inc.	Microporous zirconium silicate for the treatment of hyperkalemia
US9592253B1 (en) *	2015-10-14	2017-03-14	ZS Pharma, Inc.	Extended use zirconium silicate compositions and methods of use thereof
US10668098B2 (en) *	2017-07-07	2020-06-02	Hemocleanse Technology Llc	Oral sorbent for removing toxins of kidney failure combining anion and cation exchangers
AU2018360868B2 (en) *	2017-11-03	2025-01-02	Tricida, Inc.	Method of treating acid-base disorders
WO2019092179A1 (fr) *	2017-11-10	2019-05-16	Sandoz Ag	Compositions pharmaceutiques comprenant zs-9
BR112021017791A2 (pt) *	2019-03-13	2022-02-01	Astrazeneca Ab	Agentes de ligação ao potássio para uso em pacientes em hemodiálise
US20240000940A1 (en) *	2020-12-01	2024-01-04	Nanobiotix S.A.	Porous, high-z and carbon-free particles as radioenhancers
CN117342570B (zh) *	2023-09-04	2026-02-10	杭州国瑞生物科技有限公司	一种环硅酸锆钠的a晶型及其制备方法
CN117735564B (zh) *	2023-12-19	2025-12-19	杭州国瑞生物科技有限公司	一种环硅酸锆钠的b晶型及其制备方法与应用
CN118458789A (zh) *	2024-05-11	2024-08-09	上海博悦生物科技有限公司	一种环硅酸锆钠相关晶型zs-7的制备方法
CN120172420B (zh) *	2025-03-21	2025-12-23	时森海(杭州)医药科技有限公司	控制粒径分布的环硅酸锆钠及其制备方法
CN120984211A (zh) *	2025-06-13	2025-11-21	时森海(杭州)医药科技有限公司	生产环硅酸锆钠的反应器和方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3329480A (en) *	1963-10-18	1967-07-04	Union Oil Co	Crystalline zircono-silicate zeolites
US4581141A (en) *	1978-02-27	1986-04-08	Purdue Research Foundation	Dialysis material and method for removing uremic substances
JP3310282B2 (ja) *	1990-05-28	2002-08-05	エンゲルハード・コーポレーシヨン	少なくとも１個の正八面体部位と少なくとも１種の型の正四面体部位とを有する大孔モレキュラーシーブ
US5338527A (en) *	1992-08-20	1994-08-16	Uop	Zirconium silicate composition, method of preparation and uses thereof
US5888472A (en) *	1997-04-08	1999-03-30	Uop Llc	Zirconium silicate molecular sieves and process using the same
US5891417A (en) *	1997-04-08	1999-04-06	Uop Llc	Zirconium silicate and zirconium germanate molecular sieves and process using the same
EP1038580B1 (fr) *	1999-03-26	2005-05-25	Uop Llc	Procédé d'adsorption d'ions ammonium utilisant des tamis moléculaires à base de silicate de zirconium et germanate de zirconium
US6099737A (en)	1999-03-29	2000-08-08	Uop Llc	Process for removing toxins from blood using zirconium metallate or titanium metallate compositions
US6332985B1 (en) *	1999-03-29	2001-12-25	Uop Llc	Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions
AU2002242103A1 (en) *	2001-02-06	2002-08-19	Ash Medical Systems, Inc.	Monovalent-selective cation exchangers as oral sorbent therapy
US6579460B1 (en)	2001-03-13	2003-06-17	Uop Llc	Process and composition for removing toxins from bodily fluids
US6814871B1 (en)	2001-07-13	2004-11-09	Uop Llc	Process for removing pollutants from aqueous streams
US7556799B2 (en) *	2004-03-30	2009-07-07	Relypsa, Inc.	Ion binding polymers and uses thereof
WO2010144865A2 (fr) *	2009-06-12	2010-12-16	Meritage Pharma, Inc.	Procédés de traitement de troubles gastro-intestinaux
SI2673237T2 (sl) *	2011-02-11	2025-12-31	Zs Pharma, Inc	Uporaba cirkonijevega silikata v zdravljenju hiperkalemije
US9943637B2 (en)	2012-06-11	2018-04-17	ZS Pharma, Inc.	Microporous zirconium silicate and its method of production
CN104968336A (zh) *	2012-07-11	2015-10-07	Zs制药公司	用于治疗高钙血症患者高钾血症的微孔硅酸锆以及用于治疗高钾血症的改进的含钙组合物
CN104797263B (zh) *	2012-10-22	2018-02-09	Zs制药公司	用于治疗高钾血症的微孔硅酸锆

2014
- 2014-11-07 CA CA2929978A patent/CA2929978C/fr active Active
- 2014-11-07 EP EP24165451.6A patent/EP4378577A3/fr active Pending
- 2014-11-07 JP JP2016528228A patent/JP2016535754A/ja active Pending
- 2014-11-07 US US14/536,056 patent/US20150290242A1/en not_active Abandoned
- 2014-11-07 EP EP14860387.1A patent/EP3065710A4/fr not_active Withdrawn
- 2014-11-07 MX MX2016005940A patent/MX392710B/es unknown
- 2014-11-07 KR KR1020167015281A patent/KR102332954B1/ko active Active
- 2014-11-07 WO PCT/US2014/064548 patent/WO2015070019A1/fr not_active Ceased
- 2014-11-07 AU AU2014346576A patent/AU2014346576B2/en active Active
- 2014-11-07 CN CN201480072530.5A patent/CN106170283B/zh active Active
- 2014-11-10 TW TW103138968A patent/TW201607543A/zh unknown
2015
- 2015-06-26 US US14/752,364 patent/US20150374748A1/en not_active Abandoned
2016
- 2016-05-06 CL CL2016001095A patent/CL2016001095A1/es unknown
- 2016-05-08 IL IL245526A patent/IL245526B/en active IP Right Grant
- 2016-05-10 PH PH12016500864A patent/PH12016500864A1/en unknown
- 2016-05-11 ZA ZA201603171A patent/ZA201603171B/en unknown

Also Published As

Publication number	Publication date
TW201607543A (zh)	2016-03-01
JP2016535754A (ja)	2016-11-17
MX392710B (es)	2025-03-24
WO2015070019A1 (fr)	2015-05-14
IL245526A0 (en)	2016-06-30
CN106170283A (zh)	2016-11-30
AU2014346576A1 (en)	2016-06-09
CL2016001095A1 (es)	2016-11-11
EP3065710A4 (fr)	2017-05-17
EP4378577A2 (fr)	2024-06-05
EP3065710A1 (fr)	2016-09-14
IL245526B (en)	2020-01-30
CA2929978C (fr)	2021-11-30
CN106170283B (zh)	2019-08-20
KR102332954B1 (ko)	2021-11-29
EP4378577A3 (fr)	2024-10-23
AU2014346576B2 (en)	2020-03-26
ZA201603171B (en)	2020-11-25
KR20160073424A (ko)	2016-06-24
MX2016005940A (es)	2016-08-17
US20150290242A1 (en)	2015-10-15
CA2929978A1 (fr)	2015-05-14
US20150374748A1 (en)	2015-12-31

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