PH20444A - Enhancement of intranasal absorption of calcitonin by formulation with surfactants - Google Patents

Enhancement of intranasal absorption of calcitonin by formulation with surfactants

Info

Publication number: PH20444A
Authority: PH; Philippines
Prior art keywords: calcitonin; enhancement; surfactants; formulation; intranasal absorption
Prior art date: 1982-12-29

Application number

PH30054A

Other languages

English (en)

Inventor

Daniel Mufson

Musetta A Hanson

Original Assignee

Armour Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-29

Filing date

1983-12-29

Publication date

1987-01-09

1983-12-29 Application filed by Armour Pharma filed Critical Armour Pharma

1987-01-09 Publication of PH20444A publication Critical patent/PH20444A/en

Links

239000004094 surface-active agent Substances 0.000 title abstract 2
102000055006 Calcitonin Human genes 0.000 title 1
108060001064 Calcitonin Proteins 0.000 title 1
238000010521 absorption reaction Methods 0.000 title 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title 1
229960004015 calcitonin Drugs 0.000 title 1
238000009472 formulation Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000012736 aqueous medium Substances 0.000 abstract 1
230000004097 bone metabolism Effects 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Otolaryngology (AREA)
Endocrinology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

PH30054A 1982-12-29 1983-12-29 Enhancement of intranasal absorption of calcitonin by formulation with surfactants PH20444A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45412882A	1982-12-29	1982-12-29

Publications (1)

Publication Number	Publication Date
PH20444A true PH20444A (en)	1987-01-09

Family

ID=23803421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH30054A PH20444A (en)	1982-12-29	1983-12-29	Enhancement of intranasal absorption of calcitonin by formulation with surfactants

Country Status (13)

Country	Link
EP (1)	EP0115627B1 (de)
JP (1)	JPS59130820A (de)
AT (1)	ATE26215T1 (de)
AU (1)	AU572815B2 (de)
CA (1)	CA1222948A (de)
DE (1)	DE3370586D1 (de)
DK (1)	DK602783A (de)
IE (1)	IE56441B1 (de)
IL (1)	IL70489A0 (de)
MX (1)	MX7547E (de)
NZ (1)	NZ206728A (de)
PH (1)	PH20444A (de)
ZA (1)	ZA839655B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH657779A5 (de) *	1982-10-05	1986-09-30	Sandoz Ag	Galenische zusammensetzungen enthaltend calcitonin.
JPS5989619A (ja) *	1982-10-05	1984-05-23	サンド・アクチエンゲゼルシヤフト	カルシトニン組成物およびその用途
GB8514090D0 (en) *	1985-06-04	1985-07-10	Sandoz Ltd	Organic compounds
JPS61267528A (ja) *	1984-11-26	1986-11-27	Yamanouchi Pharmaceut Co Ltd	吸収促進剤を含有するカルシトニン経鼻剤
JPS61194034A (ja) *	1985-02-25	1986-08-28	Teijin Ltd	経鼻投与用粉末状組成物
JPH0651637B2 (ja) *	1985-03-28	1994-07-06	エーザイ株式会社	ペプタイドの吸着防止組成物
GB2177914B (en) *	1985-06-04	1989-10-25	Chugai Pharmaceutical Co Ltd	A pharmaceutical composition containing human erythropoietin and a surface active agent for nasal administration for the treatment of anemia
US4692441A (en) *	1985-08-16	1987-09-08	Merck & Co., Inc.	Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities
US4731360A (en) *	1985-08-16	1988-03-15	Merck & Co., Inc.	Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments
DE3601923A1 (de) *	1986-01-23	1987-07-30	Behringwerke Ag	Nasal applizierbares arzneimittel, verfahren zu seiner herstellung und seine verwendung
CA1291036C (en) *	1986-04-23	1991-10-22	Edwin I. Stoltz	Nasal administration of drugs
MY102411A (en) *	1986-12-23	1992-06-17	Ciba Geigy Ag	Nasal solutions
EP0296227A1 (de) *	1987-01-08	1988-12-28	Nastech Pharmaceutical Company, Inc.	Verabreichung von aminosäuren durch die nase
HU203204B (en) *	1987-09-15	1991-06-28	Sandoz Ag	Process for producing suppository containing calcitonin and taurocholic acid
EP0327756B1 (de) *	1987-11-13	1994-01-26	Smithkline Beecham Farmaceutici S.p.A.	Ein Calcitonin sowie ein Glycyrrhizinat als Absorptionsförderer enthaltende Arzneimittel
HU206367B (en) *	1988-04-30	1992-10-28	Sandoz Ag	Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts
GR880100604A (el) *	1988-09-14	1994-03-31	Sandoz Ag	Βελτιώσεις σε ή σχετικά με καλσιτονίνες.
US5514365A (en) *	1988-10-11	1996-05-07	Schiapparelli Salute S.P.A.	Pharmaceutical compositions comprising calcitonin for intranasal administration
US5182258A (en) *	1989-03-20	1993-01-26	Orbon Corporation	Systemic delivery of polypeptides through the eye
IT8920486A0 (it) *	1989-05-12	1989-05-12	Isf Spa	Composizioni farmaceutiche.
JP2514249B2 (ja) *	1989-05-23	1996-07-10	帝人株式会社	安定化されたカルシトニン類医薬組成物
JP2911496B2 (ja) *	1989-09-11	1999-06-23	帝國製薬株式会社	生理活性ポリペプチド含有高吸収性経膣剤
JPH0643339B2 (ja) *	1990-05-25	1994-06-08	旭化成工業株式会社	カルシトニン類水溶液組成物の安定化法
JPH078806B2 (ja) *	1990-08-16	1995-02-01	旭化成工業株式会社	カルシトニン類含有経鼻投与用乳剤
IT1242019B (it) *	1990-11-20	1994-02-02	Ripari Gero Ist Farm Biolog	Composizioni farmaceutiche acquose a base di calcitonina, da somministrarsi per via nasale.
DE4222647A1 (de) *	1991-07-15	1993-01-21	Sandoz Ag	Peptid-zubereitungen
JPH06305952A (ja) *	1993-04-27	1994-11-01	Sumitomo Pharmaceut Co Ltd	スレオ−３−（３，４−ジヒドロキシフェニル）セリン経鼻投与製剤
US5514670A (en) *	1993-08-13	1996-05-07	Pharmos Corporation	Submicron emulsions for delivery of peptides
US5744155A (en) *	1993-08-13	1998-04-28	Friedman; Doron	Bioadhesive emulsion preparations for enhanced drug delivery
JPH11292787A (ja) *	1995-08-15	1999-10-26	Asahi Chem Ind Co Ltd	生理活性ペプチドを含有する経粘膜投与製剤
IT1282374B1 (it) *	1996-01-31	1998-03-20	Therapicon Srl	Composizioni farmaceutiche parenterali a base di calcitonine sintetiche a ph controllato con basso indice di dolorosita'
EP0983769A4 (de)	1997-04-14	2002-05-02	Mitsubishi Tokyo Pharm Inc	Permucose formulierung
TWI243687B (en)	1998-04-21	2005-11-21	Teijin Ltd	Pharmaceutical composition for application to mucosa
JP2000247911A (ja)	1999-02-26	2000-09-12	Hisamitsu Pharmaceut Co Inc	大腸用吸収促進剤
AR026073A1 (es)	1999-10-20	2002-12-26	Nycomed Gmbh	Composicion farmaceutica acuosa que contiene ciclesonida
CN1183965C (zh)	2000-02-04	2005-01-12	尤尼金实验室公司	鼻内降钙素制剂
US7591999B2 (en)	2003-03-04	2009-09-22	Mitsubishi Tanabe Pharma Corporation	Powdery preparation for nasal administration
US7812120B2 (en)	2003-03-21	2010-10-12	Par Pharmaceutical, Inc.	Nasal calcitonin formulations containing chlorobutanol

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2254061A1 (de) *	1972-11-04	1974-05-16	Hoechst Ag	Lh-releasing hormon zur nasalen applikation
CA1098444A (en) *	1975-05-26	1981-03-31	Leo Geller	Peptide preparations with prolonged action
GB1527605A (en) *	1975-08-20	1978-10-04	Takeda Chemical Industries Ltd	Insulin preparation for intranasal administration
US4241051A (en) *	1977-11-04	1980-12-23	Christie Robert B	Calcitonin
JPS56122309A (en) *	1980-03-03	1981-09-25	Teijin Ltd	Calcitonin pharmaceutical for rectal administration
AU6596080A (en) *	1981-01-02	1981-06-25	Henkel Kgaa	Treatment of disorders of calcium metabolism
JPS5989619A (ja) *	1982-10-05	1984-05-23	サンド・アクチエンゲゼルシヤフト	カルシトニン組成物およびその用途
CH657779A5 (de) *	1982-10-05	1986-09-30	Sandoz Ag	Galenische zusammensetzungen enthaltend calcitonin.

1983
- 1983-12-20 AU AU22596/83A patent/AU572815B2/en not_active Ceased
- 1983-12-20 IL IL70489A patent/IL70489A0/xx unknown
- 1983-12-22 CA CA000444099A patent/CA1222948A/en not_active Expired
- 1983-12-23 EP EP83113070A patent/EP0115627B1/de not_active Expired
- 1983-12-23 DE DE8383113070T patent/DE3370586D1/de not_active Expired
- 1983-12-23 AT AT83113070T patent/ATE26215T1/de not_active IP Right Cessation
- 1983-12-26 MX MX8310951U patent/MX7547E/es unknown
- 1983-12-27 JP JP58244931A patent/JPS59130820A/ja active Pending
- 1983-12-28 ZA ZA839655A patent/ZA839655B/xx unknown
- 1983-12-28 DK DK602783A patent/DK602783A/da not_active Application Discontinuation
- 1983-12-29 IE IE3071/83A patent/IE56441B1/xx unknown
- 1983-12-29 PH PH30054A patent/PH20444A/en unknown
1984
- 1984-01-05 NZ NZ206728A patent/NZ206728A/en unknown

Also Published As

Publication number	Publication date
DK602783A (da)	1984-06-30
IE833071L (en)	1984-06-29
EP0115627A1 (de)	1984-08-15
AU572815B2 (en)	1988-05-19
JPS59130820A (ja)	1984-07-27
DK602783D0 (da)	1983-12-28
IE56441B1 (en)	1991-07-31
DE3370586D1 (en)	1987-05-07
AU2259683A (en)	1984-07-05
ZA839655B (en)	1984-08-29
ATE26215T1 (de)	1987-04-15
EP0115627B1 (de)	1987-04-01
MX7547E (es)	1989-09-14
NZ206728A (en)	1986-02-21
CA1222948A (en)	1987-06-16
IL70489A0 (en)	1984-03-30

Publication	Publication Date	Title
DE3370586D1 (en)	1987-05-07	Enhancement of intranasal absorption of calcitonin by formulation with surfactants
HRP920667B1 (en)	1998-06-30	Application of fultripine active substance for preventing muscle deformation
SE8601709D0 (sv)	1986-04-16	Farmaceutiskt medel samt komposition innehallande detta
HU900108D0 (en)	1990-03-28	Composition of controlled active ingredient delivery, operating by hydrogel
IT1142135B (it)	1986-10-08	Polietilenimmina impiegata per l'assorbimento di sostanze alfattivamente attive
IE830777L (en)	1983-11-03	Compositions of imazolil and hexamidine isethionate for acne
HUT41951A (en)	1987-06-29	Process for producing insecticide compositions containing fluorinated ethers as active agents and process for producing the active agents
PH21102A (en)	1987-07-16	Improvements in or relating to benzothiophene derivatives as antiastmatic agents
GB2090529A (en)	1982-07-14	Thrombosis-prophylactic and curing agent
ZA825971B (en)	1983-06-29	Stable s-adenosylmethionine salts the process for their preparation and therapeutic compositions which contain them as active principle
CA2002472A1 (en)	1990-05-10	Liquid oral formulation
FR2522266B1 (fr)	1987-07-31	Procede de preparation d'un agent fibrinolytiquement actif et agent obtenu
EP0180737A3 (en)	1986-05-28	Use of preparations containing gamma-interferon (ifn-gamma) for treating rheumatic diseases
DE3363447D1 (en)	1986-06-19	Process for the preparation of optically active thiol compounds
EP0114048A3 (en)	1984-08-29	Use of d,l and d-carazolole as an antiglaucoma agent, and pharmaceutical compositions containing them
DE3272384D1 (en)	1986-09-04	Medicinal composition for the treatment of certain neuroviroses
IL88737A (en)	1992-09-06	Aqueous pharmaceutical dithranol formulations for topical use
ZA814902B (en)	1982-08-25	Novel thiazol-2-yl-oxamic acid derivatives,their preparation and therapeutic agents containing these compounds
JPS5739866A (en)	1982-03-05	Face frame body of face mask for ball game
IL71051A (en)	1988-02-29	Compositions containing active lipids for the treatment of cystic fibrosis
EP0092386A3 (en)	1985-03-06	Hydantoin therapeutic agents
DE3174977D1 (en)	1986-08-28	Bioactive composition containing vegetable agents
IT8335937V0 (it)	1983-07-06	Bastoncino per l'applicazione di agenti attivi negli occhi
SU952068A1 (ru)	1994-11-30	Активное вещество для жидкостных лазеров
IT1272740B (it)	1997-06-26	Composizioni farmaceutiche contenenti una sostanza attiva fosfatidilinositolo atte alla terapia delle neurpatie periferiche da diabete mellito