PH23389A - 1-substituted-4-(thiazolyl-2-)piperazines piperidines and tetrahydropyridines useful as anxiolytic psychogeriatric antidepressant and antischizophrenic agents - Google Patents
1-substituted-4-(thiazolyl-2-)piperazines piperidines and tetrahydropyridines useful as anxiolytic psychogeriatric antidepressant and antischizophrenic agentsInfo
- Publication number
- PH23389A PH23389A PH33910A PH33910A PH23389A PH 23389 A PH23389 A PH 23389A PH 33910 A PH33910 A PH 33910A PH 33910 A PH33910 A PH 33910A PH 23389 A PH23389 A PH 23389A
- Authority
- PH
- Philippines
- Prior art keywords
- psychogeriatric
- tetrahydropyridines
- piperazines
- anxiolytic
- antidepressant
- Prior art date
Links
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 230000002932 anti-schizophrenic effect Effects 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- 239000002249 anxiolytic agent Substances 0.000 title 1
- 230000000949 anxiolytic effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- -1 piperazines piperidines Chemical class 0.000 title 1
- 125000004853 tetrahydropyridinyl group Chemical class N1(CCCC=C1)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3522354 | 1985-06-22 | ||
| DE3522353 | 1985-06-22 | ||
| DE3522351 | 1985-06-22 | ||
| DE3605868 | 1986-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH23389A true PH23389A (en) | 1989-07-26 |
Family
ID=27433378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH33910A PH23389A (en) | 1985-06-22 | 1986-06-20 | 1-substituted-4-(thiazolyl-2-)piperazines piperidines and tetrahydropyridines useful as anxiolytic psychogeriatric antidepressant and antischizophrenic agents |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4737500A (fr) |
| AU (1) | AU5894086A (fr) |
| BE (1) | BE904945A (fr) |
| CH (1) | CH668426A5 (fr) |
| DK (1) | DK292986A (fr) |
| ES (2) | ES8802154A1 (fr) |
| FI (1) | FI862644A7 (fr) |
| FR (1) | FR2587342A1 (fr) |
| GB (1) | GB2177395B (fr) |
| GR (1) | GR861601B (fr) |
| HU (1) | HUT43600A (fr) |
| IL (1) | IL79178A0 (fr) |
| IT (1) | IT1203806B (fr) |
| LU (1) | LU86487A1 (fr) |
| NL (1) | NL8601494A (fr) |
| PH (1) | PH23389A (fr) |
| SE (1) | SE8602723L (fr) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| NL8601494A (nl) * | 1985-06-22 | 1987-01-16 | Sandoz Ag | Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten. |
| MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| FR2612187B1 (fr) * | 1987-03-12 | 1989-07-21 | Sanofi Sa | Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant |
| US4804751A (en) * | 1987-06-30 | 1989-02-14 | American Home Products Corporation | Polycyclic hydrocarbon succinimides with psychotropic activity |
| EP0307141B1 (fr) * | 1987-09-10 | 1993-01-13 | MERCK SHARP & DOHME LTD. | Oxazoles et thiazoles pour le traitement de la démence sénile |
| US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
| EP0350145A3 (fr) * | 1988-04-28 | 1990-07-04 | Yamanouchi Pharmaceutical Co. Ltd. | Derivés de Pyridylthiazolidine carboxamide et intermédiaires et leur production |
| US4935424A (en) * | 1988-05-27 | 1990-06-19 | Warner-Lambert Company | 4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents |
| US4957916A (en) * | 1988-08-05 | 1990-09-18 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
| US5015740A (en) * | 1988-08-05 | 1991-05-14 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
| FI911285A7 (fi) * | 1988-09-16 | 1991-03-15 | Pfizer | Antipsykoottisia bisyklisiä 4-/4-(3-bentsisotiatsolyyli)-1-piperatsiny yli/butyylisiltaimidejä |
| US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| US5130315A (en) * | 1991-01-10 | 1992-07-14 | Raymond R. Wittekind | 1-piperazinyl-2-butenes and -2-butynes |
| US5194436A (en) * | 1991-01-10 | 1993-03-16 | Hoechst-Roussel Pharmaceuticals Inc. | 1-piperazinyl-2-butenes and -2-butynes |
| IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
| CN1074923C (zh) * | 1993-11-19 | 2001-11-21 | 詹森药业有限公司 | 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类 |
| US5889010A (en) * | 1995-05-18 | 1999-03-30 | Pfizer Inc. | Benzimidazole derivatives having dopaminergic activity |
| DE19746612A1 (de) | 1997-10-22 | 1999-04-29 | Basf Ag | 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung |
| US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
| US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| AU2005235422B2 (en) * | 2004-04-22 | 2011-08-11 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for the treatment of sexual disorders II |
| US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
| US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
| JP2008511569A (ja) * | 2004-09-03 | 2008-04-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 注意欠如活動過多障害の治療方法 |
| WO2006096435A1 (fr) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Compositions pharmaceutiques utiles dans le traitement et/ou la prevention de la depression |
| WO2006096434A2 (fr) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Compositions pharmaceutiques permettant de traiter et/ou de prevenir les troubles de l'anxiete |
| WO2006096439A2 (fr) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Compositions pharmaceutiques destinees au traitement et/ou a la prevention de la schizophrenie et de maladies associees |
| WO2006119884A2 (fr) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Methode de traitement de la toxicomanie |
| US20060264511A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug-induced sexual dysfunction |
| JP2009503020A (ja) | 2005-08-03 | 2009-01-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肥満症の治療におけるフリバンセリンの使用 |
| US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
| CA2626134C (fr) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Derives de benzimidazolone utiles pour le traitement des troubles premenstruels et d'autres troubles sexuels chez la femme |
| US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
| MX2008013827A (es) * | 2006-05-09 | 2008-11-10 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de trastornos posmenopausicos del deseo sexual. |
| EP2037927B1 (fr) * | 2006-06-30 | 2010-01-27 | Boehringer Ingelheim International GmbH | Flibansérine dans le traitement de l'incontinence urinaire et des maladies associées |
| WO2008006838A1 (fr) * | 2006-07-14 | 2008-01-17 | Boehringer Ingelheim International Gmbh | Utilisation de flibansérine pour le traitement de troubles sexuels chez les femmes |
| JP5793828B2 (ja) | 2006-08-14 | 2015-10-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フリバンセリンの製剤及びその製造方法 |
| CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
| KR20090045945A (ko) | 2006-08-25 | 2009-05-08 | 베링거 인겔하임 인터내셔날 게엠베하 | 제어 방출 시스템 및 이의 제조방법 |
| WO2008121019A1 (fr) * | 2007-03-29 | 2008-10-09 | Obschestvo S Ogranishennoi Otvetstvennostu 'farmving' | Produit à activité anti-allergique anti-histaminique et procédé de fabrication correspondant |
| CL2008002693A1 (es) * | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
| CA2686480A1 (fr) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | Nouveaux sels |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL297170A (fr) * | 1963-04-04 | 1900-01-01 | ||
| DE1595923A1 (de) * | 1965-02-20 | 1969-11-27 | Merck Ag E | 1-Aralkyl-4-(thiazolyl-2)-piperazine und Verfahren zu ihrer Herstellung |
| BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
| JPS5246935B1 (fr) * | 1971-04-06 | 1977-11-29 | ||
| BE787059A (fr) * | 1971-08-03 | 1973-02-01 | Wander Ag Dr A | Nouveaux derives du thiazole, leur preparation et leur application comme medicaments |
| CH583232A5 (fr) * | 1973-02-02 | 1976-12-31 | Wander Ag Dr A | |
| US4182763A (en) * | 1978-05-22 | 1980-01-08 | Mead Johnson & Company | Buspirone anti-anxiety method |
| US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
| DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| NL8601494A (nl) * | 1985-06-22 | 1987-01-16 | Sandoz Ag | Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten. |
-
1986
- 1986-06-09 NL NL8601494A patent/NL8601494A/nl not_active Application Discontinuation
- 1986-06-09 HU HU862433A patent/HUT43600A/hu unknown
- 1986-06-12 CH CH2373/86A patent/CH668426A5/de not_active IP Right Cessation
- 1986-06-18 SE SE8602723A patent/SE8602723L/xx not_active Application Discontinuation
- 1986-06-18 FR FR8608893A patent/FR2587342A1/fr active Pending
- 1986-06-18 BE BE1/011508A patent/BE904945A/fr not_active IP Right Cessation
- 1986-06-19 FI FI862644A patent/FI862644A7/fi not_active IP Right Cessation
- 1986-06-19 GB GB8614974A patent/GB2177395B/en not_active Expired
- 1986-06-20 IT IT48157/86A patent/IT1203806B/it active
- 1986-06-20 LU LU86487A patent/LU86487A1/fr unknown
- 1986-06-20 DK DK292986A patent/DK292986A/da not_active Application Discontinuation
- 1986-06-20 AU AU58940/86A patent/AU5894086A/en not_active Abandoned
- 1986-06-20 IL IL79178A patent/IL79178A0/xx unknown
- 1986-06-20 GR GR861601A patent/GR861601B/el unknown
- 1986-06-20 ES ES556363A patent/ES8802154A1/es not_active Expired
- 1986-06-20 PH PH33910A patent/PH23389A/en unknown
- 1986-06-20 US US06/876,617 patent/US4737500A/en not_active Expired - Fee Related
-
1987
- 1987-09-15 ES ES557723A patent/ES8802045A1/es not_active Expired
-
1988
- 1988-02-02 US US07/151,349 patent/US4892879A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SE8602723D0 (sv) | 1986-06-18 |
| ES8802045A1 (es) | 1988-03-16 |
| FI862644A7 (fi) | 1986-12-23 |
| IL79178A0 (en) | 1986-09-30 |
| GB2177395A (en) | 1987-01-21 |
| DK292986D0 (da) | 1986-06-20 |
| GB8614974D0 (en) | 1986-07-23 |
| US4737500A (en) | 1988-04-12 |
| IT8648157A0 (it) | 1986-06-20 |
| NL8601494A (nl) | 1987-01-16 |
| ES556363A0 (es) | 1988-04-01 |
| AU5894086A (en) | 1986-12-24 |
| FR2587342A1 (fr) | 1987-03-20 |
| BE904945A (fr) | 1986-12-18 |
| GB2177395B (en) | 1989-04-26 |
| DK292986A (da) | 1986-12-23 |
| ES557723A0 (es) | 1988-03-16 |
| GR861601B (en) | 1986-10-20 |
| LU86487A1 (fr) | 1987-01-13 |
| IT1203806B (it) | 1989-02-23 |
| HUT43600A (en) | 1987-11-30 |
| ES8802154A1 (es) | 1988-04-01 |
| CH668426A5 (de) | 1988-12-30 |
| SE8602723L (sv) | 1986-12-23 |
| FI862644A0 (fi) | 1986-06-19 |
| US4892879A (en) | 1990-01-09 |
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