PH23389A - 1-substituted-4-(thiazolyl-2-)piperazines piperidines and tetrahydropyridines useful as anxiolytic psychogeriatric antidepressant and antischizophrenic agents - Google Patents

1-substituted-4-(thiazolyl-2-)piperazines piperidines and tetrahydropyridines useful as anxiolytic psychogeriatric antidepressant and antischizophrenic agents

Info

Publication number
PH23389A
PH23389A PH33910A PH33910A PH23389A PH 23389 A PH23389 A PH 23389A PH 33910 A PH33910 A PH 33910A PH 33910 A PH33910 A PH 33910A PH 23389 A PH23389 A PH 23389A
Authority
PH
Philippines
Prior art keywords
psychogeriatric
tetrahydropyridines
piperazines
anxiolytic
antidepressant
Prior art date
Application number
PH33910A
Other languages
English (en)
Inventor
Dieter Sorg
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of PH23389A publication Critical patent/PH23389A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PH33910A 1985-06-22 1986-06-20 1-substituted-4-(thiazolyl-2-)piperazines piperidines and tetrahydropyridines useful as anxiolytic psychogeriatric antidepressant and antischizophrenic agents PH23389A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3522351 1985-06-22
DE3522353 1985-06-22
DE3522354 1985-06-22
DE3605868 1986-02-24

Publications (1)

Publication Number Publication Date
PH23389A true PH23389A (en) 1989-07-26

Family

ID=27433378

Family Applications (1)

Application Number Title Priority Date Filing Date
PH33910A PH23389A (en) 1985-06-22 1986-06-20 1-substituted-4-(thiazolyl-2-)piperazines piperidines and tetrahydropyridines useful as anxiolytic psychogeriatric antidepressant and antischizophrenic agents

Country Status (17)

Country Link
US (2) US4737500A (fr)
AU (1) AU5894086A (fr)
BE (1) BE904945A (fr)
CH (1) CH668426A5 (fr)
DK (1) DK292986A (fr)
ES (2) ES8802154A1 (fr)
FI (1) FI862644A7 (fr)
FR (1) FR2587342A1 (fr)
GB (1) GB2177395B (fr)
GR (1) GR861601B (fr)
HU (1) HUT43600A (fr)
IL (1) IL79178A0 (fr)
IT (1) IT1203806B (fr)
LU (1) LU86487A1 (fr)
NL (1) NL8601494A (fr)
PH (1) PH23389A (fr)
SE (1) SE8602723L (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
NL8601494A (nl) * 1985-06-22 1987-01-16 Sandoz Ag Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten.
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2612187B1 (fr) * 1987-03-12 1989-07-21 Sanofi Sa Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant
US4804751A (en) * 1987-06-30 1989-02-14 American Home Products Corporation Polycyclic hydrocarbon succinimides with psychotropic activity
EP0307141B1 (fr) * 1987-09-10 1993-01-13 MERCK SHARP & DOHME LTD. Oxazoles et thiazoles pour le traitement de la démence sénile
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
EP0350145A3 (fr) * 1988-04-28 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. Derivés de Pyridylthiazolidine carboxamide et intermédiaires et leur production
US4935424A (en) * 1988-05-27 1990-06-19 Warner-Lambert Company 4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
WO1990002552A1 (fr) * 1988-09-16 1990-03-22 Pfizer Inc. Imides bicycliques polynucleaires de 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyle a usage antipsychotique
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US5194436A (en) * 1991-01-10 1993-03-16 Hoechst-Roussel Pharmaceuticals Inc. 1-piperazinyl-2-butenes and -2-butynes
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes
IT1251144B (it) * 1991-07-30 1995-05-04 Boehringer Ingelheim Italia Derivati del benzimidazolone
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
DE19746612A1 (de) 1997-10-22 1999-04-29 Basf Ag 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung
US7183410B2 (en) * 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
MXPA06012059A (es) * 2004-04-22 2007-01-25 Boehringer Ingelheim Int Nuevas composiciones farmaceuticas para el tratamiento de los trastornos sexuales ii.
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
EP1789048A1 (fr) * 2004-09-03 2007-05-30 Boehringer Ingelheim International GmbH Methode de traitement du trouble de l'hyperactivite avec deficit de l'attention
US20060199805A1 (en) * 2005-03-04 2006-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
EP1858516A1 (fr) * 2005-03-04 2007-11-28 Boehringer Ingelheim International GmbH Compositions pharmaceutiques utiles dans le traitement et/ou la prevention de la depression
WO2006096439A2 (fr) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Compositions pharmaceutiques destinees au traitement et/ou a la prevention de la schizophrenie et de maladies associees
EP1904182A2 (fr) * 2005-05-06 2008-04-02 Boehringer Ingelheim International GmbH Methode de traitement de la toxicomanie avec flibanserine
CA2608363A1 (fr) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Procede pour le traitement de dysfonctionnements sexuels d'origine medicamenteuse
US8227476B2 (en) 2005-08-03 2012-07-24 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US20070123540A1 (en) * 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
CA2626134C (fr) 2005-10-29 2013-12-24 Boehringer Ingelheim International Gmbh Derives de benzimidazolone utiles pour le traitement des troubles premenstruels et d'autres troubles sexuels chez la femme
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
JP2009536176A (ja) * 2006-05-09 2009-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 閉経後の性的欲求障害の治療のためのフリバンセリンの使用
US20090312242A1 (en) * 2006-06-30 2009-12-17 Ramiro Castro Flibanserin for the treatment of urinary incontinence and related diseases
US20090318469A1 (en) * 2006-07-14 2009-12-24 Boehringer Ingelheim International Gmbh Use of Flibanserin for the Treatment of Sexual Disorders in Females
CA2660476C (fr) 2006-08-14 2015-11-17 Boehringer Ingelheim International Gmbh Formulations de flibanserine et leur procede de fabrication
CL2007002214A1 (es) 2006-08-14 2008-03-07 Boehringer Ingelheim Int Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp
EP2056797A2 (fr) 2006-08-25 2009-05-13 Boehringer Ingelheim International GmbH Système de libération contrôlée et procédé de préparation correspondant
PT2159226T (pt) * 2007-03-29 2016-12-16 Joint-Stock Company Obninsk Chemical Pharmaceutical Company Agente anti-histamínico e antialérgico e um método para a produção do mesmo
PE20091188A1 (es) * 2007-09-12 2009-08-31 Boehringer Ingelheim Int Compuesto 1-[2-(4-(3-trifluorometil-fenil)piperazin-1-il)etil]-2,3-dihidro-1h-benzimidazol-2-ona (flibanserina), sus sales de adicion y composiciones farmaceuticas que los contienen
CA2686480A1 (fr) 2008-12-15 2010-06-15 Boehringer Ingelheim International Gmbh Nouveaux sels

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297170A (fr) * 1963-04-04 1900-01-01
DE1595923A1 (de) * 1965-02-20 1969-11-27 Merck Ag E 1-Aralkyl-4-(thiazolyl-2)-piperazine und Verfahren zu ihrer Herstellung
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
JPS5246935B1 (fr) * 1971-04-06 1977-11-29
BE787059A (fr) * 1971-08-03 1973-02-01 Wander Ag Dr A Nouveaux derives du thiazole, leur preparation et leur application comme medicaments
CH583232A5 (fr) * 1973-02-02 1976-12-31 Wander Ag Dr A
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
NL8601494A (nl) * 1985-06-22 1987-01-16 Sandoz Ag Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten.

Also Published As

Publication number Publication date
GB8614974D0 (en) 1986-07-23
SE8602723D0 (sv) 1986-06-18
ES8802045A1 (es) 1988-03-16
FI862644A7 (fi) 1986-12-23
FI862644A0 (fi) 1986-06-19
NL8601494A (nl) 1987-01-16
DK292986D0 (da) 1986-06-20
US4892879A (en) 1990-01-09
DK292986A (da) 1986-12-23
CH668426A5 (de) 1988-12-30
IT8648157A0 (it) 1986-06-20
GB2177395A (en) 1987-01-21
GR861601B (en) 1986-10-20
US4737500A (en) 1988-04-12
IT1203806B (it) 1989-02-23
SE8602723L (sv) 1986-12-23
BE904945A (fr) 1986-12-18
HUT43600A (en) 1987-11-30
IL79178A0 (en) 1986-09-30
GB2177395B (en) 1989-04-26
ES8802154A1 (es) 1988-04-01
ES556363A0 (es) 1988-04-01
ES557723A0 (es) 1988-03-16
LU86487A1 (fr) 1987-01-13
FR2587342A1 (fr) 1987-03-20
AU5894086A (en) 1986-12-24

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