BE904945A - Nouveaux derives du thiazole, leur preparation et leur utilisation en therapeutique. - Google Patents

Nouveaux derives du thiazole, leur preparation et leur utilisation en therapeutique.

Info

Publication number
BE904945A
BE904945A BE1/011508A BE1011508A BE904945A BE 904945 A BE904945 A BE 904945A BE 1/011508 A BE1/011508 A BE 1/011508A BE 1011508 A BE1011508 A BE 1011508A BE 904945 A BE904945 A BE 904945A
Authority
BE
Belgium
Prior art keywords
thiazole derivatives
therapeutics
preparation
novel thiazole
novel
Prior art date
Application number
BE1/011508A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE904945A publication Critical patent/BE904945A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Dérivés du thiazole dans laquelle R1 et R2 représentent l'hydrogène ou des restes organiques variés, W représente un groupe alkylène, alcénylène ou alcynylène, X-Y représente N-CH2, C=CH ou Ch-CH2 et R3 représente un reste hétérocyclique varié lié par l'atome d'azote. Ces composés peuvent etre utilisés comme médicaments.
BE1/011508A 1985-06-22 1986-06-18 Nouveaux derives du thiazole, leur preparation et leur utilisation en therapeutique. BE904945A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3522351 1985-06-22
DE3522353 1985-06-22
DE3522354 1985-06-22
DE3605868 1986-02-24

Publications (1)

Publication Number Publication Date
BE904945A true BE904945A (fr) 1986-12-18

Family

ID=27433378

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011508A BE904945A (fr) 1985-06-22 1986-06-18 Nouveaux derives du thiazole, leur preparation et leur utilisation en therapeutique.

Country Status (17)

Country Link
US (2) US4737500A (fr)
AU (1) AU5894086A (fr)
BE (1) BE904945A (fr)
CH (1) CH668426A5 (fr)
DK (1) DK292986A (fr)
ES (2) ES8802154A1 (fr)
FI (1) FI862644A7 (fr)
FR (1) FR2587342A1 (fr)
GB (1) GB2177395B (fr)
GR (1) GR861601B (fr)
HU (1) HUT43600A (fr)
IL (1) IL79178A0 (fr)
IT (1) IT1203806B (fr)
LU (1) LU86487A1 (fr)
NL (1) NL8601494A (fr)
PH (1) PH23389A (fr)
SE (1) SE8602723L (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307141A3 (en) * 1987-09-10 1989-04-12 Merck Sharp & Dohme Ltd. Oxazoles and thiazoles for the treatment of senile dementia
EP0526434A1 (fr) * 1991-07-30 1993-02-03 BOEHRINGER INGELHEIM ITALIA S.p.A. Dérivés de benzimidazolone comme antagonistes de 5-HT1A et 5-HT2
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
US7420057B2 (en) 2001-08-02 2008-09-02 Boehringer Ingelheim Pharma Kg Stable polymorph of flibanserin
US7923449B2 (en) 2005-10-29 2011-04-12 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US8227471B2 (en) 2001-10-20 2012-07-24 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US8227476B2 (en) 2005-08-03 2012-07-24 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US8512748B2 (en) 2006-08-25 2013-08-20 Boehringer Ingelheim International Gmbh Controlled release system and method for manufacturing the same
US8545886B2 (en) 2006-08-14 2013-10-01 Boehringer Ingelheim International Gmbh Extended release tablet formulations of flibanserin and method for manufacturing the same
US8658207B2 (en) 2006-08-14 2014-02-25 Boehringer Ingelheim International Gmbh Extended release tablet formulations of flibanserin and method for manufacturing the same
US9546141B2 (en) 2008-12-15 2017-01-17 Sprout Pharmaceuticals, Inc. Salts
US10004731B2 (en) 2006-06-30 2018-06-26 Sprout Pharmaceuticals, Inc. Flibanserin for the treatment of urinary incontinence and related diseases
US10166230B2 (en) 2007-09-12 2019-01-01 Sprout Pharmaceuticals Inc. Treatment of vasomotor symptoms
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
NL8601494A (nl) * 1985-06-22 1987-01-16 Sandoz Ag Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten.
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2612187B1 (fr) * 1987-03-12 1989-07-21 Sanofi Sa Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant
US4804751A (en) * 1987-06-30 1989-02-14 American Home Products Corporation Polycyclic hydrocarbon succinimides with psychotropic activity
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
EP0350145A3 (fr) * 1988-04-28 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. Derivés de Pyridylthiazolidine carboxamide et intermédiaires et leur production
US4935424A (en) * 1988-05-27 1990-06-19 Warner-Lambert Company 4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
WO1990002552A1 (fr) * 1988-09-16 1990-03-22 Pfizer Inc. Imides bicycliques polynucleaires de 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyle a usage antipsychotique
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US5194436A (en) * 1991-01-10 1993-03-16 Hoechst-Roussel Pharmaceuticals Inc. 1-piperazinyl-2-butenes and -2-butynes
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
DE19746612A1 (de) 1997-10-22 1999-04-29 Basf Ag 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
MXPA06012059A (es) * 2004-04-22 2007-01-25 Boehringer Ingelheim Int Nuevas composiciones farmaceuticas para el tratamiento de los trastornos sexuales ii.
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
EP1789048A1 (fr) * 2004-09-03 2007-05-30 Boehringer Ingelheim International GmbH Methode de traitement du trouble de l'hyperactivite avec deficit de l'attention
US20060199805A1 (en) * 2005-03-04 2006-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
EP1858516A1 (fr) * 2005-03-04 2007-11-28 Boehringer Ingelheim International GmbH Compositions pharmaceutiques utiles dans le traitement et/ou la prevention de la depression
WO2006096439A2 (fr) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Compositions pharmaceutiques destinees au traitement et/ou a la prevention de la schizophrenie et de maladies associees
EP1904182A2 (fr) * 2005-05-06 2008-04-02 Boehringer Ingelheim International GmbH Methode de traitement de la toxicomanie avec flibanserine
CA2608363A1 (fr) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Procede pour le traitement de dysfonctionnements sexuels d'origine medicamenteuse
US20070123540A1 (en) * 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
JP2009536176A (ja) * 2006-05-09 2009-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 閉経後の性的欲求障害の治療のためのフリバンセリンの使用
US20090318469A1 (en) * 2006-07-14 2009-12-24 Boehringer Ingelheim International Gmbh Use of Flibanserin for the Treatment of Sexual Disorders in Females
PT2159226T (pt) * 2007-03-29 2016-12-16 Joint-Stock Company Obninsk Chemical Pharmaceutical Company Agente anti-histamínico e antialérgico e um método para a produção do mesmo

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297170A (fr) * 1963-04-04 1900-01-01
DE1595923A1 (de) * 1965-02-20 1969-11-27 Merck Ag E 1-Aralkyl-4-(thiazolyl-2)-piperazine und Verfahren zu ihrer Herstellung
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
JPS5246935B1 (fr) * 1971-04-06 1977-11-29
BE787059A (fr) * 1971-08-03 1973-02-01 Wander Ag Dr A Nouveaux derives du thiazole, leur preparation et leur application comme medicaments
CH583232A5 (fr) * 1973-02-02 1976-12-31 Wander Ag Dr A
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
NL8601494A (nl) * 1985-06-22 1987-01-16 Sandoz Ag Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten.

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307141A3 (en) * 1987-09-10 1989-04-12 Merck Sharp & Dohme Ltd. Oxazoles and thiazoles for the treatment of senile dementia
EP0526434A1 (fr) * 1991-07-30 1993-02-03 BOEHRINGER INGELHEIM ITALIA S.p.A. Dérivés de benzimidazolone comme antagonistes de 5-HT1A et 5-HT2
WO1993003016A1 (fr) * 1991-07-30 1993-02-18 Boehringer Ingelheim Italia S.P.A. DERIVES DE BENZIMIDAZOLONE UTILISES COMME ANTAGONISTES DE 5-HT1A et de 5-HT¿2?
US5576318A (en) * 1991-07-30 1996-11-19 Boehringer Ingelheim Italia S.P.A. Benzimidazolone derivatives
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
US7420057B2 (en) 2001-08-02 2008-09-02 Boehringer Ingelheim Pharma Kg Stable polymorph of flibanserin
US11058683B2 (en) 2001-10-20 2021-07-13 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US8227471B2 (en) 2001-10-20 2012-07-24 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US9468639B2 (en) 2001-10-20 2016-10-18 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US8227476B2 (en) 2005-08-03 2012-07-24 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US10335407B2 (en) 2005-08-03 2019-07-02 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US10874668B2 (en) 2005-08-03 2020-12-29 Sprout Pharmaceuticals, Inc. Use of Flibanserin in the treatment of obesity
US7923449B2 (en) 2005-10-29 2011-04-12 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US10004731B2 (en) 2006-06-30 2018-06-26 Sprout Pharmaceuticals, Inc. Flibanserin for the treatment of urinary incontinence and related diseases
US8545886B2 (en) 2006-08-14 2013-10-01 Boehringer Ingelheim International Gmbh Extended release tablet formulations of flibanserin and method for manufacturing the same
US8658207B2 (en) 2006-08-14 2014-02-25 Boehringer Ingelheim International Gmbh Extended release tablet formulations of flibanserin and method for manufacturing the same
US8512748B2 (en) 2006-08-25 2013-08-20 Boehringer Ingelheim International Gmbh Controlled release system and method for manufacturing the same
US10166230B2 (en) 2007-09-12 2019-01-01 Sprout Pharmaceuticals Inc. Treatment of vasomotor symptoms
US9546141B2 (en) 2008-12-15 2017-01-17 Sprout Pharmaceuticals, Inc. Salts

Also Published As

Publication number Publication date
GB8614974D0 (en) 1986-07-23
SE8602723D0 (sv) 1986-06-18
ES8802045A1 (es) 1988-03-16
FI862644A7 (fi) 1986-12-23
FI862644A0 (fi) 1986-06-19
NL8601494A (nl) 1987-01-16
DK292986D0 (da) 1986-06-20
PH23389A (en) 1989-07-26
US4892879A (en) 1990-01-09
DK292986A (da) 1986-12-23
CH668426A5 (de) 1988-12-30
IT8648157A0 (it) 1986-06-20
GB2177395A (en) 1987-01-21
GR861601B (en) 1986-10-20
US4737500A (en) 1988-04-12
IT1203806B (it) 1989-02-23
SE8602723L (sv) 1986-12-23
HUT43600A (en) 1987-11-30
IL79178A0 (en) 1986-09-30
GB2177395B (en) 1989-04-26
ES8802154A1 (es) 1988-04-01
ES556363A0 (es) 1988-04-01
ES557723A0 (es) 1988-03-16
LU86487A1 (fr) 1987-01-13
FR2587342A1 (fr) 1987-03-20
AU5894086A (en) 1986-12-24

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SANDOZ S.A.

Effective date: 19900630