PH24814A - Method of increasing tear production by topical administration of cyclosporin - Google Patents

Method of increasing tear production by topical administration of cyclosporin

Info

Publication number: PH24814A
Authority: PH; Philippines
Prior art keywords: cyclosporine; tear production; cyclosporin; topical administration; enhance
Prior art date: 1987-09-03

Application number

PH37495A

Other languages

English (en)

Inventor

Renee Kaswan

Original Assignee

Univ Georgia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-03

Filing date

1988-09-02

Publication date

1990-10-30

1987-09-03 Priority claimed from US07/092,466 external-priority patent/US4839342A/en

1988-09-02 Application filed by Univ Georgia filed Critical Univ Georgia

1990-10-30 Publication of PH24814A publication Critical patent/PH24814A/en

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
108010036949 Cyclosporine Proteins 0.000 title abstract 4
229960001265 ciclosporin Drugs 0.000 title abstract 4
229930182912 cyclosporin Natural products 0.000 title abstract 4
230000004489 tear production Effects 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 title 1
238000000034 method Methods 0.000 title 1
238000011200 topical administration Methods 0.000 title 1
239000000203 mixture Substances 0.000 abstract 3
239000002285 corn oil Substances 0.000 abstract 2
235000005687 corn oil Nutrition 0.000 abstract 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 2
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 abstract 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
229940087168 alpha tocopherol Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
-1 antifungals Substances 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
235000006708 antioxidants Nutrition 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
229940121357 antivirals Drugs 0.000 abstract 1
OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 abstract 1
229960003870 bromhexine Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003246 corticosteroid Substances 0.000 abstract 1
229960001334 corticosteroids Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003172 expectorant agent Substances 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
229960002216 methylparaben Drugs 0.000 abstract 1
229940066491 mucolytics Drugs 0.000 abstract 1
229960001416 pilocarpine Drugs 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
229960000984 tocofersolan Drugs 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
239000005526 vasoconstrictor agent Substances 0.000 abstract 1
239000000080 wetting agent Substances 0.000 abstract 1
239000002076 α-tocopherol Substances 0.000 abstract 1
235000004835 α-tocopherol Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PH37495A 1987-09-03 1988-09-02 Method of increasing tear production by topical administration of cyclosporin PH24814A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/092,466 US4839342A (en)	1987-09-03	1987-09-03	Method of increasing tear production by topical administration of cyclosporin
US11721887A	1987-11-04	1987-11-04
US18782388A	1988-04-29	1988-04-29

Publications (1)

Publication Number	Publication Date
PH24814A true PH24814A (en)	1990-10-30

Family

ID=27377210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH37495A PH24814A (en)	1987-09-03	1988-09-02	Method of increasing tear production by topical administration of cyclosporin

Country Status (12)

Country	Link
US (1)	US5411952A (es)
EP (1)	EP0391909B1 (es)
JP (1)	JPH0667850B2 (es)
KR (1)	KR920003601B1 (es)
AT (1)	ATE109970T1 (es)
DE (1)	DE3851152T2 (es)
DK (1)	DK54390A (es)
ES (1)	ES2012116A6 (es)
GR (1)	GR1000558B (es)
IE (1)	IE65582B1 (es)
PH (1)	PH24814A (es)
WO (1)	WO1989001772A1 (es)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4996193A (en) *	1989-03-03	1991-02-26	The Regents Of The University Of California	Combined topical and systemic method of administration of cyclosporine
US5540931A (en) *	1989-03-03	1996-07-30	Charles W. Hewitt	Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
CA1340994C (en) *	1989-09-21	2000-05-16	Rudolf Edgar Dr. Falk	Treatment of conditions and disease
ZA927277B (en) *	1991-10-02	1993-05-19	Boston Ocular Res	Dry eye treatment process and solution.
SG45449A1 (en)	1992-05-13	1998-01-16	Sandoz Ltd	Ophthalmic compositions
US5830508A (en)	1992-08-06	1998-11-03	Deo Corporation	Composition for treating dry eye
US5366739A (en) *	1992-08-06	1994-11-22	Deo Corporation	Method of ophthalmic drug delivery
US5686436A (en)	1993-05-13	1997-11-11	Hiv Diagnostics, Inc.	Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5474979A (en) *	1994-05-17	1995-12-12	Allergan, Inc.	Nonirritating emulsions for sensitive tissue
IE75744B1 (en) *	1995-04-03	1997-09-24	Elan Corp Plc	Controlled release biodegradable micro- and nanospheres containing cyclosporin
US5869079A (en) *	1995-06-02	1999-02-09	Oculex Pharmaceuticals, Inc.	Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5858401A (en)	1996-01-22	1999-01-12	Sidmak Laboratories, Inc.	Pharmaceutical composition for cyclosporines
WO1997029776A1 (en)	1996-02-13	1997-08-21	G.D. Searle & Co.	Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors
AU1952597A (en)	1996-02-13	1997-09-02	G.D. Searle & Co.	Combinations, having immunosuppressive effects, containing cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
CA2238029A1 (en) *	1996-03-05	1997-09-12	Medinox, Inc.	Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor
DE69832984T2 (de)	1997-10-08	2006-09-21	Isotechnika, Inc., Edmonton	DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
US6861411B1 (en)	1997-12-02	2005-03-01	Pfizer, Inc.	Method of treating eye infections with azithromycin
US5981607A (en) *	1998-01-20	1999-11-09	Allergan	Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
GB9818278D0 (en) *	1998-08-22	1998-10-14	Smith & Nephew	Compositions
US6217895B1 (en)	1999-03-22	2001-04-17	Control Delivery Systems	Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) *	1999-03-22	2004-06-24	Control Delivery Systems, Inc.	Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
US6255280B1 (en)	1999-04-08	2001-07-03	University Of Kentucky Research Foundation	Protection against traumatic brain injury
US6254860B1 (en) *	1999-04-13	2001-07-03	Allergan Sales, Inc.	Ocular treatment using cyclosporin-A derivatives
ATE402925T2 (de) *	1999-10-15	2008-08-15	Sucampo Ag	Neue zusammensetzung enthaltend eine bicyclische verbindung und ein glycerid
PT1142566E (pt)	2000-04-07	2004-02-27	Medidom Lab	Formulacao oftalmica topica na forma de uma solucao aquosa e uso de uma ciclosporina em associacao com acido hialuronico ou um de seus sais e com polisorbato 80
US6375972B1 (en)	2000-04-26	2002-04-23	Control Delivery Systems, Inc.	Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20030021816A1 (en) *	2001-06-06	2003-01-30	Sewon Kang	Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes
HRP20070058B1 (hr)	2001-10-19	2014-05-23	Isotechnika Inc.	Sinteza ciklosporinskih analoga
KR20030065831A (ko) *	2002-02-01	2003-08-09	주식회사 태평양	사이클로스포린을 함유한 지속 방출형 약학적 조성물
US8871241B2 (en) *	2002-05-07	2014-10-28	Psivida Us, Inc.	Injectable sustained release delivery devices
US6930127B2 (en) *	2002-08-15	2005-08-16	Eaton Veterinary Laboratories, Inc.	Veterinary treatment of ophthalmic disease in animals using topical tacrolimus
US7354574B2 (en)	2002-11-07	2008-04-08	Advanced Ocular Systems Limited	Treatment of ocular disease
CA2518265A1 (en) *	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Novel cyclosporins
US20040185068A1 (en) *	2003-03-18	2004-09-23	Zhi-Jian Yu	Self-emulsifying compositions, methods of use and preparation
EP1608347B1 (en) *	2003-03-28	2014-08-13	Sigmoid Pharma Limited	Solid oral dosage form containing seamless microcapsules
US7083802B2 (en)	2003-07-31	2006-08-01	Advanced Ocular Systems Limited	Treatment of ocular disease
US20050059583A1 (en)	2003-09-15	2005-03-17	Allergan, Inc.	Methods of providing therapeutic effects using cyclosporin components
JP2007505932A (ja)	2003-09-18	2007-03-15	マクサイト，インコーポレイテッド	経強膜送達
US7083803B2 (en)	2003-09-19	2006-08-01	Advanced Ocular Systems Limited	Ocular solutions
US7087237B2 (en)	2003-09-19	2006-08-08	Advanced Ocular Systems Limited	Ocular solutions
EP1706095B1 (en)	2004-01-20	2008-12-24	Allergan, Inc.	Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US7923471B2 (en) *	2004-05-14	2011-04-12	Alcon, Inc.	Method of treating dry eye disorders and uveitis
US20050277584A1 (en) *	2004-06-09	2005-12-15	Allergan, Inc.	Pharmaceutical compositions comprising cyclosporins
US20070292523A1 (en) *	2004-09-27	2007-12-20	Joey Moodley	Dihydropyrimidine Formulations
US7378391B2 (en) *	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008514702A (ja) *	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
WO2006041631A2 (en) *	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7135455B2 (en) *	2004-11-15	2006-11-14	Allergan, Inc	Methods for the therapeutic use of cyclosporine components
US7151085B2 (en)	2004-11-15	2006-12-19	Allergan, Inc.	Therapeutic methods using cyclosporine components
US20060148686A1 (en) *	2004-12-30	2006-07-06	Bausch & Lomb Incorporated	Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy
CA2597590A1 (en)	2005-02-09	2006-08-17	Macusight, Inc.	Formulations for ocular treatment
WO2007011880A2 (en)	2005-07-18	2007-01-25	Minu, L.L.C.	Enhanced ocular neuroprotection/neurostimulation
US20070014760A1 (en) *	2005-07-18	2007-01-18	Peyman Gholam A	Enhanced recovery following ocular surgery
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
EP3103468B1 (en) *	2005-10-14	2020-07-15	Allergan, Inc.	Prevention of drug-associated keratoconjunctivitis with a cyclosporin
US8067433B2 (en) *	2005-11-09	2011-11-29	Zalicus Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
KR101478164B1 (ko)	2006-02-09	2014-12-31	산텐 세이야꾸 가부시키가이샤	안정한 제제와 그 제조 및 사용 방법
US7655625B2 (en) *	2006-02-13	2010-02-02	Allergan, Inc.	Methods of treating blepharospasm using cyclosporine components
US7557082B2 (en)	2006-03-03	2009-07-07	Allergan, Inc.	Treatment with cyclosporin A
US20070219127A1 (en) *	2006-03-20	2007-09-20	Walt John G	Cyclosporin a compositions
AU2007230964B2 (en)	2006-03-23	2012-07-19	Santen Pharmaceutical Co., Ltd.	Formulations and methods for vascular permeability-related diseases or conditions
US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US20080146497A1 (en) *	2006-07-25	2008-06-19	Graham Richard S	Cyclosporin Compositions
EP2061440A2 (en)	2007-04-04	2009-05-27	Sigmoid Pharma Limited	A pharmaceutical composition of tacrolimus
CN101687013A (zh) *	2007-05-04	2010-03-31	阿勒根公司	环孢菌素在治疗具有人工晶状体的患者中的用途
US20090081277A1 (en) *	2007-09-21	2009-03-26	Allergan, Inc.	Pharmaceutical formulations and methods for treating ocular conditions
JP5668476B2 (ja)	2007-10-08	2015-02-12	オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃ．	カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物
ITMI20080003A1 (it) *	2008-01-02	2009-07-03	Alfredo Pulpito	Composizioni per uso oftalmico
JP2011527339A (ja) *	2008-07-09	2011-10-27	アスプレバインターナショナルリミテッド	眼障害を処置するためのミコフェノール酸ナトリウムのｐＨ特異的な溶液
US9445975B2 (en) *	2008-10-03	2016-09-20	Access Business Group International, Llc	Composition and method for preparing stable unilamellar liposomal suspension
JP2012514645A (ja) *	2009-01-08	2012-06-28	アラーガンインコーポレイテッド	爪成長の増進用組成物
US20110009339A1 (en) *	2009-04-14	2011-01-13	Allergan, Inc	Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
EP2471518B1 (en)	2009-05-18	2017-08-23	Sigmoid Pharma Limited	Composition comprising oil drops
NO2437762T3 (es)	2009-06-05	2018-01-06
EP2440185B1 (en) *	2009-06-09	2015-04-08	Aurinia Pharmaceuticals Inc.	Topical drug delivery systems for ophthalmic use
EP2464341B1 (en)	2009-08-12	2022-07-06	Sublimity Therapeutics Limited	Immunomodulatory compositions comprising a polymer matrix and an oil phase
EP2335735A1 (en)	2009-12-14	2011-06-22	Novaliq GmbH	Pharmaceutical composition for treatment of dry eye syndrome
US20110238036A1 (en) *	2009-12-23	2011-09-29	Psivida Us, Inc.	Sustained release delivery devices
GB201020032D0 (en)	2010-11-25	2011-01-12	Sigmoid Pharma Ltd	Composition
US8957048B2 (en)	2011-10-06	2015-02-17	Allergan, Inc.	Compositions for the treatment of dry eye
KR102029513B1 (ko)	2011-11-15	2019-10-07	알러간, 인코포레이티드	사이클로스포린 제2형의 지속 작용 제형
JP6363506B2 (ja)	2011-11-15	2018-07-25	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	シクロスポリンａ２型の懸濁剤
CN104039813B (zh)	2011-11-15	2017-08-29	阿勒根公司	环孢菌素a形式2及其制备方法
US9907826B2 (en)	2011-12-07	2018-03-06	Allergan, Inc.	Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20130266615A1 (en) *	2012-04-10	2013-10-10	Bin Wu	Non-immunogenic delivery vehicle for beta-, gamma-, and delta-tocopherols and methods of using and making same
EP2844268A4 (en) *	2012-04-20	2015-11-25	Univ Howard	METHOD FOR THE TREATMENT OF EYE DISEASE AND COMPOSITIONS FOR THE TREATMENT OF EYE DISEASE
GB201212010D0 (en)	2012-07-05	2012-08-22	Sigmoid Pharma Ltd	Formulations
GB201319791D0 (en)	2013-11-08	2013-12-25	Sigmoid Pharma Ltd	Formulations
WO2016071515A1 (en)	2014-11-07	2016-05-12	Sigmoid Pharma Limited	Compositions comprising cyclosporin
KR102487299B1 (ko)	2014-11-25	2023-01-10	알러간, 인코포레이티드	안정화된 오메가-3 안과용 조성물
US9820954B2 (en)	2015-08-19	2017-11-21	Jenivision Inc.	Quantitative peri-orbital application of ophthalmology drugs
US20190224275A1 (en)	2017-05-12	2019-07-25	Aurinia Pharmaceuticals Inc.	Protocol for treatment of lupus nephritis
JP7598699B2 (ja) *	2017-06-01	2024-12-12	ロート製薬株式会社	視覚機能の再活性化用眼科組成物
WO2022251710A2 (en)	2021-05-28	2022-12-01	Sight Sciences, Inc.	Intraocular devices, systems, and methods
WO2025248489A1 (en) *	2024-05-29	2025-12-04	Sight Sciences, Inc.	Bio-erodible ocular implants for treatment of conditions of the eye

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3608073A (en) *	1968-07-16	1971-09-21	Barnes Hind Pharm Inc	Emulsion of pilocarpine for ophthalmic use
CH614931A5 (es) *	1975-11-04	1979-12-28	Sandoz Ag
US4210581A (en) *	1975-11-04	1980-07-01	Sandoz Ltd.	Organic compounds
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
US4115544A (en) *	1976-08-18	1978-09-19	Alza Corporation	Ocular system made of bioerodible esters having linear ether
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
FI65914C (fi) *	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
US4215199A (en) *	1978-06-05	1980-07-29	Sandoz Ltd.	Antibiotic production
SE448386B (sv) *	1978-10-18	1987-02-16	Sandoz Ag	Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) *	1980-02-14	1983-08-02	Sandoz Ltd.	Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0098457B1 (en) *	1980-02-14	1987-08-05	Sandoz Ag	(1s,2r,3r)- and (1r,2s,3s)-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes useful in the total synthesis of cyclosporins and processes for their production
DE3260468D1 (en) *	1981-01-09	1984-09-06	Sandoz Ag	Novel cyclosporins
WO1983001252A1 (en) *	1981-10-09	1983-04-14	Hakanson, Rolf	A drug based on a substance p antagonist
EP0145714A1 (en) *	1983-05-25	1985-06-26	Alcon Laboratories, Inc.	Ophthalmic gel
US4708861A (en) *	1984-02-15	1987-11-24	The Liposome Company, Inc.	Liposome-gel compositions
CH667274A5 (de) *	1984-03-23	1988-09-30	Sandoz Ag	Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4963367A (en) *	1984-04-27	1990-10-16	Medaphore, Inc.	Drug delivery compositions and methods
DE3580717D1 (de) *	1984-08-02	1991-01-10	Sandoz Ag	Pharmazeutische anwendung von (nva)2-cyclosporine.
GB8422253D0 (en) *	1984-09-04	1984-10-10	Sandoz Ltd	Organic compounds
EP0194972B1 (en) *	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
US4649047A (en) *	1985-03-19	1987-03-10	University Of Georgia Research Foundation, Inc.	Ophthalmic treatment by topical administration of cyclosporin
JPS61249918A (ja) *	1985-04-26	1986-11-07	Yutaka Mizushima	点眼剤
US4745100A (en) *	1985-05-14	1988-05-17	Eye Research Institute Of Retina Foundation	Stimulation of tear secretion
US4861580A (en) *	1985-10-15	1989-08-29	The Liposome Company, Inc.	Composition using salt form of organic acid derivative of alpha-tocopheral
GB8528032D0 (en) *	1985-11-13	1985-12-18	Ici Plc	Ocular treatment
US4923699A (en) *	1988-06-03	1990-05-08	Kaufman Herbert E	Eye treatment suspension

1988
- 1988-08-31 WO PCT/US1988/003039 patent/WO1989001772A1/en not_active Ceased
- 1988-08-31 KR KR1019890700680A patent/KR920003601B1/ko not_active Expired
- 1988-08-31 EP EP88908033A patent/EP0391909B1/en not_active Expired - Lifetime
- 1988-08-31 DE DE3851152T patent/DE3851152T2/de not_active Expired - Lifetime
- 1988-08-31 AT AT88908033T patent/ATE109970T1/de not_active IP Right Cessation
- 1988-08-31 JP JP63507463A patent/JPH0667850B2/ja not_active Expired - Lifetime
- 1988-09-02 ES ES8802718A patent/ES2012116A6/es not_active Expired - Lifetime
- 1988-09-02 PH PH37495A patent/PH24814A/en unknown
- 1988-09-02 IE IE266388A patent/IE65582B1/en not_active IP Right Cessation
- 1988-09-05 GR GR880100578A patent/GR1000558B/el not_active IP Right Cessation
1990
- 1990-02-06 US US07/474,683 patent/US5411952A/en not_active Expired - Lifetime
- 1990-03-01 DK DK054390A patent/DK54390A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
DK54390D0 (da)	1990-03-01
KR920003601B1 (ko)	1992-05-04
US5411952A (en)	1995-05-02
IE882663L (en)	1989-03-03
EP0391909A1 (en)	1990-10-17
IE65582B1 (en)	1995-11-01
DE3851152T2 (de)	1995-01-26
JPH03503159A (ja)	1991-07-18
ES2012116A6 (es)	1990-03-01
KR890701084A (ko)	1989-12-19
GR880100578A (en)	1989-06-22
DK54390A (da)	1990-05-03
ATE109970T1 (de)	1994-09-15
EP0391909B1 (en)	1994-08-17
JPH0667850B2 (ja)	1994-08-31
WO1989001772A1 (en)	1989-03-09
DE3851152D1 (de)	1994-09-22
GR1000558B (el)	1992-08-26

Publication	Publication Date	Title
IE882663L (en)	1989-03-03	Ocular cyclosporin composition
MX9702349A (es)	1997-06-28	Usos de derivado de 9-deoxi prostaglandina para tratar glaucoma.
IE831611L (en)	1984-01-13	Topical anti-inflammatory compositions
DK0703774T3 (da)	1999-02-22	Stærktskummende oral sammensætning
CA2059403A1 (en)	1992-07-16	Use of Carrageenans in Topical Ophthalmic Compositions
ES2163530T3 (es)	2002-02-01	Aplicacion de superoxido dismutasa (sod) en liposomas.
ES8507573A1 (es)	1985-09-01	Procedimiento para la fabricacion de fracciones de acido hialuronico
IE811654L (en)	1982-02-01	Ophthalmic composition
AU4150793A (en)	1994-01-06	Non-irritating dentifrice
DE3172298D1 (en)	1985-10-24	Pharmaceutical compositions
US4197301A (en)	1980-04-08	Topical ophthalmic use of Prazosin
DE69928806D1 (de)	2006-01-12	(-)-pseudoephedrin als sympathomimetisches arzneimittel
DE3167210D1 (en)	1984-12-20	Pharmaceutical composition
KR880007068A (ko)	1988-08-26	13-시스 레티노산의 용도
KR950000138A (ko)	1995-01-03	안(眼)국소용 조성물
KR950702422A (ko)	1995-07-29	(에스)-티몰롤 헤미하이드레이트를 함유하는 안약 국소 조성물(ophthalmic topical composition containing (s)-timolol hemihydrate)
EP0345028A3 (en)	1992-01-22	Treatment of glaucoma using phosphodiesterase inhibitor
RU95106983A (ru)	1997-11-27	Офтальмологический состав, способ его получения и средство для офтальмологического состава
CA2330659A1 (en)	1999-12-09	Using ngali nut oil to treat/relieve manifestations of arthritis and other similar conditions
US4188394A (en)	1980-02-12	Ophthalmic composition and method of use
MY100229A (en)	1990-05-29	Topical anti-inflammatory compositions.
IT1241928B (it)	1994-02-01	Composizione oftalmica per l'uso nel mantenimento della midriasi oculare
IT1257884B (it)	1996-02-16	Formulazioni farmaceutiche per il trattamento di malattie periferiche vascolari a base di vincamina o di un suo sale farmaceuticamente accettabile.