PH25857A - 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function - Google Patents

3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function

Info

Publication number: PH25857A
Authority: PH; Philippines
Prior art keywords: cell function; oxindole; carboxamides; substituted; suppressing
Prior art date: 1988-04-13

Application number

PH38415A

Other languages

English (en)

Inventor

Henry James Showell

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-13

Filing date

1989-03-31

Publication date

1991-12-02

1989-03-31 Application filed by Pfizer filed Critical Pfizer

1991-12-02 Publication of PH25857A publication Critical patent/PH25857A/en

Links

210000001744 T-lymphocyte Anatomy 0.000 title abstract 4
-1 3-substituted-2-oxindole-1-carboxamides Chemical class 0.000 title abstract 2
241000124008 Mammalia Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)

PH38415A 1988-04-13 1989-03-31 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function PH25857A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/181,142 US4853409A (en)	1988-04-13	1988-04-13	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function

Publications (1)

Publication Number	Publication Date
PH25857A true PH25857A (en)	1991-12-02

Family

ID=22663072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH38415A PH25857A (en)	1988-04-13	1989-03-31	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function

Country Status (17)

Country	Link
US (1)	US4853409A (fr)
EP (1)	EP0337628B1 (fr)
JP (1)	JPH01311022A (fr)
KR (1)	KR920002328B1 (fr)
AT (1)	ATE89725T1 (fr)
AU (1)	AU601326B2 (fr)
CA (1)	CA1324762C (fr)
DE (1)	DE68906707T2 (fr)
DK (1)	DK174289A (fr)
HU (1)	HU204996B (fr)
IE (1)	IE62751B1 (fr)
IL (1)	IL89872A (fr)
MY (1)	MY103872A (fr)
NZ (1)	NZ228712A (fr)
PH (1)	PH25857A (fr)
PT (1)	PT90249B (fr)
ZA (1)	ZA892622B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) *	1990-03-19	1991-04-09	Pfizer Inc.	Tenidap as an inhibitor of the release of elastase by neutrophils
US5122534A (en) *	1991-02-08	1992-06-16	Pfizer Inc.	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
DE4111306C2 (de) *	1991-04-08	1994-06-01	Mack Chem Pharm	Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
DE4111305C2 (de) *	1991-04-08	1994-12-01	Mack Chem Pharm	Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5298522A (en) *	1993-01-22	1994-03-29	Pfizer Inc.	6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
NZ261449A (en) *	1993-01-22	1996-08-27	Pfizer	Lysine salt of 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1- carboxamide and pharmaceutical compositions thereof
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
IL118815A (en) *	1995-07-13	2000-06-29	Anormed Inc	N,N-diethyl-8,8-dipropyl-2-azaspiro¬4.5¾decane-2-propanamine dimaleate and pharmaceutical compositions comprising it
AU7503496A (en) *	1995-12-19	1997-07-14	Pfizer Inc.	Stable, long acting salts of indole derivatives for the treatment of joint diseases
EP0826685A1 (fr) *	1996-08-21	1998-03-04	Pfizer Inc.	Sels de carboxamides stables à effet prolongé destinés au traitement des maladies articulaires
WO2006105796A1 (fr) *	2005-04-08	2006-10-12	Leo Pharma A/S	Nouveaux dérivés d'indolinone
EP2886541A1 (fr) *	2013-12-19	2015-06-24	Sanofi	Dérivés d'oxindole, leur préparation et leur utilisation thérapeutique pour traiter les troubles liés à l'AMPK

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3413572A1 (de) *	1984-04-11	1985-10-24	Hoechst Ag, 6230 Frankfurt	Oxindol-verbindungen zur behandlung der epilepsie
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
WO1987004618A1 (fr) *	1986-01-30	1987-08-13	University Of Utah	Traitement de l'osteoporose
WO1988005656A1 (fr) *	1987-02-02	1988-08-11	Pfizer Inc.	Sel de sodium en cristaux anhydres de 5-chloro-3-(2-thenoyle)-2-oxindole-1-carboxamide

1988
- 1988-04-13 US US07/181,142 patent/US4853409A/en not_active Expired - Lifetime
1989
- 1989-03-28 DE DE8989303050T patent/DE68906707T2/de not_active Expired - Fee Related
- 1989-03-28 AT AT89303050T patent/ATE89725T1/de not_active IP Right Cessation
- 1989-03-28 EP EP89303050A patent/EP0337628B1/fr not_active Expired - Lifetime
- 1989-03-31 PH PH38415A patent/PH25857A/en unknown
- 1989-04-06 IL IL8987289A patent/IL89872A/en not_active IP Right Cessation
- 1989-04-08 MY MYPI89000448A patent/MY103872A/en unknown
- 1989-04-10 JP JP1090492A patent/JPH01311022A/ja active Pending
- 1989-04-11 ZA ZA892622A patent/ZA892622B/xx unknown
- 1989-04-11 PT PT90249A patent/PT90249B/pt not_active IP Right Cessation
- 1989-04-11 CA CA000596306A patent/CA1324762C/fr not_active Expired - Fee Related
- 1989-04-12 AU AU32712/89A patent/AU601326B2/en not_active Ceased
- 1989-04-12 KR KR1019890004822A patent/KR920002328B1/ko not_active Expired
- 1989-04-12 IE IE117189A patent/IE62751B1/en not_active IP Right Cessation
- 1989-04-12 DK DK174289A patent/DK174289A/da not_active Application Discontinuation
- 1989-04-12 HU HU891754A patent/HU204996B/hu not_active IP Right Cessation
- 1989-04-12 NZ NZ228712A patent/NZ228712A/en unknown

Also Published As

Publication number	Publication date
HU204996B (en)	1992-03-30
JPH01311022A (ja)	1989-12-15
IE891171L (en)	1989-10-13
AU601326B2 (en)	1990-09-06
PT90249B (pt)	1994-06-30
IL89872A0 (en)	1989-12-15
IE62751B1 (en)	1995-02-22
KR890015740A (ko)	1989-11-25
HUT52376A (en)	1990-07-28
DE68906707T2 (de)	1993-09-16
CA1324762C (fr)	1993-11-30
PT90249A (pt)	1989-11-10
US4853409A (en)	1989-08-01
KR920002328B1 (ko)	1992-03-21
MY103872A (en)	1993-09-30
ZA892622B (en)	1990-11-28
EP0337628A3 (fr)	1991-01-02
IL89872A (en)	1994-06-24
NZ228712A (en)	1997-02-24
DE68906707D1 (de)	1993-07-01
ATE89725T1 (de)	1993-06-15
EP0337628A2 (fr)	1989-10-18
DK174289A (da)	1989-10-16
EP0337628B1 (fr)	1993-05-26
AU3271289A (en)	1989-10-19
DK174289D0 (da)	1989-04-12

Publication	Publication Date	Title
IE891171L (en)	1989-10-13	3-substituted-2-oxindole-1-carboxamides for suppressing¹t-cell function
EP0363415A4 (en)	1993-03-17	Compounds for the treatment of alzheimer's disease
SG45280A1 (en)	1998-01-16	Methods for inhibiting smooth muslce cell proliferation and restinosis
CA2029420A1 (fr)	1991-05-22	Compositions pharmaceutiques et methodes permettant d'inhiber la reaction de maillard
IL87421A0 (en)	1989-01-31	Pharmaceutical compositions containing 5-amino(or substituted amino)-1,2,3-triazoles
ATE78166T1 (de)	1992-08-15	Monosaccharide enthaltende zusammensetzung zum heilen von wunden.
ATE89724T1 (de)	1993-06-15	3-substituierte 2-oxindol-1-carboxamid-derivate als hemmer der biosynthese des interleukins-1.
FI891473A0 (fi)	1989-03-28	Menetelmä terapeuttisesti käyttökelpoisten 4-aryyli-4-piperidiinikarbinolien valmistamiseksi
EP0334685A3 (fr)	1991-01-30	Analogues de Bradykinine, leur synthèse et leur emploi en thérapeutique
GR3025518T3 (en)	1998-02-27	Use of the N-n-butyl derivative of desoxynojirimycin in the manufacture of a medicament inhibiting HIV-Virus
IL78954A0 (en)	1986-09-30	Spiro-imidazolidines and pharmaceutical compositions containing them
IL92867A0 (en)	1990-09-17	N-pyridinyl-9h-carbazol-9-amines,a process for their preparation and their use as medicaments
FR2584073B1 (fr)	1988-08-19	Analogues d'amino-prostaglandines a substituant 5,6-epoxy-7-oxabicycloheptane, utilisables pour le traitement des thromboses
GB8823605D0 (en)	1988-11-16	Therapeutic agents
DE3887426D1 (de)	1994-03-10	Eperisone als Hypotonikum.
EP0458537A3 (en)	1992-07-08	Therapeutic compound for the treatment of bronchitis
GB2201343B (en)	1990-11-14	Ponalrestat as a hypouricaemic agent
EP0370821A3 (fr)	1991-10-23	Dérivés de 1,4-dihydropyridine
RU93052163A (ru)	1997-01-27	(s) - (+) - гидроксихлорохин и композиция для лечения
IT8421168V0 (it)	1984-03-09	Ferro per il trattamento delle callosita'.
IT8024828A0 (it)	1980-09-22	Impiego dell'alfa-chetoglutarato di piridossina nella terapia della iperlattacidemia.