PT90249A - Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas para a supressao da funcao das celulas t - Google Patents

Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas para a supressao da funcao das celulas t

Info

Publication number: PT90249A
Authority: PT; Portugal
Prior art keywords: oxindole; carboxamides; substituted; cell; mammal
Prior art date: 1988-04-13

Application number

PT90249A

Other languages

English (en)

Other versions

PT90249B (pt

Inventor

Henry James Showell

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-13

Filing date

1989-04-11

Publication date

1989-11-10

1989-04-11 Application filed by Pfizer filed Critical Pfizer

1989-11-10 Publication of PT90249A publication Critical patent/PT90249A/pt

1994-06-30 Publication of PT90249B publication Critical patent/PT90249B/pt

Links

238000000034 method Methods 0.000 title abstract 2
238000002156 mixing Methods 0.000 title 1
210000001744 T-lymphocyte Anatomy 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
-1 3-substituted-2-oxindole-1-carboxamides Chemical class 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)

PT90249A 1988-04-13 1989-04-11 Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas para a supressao da funcao das celulas t PT90249B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/181,142 US4853409A (en)	1988-04-13	1988-04-13	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function

Publications (2)

Publication Number	Publication Date
PT90249A true PT90249A (pt)	1989-11-10
PT90249B PT90249B (pt)	1994-06-30

Family

ID=22663072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT90249A PT90249B (pt)	1988-04-13	1989-04-11	Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas para a supressao da funcao das celulas t

Country Status (17)

Country	Link
US (1)	US4853409A (pt)
EP (1)	EP0337628B1 (pt)
JP (1)	JPH01311022A (pt)
KR (1)	KR920002328B1 (pt)
AT (1)	ATE89725T1 (pt)
AU (1)	AU601326B2 (pt)
CA (1)	CA1324762C (pt)
DE (1)	DE68906707T2 (pt)
DK (1)	DK174289A (pt)
HU (1)	HU204996B (pt)
IE (1)	IE62751B1 (pt)
IL (1)	IL89872A (pt)
MY (1)	MY103872A (pt)
NZ (1)	NZ228712A (pt)
PH (1)	PH25857A (pt)
PT (1)	PT90249B (pt)
ZA (1)	ZA892622B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) *	1990-03-19	1991-04-09	Pfizer Inc.	Tenidap as an inhibitor of the release of elastase by neutrophils
US5122534A (en) *	1991-02-08	1992-06-16	Pfizer Inc.	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
DE4111306C2 (de) *	1991-04-08	1994-06-01	Mack Chem Pharm	Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
DE4111305C2 (de) *	1991-04-08	1994-12-01	Mack Chem Pharm	Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5298522A (en) *	1993-01-22	1994-03-29	Pfizer Inc.	6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
CN1116822A (zh) *	1993-01-22	1996-02-14	美国辉瑞有限公司	6-氯-5-氟-3-(2-噻吩甲酰)-2-羟吲哚-1-羰酰胺的赖氨酸盐
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
SK281254B6 (sk) *	1995-07-13	2001-01-18	Smithkline Beecham Corporation	Použitie@kán-2-propánamínu, farmaceutický prostriedok s jeho obsahom a jeho použitie
AU7503496A (en) *	1995-12-19	1997-07-14	Pfizer Inc.	Stable, long acting salts of indole derivatives for the treatment of joint diseases
EP0826685A1 (en) *	1996-08-21	1998-03-04	Pfizer Inc.	Stable, long acting salts of carboxamides for the treatment of joint disease
WO2006105796A1 (en) *	2005-04-08	2006-10-12	Leo Pharma A/S	Novel indolinone derivatives
EP2886541A1 (en) *	2013-12-19	2015-06-24	Sanofi	Oxindole derivatives, preparation thereof and therapeutic use in the treatment of AMPK-related diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3413572A1 (de) *	1984-04-11	1985-10-24	Hoechst Ag, 6230 Frankfurt	Oxindol-verbindungen zur behandlung der epilepsie
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
JPH01501705A (ja) *	1986-01-30	1989-06-15	ユニバ−シテイ・オブ・ユタ	骨損失の治療
RO105052B1 (en) *	1987-02-02	1994-12-01	Pfizer	Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide

1988
- 1988-04-13 US US07/181,142 patent/US4853409A/en not_active Expired - Lifetime
1989
- 1989-03-28 AT AT89303050T patent/ATE89725T1/de not_active IP Right Cessation
- 1989-03-28 EP EP89303050A patent/EP0337628B1/en not_active Expired - Lifetime
- 1989-03-28 DE DE8989303050T patent/DE68906707T2/de not_active Expired - Fee Related
- 1989-03-31 PH PH38415A patent/PH25857A/en unknown
- 1989-04-06 IL IL8987289A patent/IL89872A/en not_active IP Right Cessation
- 1989-04-08 MY MYPI89000448A patent/MY103872A/en unknown
- 1989-04-10 JP JP1090492A patent/JPH01311022A/ja active Pending
- 1989-04-11 ZA ZA892622A patent/ZA892622B/xx unknown
- 1989-04-11 PT PT90249A patent/PT90249B/pt not_active IP Right Cessation
- 1989-04-11 CA CA000596306A patent/CA1324762C/en not_active Expired - Fee Related
- 1989-04-12 KR KR1019890004822A patent/KR920002328B1/ko not_active Expired
- 1989-04-12 NZ NZ228712A patent/NZ228712A/en unknown
- 1989-04-12 AU AU32712/89A patent/AU601326B2/en not_active Ceased
- 1989-04-12 IE IE117189A patent/IE62751B1/en not_active IP Right Cessation
- 1989-04-12 HU HU891754A patent/HU204996B/hu not_active IP Right Cessation
- 1989-04-12 DK DK174289A patent/DK174289A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
PT90249B (pt)	1994-06-30
KR890015740A (ko)	1989-11-25
ZA892622B (en)	1990-11-28
IE62751B1 (en)	1995-02-22
JPH01311022A (ja)	1989-12-15
NZ228712A (en)	1997-02-24
EP0337628A2 (en)	1989-10-18
IL89872A (en)	1994-06-24
PH25857A (en)	1991-12-02
DK174289A (da)	1989-10-16
HU204996B (en)	1992-03-30
MY103872A (en)	1993-09-30
IE891171L (en)	1989-10-13
DE68906707T2 (de)	1993-09-16
EP0337628B1 (en)	1993-05-26
US4853409A (en)	1989-08-01
HUT52376A (en)	1990-07-28
KR920002328B1 (ko)	1992-03-21
ATE89725T1 (de)	1993-06-15
DK174289D0 (da)	1989-04-12
EP0337628A3 (en)	1991-01-02
IL89872A0 (en)	1989-12-15
CA1324762C (en)	1993-11-30
DE68906707D1 (de)	1993-07-01
AU601326B2 (en)	1990-09-06
AU3271289A (en)	1989-10-19

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Legal Events

Date	Code	Title	Description
1994-06-30	FG3A	Patent granted, date of granting	Effective date: 19931206
2005-08-31	MM3A	Annulment or lapse	Effective date: 20050606