ATE89725T1 - 3-substituierte 2-oxindol-1-carboxamid-derivate zur hemmung der aktivitaet der t-zellen. - Google Patents

3-substituierte 2-oxindol-1-carboxamid-derivate zur hemmung der aktivitaet der t-zellen.

Info

Publication number: ATE89725T1
Authority: AT; Austria
Prior art keywords: substituted; oxindol; inhibition; cell activity; carboxamide derivatives
Prior art date: 1988-04-13

Application number

AT89303050T

Other languages

English (en)

Inventor

Henry James Showell

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-13

Filing date

1989-03-28

Publication date

1993-06-15

1989-03-28 Application filed by Pfizer filed Critical Pfizer

1993-06-15 Application granted granted Critical

1993-06-15 Publication of ATE89725T1 publication Critical patent/ATE89725T1/de

Links

UYINJAQCJCYCGO-UHFFFAOYSA-N 2-oxo-3h-indole-1-carboxamide Chemical class C1=CC=C2N(C(=O)N)C(=O)CC2=C1 UYINJAQCJCYCGO-UHFFFAOYSA-N 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
210000001744 T-lymphocyte Anatomy 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
-1 3-substituted-2-oxindole-1-carboxamides Chemical class 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)

AT89303050T 1988-04-13 1989-03-28 3-substituierte 2-oxindol-1-carboxamid-derivate zur hemmung der aktivitaet der t-zellen. ATE89725T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/181,142 US4853409A (en)	1988-04-13	1988-04-13	3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
EP89303050A EP0337628B1 (de)	1988-04-13	1989-03-28	3-Substituierte 2-Oxindol-1-carboxamid-Derivate zur Hemmung der Aktivität der T-Zellen

Publications (1)

Publication Number	Publication Date
ATE89725T1 true ATE89725T1 (de)	1993-06-15

Family

ID=22663072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89303050T ATE89725T1 (de)	1988-04-13	1989-03-28	3-substituierte 2-oxindol-1-carboxamid-derivate zur hemmung der aktivitaet der t-zellen.

Country Status (17)

Country	Link
US (1)	US4853409A (de)
EP (1)	EP0337628B1 (de)
JP (1)	JPH01311022A (de)
KR (1)	KR920002328B1 (de)
AT (1)	ATE89725T1 (de)
AU (1)	AU601326B2 (de)
CA (1)	CA1324762C (de)
DE (1)	DE68906707T2 (de)
DK (1)	DK174289A (de)
HU (1)	HU204996B (de)
IE (1)	IE62751B1 (de)
IL (1)	IL89872A (de)
MY (1)	MY103872A (de)
NZ (1)	NZ228712A (de)
PH (1)	PH25857A (de)
PT (1)	PT90249B (de)
ZA (1)	ZA892622B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) *	1990-03-19	1991-04-09	Pfizer Inc.	Tenidap as an inhibitor of the release of elastase by neutrophils
US5122534A (en) *	1991-02-08	1992-06-16	Pfizer Inc.	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
DE4111305C2 (de) *	1991-04-08	1994-12-01	Mack Chem Pharm	Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
DE4111306C2 (de) *	1991-04-08	1994-06-01	Mack Chem Pharm	Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
NZ261449A (en) *	1993-01-22	1996-08-27	Pfizer	Lysine salt of 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1- carboxamide and pharmaceutical compositions thereof
US5298522A (en) *	1993-01-22	1994-03-29	Pfizer Inc.	6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
BG62359B1 (bg) *	1995-07-13	1999-09-30	Anormed	N,n-диетил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанаминдималеат
WO1997022605A1 (en) *	1995-12-19	1997-06-26	Pfizer Inc.	Stable, long acting salts of indole derivatives for the treatment of joint diseases
EP0826685A1 (de) *	1996-08-21	1998-03-04	Pfizer Inc.	Stabile, lange aktive Salze von Carboxamiden für die Behandlung von Gelenkskrankheiten
WO2006105796A1 (en) *	2005-04-08	2006-10-12	Leo Pharma A/S	Novel indolinone derivatives
EP2886541A1 (de) *	2013-12-19	2015-06-24	Sanofi	Oxindolderivate, ihre Herstellung und ihre therapeutische Verwendung zur Behandlung von durch AMPK vermittelten Erkrankungen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3413572A1 (de) *	1984-04-11	1985-10-24	Hoechst Ag, 6230 Frankfurt	Oxindol-verbindungen zur behandlung der epilepsie
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
JPH01501705A (ja) *	1986-01-30	1989-06-15	ユニバ−シテイ・オブ・ユタ	骨損失の治療
US5036099A (en) *	1987-02-02	1991-07-30	Pfizer Inc.	Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide

1988
- 1988-04-13 US US07/181,142 patent/US4853409A/en not_active Expired - Lifetime
1989
- 1989-03-28 EP EP89303050A patent/EP0337628B1/de not_active Expired - Lifetime
- 1989-03-28 DE DE8989303050T patent/DE68906707T2/de not_active Expired - Fee Related
- 1989-03-28 AT AT89303050T patent/ATE89725T1/de not_active IP Right Cessation
- 1989-03-31 PH PH38415A patent/PH25857A/en unknown
- 1989-04-06 IL IL8987289A patent/IL89872A/en not_active IP Right Cessation
- 1989-04-08 MY MYPI89000448A patent/MY103872A/en unknown
- 1989-04-10 JP JP1090492A patent/JPH01311022A/ja active Pending
- 1989-04-11 ZA ZA892622A patent/ZA892622B/xx unknown
- 1989-04-11 PT PT90249A patent/PT90249B/pt not_active IP Right Cessation
- 1989-04-11 CA CA000596306A patent/CA1324762C/en not_active Expired - Fee Related
- 1989-04-12 HU HU891754A patent/HU204996B/hu not_active IP Right Cessation
- 1989-04-12 DK DK174289A patent/DK174289A/da not_active Application Discontinuation
- 1989-04-12 IE IE117189A patent/IE62751B1/en not_active IP Right Cessation
- 1989-04-12 AU AU32712/89A patent/AU601326B2/en not_active Ceased
- 1989-04-12 NZ NZ228712A patent/NZ228712A/en unknown
- 1989-04-12 KR KR1019890004822A patent/KR920002328B1/ko not_active Expired

Also Published As

Publication number	Publication date
DE68906707T2 (de)	1993-09-16
IL89872A (en)	1994-06-24
IE62751B1 (en)	1995-02-22
AU3271289A (en)	1989-10-19
IE891171L (en)	1989-10-13
EP0337628B1 (de)	1993-05-26
IL89872A0 (en)	1989-12-15
US4853409A (en)	1989-08-01
JPH01311022A (ja)	1989-12-15
PT90249B (pt)	1994-06-30
DK174289D0 (da)	1989-04-12
MY103872A (en)	1993-09-30
ZA892622B (en)	1990-11-28
EP0337628A3 (de)	1991-01-02
CA1324762C (en)	1993-11-30
DE68906707D1 (de)	1993-07-01
PH25857A (en)	1991-12-02
PT90249A (pt)	1989-11-10
DK174289A (da)	1989-10-16
HU204996B (en)	1992-03-30
KR920002328B1 (ko)	1992-03-21
AU601326B2 (en)	1990-09-06
HUT52376A (en)	1990-07-28
NZ228712A (en)	1997-02-24
KR890015740A (ko)	1989-11-25
EP0337628A2 (de)	1989-10-18

Legal Events

Date	Code	Title	Description
1994-01-15	UEP	Publication of translation of european patent specification
2005-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE89725T1 (de)	1993-06-15	3-substituierte 2-oxindol-1-carboxamid-derivate zur hemmung der aktivitaet der t-zellen.
ATE121939T1 (de)	1995-05-15	Ascorbinsäure-tocopheryl-phosphatdiester zur hemmung der maillard-reaktion.
DK599789A (da)	1990-05-30	3,5-di-tertiaer-butyl-4-hydroxyphenyl-1,3,4-thiadazoler og -oxadiazoler samt 3,5-di-tertiaer-butyl-4-hydroxyphenyl-1,2,4-thiadazoler, -oxadiazoler og -triazoler som anti-inflammatoriske midler
PT86785A (pt)	1988-03-01	Novel naphthalene derivatives having use as antiallergy and antiinflammatory agents
DE68906706D1 (de)	1993-07-01	3-substituierte 2-oxindol-1-carboxamid-derivate als hemmer der biosynthese des interleukins-1.
ATE46332T1 (de)	1989-09-15	Spiro-imidazolidine als aldose-reduktaseinhibitoren.
DE68912376D1 (de)	1994-03-03	Analoge von Bradykinin, dessen Synthese und dessen Benutzung in der Therapie.
DK52685A (da)	1985-09-20	N,3-diacyl-2-oxindol-1-carboxamid-forbindelser og mellemprodukter ved deres fremstilling samt farmaceutisk praeparat
ATE137759T1 (de)	1996-05-15	S'-adenosyl-methionin-decarboxylase-inhibitoren
DK544689D0 (da)	1989-11-01	Terapeutisk aktive forbindelser
DK520787D0 (da)	1987-10-05	Terapeutisk middel indeholdende propentofyllin eller derivater deraf til brug ved behandling af peptisk ulcus
GR3015704T3 (en)	1995-07-31	Glycerin derivative and its pharmacological use.
NO872812L (no)	1988-01-08	4-nitrogensubstituerte isokinolinolforbindelser med terapeutisk aktivitet og fremgangsmte for deres fremstilling.
ATE100710T1 (de)	1994-02-15	Eperisone als hypotonikum.
ES2053808T3 (es)	1994-08-01	Nuevos compuestos azolicos.
DE3874978D1 (de)	1992-11-05	Ponalrestat enthaltendes hyperurikaemie-mittel.
ATE95697T1 (de)	1993-10-15	Uricosuretische zusammensetzung.
DE68918240D1 (de)	1994-10-20	1,4-Dihydropyridin-Derivate.
ATE81465T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
ES8604174A1 (es)	1986-01-16	Procedimiento para la obtencion de isoxazoles