PH26140A - A process for the preparation of a hypoallergenic whey protein hydrolyzate and food - Google Patents

A process for the preparation of a hypoallergenic whey protein hydrolyzate and food Download PDF

Info

Publication number: PH26140A
Authority: PH; Philippines
Prior art keywords: hydrolyzate; minutes; whey; process according; temperature
Prior art date: 1987-12-23

Application number

PH37927A

Other languages

English (en)

Inventor

Rolf Jost

Niklaus Meister

Julio Cesar Monti

Original Assignee

Nestec Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-23

Filing date

1988-12-15

Publication date

1992-03-18

1988-12-15 Application filed by Nestec Sa filed Critical Nestec Sa

1992-03-18 Publication of PH26140A publication Critical patent/PH26140A/en

Links

108010046377 Whey Proteins Proteins 0.000 title claims description 31
238000000034 method Methods 0.000 title claims description 31
102000007544 Whey Proteins Human genes 0.000 title claims description 26
238000002360 preparation method Methods 0.000 title claims description 7
230000000774 hypoallergenic effect Effects 0.000 title claims description 4
235000021119 whey protein Nutrition 0.000 title description 8
235000013305 food Nutrition 0.000 title description 7
239000003531 protein hydrolysate Substances 0.000 title description 2
235000018102 proteins Nutrition 0.000 claims description 25
102000004169 proteins and genes Human genes 0.000 claims description 25
108090000623 proteins and genes Proteins 0.000 claims description 25
102000004190 Enzymes Human genes 0.000 claims description 24
108090000790 Enzymes Proteins 0.000 claims description 24
229940088598 enzyme Drugs 0.000 claims description 24
239000005862 Whey Substances 0.000 claims description 23
238000010438 heat treatment Methods 0.000 claims description 19
108090000631 Trypsin Proteins 0.000 claims description 17
102000004142 Trypsin Human genes 0.000 claims description 17
229960001322 trypsin Drugs 0.000 claims description 17
239000012588 trypsin Substances 0.000 claims description 17
239000000203 mixture Substances 0.000 claims description 12
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 11
239000003925 fat Substances 0.000 claims description 11
239000008101 lactose Substances 0.000 claims description 11
102000008192 Lactoglobulins Human genes 0.000 claims description 10
108010060630 Lactoglobulins Proteins 0.000 claims description 10
108090000765 processed proteins & peptides Proteins 0.000 claims description 9
239000013566 allergen Substances 0.000 claims description 8
239000007788 liquid Substances 0.000 claims description 8
102000004196 processed proteins & peptides Human genes 0.000 claims description 8
108090000317 Chymotrypsin Proteins 0.000 claims description 7
229960002376 chymotrypsin Drugs 0.000 claims description 7
229910052500 inorganic mineral Inorganic materials 0.000 claims description 6
239000011707 mineral Chemical class 0.000 claims description 6
102000004407 Lactalbumin Human genes 0.000 claims description 5
108090000942 Lactalbumin Proteins 0.000 claims description 5
235000014633 carbohydrates Nutrition 0.000 claims description 5
230000003301 hydrolyzing effect Effects 0.000 claims description 5
235000021241 α-lactalbumin Nutrition 0.000 claims description 5
108060003951 Immunoglobulin Proteins 0.000 claims description 4
108010019160 Pancreatin Proteins 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
150000001720 carbohydrates Chemical class 0.000 claims description 4
238000005345 coagulation Methods 0.000 claims description 4
230000015271 coagulation Effects 0.000 claims description 4
239000012141 concentrate Substances 0.000 claims description 4
102000018358 immunoglobulin Human genes 0.000 claims description 4
229940055695 pancreatin Drugs 0.000 claims description 4
229940108461 rennet Drugs 0.000 claims description 4
108010058314 rennet Proteins 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
108010071390 Serum Albumin Proteins 0.000 claims description 3
102000007562 Serum Albumin Human genes 0.000 claims description 3
239000005018 casein Substances 0.000 claims description 3
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 3
235000021240 caseins Nutrition 0.000 claims description 3
238000001816 cooling Methods 0.000 claims description 3
230000002255 enzymatic effect Effects 0.000 claims description 3
229940072221 immunoglobulins Drugs 0.000 claims description 3
230000001954 sterilising effect Effects 0.000 claims description 3
235000013351 cheese Nutrition 0.000 claims description 2
238000001035 drying Methods 0.000 claims description 2
239000000463 material Substances 0.000 claims 5
XGWIJUOSCAQSSV-XHDPSFHLSA-N (S,S)-hexythiazox Chemical compound S([C@H]([C@@H]1C)C=2C=CC(Cl)=CC=2)C(=O)N1C(=O)NC1CCCCC1 XGWIJUOSCAQSSV-XHDPSFHLSA-N 0.000 claims 1
230000002009 allergenic effect Effects 0.000 claims 1
150000001413 amino acids Chemical class 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
230000000415 inactivating effect Effects 0.000 claims 1
238000004806 packaging method and process Methods 0.000 claims 1
230000007062 hydrolysis Effects 0.000 description 44
238000006460 hydrolysis reaction Methods 0.000 description 44
108091003079 Bovine Serum Albumin Proteins 0.000 description 24
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229940027941 immunoglobulin g Drugs 0.000 description 16
230000000951 immunodiffusion Effects 0.000 description 15
239000007864 aqueous solution Substances 0.000 description 14
239000000523 sample Substances 0.000 description 11
239000000243 solution Substances 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
238000004458 analytical method Methods 0.000 description 9
235000019197 fats Nutrition 0.000 description 9
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 9
239000006185 dispersion Substances 0.000 description 8
238000006243 chemical reaction Methods 0.000 description 7
239000000499 gel Substances 0.000 description 7
239000000843 powder Substances 0.000 description 7
239000000047 product Substances 0.000 description 7
239000007858 starting material Substances 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
238000004108 freeze drying Methods 0.000 description 6
239000011782 vitamin Substances 0.000 description 6
229940088594 vitamin Drugs 0.000 description 6
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235000013343 vitamin Nutrition 0.000 description 6
206010020751 Hypersensitivity Diseases 0.000 description 5
238000001514 detection method Methods 0.000 description 5
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239000012895 dilution Substances 0.000 description 5
241000283690 Bos taurus Species 0.000 description 4
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
230000007815 allergy Effects 0.000 description 4
235000013336 milk Nutrition 0.000 description 4
210000004080 milk Anatomy 0.000 description 4
238000001694 spray drying Methods 0.000 description 4
238000000108 ultra-filtration Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
229920001817 Agar Polymers 0.000 description 3
239000005913 Maltodextrin Substances 0.000 description 3
229920002774 Maltodextrin Polymers 0.000 description 3
102000035195 Peptidases Human genes 0.000 description 3
108091005804 Peptidases Proteins 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
239000008272 agar Substances 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
239000011575 calcium Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000001962 electrophoresis Methods 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
229940035034 maltodextrin Drugs 0.000 description 3
239000008267 milk Substances 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
238000000926 separation method Methods 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
239000008107 starch Substances 0.000 description 3
239000000758 substrate Substances 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Natural products CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
239000007983 Tris buffer Substances 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
208000026935 allergic disease Diseases 0.000 description 2
235000009508 confectionery Nutrition 0.000 description 2
230000007071 enzymatic hydrolysis Effects 0.000 description 2
238000006047 enzymatic hydrolysis reaction Methods 0.000 description 2
239000012634 fragment Substances 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
230000000977 initiatory effect Effects 0.000 description 2
235000016709 nutrition Nutrition 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
238000004448 titration Methods 0.000 description 2
238000011282 treatment Methods 0.000 description 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
RSDQBPGKMDFRHH-MJVIGCOGSA-N (3s,3as,5ar,9bs)-3,5a,9-trimethyl-3a,4,5,7,8,9b-hexahydro-3h-benzo[g][1]benzofuran-2,6-dione Chemical compound O=C([C@]1(C)CC2)CCC(C)=C1[C@@H]1[C@@H]2[C@H](C)C(=O)O1 RSDQBPGKMDFRHH-MJVIGCOGSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
235000003255 Carthamus tinctorius Nutrition 0.000 description 1
244000020518 Carthamus tinctorius Species 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
241000282412 Homo Species 0.000 description 1
241000282414 Homo sapiens Species 0.000 description 1
102000014171 Milk Proteins Human genes 0.000 description 1
108010011756 Milk Proteins Proteins 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
239000004365 Protease Substances 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
RSDQBPGKMDFRHH-UHFFFAOYSA-N Taurin Natural products C1CC2(C)C(=O)CCC(C)=C2C2C1C(C)C(=O)O2 RSDQBPGKMDFRHH-UHFFFAOYSA-N 0.000 description 1
101710162629 Trypsin inhibitor Proteins 0.000 description 1
229940122618 Trypsin inhibitor Drugs 0.000 description 1
241000112708 Vates Species 0.000 description 1
YVNQAIFQFWTPLQ-UHFFFAOYSA-O [4-[[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylidene]-3-methylcyclohexa-2,5-dien-1-ylidene]-ethyl-[(3-sulfophenyl)methyl]azanium Chemical compound C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C(=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S(O)(=O)=O)C)C=2C(=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S(O)(=O)=O)C)C=C1 YVNQAIFQFWTPLQ-UHFFFAOYSA-O 0.000 description 1
230000029936 alkylation Effects 0.000 description 1
238000005804 alkylation reaction Methods 0.000 description 1
235000020244 animal milk Nutrition 0.000 description 1
239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000001354 calcium citrate Substances 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
235000019864 coconut oil Nutrition 0.000 description 1
239000003240 coconut oil Substances 0.000 description 1
210000003022 colostrum Anatomy 0.000 description 1
235000021277 colostrum Nutrition 0.000 description 1
229940000425 combination drug Drugs 0.000 description 1
NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000000378 dietary effect Effects 0.000 description 1
239000012470 diluted sample Substances 0.000 description 1
230000008034 disappearance Effects 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
238000000909 electrodialysis Methods 0.000 description 1
230000007515 enzymatic degradation Effects 0.000 description 1
ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
235000020256 human milk Nutrition 0.000 description 1
210000004251 human milk Anatomy 0.000 description 1
239000000413 hydrolysate Substances 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
238000012432 intermediate storage Methods 0.000 description 1
PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
239000004337 magnesium citrate Substances 0.000 description 1
229960005336 magnesium citrate Drugs 0.000 description 1
235000002538 magnesium citrate Nutrition 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000007065 protein hydrolysis Effects 0.000 description 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
239000012465 retentate Substances 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
241000894007 species Species 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
235000013337 tricalcium citrate Nutrition 0.000 description 1
PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Nutrition Science (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Dairy Products (AREA)

PH37927A 1987-12-23 1988-12-15 A process for the preparation of a hypoallergenic whey protein hydrolyzate and food PH26140A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP87119104A EP0321603A1 (de)	1987-12-23	1987-12-23	Verfahren zur Herstellung eines Molke-Eiweisshydrolysates und eines hypoallergenen Nahrungsmittels

Publications (1)

Publication Number	Publication Date
PH26140A true PH26140A (en)	1992-03-18

Family

ID=8197538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH37927A PH26140A (en)	1987-12-23	1988-12-15	A process for the preparation of a hypoallergenic whey protein hydrolyzate and food

Country Status (11)

Country	Link
US (1)	US5039532A (de)
EP (1)	EP0321603A1 (de)
JP (1)	JPH0677504B2 (de)
AU (1)	AU613684B2 (de)
CA (1)	CA1334064C (de)
DE (1)	DE3877733T2 (de)
ES (1)	ES2053690T3 (de)
MX (1)	MX169602B (de)
PH (1)	PH26140A (de)
PT (1)	PT89325B (de)
ZA (1)	ZA889280B (de)

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CA1341151C (en) *	1985-09-10	2000-12-05	Elias Klein	Osmotic agents form peritoneal dialysis
ATE84680T1 (de) *	1987-12-23	1993-02-15	Nestle Sa	Verfahren zur herstellung eines molkeeiweisshydrolysates und eines hypoallergenen nahrungsmittels.
JP2794305B2 (ja) *	1988-07-20	1998-09-03	明治乳業株式会社	牛乳乳清蛋白質中のβ―ラクトログロブリンの選択的酵素分解方法
DK351189A (da) *	1988-07-20	1990-01-21	Meiji Milk Prod Co Ltd	Selektiv, enzymatisk nedbrydelse af beta-laktoglobulin indeholdt i koeers maelkeserumprotein
NZ234810A (en) *	1989-08-08	1992-07-28	Swordfish International Ltd	Making a hypoallergenic nutritional formula based on meat
JPH0683653B2 (ja) *	1989-09-14	1994-10-26	大塚製薬株式会社	栄養液剤組成物
EP0421309B2 (de) *	1989-10-02	2001-08-16	Novartis Nutrition AG	Proteinhydrolysaten
US5266473A (en) *	1992-01-28	1993-11-30	Kellogg Company	Method for decreasing the allergenicity of psyllium seed husk by enzyme treatment
US5902617A (en) *	1992-05-19	1999-05-11	Pabst; Patrea L.	Enzyme supplemented baby formula
US5486368A (en) *	1992-05-28	1996-01-23	Dmv Usa, Inc.	Production of a cultured yeast product from whey permeate, yeast cream and yeast centrate
US5378488A (en) *	1993-06-10	1995-01-03	Abbott Laboratories	Aseptic processing of infant formula
JPH078691A (ja) *	1993-06-24	1995-01-13	Toshiba Corp	衣類乾燥機
US5405637A (en) *	1993-06-30	1995-04-11	Bristol-Myers Squibb Company	Milk protein partial hydrolysate and infant formula containing same
JP2683492B2 (ja) *	1993-09-07	1997-11-26	雪印乳業株式会社	ミセル状ホエー蛋白質、その溶液、その粉末およびミセル状ホエー蛋白質の製造法
US6348346B1 (en) *	1994-05-27	2002-02-19	University Of Kentucky Research Foundation	Method of inhibiting binding activity of immunoglobulins
US6274141B1 (en) *	1995-02-28	2001-08-14	Doyle W. Boatwright	Enzymatic dietary treatment for hydrolyzing BSA
US5618689A (en) *	1995-05-25	1997-04-08	Nestec S.A.	Enhanced procedures for preparing food hydrolysates
DK0782825T3 (da) *	1995-08-08	2003-03-24	Snow Brand Milk Products Co Ltd	Modificeret valleprotein og proces til fremstilling af dette
PT827697E (pt) *	1996-09-06	2002-11-29	Nestle Sa	Inducao da tolerancia ao leite de vaca
DK0832565T3 (da) *	1996-09-24	2000-11-20	Nestle Sa	Mælkeerstatningsprodukt og fremgangsmåde til fremstilling deraf
DE69805114T2 (de) *	1997-02-10	2002-08-22	Societe Des Produits Nestle S.A., Vevey	Für die zubereitung eines hypoallergenischen breies verwendbares pulver
DK0922392T3 (da)	1997-12-12	2003-06-23	Nestle Sa	Fremgangsmåde til fremstilling af et næringsmiddel baseret på proteinhydrolysat
AU761477B2 (en) *	1998-06-17	2003-06-05	New Zealand Dairy Board	Bioactive whey protein hydrolysate
US6403142B1 (en) *	1998-12-11	2002-06-11	Ralston Purina Company	Hypoallergenic pet food
MY129566A (en)	1999-01-19	2007-04-30	Nestle Sa	A hypoallergenic composition containing tolerogenic peptides inducing oral tolerance
US6998259B1 (en)	1999-05-20	2006-02-14	Davisco Foods International	Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
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Also Published As

Publication number	Publication date
JPH022319A (ja)	1990-01-08
US5039532A (en)	1991-08-13
JPH0677504B2 (ja)	1994-10-05
MX169602B (es)	1993-07-14
CA1334064C (en)	1995-01-24
ZA889280B (en)	1989-09-27
EP0321603A1 (de)	1989-06-28
PT89325A (pt)	1989-12-29
AU613684B2 (en)	1991-08-08
DE3877733T2 (de)	1993-06-09
AU2659688A (en)	1989-06-29
ES2053690T3 (es)	1994-08-01
DE3877733D1 (de)	1993-03-04
PT89325B (pt)	1993-08-31

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