PH26376A - Heterocyclic bisphosphonic acid derivatives - Google Patents

Heterocyclic bisphosphonic acid derivatives Download PDF

Info

Publication number
PH26376A
PH26376A PH39086A PH39086A PH26376A PH 26376 A PH26376 A PH 26376A PH 39086 A PH39086 A PH 39086A PH 39086 A PH39086 A PH 39086A PH 26376 A PH26376 A PH 26376A
Authority
PH
Philippines
Prior art keywords
hydrogen atom
lower alkyl
general formula
hydroxyl group
alkyl group
Prior art date
Application number
PH39086A
Other languages
English (en)
Inventor
Yasuo Isomura
Makoto Takeuchi
Tetsushi Abe
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of PH26376A publication Critical patent/PH26376A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PH39086A 1988-08-12 1989-08-11 Heterocyclic bisphosphonic acid derivatives PH26376A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20153588 1988-08-12
JP20153688 1988-08-12

Publications (1)

Publication Number Publication Date
PH26376A true PH26376A (en) 1992-06-01

Family

ID=26512843

Family Applications (1)

Application Number Title Priority Date Filing Date
PH39086A PH26376A (en) 1988-08-12 1989-08-11 Heterocyclic bisphosphonic acid derivatives

Country Status (14)

Country Link
US (2) US4990503A (fr)
EP (1) EP0354806B1 (fr)
KR (1) KR0156239B1 (fr)
CN (1) CN1027167C (fr)
AT (1) ATE129714T1 (fr)
AU (1) AU624405B2 (fr)
CA (1) CA1332058C (fr)
DE (1) DE68924681T2 (fr)
DK (1) DK170257B1 (fr)
ES (1) ES2082780T3 (fr)
GR (1) GR3018086T3 (fr)
HU (2) HU205766B (fr)
IE (1) IE71185B1 (fr)
PH (1) PH26376A (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521622B1 (fr) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Esters de l'acide pyrazolopyrimidine et pyrimidinyl bisphosphonique comme anti-inflammatoires
TW222637B (fr) * 1991-12-12 1994-04-21 Hoechst Ag
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
JPH05345791A (ja) * 1992-03-18 1993-12-27 Hoechst Japan Ltd 環状アミノメチレンビスホスホン酸誘導体
WO1994000462A1 (fr) * 1992-06-23 1994-01-06 Yamanouchi Pharmaceutical Co., Ltd. Nouveau cristal de monohydrate de derive de bis(acide phosphonique) heterocyclique
AU4859493A (en) * 1992-10-09 1994-05-09 Upjohn Company, The Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
DE59309360D1 (de) * 1992-12-02 1999-03-18 Hoechst Ag Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH06298779A (ja) * 1993-04-15 1994-10-25 Hoechst Japan Ltd ヘテロ環イミノビスメチレンビスホスホン酸誘導体
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US6284748B1 (en) 1997-03-07 2001-09-04 Metabasis Therapeutics, Inc. Purine inhibitors of fructose 1,6-bisphosphatase
US6054587A (en) 1997-03-07 2000-04-25 Metabasis Therapeutics, Inc. Indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US7008645B2 (en) * 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
TW476649B (en) 1998-12-25 2002-02-21 Yamanouchi Pharma Co Ltd Pharmaceutical composition for treating bone disease of multiple myeloma
US20030036537A1 (en) * 2001-07-16 2003-02-20 Marc Lecouvey Bisphosphonate derivatives, their preparations and uses
HRP20041013B1 (hr) 2002-12-20 2013-10-25 F. Hoffmann - La Roche Ag Formulacija visoke doze ibandronata
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20060051407A1 (en) * 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
US10517883B2 (en) * 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
US20070191311A1 (en) * 2004-01-30 2007-08-16 Shuichiro Kakimoto P2x receptor inhibitor
CN101531681B (zh) * 2008-03-10 2013-06-05 北京德众万全医药科技有限公司 一种高纯度的米诺膦酸及其制备方法
EP2350076B1 (fr) * 2008-09-22 2013-08-21 Isis Innovation Ltd Imidazo[1,2- alpha]pyridinyle bisphosphonates
WO2010033980A2 (fr) * 2008-09-22 2010-03-25 Isis Innovation Ltd. 4-azaindole bisphosphonates
EP2493905B1 (fr) 2009-10-26 2016-11-30 Warner Chilcott Company, LLC Composés bisphosphonates destinés au traitement de troubles du métabolisme osseux
CN101973993A (zh) * 2010-11-05 2011-02-16 天津药物研究院 一种制备2-[咪唑并(1,2-a)吡啶-3-基]乙酸的方法
CN102153585B (zh) * 2011-02-24 2013-04-17 北京欧克兰医药技术开发中心 一种米诺膦酸中间体的合成方法及米诺膦酸的合成
CN102268042B (zh) * 2011-06-01 2014-06-25 广东宏远集团药业有限公司 一种米诺膦酸晶型ii及其制备方法
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
CN107033187A (zh) * 2017-04-28 2017-08-11 江苏笃诚医药科技股份有限公司 一种米诺膦酸的制备方法
KR20220115062A (ko) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ATE64397T1 (de) * 1986-11-21 1991-06-15 Ciba Geigy Ag Aromatisch substituierte azacycloalkylalkandiphosphons|uren.
DE3640938A1 (de) * 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
EP0317505A1 (fr) * 1987-11-13 1989-05-24 Ciba-Geigy Ag Acides azacycloalkylalcanediphosphoniques

Also Published As

Publication number Publication date
GR3018086T3 (en) 1996-02-29
DE68924681D1 (de) 1995-12-07
IE71185B1 (en) 1997-01-29
DK394789A (da) 1990-02-13
CN1040590A (zh) 1990-03-21
HUT51637A (en) 1990-05-28
DK394789D0 (da) 1989-08-11
KR0156239B1 (ko) 1998-12-01
KR900003186A (ko) 1990-03-26
US4990503A (en) 1991-02-05
CA1332058C (fr) 1994-09-20
HU205766B (en) 1992-06-29
EP0354806B1 (fr) 1995-11-02
US5039669A (en) 1991-08-13
DE68924681T2 (de) 1996-04-04
EP0354806A3 (fr) 1991-05-02
ES2082780T3 (es) 1996-04-01
IE892601L (en) 1990-02-12
EP0354806A2 (fr) 1990-02-14
AU624405B2 (en) 1992-06-11
CN1027167C (zh) 1994-12-28
HU211949A9 (en) 1996-01-29
DK170257B1 (da) 1995-07-17
AU3941989A (en) 1990-02-15
ATE129714T1 (de) 1995-11-15

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