PH26816A - Diol-containing renin inhibitors - Google Patents

Diol-containing renin inhibitors Download PDF

Info

Publication number
PH26816A
PH26816A PH38698A PH38698A PH26816A PH 26816 A PH26816 A PH 26816A PH 38698 A PH38698 A PH 38698A PH 38698 A PH38698 A PH 38698A PH 26816 A PH26816 A PH 26816A
Authority
PH
Philippines
Prior art keywords
nhch
cad
phe
mmole
lower alkyl
Prior art date
Application number
PH38698A
Other languages
English (en)
Inventor
Richard Himmelsbach
John Cooke Hodges
James Stanley Kaltenbronn
Joseph Thomas Repine
Ila Sircar
William Chester Patt
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Priority to PH40714A priority Critical patent/PH27036A/en
Publication of PH26816A publication Critical patent/PH26816A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH38698A 1988-05-27 1989-05-25 Diol-containing renin inhibitors PH26816A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PH40714A PH27036A (en) 1988-05-27 1990-06-21 Process for the preparation of diol containing renin inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19999088A 1988-05-27 1988-05-27
US07/321,638 US5036053A (en) 1988-05-27 1989-03-15 Diol-containing renin inhibitors

Publications (1)

Publication Number Publication Date
PH26816A true PH26816A (en) 1992-11-05

Family

ID=26895354

Family Applications (1)

Application Number Title Priority Date Filing Date
PH38698A PH26816A (en) 1988-05-27 1989-05-25 Diol-containing renin inhibitors

Country Status (11)

Country Link
US (1) US5036053A (fr)
EP (1) EP0343654A3 (fr)
JP (1) JPH0267297A (fr)
KR (1) KR900018137A (fr)
AU (1) AU625456B2 (fr)
DK (1) DK258589A (fr)
FI (1) FI892521L (fr)
NO (1) NO892136L (fr)
NZ (1) NZ229281A (fr)
PH (1) PH26816A (fr)
PT (1) PT90659B (fr)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
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US5373017A (en) * 1992-08-14 1994-12-13 G. D. Searle & Co. Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
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US11958856B2 (en) 2021-07-22 2024-04-16 Janssen Pharmaceutica Nv Substituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors
US12286429B2 (en) 2021-07-22 2025-04-29 Janssen Pharmaceutica Nv 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives useful as a factor XIa inhibitors

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
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EP0249096B1 (fr) * 1986-06-10 1995-01-11 Merck Patent Gmbh Dérivés d'acides aminés inhibant la rénine.

Also Published As

Publication number Publication date
EP0343654A3 (fr) 1991-05-29
DK258589A (da) 1989-11-28
NZ229281A (en) 1991-11-26
AU625456B2 (en) 1992-07-09
PT90659B (pt) 1994-10-31
NO892136D0 (no) 1989-05-26
FI892521A7 (fi) 1989-11-28
NO892136L (no) 1989-11-28
DK258589D0 (da) 1989-05-26
EP0343654A2 (fr) 1989-11-29
FI892521A0 (fi) 1989-05-24
KR900018137A (ko) 1990-12-20
JPH0267297A (ja) 1990-03-07
AU3463389A (en) 1989-11-30
PT90659A (pt) 1989-11-30
US5036053A (en) 1991-07-30
FI892521L (fi) 1989-11-28

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