PH26858A - Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones - Google Patents

Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones Download PDF

Info

Publication number: PH26858A
Authority: PH; Philippines
Prior art keywords: group; hvdrogen; subst; phenyl; alkoxy
Prior art date: 1989-11-13

Application number

PH41541A

Other languages

English (en)

Inventor

Sai Prasad Sunkara

Winton D Jones

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-13

Filing date

1990-11-13

Publication date

1992-11-16

1990-11-13 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1992-11-16 Publication of PH26858A publication Critical patent/PH26858A/en

Links

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ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000155 melt Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
210000004779 membrane envelope Anatomy 0.000 description 1
AFCCDDWKHLHPDF-UHFFFAOYSA-M metam-sodium Chemical compound [Na+].CNC([S-])=S AFCCDDWKHLHPDF-UHFFFAOYSA-M 0.000 description 1
125000006178 methyl benzyl group Chemical group 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
XNLICIUVMPYHGG-UHFFFAOYSA-N methyl n-propyl ketone Natural products CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
229940105132 myristate Drugs 0.000 description 1
125000006606 n-butoxy group Chemical group 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
OVWIGQXNKGEUQN-UHFFFAOYSA-N pentan-2-one Chemical compound [CH2]C(=O)CCC OVWIGQXNKGEUQN-UHFFFAOYSA-N 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
125000003884 phenylalkyl group Chemical group 0.000 description 1
125000004344 phenylpropyl group Chemical group 0.000 description 1
IOUNQDKNJZEDEP-UHFFFAOYSA-N phosalone Chemical compound C1=C(Cl)C=C2OC(=O)N(CSP(=S)(OCC)OCC)C2=C1 IOUNQDKNJZEDEP-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
201000000317 pneumocystosis Diseases 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
229940116317 potato starch Drugs 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
239000004576 sand Substances 0.000 description 1
239000000344 soap Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000007892 solid unit dosage form Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
241000894007 species Species 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000002311 subsequent effect Effects 0.000 description 1
150000003871 sulfonates Chemical class 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
210000002845 virion Anatomy 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PH41541A 1989-11-13 1990-11-13 Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones PH26858A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US43626489A	1989-11-13	1989-11-13

Publications (1)

Publication Number	Publication Date
PH26858A true PH26858A (en)	1992-11-16

Family

ID=23731771

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH41541A PH26858A (en)	1989-11-13	1990-11-13	Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones

Country Status (7)

Country	Link
EP (1)	EP0428103A3 (de)
JP (1)	JP2927932B2 (de)
KR (1)	KR0162638B1 (de)
AU (1)	AU630248B2 (de)
IE (1)	IE904075A1 (de)
PH (1)	PH26858A (de)
ZA (1)	ZA908935B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5514781A (en) *	1994-04-11	1996-05-07	Bayer Corporation	Use of azoles as virucidal agents in solutions of biologically active proteins
US6291446B1 (en) *	1998-03-05	2001-09-18	Eli Lilly And Company	Therapeutic treatment for cytomegalovirus infection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4698353A (en) *	1985-11-13	1987-10-06	Merrell Dow Pharmaceuticals Inc.	Cardiotonic heterocyclic oxazolones

1990
- 1990-11-07 ZA ZA908935A patent/ZA908935B/xx unknown
- 1990-11-08 AU AU65925/90A patent/AU630248B2/en not_active Ceased
- 1990-11-12 EP EP19900121630 patent/EP0428103A3/en not_active Withdrawn
- 1990-11-12 KR KR1019900018250A patent/KR0162638B1/ko not_active Expired - Fee Related
- 1990-11-12 IE IE407590A patent/IE904075A1/en unknown
- 1990-11-13 JP JP2304168A patent/JP2927932B2/ja not_active Expired - Lifetime
- 1990-11-13 PH PH41541A patent/PH26858A/en unknown

Also Published As

Publication number	Publication date
KR910009263A (ko)	1991-06-28
KR0162638B1 (ko)	1998-12-01
EP0428103A2 (de)	1991-05-22
JP2927932B2 (ja)	1999-07-28
AU630248B2 (en)	1992-10-22
JPH03170426A (ja)	1991-07-24
IE904075A1 (en)	1991-05-22
ZA908935B (en)	1991-08-28
AU6592590A (en)	1991-05-16
EP0428103A3 (en)	1991-12-11

Publication	Publication Date	Title
Sarin et al.	1987	Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone
AU606391B2 (en)	1991-02-07	3'-azido-2',3'-dideoxyuridine anti-retroviral composition
DE68925278T2 (de)	1996-09-19	Hemmung von htlv-iii durch exogene oligonukleotide
DE3853779T2 (de)	1995-09-07	Hiv-1 neutralisierende monoklonale antikörper.
EA012650B1 (ru)	2009-12-30	ПРИМЕНЕНИЕ [D-MeAla]-[EtVal]-ЦИКЛОСПОРИНА ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИИ ГЕПАТИТА С И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ [D-MeAla]-[EtVal]-ЦИКЛОСПОРИН
EP0630245B1 (de)	1999-01-20	Proteinkinase c-inhibitor
Balzarini et al.	1987	The 2′, 3′-dideoxyriboside of 2, 6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication invitro
AU608853B2 (en)	1991-04-18	Inhibitors of glycoprotein processing having anti- retroviral activity
AU593405B2 (en)	1990-02-08	The use of 3-deoxy-thymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US5026716A (en)	1991-06-25	Method of treatment of anxiety and anxio-depressive disorders
FR2801587B1 (fr)	2002-01-11	Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA1304360C (en)	1992-06-30	Use of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2', 3'-didehydrocytidine) in treating patients infected with retroviruses
US20020142940A1 (en)	2002-10-03	Method of inhibiting viral infection using HMG-COA reductase inhibitors and isoprenylation inhibitors
EP0345751A1 (de)	1989-12-13	Antiretrovirale difluorierte Nucleoside
EP0542630A2 (de)	1993-05-19	Verwendung von Amphotericin B-Derivaten als Proteasehemmer
US5616577A (en)	1997-04-01	Protein Kinase C inhibitor
US5026726A (en)	1991-06-25	Gossylic iminolactones and gossylic lactones and their anti-viral activities
PH26858A (en)	1992-11-16	Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones
US5079239A (en)	1992-01-07	Sterol disulfates and methods of use
US5593999A (en)	1997-01-14	Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
US5061715A (en)	1991-10-29	Prevention of glycoprotein enveloped virus infectivity by quinolyl- and isoquinolyloxazole-2-zones
US5077279A (en)	1991-12-31	3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US5063238A (en)	1991-11-05	Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones
JPH0678230B2 (ja)	1994-10-05	好中球によるエラスターゼの遊離の阻害剤としてのテニダップ
WO1998033505A1 (en)	1998-08-06	Antiviral agents