PH26968A - Medicaments - Google Patents

Medicaments Download PDF

Info

Publication number: PH26968A
Authority: PH; Philippines
Prior art keywords: methyl; compound; formula; group; imidazol
Prior art date: 1988-09-01

Application number

PH39187A

Other languages

English (en)

Inventor

Ian Harold Coates

Alexander William Oxford

Peter Charles North

Michael Tyers

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-01

Filing date

1989-08-31

Publication date

1992-12-28

1989-08-31 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1992-12-28 Publication of PH26968A publication Critical patent/PH26968A/en

Links

239000003814 drug Substances 0.000 title claims description 6
150000001875 compounds Chemical class 0.000 claims description 49
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
239000004480 active ingredient Substances 0.000 claims description 19
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 19
-1 phenylmethoxymethyl Chemical group 0.000 claims description 19
150000003839 salts Chemical class 0.000 claims description 17
238000000034 method Methods 0.000 claims description 15
238000011282 treatment Methods 0.000 claims description 14
125000000217 alkyl group Chemical group 0.000 claims description 13
239000012453 solvate Substances 0.000 claims description 13
208000010877 cognitive disease Diseases 0.000 claims description 11
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
241000282414 Homo sapiens Species 0.000 claims description 6
241001465754 Metazoa Species 0.000 claims description 5
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims description 2
239000003405 delayed action preparation Substances 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
125000002883 imidazolyl group Chemical group 0.000 claims description 2
HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims description 2
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GQMYQEAXTITUAE-UHFFFAOYSA-N 1H-indole-5-carboxamide Chemical compound NC(=O)C1=CC=C2NC=CC2=C1 GQMYQEAXTITUAE-UHFFFAOYSA-N 0.000 claims 1
XLSZMDLNRCVEIJ-UHFFFAOYSA-N 4-methylimidazole Chemical compound CC1=CNC=N1 XLSZMDLNRCVEIJ-UHFFFAOYSA-N 0.000 claims 1
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FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
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150000003892 tartrate salts Chemical class 0.000 description 1
238000010998 test method Methods 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000012549 training Methods 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
210000001186 vagus nerve Anatomy 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PH39187A 1988-09-01 1989-08-31 Medicaments PH26968A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888820651A GB8820651D0 (en)	1988-09-01	1988-09-01	Medicaments

Publications (1)

Publication Number	Publication Date
PH26968A true PH26968A (en)	1992-12-28

Family

ID=10643003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH39187A PH26968A (en)	1988-09-01	1989-08-31	Medicaments

Country Status (10)

Country	Link
EP (1)	EP0357415A3 (fr)
JP (1)	JPH02180824A (fr)
KR (1)	KR900004340A (fr)
AU (1)	AU627769B2 (fr)
CA (1)	CA1330536C (fr)
DK (1)	DK432689A (fr)
GB (1)	GB8820651D0 (fr)
IL (1)	IL91482A0 (fr)
PH (1)	PH26968A (fr)
ZA (1)	ZA896675B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276050A (en) *	1989-08-01	1994-01-04	Glaxo Group Limited	Medicaments
EP0492020A1 (fr) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Utilisation de certains esters de la hexahydro-8-hydroxy-2,6-méthano-2H-quinolizine-3(4H)-one et des composés apparentés pour le traitement des maladies cognitives
DK148292D0 (da) *	1992-12-09	1992-12-09	Lundbeck & Co As H	Forbindelser
JPH08507514A (ja) *	1993-03-08	1996-08-13	藤沢薬品工業株式会社	脳血管性疾患を治療または予防するための薬物
GB0305553D0 (en) *	2003-03-11	2003-04-16	Glaxo Group Ltd	Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4605652A (en) *	1985-02-04	1986-08-12	A. H. Robins Company, Inc.	Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
US4624961A (en) *	1985-04-17	1986-11-25	A. H. Robins Company, Incorporated	Method for enhancing memory or correcting memory deficiency with arylamidopyrazolidines and arylamidodiazabicycloalkanes
GR871809B (en) *	1986-11-28	1988-03-07	Glaxo Group Ltd	Process for the preparation of tricyclic ketones
JP2608078B2 (ja) *	1986-12-17	1997-05-07	グラクソ、グループ、リミテッド	医薬
EP0551963A3 (en) *	1986-12-17	1993-09-01	Glaxo Group Limited	Use of heterocyclic derivatives for the manufacture of medicaments
NZ226032A (en) *	1987-09-03	1991-12-23	Glaxo Group Ltd	2-(imidazolylmethyl)-pyrido or-azepino(4,3-b)indole-1(2h)-one derivatives; preparatory processes and pharmaceutical compositions

1988
- 1988-09-01 GB GB888820651A patent/GB8820651D0/en active Pending
1989
- 1989-08-31 KR KR1019890012466A patent/KR900004340A/ko not_active Withdrawn
- 1989-08-31 CA CA000609996A patent/CA1330536C/fr not_active Expired - Fee Related
- 1989-08-31 ZA ZA896675A patent/ZA896675B/xx unknown
- 1989-08-31 AU AU40967/89A patent/AU627769B2/en not_active Ceased
- 1989-08-31 EP EP89308805A patent/EP0357415A3/fr not_active Withdrawn
- 1989-08-31 IL IL91482A patent/IL91482A0/xx unknown
- 1989-08-31 JP JP1226380A patent/JPH02180824A/ja active Pending
- 1989-08-31 PH PH39187A patent/PH26968A/en unknown
- 1989-08-31 DK DK432689A patent/DK432689A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA1330536C (fr)	1994-07-05
DK432689A (da)	1990-03-02
KR900004340A (ko)	1990-04-12
JPH02180824A (ja)	1990-07-13
AU4096789A (en)	1990-03-08
IL91482A0 (en)	1990-04-29
EP0357415A3 (fr)	1990-08-08
AU627769B2 (en)	1992-09-03
ZA896675B (en)	1990-09-26
DK432689D0 (da)	1989-08-31
EP0357415A2 (fr)	1990-03-07
GB8820651D0 (en)	1988-10-05

Publication	Publication Date	Title
EP0279114B2 (fr)	1995-08-23	Médicaments pour le traitement ou la prévention du syndrome associé à un état de manque
IL87658A (en)	1994-06-24	Tetrahydro-2- (1h-imidazolylmethyl) pyrido- (and azepino)[4,3-(b)] indol-1-ones, their preparation and pharmaceutical compositions containing them
GB2200046A (en)	1988-07-27	Pharmaceutical compositions for gastric disorders
EP0276559B1 (fr)	1992-08-05	Emploi de dérivés de cétone pour le traitement de la dépression
EP0278161B1 (fr)	1992-04-01	Dérivés de cétone comme médicaments pour le traitement ou la prévention du syndrome associé à un état de manque
EP0275668B1 (fr)	1992-09-30	Emploi de dérivés de cétone pour le traitement de troubles de la démence
CA1330536C (fr)	1994-07-05	Medicament pour le traitement d'un trouble cognitif
US5229407A (en)	1993-07-20	Medicaments
CA1330535C (fr)	1994-07-05	Medicament pour le traitement de la depression
AU627768B2 (en)	1992-09-03	The use of lactam derivatives in the treatment of addiction
US5221687A (en)	1993-06-22	Medicaments
CA2022379A1 (fr)	1991-02-02	Medicaments
EP0269452A2 (fr)	1988-06-01	Application de dérivés de cétone pour la fabrication de médicaments
US5276050A (en)	1994-01-04	Medicaments
IL95244A (en)	1994-07-31	Pharmaceutical compositions containing derivatives of 2,3,4,5-tetrahydro-2-(1h-imidazol-4-ylmethyl)-[4,3-b]- indol-1-one and the corresponding azepine homolog for the treatment of conditions involving excessive eating
CA2022380A1 (fr)	1991-02-02	Medicaments