PH27328A - Process for the preparation of 4-demthoxydaunomycinone the aglycone of 4-demethoxy daunorubicin - Google Patents

Process for the preparation of 4-demthoxydaunomycinone the aglycone of 4-demethoxy daunorubicin

Info

Publication number: PH27328A
Authority: PH; Philippines
Prior art keywords: aglycone; demethoxy; daunomycinone; group; demthoxydaunomycinone
Prior art date: 1988-02-12

Application number

PH38165A

Other languages

English (en)

Inventor

Sylvia De Bernadinis

Walter Cabri

Tiziano Martinengo

Franco Francalanci

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-12

Filing date

1989-02-06

Publication date

1993-06-08

1989-02-06 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1993-06-08 Publication of PH27328A publication Critical patent/PH27328A/en

Links

TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 title abstract 2
PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 title abstract 2
XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 title abstract 2
XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 title abstract 2
PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 title abstract 2
229960000908 idarubicin Drugs 0.000 title abstract 2
XYDJGVROLWFENK-YBTHPKLGSA-N (7s,9s)-9-acetyl-4,6,7,9,11-pentahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=C(O)C=CC=C2C(=O)C2=C1C(O)=C1[C@@H](O)C[C@@](C(=O)C)(O)CC1=C2O XYDJGVROLWFENK-YBTHPKLGSA-N 0.000 abstract 1
ZUFQFGSMHXKORU-UHFFFAOYSA-N 9-acetyl-6,7,9,11-tetrahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C1C(O)CC(C(=O)C)(O)CC1=C2O ZUFQFGSMHXKORU-UHFFFAOYSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000001989 diazonium salts Chemical class 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/38—Quinones containing —CHO or non—quinoid keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PH38165A 1988-02-12 1989-02-06 Process for the preparation of 4-demthoxydaunomycinone the aglycone of 4-demethoxy daunorubicin PH27328A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888803301A GB8803301D0 (en)	1988-02-12	1988-02-12	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin

Publications (1)

Publication Number	Publication Date
PH27328A true PH27328A (en)	1993-06-08

Family

ID=10631620

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH38165A PH27328A (en)	1988-02-12	1989-02-06	Process for the preparation of 4-demthoxydaunomycinone the aglycone of 4-demethoxy daunorubicin

Country Status (26)

Country	Link
US (1)	US5015745A (ru)
EP (1)	EP0328399B1 (ru)
JP (1)	JP2784202B2 (ru)
KR (1)	KR970000484B1 (ru)
CN (1)	CN1020592C (ru)
AT (1)	ATE92457T1 (ru)
AU (1)	AU605960B2 (ru)
CA (1)	CA1339634C (ru)
CS (1)	CS273198B2 (ru)
DE (1)	DE68907934T2 (ru)
DK (1)	DK170248B1 (ru)
ES (1)	ES2059718T3 (ru)
FI (1)	FI92186C (ru)
GB (1)	GB8803301D0 (ru)
HU (1)	HU200979B (ru)
IE (1)	IE62954B1 (ru)
IL (1)	IL89198A (ru)
MY (1)	MY104941A (ru)
NO (1)	NO169483C (ru)
NZ (1)	NZ227873A (ru)
PH (1)	PH27328A (ru)
PT (1)	PT89663B (ru)
RU (1)	RU1819256C (ru)
UA (1)	UA19151A (ru)
YU (1)	YU47206B (ru)
ZA (1)	ZA891018B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ224252A (en) *	1987-04-21	1991-09-25	Erba Carlo Spa	An anthracycline glycoside and its preparation
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
IT1275953B1 (it) *	1995-03-22	1997-10-24	Sicor Spa	Procedimento per la preparazione di antibiotici della classe delle antracicline
AUPQ319799A0 (en) *	1999-10-01	1999-10-28	Institute Of Drug Technology Australia Limited	Chemical methods
US7053191B2 (en)	2003-05-21	2006-05-30	Solux Corporation	Method of preparing 4-R-substituted 4-demethoxydaunorubicin
TW200621698A (en) *	2004-08-23	2006-07-01	Sicor Inc	Synthesis of idarubicin aglycone
DE06848583T1 (de)	2005-12-13	2011-03-17	Solux Corporation, San Diego	Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en)	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en)	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en)	2011-04-29	2014-09-30	Synbias Pharma Ag	Method of producing 4-demethoxydaunorubicin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3862225A (en) *	1961-08-18	1975-01-21	Pfizer	D-ring substituted tetracyclines
US4020270A (en) *	1974-05-02	1977-04-26	Societa' Farmaceutici Italia S.P.A.	L-lyxohex-1-enopyranose derivative
GB1467383A (en) *	1974-06-12	1977-03-16	Farmaceutici Italia	Daunomycin analogues
GB1500421A (en) *	1975-01-22	1978-02-08	Farmaceutici Italia	Optically active anthracyclinones
GB1509875A (en) *	1976-06-14	1978-05-04	Farmaceutici Italia	Optically active anthracyclinones and anthracycline glycosides
GB1527050A (en) *	1976-06-19	1978-10-04	Farmaceutici Italia	Optically active anthracyclinones
GB8317037D0 (en) *	1983-06-23	1983-07-27	Erba Farmitalia	6-deoxyanthracyclines
US4495103A (en) *	1982-07-30	1985-01-22	Sumitomo Chemical Company, Ltd.	Preparation of optically active 4-demethoxydaunomycinone
EP0159357B1 (en) *	1983-10-19	1992-09-09	The University Of Melbourne	Carminomycinone precursors and analogues and derivatives thereof
NZ224252A (en) *	1987-04-21	1991-09-25	Erba Carlo Spa	An anthracycline glycoside and its preparation
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
GB8824947D0 (en) *	1988-10-25	1988-11-30	Erba Carlo Spa	New 4-substituted anthracyclinones & process for preparing them

1988
- 1988-02-12 GB GB888803301A patent/GB8803301D0/en active Pending
1989
- 1989-02-06 US US07/306,559 patent/US5015745A/en not_active Expired - Lifetime
- 1989-02-06 PH PH38165A patent/PH27328A/en unknown
- 1989-02-07 IL IL8919889A patent/IL89198A/en not_active IP Right Cessation
- 1989-02-07 CS CS80789A patent/CS273198B2/cs unknown
- 1989-02-07 IE IE38389A patent/IE62954B1/en not_active IP Right Cessation
- 1989-02-07 NZ NZ227873A patent/NZ227873A/xx unknown
- 1989-02-08 KR KR1019890001402A patent/KR970000484B1/ko not_active Expired - Fee Related
- 1989-02-08 AU AU29745/89A patent/AU605960B2/en not_active Ceased
- 1989-02-08 YU YU31089A patent/YU47206B/sh unknown
- 1989-02-09 ZA ZA891018A patent/ZA891018B/xx unknown
- 1989-02-09 NO NO890566A patent/NO169483C/no unknown
- 1989-02-09 PT PT89663A patent/PT89663B/pt not_active IP Right Cessation
- 1989-02-09 JP JP1030929A patent/JP2784202B2/ja not_active Expired - Fee Related
- 1989-02-09 UA UA4613419A patent/UA19151A/ru unknown
- 1989-02-09 FI FI890612A patent/FI92186C/fi active IP Right Grant
- 1989-02-09 RU SU894613419A patent/RU1819256C/ru not_active IP Right Cessation
- 1989-02-10 AT AT89301282T patent/ATE92457T1/de not_active IP Right Cessation
- 1989-02-10 ES ES89301282T patent/ES2059718T3/es not_active Expired - Lifetime
- 1989-02-10 MY MYPI89000165A patent/MY104941A/en unknown
- 1989-02-10 HU HU89630A patent/HU200979B/hu unknown
- 1989-02-10 CN CN89100740A patent/CN1020592C/zh not_active Expired - Fee Related
- 1989-02-10 EP EP89301282A patent/EP0328399B1/en not_active Expired - Lifetime
- 1989-02-10 DK DK063889A patent/DK170248B1/da not_active IP Right Cessation
- 1989-02-10 DE DE89301282T patent/DE68907934T2/de not_active Expired - Fee Related
- 1989-02-10 CA CA000590705A patent/CA1339634C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RU1819256C (en)	1993-05-30
KR890012931A (ko)	1989-09-20
DK63889D0 (da)	1989-02-10
UA19151A (ru)	1997-12-25
FI92186C (fi)	1994-10-10
ZA891018B (en)	1989-10-25
HU200979B (en)	1990-09-28
CS273198B2 (en)	1991-03-12
NO169483C (no)	1992-07-01
EP0328399A2 (en)	1989-08-16
FI890612A0 (fi)	1989-02-09
US5015745A (en)	1991-05-14
IE62954B1 (en)	1995-02-20
EP0328399B1 (en)	1993-08-04
CS80789A2 (en)	1990-06-13
NO890566D0 (no)	1989-02-09
KR970000484B1 (ko)	1997-01-13
ES2059718T3 (es)	1994-11-16
JP2784202B2 (ja)	1998-08-06
YU31089A (en)	1990-08-31
FI92186B (fi)	1994-06-30
IE890383L (en)	1989-08-12
AU605960B2 (en)	1991-01-24
NZ227873A (en)	1990-09-26
HUT49319A (en)	1989-09-28
DE68907934D1 (de)	1993-09-09
NO890566L (no)	1989-08-11
GB8803301D0 (en)	1988-03-09
DK63889A (da)	1989-08-13
EP0328399A3 (en)	1990-03-07
IL89198A (en)	1994-10-07
PT89663A (pt)	1989-10-04
DK170248B1 (da)	1995-07-17
ATE92457T1 (de)	1993-08-15
IL89198A0 (en)	1989-09-10
CN1037152A (zh)	1989-11-15
JPH021423A (ja)	1990-01-05
CA1339634C (en)	1998-01-20
NO169483B (no)	1992-03-23
MY104941A (en)	1994-07-30
DE68907934T2 (de)	1994-04-28
PT89663B (pt)	1994-02-28
FI890612L (fi)	1989-08-13
CN1020592C (zh)	1993-05-12
AU2974589A (en)	1989-08-17
YU47206B (sh)	1995-01-31

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AU581052B2 (en)	1989-02-09	Preparation process of (6R)-tetrahydro-L-biopterin
AU650143B2 (en)	1994-06-09	4a-substituted avermectin derivatives
ZA891018B (en)	1989-10-25	Process for the preparation of 4-demethoxydaunomycinone,the aglycone of 4-demethoxy-daunorubicin
ATE148501T1 (de)	1997-02-15	Durch aromaten substituiertes glykosid
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GR1001203B (el)	1993-06-21	Μεθοδος παρασκευης της ενωσεως 24r-σκυμνολη.
TW342392B (en)	1998-10-11	Anomeric fluororibosyl amines
PT88952A (pt)	1988-12-01	Processo para a preparacao de avermectinas etiladas
JPS55164672A (en)	1980-12-22	Azetidine derivative and its preparation
DK0567767T3 (da)	1999-02-01	Krystallinske former af endo-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazol-1-carboxamid-hydroc
EP0335369A3 (en)	1990-03-28	New anthracycline derivatives and processes for the preparation of the same
DE3479999D1 (en)	1989-11-09	Pharmaceutical compositions containing compounds with a flavanone skeleton and process for the preparation of said compounds
CA2003107A1 (en)	1990-06-23	Process for the production of n,n'-bis-(3-aminophenyl)-ureas
TW290431B (ru)	1996-11-11