PT89663A - Processo para a preparacao da aglicona de 4-desmetoxi-daunorrubicina designada por 4-toxidaunomicinona - Google Patents

Processo para a preparacao da aglicona de 4-desmetoxi-daunorrubicina designada por 4-toxidaunomicinona

Info

Publication number: PT89663A
Authority: PT; Portugal
Prior art keywords: daunorubicin; daunomycinone; group; toxidaunomycinone; desmetoxy
Prior art date: 1988-02-12

Application number

PT89663A

Other languages

English (en)

Other versions

PT89663B (pt

Inventor

Walter Cabri

Tiziano Martinengo

Silvia De Bernardinis

Franco Francalanci

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-12

Filing date

1989-02-09

Publication date

1989-10-04

1989-02-09 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1989-10-04 Publication of PT89663A publication Critical patent/PT89663A/pt

1994-02-28 Publication of PT89663B publication Critical patent/PT89663B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/38—Quinones containing —CHO or non—quinoid keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT89663A 1988-02-12 1989-02-09 Processo para a preparacao da aglicona de 4-desmetoxi-daunorrubicina designada por 4-toxidaunomicinona PT89663B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888803301A GB8803301D0 (en)	1988-02-12	1988-02-12	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin

Publications (2)

Publication Number	Publication Date
PT89663A true PT89663A (pt)	1989-10-04
PT89663B PT89663B (pt)	1994-02-28

Family

ID=10631620

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT89663A PT89663B (pt)	1988-02-12	1989-02-09	Processo para a preparacao da aglicona de 4-desmetoxi-daunorrubicina designada por 4-toxidaunomicinona

Country Status (26)

Country	Link
US (1)	US5015745A (pt)
EP (1)	EP0328399B1 (pt)
JP (1)	JP2784202B2 (pt)
KR (1)	KR970000484B1 (pt)
CN (1)	CN1020592C (pt)
AT (1)	ATE92457T1 (pt)
AU (1)	AU605960B2 (pt)
CA (1)	CA1339634C (pt)
CS (1)	CS273198B2 (pt)
DE (1)	DE68907934T2 (pt)
DK (1)	DK170248B1 (pt)
ES (1)	ES2059718T3 (pt)
FI (1)	FI92186C (pt)
GB (1)	GB8803301D0 (pt)
HU (1)	HU200979B (pt)
IE (1)	IE62954B1 (pt)
IL (1)	IL89198A (pt)
MY (1)	MY104941A (pt)
NO (1)	NO169483C (pt)
NZ (1)	NZ227873A (pt)
PH (1)	PH27328A (pt)
PT (1)	PT89663B (pt)
RU (1)	RU1819256C (pt)
UA (1)	UA19151A (pt)
YU (1)	YU47206B (pt)
ZA (1)	ZA891018B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ224252A (en) *	1987-04-21	1991-09-25	Erba Carlo Spa	An anthracycline glycoside and its preparation
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
IT1275953B1 (it) *	1995-03-22	1997-10-24	Sicor Spa	Procedimento per la preparazione di antibiotici della classe delle antracicline
AUPQ319799A0 (en) *	1999-10-01	1999-10-28	Institute Of Drug Technology Australia Limited	Chemical methods
US7053191B2 (en)	2003-05-21	2006-05-30	Solux Corporation	Method of preparing 4-R-substituted 4-demethoxydaunorubicin
TW200621698A (en) *	2004-08-23	2006-07-01	Sicor Inc	Synthesis of idarubicin aglycone
WO2007070820A2 (en)	2005-12-13	2007-06-21	Solux Corporation	Method for preparing 4-demethyldaunorubicin
US8802830B2 (en)	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en)	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) *	2011-04-29	2014-09-30	Synbias Pharma Ag	Method of producing 4-demethoxydaunorubicin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3862225A (en) *	1961-08-18	1975-01-21	Pfizer	D-ring substituted tetracyclines
US4020270A (en) *	1974-05-02	1977-04-26	Societa' Farmaceutici Italia S.P.A.	L-lyxohex-1-enopyranose derivative
GB1467383A (en) *	1974-06-12	1977-03-16	Farmaceutici Italia	Daunomycin analogues
GB1500421A (en) *	1975-01-22	1978-02-08	Farmaceutici Italia	Optically active anthracyclinones
GB1509875A (en) *	1976-06-14	1978-05-04	Farmaceutici Italia	Optically active anthracyclinones and anthracycline glycosides
GB1527050A (en) *	1976-06-19	1978-10-04	Farmaceutici Italia	Optically active anthracyclinones
GB8317037D0 (en) *	1983-06-23	1983-07-27	Erba Farmitalia	6-deoxyanthracyclines
US4495103A (en) *	1982-07-30	1985-01-22	Sumitomo Chemical Company, Ltd.	Preparation of optically active 4-demethoxydaunomycinone
EP0159357B1 (en) *	1983-10-19	1992-09-09	The University Of Melbourne	Carminomycinone precursors and analogues and derivatives thereof
NZ224252A (en) *	1987-04-21	1991-09-25	Erba Carlo Spa	An anthracycline glycoside and its preparation
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
GB8824947D0 (en) *	1988-10-25	1988-11-30	Erba Carlo Spa	New 4-substituted anthracyclinones & process for preparing them

1988
- 1988-02-12 GB GB888803301A patent/GB8803301D0/en active Pending
1989
- 1989-02-06 PH PH38165A patent/PH27328A/en unknown
- 1989-02-06 US US07/306,559 patent/US5015745A/en not_active Expired - Lifetime
- 1989-02-07 CS CS80789A patent/CS273198B2/cs unknown
- 1989-02-07 IE IE38389A patent/IE62954B1/en not_active IP Right Cessation
- 1989-02-07 IL IL8919889A patent/IL89198A/en not_active IP Right Cessation
- 1989-02-07 NZ NZ227873A patent/NZ227873A/xx unknown
- 1989-02-08 YU YU31089A patent/YU47206B/sh unknown
- 1989-02-08 AU AU29745/89A patent/AU605960B2/en not_active Ceased
- 1989-02-08 KR KR1019890001402A patent/KR970000484B1/ko not_active Expired - Fee Related
- 1989-02-09 PT PT89663A patent/PT89663B/pt not_active IP Right Cessation
- 1989-02-09 ZA ZA891018A patent/ZA891018B/xx unknown
- 1989-02-09 RU SU894613419A patent/RU1819256C/ru not_active IP Right Cessation
- 1989-02-09 FI FI890612A patent/FI92186C/fi active IP Right Grant
- 1989-02-09 NO NO890566A patent/NO169483C/no unknown
- 1989-02-09 UA UA4613419A patent/UA19151A/uk unknown
- 1989-02-09 JP JP1030929A patent/JP2784202B2/ja not_active Expired - Fee Related
- 1989-02-10 CA CA000590705A patent/CA1339634C/en not_active Expired - Fee Related
- 1989-02-10 ES ES89301282T patent/ES2059718T3/es not_active Expired - Lifetime
- 1989-02-10 AT AT89301282T patent/ATE92457T1/de not_active IP Right Cessation
- 1989-02-10 CN CN89100740A patent/CN1020592C/zh not_active Expired - Fee Related
- 1989-02-10 EP EP89301282A patent/EP0328399B1/en not_active Expired - Lifetime
- 1989-02-10 MY MYPI89000165A patent/MY104941A/en unknown
- 1989-02-10 DE DE89301282T patent/DE68907934T2/de not_active Expired - Fee Related
- 1989-02-10 DK DK063889A patent/DK170248B1/da not_active IP Right Cessation
- 1989-02-10 HU HU89630A patent/HU200979B/hu unknown

Also Published As

Publication number	Publication date
EP0328399A3 (en)	1990-03-07
CS273198B2 (en)	1991-03-12
NO890566L (no)	1989-08-11
JPH021423A (ja)	1990-01-05
CS80789A2 (en)	1990-06-13
UA19151A (uk)	1997-12-25
FI92186B (fi)	1994-06-30
PH27328A (en)	1993-06-08
CN1037152A (zh)	1989-11-15
EP0328399B1 (en)	1993-08-04
PT89663B (pt)	1994-02-28
EP0328399A2 (en)	1989-08-16
KR890012931A (ko)	1989-09-20
HUT49319A (en)	1989-09-28
NO890566D0 (no)	1989-02-09
FI890612L (fi)	1989-08-13
HU200979B (en)	1990-09-28
NO169483C (no)	1992-07-01
IE62954B1 (en)	1995-02-20
IL89198A0 (en)	1989-09-10
CA1339634C (en)	1998-01-20
ATE92457T1 (de)	1993-08-15
JP2784202B2 (ja)	1998-08-06
DK170248B1 (da)	1995-07-17
FI92186C (fi)	1994-10-10
DE68907934D1 (de)	1993-09-09
GB8803301D0 (en)	1988-03-09
DE68907934T2 (de)	1994-04-28
DK63889A (da)	1989-08-13
IE890383L (en)	1989-08-12
MY104941A (en)	1994-07-30
DK63889D0 (da)	1989-02-10
US5015745A (en)	1991-05-14
NO169483B (no)	1992-03-23
AU605960B2 (en)	1991-01-24
FI890612A0 (fi)	1989-02-09
IL89198A (en)	1994-10-07
AU2974589A (en)	1989-08-17
KR970000484B1 (ko)	1997-01-13
YU47206B (sh)	1995-01-31
YU31089A (en)	1990-08-31
ZA891018B (en)	1989-10-25
NZ227873A (en)	1990-09-26
CN1020592C (zh)	1993-05-12
ES2059718T3 (es)	1994-11-16
RU1819256C (en)	1993-05-30

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Legal Events

Date	Code	Title	Description
1994-02-28	FG3A	Patent granted, date of granting	Effective date: 19930809
1997-03-31	PC3A	Transfer or assignment	Free format text: 961212 PHARMACIA & UPJOHN S.P.A. IT
1997-03-31	TE3A	Change of address (patent)
2008-02-25	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20080211
2009-02-17	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090209