ATE92457T1 - Verfahren zur herstellung von 4demethoxydaunomycinon, das aglycon von 4demethoxydaunorubicin. - Google Patents

Verfahren zur herstellung von 4demethoxydaunomycinon, das aglycon von 4demethoxydaunorubicin.

Info

Publication number: ATE92457T1
Authority: AT; Austria
Prior art keywords: daunomycinone; group; aglycone; amino; demethoxy
Prior art date: 1988-02-12

Application number

AT89301282T

Other languages

English (en)

Inventor

Bernardinis Silvia De

Walter Cabri

Tiziano Martinengo

Franco Francalanci

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-12

Filing date

1989-02-10

Publication date

1993-08-15

1989-02-10 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1993-08-15 Application granted granted Critical

1993-08-15 Publication of ATE92457T1 publication Critical patent/ATE92457T1/de

Links

ZUFQFGSMHXKORU-UHFFFAOYSA-N 9-acetyl-6,7,9,11-tetrahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C1C(O)CC(C(=O)C)(O)CC1=C2O ZUFQFGSMHXKORU-UHFFFAOYSA-N 0.000 title abstract 2
TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 title abstract 2
PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 title abstract 2
XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 title abstract 2
XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 title abstract 2
PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 title abstract 2
229960000908 idarubicin Drugs 0.000 title abstract 2
XYDJGVROLWFENK-YBTHPKLGSA-N (7s,9s)-9-acetyl-4,6,7,9,11-pentahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=C(O)C=CC=C2C(=O)C2=C1C(O)=C1[C@@H](O)C[C@@](C(=O)C)(O)CC1=C2O XYDJGVROLWFENK-YBTHPKLGSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000001989 diazonium salts Chemical class 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/38—Quinones containing —CHO or non—quinoid keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT89301282T 1988-02-12 1989-02-10 Verfahren zur herstellung von 4demethoxydaunomycinon, das aglycon von 4demethoxydaunorubicin. ATE92457T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB888803301A GB8803301D0 (en)	1988-02-12	1988-02-12	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
EP89301282A EP0328399B1 (de)	1988-02-12	1989-02-10	Verfahren zur Herstellung von 4-Demethoxydaunomycinon, das Aglycon von 4-Demethoxydaunorubicin

Publications (1)

Publication Number	Publication Date
ATE92457T1 true ATE92457T1 (de)	1993-08-15

Family

ID=10631620

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89301282T ATE92457T1 (de)	1988-02-12	1989-02-10	Verfahren zur herstellung von 4demethoxydaunomycinon, das aglycon von 4demethoxydaunorubicin.

Country Status (26)

Country	Link
US (1)	US5015745A (de)
EP (1)	EP0328399B1 (de)
JP (1)	JP2784202B2 (de)
KR (1)	KR970000484B1 (de)
CN (1)	CN1020592C (de)
AT (1)	ATE92457T1 (de)
AU (1)	AU605960B2 (de)
CA (1)	CA1339634C (de)
CS (1)	CS273198B2 (de)
DE (1)	DE68907934T2 (de)
DK (1)	DK170248B1 (de)
ES (1)	ES2059718T3 (de)
FI (1)	FI92186C (de)
GB (1)	GB8803301D0 (de)
HU (1)	HU200979B (de)
IE (1)	IE62954B1 (de)
IL (1)	IL89198A (de)
MY (1)	MY104941A (de)
NO (1)	NO169483C (de)
NZ (1)	NZ227873A (de)
PH (1)	PH27328A (de)
PT (1)	PT89663B (de)
RU (1)	RU1819256C (de)
UA (1)	UA19151A (de)
YU (1)	YU47206B (de)
ZA (1)	ZA891018B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ224252A (en) *	1987-04-21	1991-09-25	Erba Carlo Spa	An anthracycline glycoside and its preparation
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
IT1275953B1 (it) *	1995-03-22	1997-10-24	Sicor Spa	Procedimento per la preparazione di antibiotici della classe delle antracicline
AUPQ319799A0 (en) *	1999-10-01	1999-10-28	Institute Of Drug Technology Australia Limited	Chemical methods
US7053191B2 (en)	2003-05-21	2006-05-30	Solux Corporation	Method of preparing 4-R-substituted 4-demethoxydaunorubicin
TW200621698A (en) *	2004-08-23	2006-07-01	Sicor Inc	Synthesis of idarubicin aglycone
DE06848583T1 (de)	2005-12-13	2011-03-17	Solux Corporation, San Diego	Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en)	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en)	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en)	2011-04-29	2014-09-30	Synbias Pharma Ag	Method of producing 4-demethoxydaunorubicin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3862225A (en) *	1961-08-18	1975-01-21	Pfizer	D-ring substituted tetracyclines
US4020270A (en) *	1974-05-02	1977-04-26	Societa' Farmaceutici Italia S.P.A.	L-lyxohex-1-enopyranose derivative
GB1467383A (en) *	1974-06-12	1977-03-16	Farmaceutici Italia	Daunomycin analogues
GB1500421A (en) *	1975-01-22	1978-02-08	Farmaceutici Italia	Optically active anthracyclinones
GB1509875A (en) *	1976-06-14	1978-05-04	Farmaceutici Italia	Optically active anthracyclinones and anthracycline glycosides
GB1527050A (en) *	1976-06-19	1978-10-04	Farmaceutici Italia	Optically active anthracyclinones
GB8317037D0 (en) *	1983-06-23	1983-07-27	Erba Farmitalia	6-deoxyanthracyclines
US4495103A (en) *	1982-07-30	1985-01-22	Sumitomo Chemical Company, Ltd.	Preparation of optically active 4-demethoxydaunomycinone
EP0159357B1 (de) *	1983-10-19	1992-09-09	The University Of Melbourne	Karminomycinonvorläufer und anlage sowie deren abkömmlinge
NZ224252A (en) *	1987-04-21	1991-09-25	Erba Carlo Spa	An anthracycline glycoside and its preparation
GB8808475D0 (en) *	1988-04-11	1988-05-11	Erba Carlo Spa	Process for preparing 4-demethoxydauno-mycinone
GB8824947D0 (en) *	1988-10-25	1988-11-30	Erba Carlo Spa	New 4-substituted anthracyclinones & process for preparing them

1988
- 1988-02-12 GB GB888803301A patent/GB8803301D0/en active Pending
1989
- 1989-02-06 US US07/306,559 patent/US5015745A/en not_active Expired - Lifetime
- 1989-02-06 PH PH38165A patent/PH27328A/en unknown
- 1989-02-07 IL IL8919889A patent/IL89198A/en not_active IP Right Cessation
- 1989-02-07 CS CS80789A patent/CS273198B2/cs unknown
- 1989-02-07 IE IE38389A patent/IE62954B1/en not_active IP Right Cessation
- 1989-02-07 NZ NZ227873A patent/NZ227873A/xx unknown
- 1989-02-08 KR KR1019890001402A patent/KR970000484B1/ko not_active Expired - Fee Related
- 1989-02-08 AU AU29745/89A patent/AU605960B2/en not_active Ceased
- 1989-02-08 YU YU31089A patent/YU47206B/sh unknown
- 1989-02-09 ZA ZA891018A patent/ZA891018B/xx unknown
- 1989-02-09 NO NO890566A patent/NO169483C/no unknown
- 1989-02-09 PT PT89663A patent/PT89663B/pt not_active IP Right Cessation
- 1989-02-09 JP JP1030929A patent/JP2784202B2/ja not_active Expired - Fee Related
- 1989-02-09 UA UA4613419A patent/UA19151A/uk unknown
- 1989-02-09 FI FI890612A patent/FI92186C/fi active IP Right Grant
- 1989-02-09 RU SU894613419A patent/RU1819256C/ru not_active IP Right Cessation
- 1989-02-10 AT AT89301282T patent/ATE92457T1/de not_active IP Right Cessation
- 1989-02-10 ES ES89301282T patent/ES2059718T3/es not_active Expired - Lifetime
- 1989-02-10 MY MYPI89000165A patent/MY104941A/en unknown
- 1989-02-10 HU HU89630A patent/HU200979B/hu unknown
- 1989-02-10 CN CN89100740A patent/CN1020592C/zh not_active Expired - Fee Related
- 1989-02-10 EP EP89301282A patent/EP0328399B1/de not_active Expired - Lifetime
- 1989-02-10 DK DK063889A patent/DK170248B1/da not_active IP Right Cessation
- 1989-02-10 DE DE89301282T patent/DE68907934T2/de not_active Expired - Fee Related
- 1989-02-10 CA CA000590705A patent/CA1339634C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RU1819256C (en)	1993-05-30
KR890012931A (ko)	1989-09-20
DK63889D0 (da)	1989-02-10
UA19151A (uk)	1997-12-25
FI92186C (fi)	1994-10-10
ZA891018B (en)	1989-10-25
HU200979B (en)	1990-09-28
CS273198B2 (en)	1991-03-12
NO169483C (no)	1992-07-01
EP0328399A2 (de)	1989-08-16
FI890612A0 (fi)	1989-02-09
US5015745A (en)	1991-05-14
IE62954B1 (en)	1995-02-20
EP0328399B1 (de)	1993-08-04
CS80789A2 (en)	1990-06-13
NO890566D0 (no)	1989-02-09
KR970000484B1 (ko)	1997-01-13
ES2059718T3 (es)	1994-11-16
JP2784202B2 (ja)	1998-08-06
YU31089A (en)	1990-08-31
FI92186B (fi)	1994-06-30
IE890383L (en)	1989-08-12
AU605960B2 (en)	1991-01-24
NZ227873A (en)	1990-09-26
HUT49319A (en)	1989-09-28
DE68907934D1 (de)	1993-09-09
NO890566L (no)	1989-08-11
GB8803301D0 (en)	1988-03-09
DK63889A (da)	1989-08-13
EP0328399A3 (en)	1990-03-07
IL89198A (en)	1994-10-07
PT89663A (pt)	1989-10-04
DK170248B1 (da)	1995-07-17
IL89198A0 (en)	1989-09-10
CN1037152A (zh)	1989-11-15
JPH021423A (ja)	1990-01-05
CA1339634C (en)	1998-01-20
NO169483B (no)	1992-03-23
MY104941A (en)	1994-07-30
DE68907934T2 (de)	1994-04-28
PH27328A (en)	1993-06-08
PT89663B (pt)	1994-02-28
FI890612L (fi)	1989-08-13
CN1020592C (zh)	1993-05-12
AU2974589A (en)	1989-08-17
YU47206B (sh)	1995-01-31

Legal Events

Date	Code	Title
1994-05-15	UEP	Publication of translation of european patent specification
1997-04-15	EEIH	Change in the person of patent owner
2007-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NO2004007I1 (no)	2004-12-20	Nebivolol-hydroklorid er det genriske oaviibttit den-folgenderacemiske blanding: (+)Ä(srrr)+(rsss) of, 9EÄiminobis(metylen)bisÄ6-ftto-3,4-dihydro-2H -1-benzopyran-2-metanolÜhydroklorid, som har den felgende struktur:
NO304945B1 (no)	1999-03-08	Forbindelse og anvendelse derav for Õ regulere fethet i hud, samt kosmetisk blanding
ATE89823T1 (de)	1993-06-15	Verfahren zur herstellung von baccatin-iiiderivaten und von desacetyl-10-baccatin-iii.
DE69420975D1 (de)	1999-11-04	Amido-siladiylverbrückte katalysatorkomponente, verfahren zur herstellung und verwendung
ATE66229T1 (de)	1991-08-15	Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin.
FR2629818B1 (fr)	1990-11-16	Procede de preparation du taxol
ATE148501T1 (de)	1997-02-15	Durch aromaten substituiertes glykosid
DE68907934D1 (de)	1993-09-09	Verfahren zur herstellung von 4-demethoxydaunomycinon, das aglycon von 4-demethoxydaunorubicin.
PT98205A (pt)	1992-05-29	Processo para a preparacao de novos derivados beta-lactamicos
KR830007549A (ko)	1983-10-21	2-옥소아제티딘 유도체의 제법
DE69403210D1 (de)	1997-06-19	Verfahren zur herstellung von n-acetylneuraminsäure
DE68904797D1 (de)	1993-03-25	Verfahren zur herstellung von 4-demethoxydaunomycinon.
ATE152722T1 (de)	1997-05-15	Verfahren zur herstellung von 9-(2-hydroxy)- ethoxy-guanin
KR860007286A (ko)	1986-10-10	Grf 유도체의 제조방법
DE3676724D1 (de)	1991-02-14	Verfahren zur indirekten beleuchtung von innenraeumen im allgemeinen, insbesondere von sogenannten offenen arbeitsraeumen und system zur indirekten beleuchtung gemaess diesem verfahren.
PT88952A (pt)	1988-12-01	Processo para a preparacao de avermectinas etiladas
KR840008367A (ko)	1984-12-14	악타플라닌 항생물질의 제조방법
DE59006539D1 (de)	1994-09-01	Verfahren zur Herstellung von Cytosinen.
ATE57520T1 (de)	1990-11-15	Verfahren zur herstellung von bromierten bisphenolen.
KR930023321A (ko)	1993-12-18	6,10,14,18-테트라메틸-5,9,13,17-노나데카테트라엔-2-온의 제조방법
DE69108930D1 (de)	1995-05-18	Aus dalbaheptide hergestellte tetrapeptidantibiotika.
ATE13876T1 (de)	1985-07-15	Verfahren zur herstellung von cycloalkenonderivaten.
BR8805299A (pt)	1990-05-29	Processo enzimatico para producao de l,l-dipeptideo aspartame
RO96329A2 (ro)	1989-02-28	Derivati de 1,1'-oxibis-4n-fenoxiacetamidobenzen si procedeu pentru prepararea acestora