PH27444A - Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes - Google Patents

Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes

Info

Publication number: PH27444A
Authority: PH; Philippines
Prior art keywords: alkyl; substituted; aryl; tetrahydronaphthalenes; amino
Prior art date: 1989-02-27

Application number

PH40083A

Other languages

English (en)

Inventor

Michael Edward Flaugh

John Mehnert Schaus

Robert Daniel Titus

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-27

Filing date

1990-02-22

Publication date

1993-07-02

1990-02-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1993-07-02 Publication of PH27444A publication Critical patent/PH27444A/en

Links

LCGFVWKNXLRFIF-UHFFFAOYSA-N 1,2,3,4-tetrahydronaphthalen-2-amine Chemical class C1=CC=C2CC(N)CCC2=C1 LCGFVWKNXLRFIF-UHFFFAOYSA-N 0.000 title abstract 2
SVWDNDQOXZHBRM-UHFFFAOYSA-N 3,4-dihydro-2h-chromen-3-amine Chemical class C1=CC=C2CC(N)COC2=C1 SVWDNDQOXZHBRM-UHFFFAOYSA-N 0.000 title abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 abstract 1
102000017911 HTR1A Human genes 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000027455 binding Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/38—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

PH40083A 1989-02-27 1990-02-22 Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes PH27444A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US31575289A	1989-02-27	1989-02-27

Publications (1)

Publication Number	Publication Date
PH27444A true PH27444A (en)	1993-07-02

Family

ID=23225899

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH40083A PH27444A (en)	1989-02-27	1990-02-22	Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes

Country Status (21)

Country	Link
US (1)	US5637624A (ja)
EP (1)	EP0385658B1 (ja)
JP (2)	JP2954255B2 (ja)
KR (1)	KR900012890A (ja)
CN (2)	CN1031262C (ja)
AT (1)	ATE116289T1 (ja)
AU (1)	AU630671B2 (ja)
CA (2)	CA2362972A1 (ja)
DE (1)	DE69015384T2 (ja)
DK (1)	DK0385658T3 (ja)
ES (1)	ES2065478T3 (ja)
GR (1)	GR3015136T3 (ja)
HU (2)	HU209481B (ja)
IE (1)	IE65769B1 (ja)
IL (5)	IL93464A (ja)
MX (1)	MX19637A (ja)
NZ (1)	NZ232628A (ja)
PH (1)	PH27444A (ja)
PT (1)	PT93218B (ja)
RU (1)	RU1826966C (ja)
ZA (1)	ZA901277B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3837809A1 (de) *	1988-11-08	1990-05-10	Merck Patent Gmbh	Tetralinderivate
AU627027B2 (en) *	1989-04-27	1992-08-13	Pharmacia & Upjohn Company	Substituted 3-amino chromans
US5616610A (en) *	1989-12-22	1997-04-01	Astra Aktiebolag	(R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5420151A (en) *	1989-12-22	1995-05-30	Aktiebolaget Astra	Chroman derivatives
EP0471515B1 (en) *	1990-08-15	1997-03-05	Eli Lilly And Company	Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes
ES2041211B1 (es) *	1992-02-17	1994-05-16	Uriach & Cia Sa J	Procedimiento para la obtencion de nuevos dihidro y tetrahidronaftalenos.
SE9301732D0 (sv) *	1993-05-18	1993-05-18	Haakan Wilhelm Wikstroem	New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
GB9514417D0 (en) *	1995-07-14	1995-09-13	Iaf Biochem Int	Novel heterocyclic compounds for the treatment of pain and use thereof
IL133080A0 (en)	1997-07-01	2001-03-19	Pfizer	Sertraline salts and sustained-release dosage forms of sertraline
FR2792529B1 (fr) *	1999-04-26	2001-09-28	Sod Conseils Rech Applic	Nouvelles compositions pharmaceutiques comprenant des derives de 2-isoxazole-8-aminotetralines
WO2005037830A1 (en) *	2003-10-10	2005-04-28	Wyeth	Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands
KR20070088798A (ko) *	2004-12-21	2007-08-29	에프. 호프만-라 로슈 아게	크로만 유도체 및 그의 5-ｈｔ 수용체 리간드로서의 용도
CN101300246A (zh) *	2005-11-03	2008-11-05	弗·哈夫曼-拉罗切有限公司	作为5－ht6抑制剂的芳基磺酰基色满类化合物作为蛋白激酶抑制剂的吲哚基马来酰亚胺衍生物
EP2098511A1 (en)	2008-03-07	2009-09-09	Solvias AG	Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring
EP2338873A1 (en)	2009-12-22	2011-06-29	Gmeiner, Peter	New aminotetraline derivatives

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3253037A (en) *	1962-06-19	1966-05-24	Ciba Geigy Corp	N-2-alkynyl-amino-benzocylo-alkanes
US3709996A (en) *	1963-08-02	1973-01-09	Aspro Nicholas Ltd	Pharmaceutical compositions containing n-cyclopropyl-1-aminoindane compounds and adapted for administration to obtain inhibition of monoamine oxidase enzyme and process
GB1037014A (en) *	1963-08-02	1966-07-20	Aspro Nicholas Ltd	Derivatives of 1-aminoindane
US3637740A (en) *	1969-04-21	1972-01-25	Pfizer	Aminobenzocycloalkane compounds
US3758640A (en) *	1970-07-20	1973-09-11	Hooker Chemical Corp	Opolymer and a polyester polymer composition comprising vinylmonomer butadiene polymer graft c
US3929891A (en) *	1971-02-08	1975-12-30	Hoechst Ag	Reduction of halonitroaromates using sulfited platinum on carbon catalysts
SE8004002L (sv) *	1980-05-29	1981-11-30	Arvidsson Folke Lars Erik	Terapeutiskt anvendbara tetralinderivat
US4320148A (en) *	1980-11-24	1982-03-16	Smithkline Corporation	2-Aminotetralin compounds, pharmaceutical compositions and method of producing central alpha1 agonist activity
JPH01503777A (ja) *	1985-10-04	1989-12-21	マツジヨ‐ニ‐ウインスロツプ・ソチエタ・ペル・アチオニ	縮合脂環式アミノアルコール類
SE8605504D0 (sv) *	1986-12-19	1986-12-19	Astra Laekemedel Ab	Novel chroman derivatives
DE3719924A1 (de) *	1986-12-22	1988-06-30	Bayer Ag	8-substituierte 2-aminotetraline
CA1331191C (en) *	1988-03-25	1994-08-02	Bengt Ronny Andersson	Therapeutically useful tetralin derivatives
DK0452390T3 (da) *	1989-01-09	1995-04-03	Upjohn Co	Halogensubstituerede aminotetraliner
JP2885317B2 (ja) *	1989-01-31	1999-04-19	三菱化学株式会社	耐衝撃熱可塑性樹脂組成物の製造方法

1990
- 1990-02-20 IL IL9346490A patent/IL93464A/en not_active IP Right Cessation
- 1990-02-20 IL IL109647A patent/IL109647A/xx not_active IP Right Cessation
- 1990-02-20 ZA ZA901277A patent/ZA901277B/xx unknown
- 1990-02-20 IL IL11471590A patent/IL114715A/xx not_active IP Right Cessation
- 1990-02-21 CA CA002362972A patent/CA2362972A1/en not_active Abandoned
- 1990-02-21 CA CA002010542A patent/CA2010542C/en not_active Expired - Fee Related
- 1990-02-21 PT PT93218A patent/PT93218B/pt not_active IP Right Cessation
- 1990-02-21 NZ NZ232628A patent/NZ232628A/en unknown
- 1990-02-22 PH PH40083A patent/PH27444A/en unknown
- 1990-02-22 DK DK90301901.6T patent/DK0385658T3/da active
- 1990-02-22 DE DE69015384T patent/DE69015384T2/de not_active Expired - Fee Related
- 1990-02-22 AT AT90301901T patent/ATE116289T1/de not_active IP Right Cessation
- 1990-02-22 EP EP90301901A patent/EP0385658B1/en not_active Expired - Lifetime
- 1990-02-22 ES ES90301901T patent/ES2065478T3/es not_active Expired - Lifetime
- 1990-02-23 KR KR1019900002287A patent/KR900012890A/ko not_active Ceased
- 1990-02-23 AU AU50144/90A patent/AU630671B2/en not_active Ceased
- 1990-02-23 JP JP2044308A patent/JP2954255B2/ja not_active Expired - Fee Related
- 1990-02-23 MX MX1963790A patent/MX19637A/es unknown
- 1990-02-26 HU HU901048A patent/HU209481B/hu not_active IP Right Cessation
- 1990-02-26 CN CN90100962A patent/CN1031262C/zh not_active Expired - Fee Related
- 1990-02-26 HU HU9202449A patent/HU221625B1/hu not_active IP Right Cessation
- 1990-02-26 RU SU4743297A patent/RU1826966C/ru active
- 1990-02-26 IE IE68490A patent/IE65769B1/en not_active IP Right Cessation
1993
- 1993-03-09 US US08/028,642 patent/US5637624A/en not_active Expired - Fee Related
1994
- 1994-05-12 IL IL10964794A patent/IL109647A0/xx unknown
1995
- 1995-02-22 GR GR950400356T patent/GR3015136T3/el unknown
- 1995-05-27 CN CN95106177A patent/CN1051990C/zh not_active Expired - Fee Related
- 1995-07-24 IL IL11471595A patent/IL114715A0/xx unknown
1999
- 1999-01-12 JP JP11005156A patent/JP3000016B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5637624A (en)	1997-06-10
JP2954255B2 (ja)	1999-09-27
IL93464A (en)	1996-10-16
HU901048D0 (en)	1990-05-28
CA2010542C (en)	2002-05-14
IL93464A0 (en)	1990-11-29
EP0385658B1 (en)	1994-12-28
JP3000016B2 (ja)	2000-01-17
IL109647A0 (en)	1994-08-26
ES2065478T3 (es)	1995-02-16
HU209481B (en)	1994-06-28
RU1826966C (ru)	1993-07-07
IE900684L (en)	1990-08-27
JPH02268151A (ja)	1990-11-01
JPH11315063A (ja)	1999-11-16
NZ232628A (en)	1992-03-26
PT93218B (pt)	1996-03-29
PT93218A (pt)	1990-08-31
KR900012890A (ko)	1990-09-03
CA2010542A1 (en)	1990-08-27
AU5014490A (en)	1990-10-25
CN1045099A (zh)	1990-09-05
DE69015384D1 (de)	1995-02-09
IL109647A (en)	1997-04-15
CN1120532A (zh)	1996-04-17
MX19637A (es)	1994-02-28
CA2362972A1 (en)	1990-08-27
IL114715A0 (en)	1995-11-27
AU630671B2 (en)	1992-11-05
HU221625B1 (hu)	2002-12-28
HUT65268A (en)	1994-05-02
DK0385658T3 (da)	1995-02-20
GR3015136T3 (en)	1995-05-31
CN1031262C (zh)	1996-03-13
DE69015384T2 (de)	1995-05-18
HUT53354A (en)	1990-10-28
HU9202449D0 (en)	1992-12-28
CN1051990C (zh)	2000-05-03
ZA901277B (en)	1991-10-30
IE65769B1 (en)	1995-11-15
ATE116289T1 (de)	1995-01-15
EP0385658A1 (en)	1990-09-05
IL114715A (en)	1997-01-10

Publication	Publication Date	Title
AU630671B2 (en)	1992-11-05	Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes
MY116454A (en)	2004-02-28	Ring-substituted 2-amino-1, 2,3,4-tetra- hydronaphthalenes and 3-aminochromanes.
AU5595490A (en)	1990-11-29	Antispasmodic agents
DE3880022D1 (de)	1993-05-13	Cycloalkylamide von (8beta)-1-alkyl-6-(substituierten) ergolinen.
FI904512A0 (fi)	1990-09-13	Menetelmä lääkeaineina käytettävien 1,3-tiatsolidinien -karbonyylikarboksiamidien valmistamiseksi
DK0556813T3 (da)	1998-08-10	Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler
DK424888D0 (da)	1988-07-29	Naphthothiazepinderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende saadanne derivater
ZA906445B (en)	1992-04-29	New 1,3-oxazines
EP0298543A3 (en)	1991-02-13	Thiapentanamide derivatives
EP1325913A3 (en)	2003-10-08	Piperidinecarboxylic acid amide derivatives
ATE91487T1 (de)	1993-07-15	Dibenzodioxazecin- und dibenzodioxaazacycloundecin-derivate.